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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DOCK8-OSBP (FusionGDB2 ID:23840) |
Fusion Gene Summary for DOCK8-OSBP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK8-OSBP | Fusion gene ID: 23840 | Hgene | Tgene | Gene symbol | DOCK8 | OSBP | Gene ID | 81704 | 5007 |
| Gene name | dedicator of cytokinesis 8 | oxysterol binding protein | |
| Synonyms | HEL-205|MRD2|ZIR8 | OSBP1 | |
| Cytomap | 9p24.3 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 81200017A24Rikepididymis luminal protein 205 | oxysterol-binding protein 1 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000382329, ENST00000382331, ENST00000432829, ENST00000453981, ENST00000469391, ENST00000493666, | ENST00000263847, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK8 [Title/Abstract] AND OSBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DOCK8(390566)-OSBP(59369311), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DOCK8 | GO:0043547 | positive regulation of GTPase activity | 28028151 |
| Tgene | OSBP | GO:0015918 | sterol transport | 24209621 |
| Fusion gene breakpoints across DOCK8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across OSBP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-83-5908-01A | DOCK8 | chr9 | 390566 | - | OSBP | chr11 | 59369311 | - |
| ChimerDB4 | LUAD | TCGA-83-5908-01A | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
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Fusion Gene ORF analysis for DOCK8-OSBP |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000382329 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| In-frame | ENST00000382331 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| In-frame | ENST00000432829 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| In-frame | ENST00000453981 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| In-frame | ENST00000469391 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| intron-3CDS | ENST00000493666 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000453981 | DOCK8 | chr9 | 390566 | + | ENST00000263847 | OSBP | chr11 | 59369311 | - | 6863 | 3082 | 112 | 4683 | 1523 |
| ENST00000432829 | DOCK8 | chr9 | 390566 | + | ENST00000263847 | OSBP | chr11 | 59369311 | - | 6863 | 3082 | 112 | 4683 | 1523 |
| ENST00000469391 | DOCK8 | chr9 | 390566 | + | ENST00000263847 | OSBP | chr11 | 59369311 | - | 6530 | 2749 | 76 | 4350 | 1424 |
| ENST00000382331 | DOCK8 | chr9 | 390566 | + | ENST00000263847 | OSBP | chr11 | 59369311 | - | 5257 | 1476 | 516 | 3077 | 853 |
| ENST00000382329 | DOCK8 | chr9 | 390566 | + | ENST00000263847 | OSBP | chr11 | 59369311 | - | 5539 | 1758 | 252 | 3359 | 1035 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000453981 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - | 0.00061416 | 0.99938583 |
| ENST00000432829 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - | 0.00061416 | 0.99938583 |
| ENST00000469391 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - | 0.000268614 | 0.99973136 |
| ENST00000382331 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - | 0.001211235 | 0.9987888 |
| ENST00000382329 | ENST00000263847 | DOCK8 | chr9 | 390566 | + | OSBP | chr11 | 59369311 | - | 0.000543748 | 0.9994562 |
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Fusion Genomic Features for DOCK8-OSBP |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DOCK8-OSBP |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:390566/chr11:59369311) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000432829 | + | 24 | 48 | 560_729 | 922 | 2032.0 | Domain | C2 DOCK-type |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000453981 | + | 24 | 48 | 560_729 | 990 | 2100.0 | Domain | C2 DOCK-type |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000469391 | + | 22 | 46 | 560_729 | 890 | 2000.0 | Domain | C2 DOCK-type |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 291_326 | 274 | 808.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 730_760 | 274 | 808.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 358_364 | 274 | 808.0 | Motif | FFAT | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 406_457 | 274 | 808.0 | Region | Sterol binding | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 493_496 | 274 | 808.0 | Region | Phosphatidylinositol 4-phosphate binding | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 522_523 | 274 | 808.0 | Region | Phosphatidylinositol 4-phosphate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000432829 | + | 24 | 48 | 1632_2066 | 922 | 2032.0 | Domain | DOCKER |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000453981 | + | 24 | 48 | 1632_2066 | 990 | 2100.0 | Domain | DOCKER |
| Hgene | DOCK8 | chr9:390566 | chr11:59369311 | ENST00000469391 | + | 22 | 46 | 1632_2066 | 890 | 2000.0 | Domain | DOCKER |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 1_93 | 274 | 808.0 | Compositional bias | Note=Ala/Gly-rich | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 88_181 | 274 | 808.0 | Domain | PH | |
| Tgene | OSBP | chr9:390566 | chr11:59369311 | ENST00000263847 | 2 | 14 | 117_122 | 274 | 808.0 | Region | Phosphatidylinositol 4-phosphate binding |
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Fusion Gene Sequence for DOCK8-OSBP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >23840_23840_1_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000382329_OSBP_chr11_59369311_ENST00000263847_length(transcript)=5539nt_BP=1758nt AGAAAGTCACAGGGTACAGCAACTCATACTTGCTCCCAGCACCAGGCCAGCCCCATTCTGCCTCCAGGGAGTCACCCAAAATAGAGAGAT GAGGGTAAAATAAGACCTAGGAATACTATTTATTTGCCTCCATGGCCTTTGAACTTGCACATCCAACGTAACGGCTCCTGTGTGTTCTTG ATTGTTCCAATTATCATTTTTCCTCTCGAATACCTGAGAGCATTCATTATTTTGCAAGAGATTTGAGAATCCCTGTGCCCTAACTTTTCT TTCCTTGATGTGGGATGTTCTTCTGTGACTAGAAACCTTCTCTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCC CGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAGATGCTAGCAATGCGATGCCGGTAAGGAGGGAAACGAACATTTGCCTCAAA TCAGGGTGGGCTGCTCACCCCTGTCACTTCACACAAGTCCGGGACTCATCAGTGTACAAAGTCCGTCTATTCCAGGCCAATACTGCTCAG CATGTGCAAGGGCTTCTGTGCCCAGGATATCAGTGGGGAAACAGGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTG TACACAGCTGTTACATACCATAATAAGTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCAC CTCCTGTTCACCTTCTACCATATCAGCTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTC TTAAATGAACGTCTTCAAACTGGATCCTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAA GTCCCATTACAGAATCCTCCCATTAAGTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACC CAGGACAACCACCTGGAGAAGTTCTTCACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATC AGCGAGATGGCGCTGGAGCATGAGCTGAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTG GTGCTGGACAAGCTCTTCCAGCTGTCCGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTG GTGGCCATCGCCAACAGTCTGCACAACAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTAC GTCTTCCGCCTGCCAGAGGTGCAAAGGGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGC CGCACATCAGCTGCTGCTGTGAGTTCAAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCA GCAGACGAGGAAGTGAAGAACATCATGTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGAT GCTCCAAGTTCACCTGCAGCCCCAAGGCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATG GTGAGAGAAACAGTCTTCAAGTATGCCTGGTTCTTCTTTGAGCTTCTGGCCTGCAGAGATTTCCTCATGTTAGCCCAGACCCATAGTAAA AAATGGCAAAAGTCACTACAGTATGAAAGAGACCAGCGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCTG GAGAGGGCCTTCCGAGGAGCCACGGTGCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAAGATCAGTGCTGCTCTGGCAAAGGG GACATGAGCGATGAAGATGATGAGAATGAATTTTTTGATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGGC AGCAATATCAGTGGAGCCAGCAGTGACATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAGACCAAAAAGGAAAAGAGAACCAGA ATACCATACAAGCCAAACTATAGCCTCAATTTATGGAGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGTA AACTTTAATGAGCCCTTGTCCATGCTTCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTAGACCGAGCTGCAAAATGTGAGAAT TCTCTAGAACAGCTCTGTTATGTTGCAGCTTTCACCGTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACTG CTTGGGGAGACCTTTGAGCTGGACCGATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTGAGTCATCATCCCCCTGCTGCTGCG CACCATGCTGAGTCCAAAAATGGCTGGACATTGCGTCAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCCC CTCGGTACCATTCATTGTATTTTCCATGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACAACTGTACACAACATTATTGTGGGC AAGTTGTGGATAGATCAGTCTGGCGAAATTGATATTGTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTAC TTCTCTCGGGATGTAGCAAGAAAGGTGACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTTGCTCTTCTGGGGACGTGGGATGAG AAAATGGAATGTTTCAAAGTACAGCCAGTCATTGGGGAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGTC ATGCTGTGGAAAAGGAATCCTTTACCGAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCTCTGACTCTCAATGCTTGGGAAAGT GGCACTGCCCCCACAGACAGCCGGTTACGACCTGACCAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCGC CTGGAGGAAAAACAAAGACTTTCCAGAAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGATGGCACACCATATGATCCCTATAAG GCACTGTGGTTTGAGCGGAAGAAGGACCCTGTTACCAAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACAG GACTGGAGCTCATGCCCGGACATTTTCTGAAACGGCAGTAACAAAAAAGAGGAGCATATAATGGAGAAGAGGACAGAGGATGTGTGGGAA AGCTGGAAGTTGTGACTCTCTTACCAAGTGCTTTCCTCAAGTTTGTCTCTCTTGACCAATCATTTTTTCCAAATCAATCACCAGAAGGAG ACACCAGTGGTGGTGATTGGCTGGTTGCCTTAGCTGATTGAAACTGAAATCGACATAGGAGATACTATGTCTGTAAGGGAGAGGTTTAGT GGCCGAAGGTTAGTGTTATTCCACATCCACGAAGTCAAGTATTCTTGGCTCTTCTTTCTCCCTCTGCCCCCATTTAAGACAATGTCACTC ACCCTCCCCTTGTAGTATCCTGCTCAGCCAAGATCTGCCTAAGATTATGATTCAGGGGCATTTTGGTGCTGTTAAAAGCAAGAGCCGAAT TTAGAAGTTCCCTTAAAAAGAAACACATAAGACTTACCAATGGAGGCATTGTGAATGGTTGCAGTGGAGCTTAGGTATAACATCATCAAG TGTGTTCACACGCGGGGTCGGTTTAATGGAGTGTCCACGCGGAGATAACTGCGATATTGGAACACCTGTGAGAGAGATTGTTCTATAGGG CTGGAATATTCAGAGTTACATTCTTGGAAGTTTCTGTTTTTACTTGCATCAAACACCCCTCTGTTGTTCTCCATCATCTTTAATAGCAAC TGGAGACCACTTTGGTCATTGGTAAGGGGGTGCATTCTCCTCACAAAGGGGTTTTATGGACTTCCTCAGGCGGAGAGCTTCTGAGAACAC AGGCAGGATGGAAAAAGACTACTAGCCACTTTTGCTTTCCCAACCCCCCTTAATGCCATCCTTCATTGTCTTTCTGGCTTCTCTTCTTCT GGCACAGTACCATTTTGGGTCTGTGCCCCAGTGTGGAGCAAAACATTGCCTGTCCCATTCTGATATACTTCAGAATTTGAGAGCAGAAGT TAATGTGGAACAAAAGTTTTCACCATCTCTCAAGCCCCAAGGACTGGAGCCACCTCTGGAATAATGTGTTAAATATCTGTATATTATATA TATGTAGAGAAAAATCTAATTTTTTGGTTTGATTTCCTTCCCATTAAGAATCTTGTTTTTTGATACCCTTGTCTCCCTGAGACTCTTTCT TGGACACGTGTTGATGTGGATGGCACTCCTGCTCTCCATCTTTTATGGGCAGAGAGATTTCAAAACCTGAGCAGGATCATGTCTGGCAGT TACTAAACAGGGACTTTGTCCATGGTTTGTATCATGGGGTGCCTACTGCTGTCTAAACTCTGCTCTCCTAATTAGCTGACTCTTGAAAAT GAAATCCTAACCTCTTTCCTGCCTCTTTTCTTTCTCTTTTCAGGAAGAGTGTGGGTAGAAAGTCCGGAGGGCAACTTCCAATTTAATTCT GCTCTGTCCGGCGCATAGGCTGAATTCCAAAAGAACTTTCTTCCTAGGATGTGGGGCTTAAAGCACCGTCATGTGGGGTGGATCAGATAA TTGCTCCTGTGGGGCCCTGGCTTCCTTCTCTGTTTGTGCAGTATTTGTTTTTGTTGTCTTGTTGAGAAATATCCCCTGTGCAACCCACCC TTGGTTGAGGATCACAAATTGAGGTGCCTTCCTTGTATGCTTTTTGTTAGTATTTTTTGTTTTTGTTCCTTAACTGCTGAGCCTCAGCCA GCGTGGGTCCTGGGGGAAATACCATTCCAAAGGAAGCCATCCCTATGGGGAAATTGGTTTTACTGGGTAAATTAATACTTTTATTTCTTC CCCTATCCCTTCCTTCCTAGTTGTGATAAACATGGGAGAGGAGTGACTTTGACTGCTGGGGAATTTCCTCCTAAGAACCTTATTCCCAAA ATAAGCCAGGGATTATGTCAAGGCTTCTTTCAAGGAGGCTCATAAAAGCAGTGACCTCATCCGGGGCTTTGGATAGAGTGAGAATTCCCC AACTAAATTGGACTTCTCTGCTTTATCCCCTTCTCTTCCTTCACCATCTGCACTACATTTCTGGCTGATCCCAATCAGATTCCCGCTAAT GGAAGAAGTTTAGAATCTTTCAGGTGGAATAAAGTCACATGAAAACAAAACACAACTATATATATTTTCAGTTTTTTTGCCTTATTGATT >23840_23840_1_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000382329_OSBP_chr11_59369311_ENST00000263847_length(amino acids)=1035AA_BP=502 MCPNFSFLDVGCSSVTRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVRRETNICLKSGWAAHPCHFTQVRDSSVYKVRLF QANTAQHVQGLLCPGYQWGNRVIFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGY SWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIR VLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLL ASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYY CSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFELLACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLA KQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETK KEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTS KPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTV HNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHE AEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGT -------------------------------------------------------------- >23840_23840_2_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000382331_OSBP_chr11_59369311_ENST00000263847_length(transcript)=5257nt_BP=1476nt GAGTATTGTCACATATCAGCCCAGAAAGTCACAGGGTACAGCAACTCATACTTGCTCCCAGCACCAGGCCAGCCCCATTCTGCCTCCAGG GAGTCACCCAAAATAGAGAGATGAGGGTAAAATAAGACCTAGGAATACTATTTATTTGCCTCCATGGCCTTTGAACTTGCACATCCAACG TAACGGCTCCTGTGTGTTCTTGATTGTTCCAATTATCATTTTTCCTCTCGAATACCTGAGAGCATTCATTATTTTGCAAGAGATTTGAGA ATCCCTGTGCCCTAACTTTTCTTTCCTTGATGTGGGATGTTCTTCTGTGACTAGAAACCTTCTCTATGTCTACCCACAGAGGCTGAACTT TGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAGATGCTAGCAATGCGATGCCGGTCATCTT TGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACACAGCTGTTACATACCATAATAATGGCTGCCAATTCTCTTAAATGAACGT CTTCAAACTGGATCCTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCCCATTACAG AATCCTCCCATTAAGTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGGACAACCAC CTGGAGAAGTTCTTCACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCGAGATGGCG CTGGAGCATGAGCTGAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGCTGGACAAG CTCTTCCAGCTGTCCGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGGCCATCGCC AACAGTCTGCACAACAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCTTCCGCCTG CCAGAGGTGCAAAGGGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCACATCAGCT GCTGCTGTGAGTTCAAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAGACGAGGAA GTGAAGAACATCATGTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTCCAAGTTCA CCTGCAGCCCCAAGGCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGAGAGAAACA GTCTTCAAGTATGCCTGGTTCTTCTTTGAGCTTCTGGCCTGCAGAGATTTCCTCATGTTAGCCCAGACCCATAGTAAAAAATGGCAAAAG TCACTACAGTATGAAAGAGACCAGCGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCTGGAGAGGGCCTTC CGAGGAGCCACGGTGCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAAGATCAGTGCTGCTCTGGCAAAGGGGACATGAGCGAT GAAGATGATGAGAATGAATTTTTTGATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGGCAGCAATATCAGT GGAGCCAGCAGTGACATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAGACCAAAAAGGAAAAGAGAACCAGAATACCATACAAG CCAAACTATAGCCTCAATTTATGGAGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGTAAACTTTAATGAG CCCTTGTCCATGCTTCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTAGACCGAGCTGCAAAATGTGAGAATTCTCTAGAACAG CTCTGTTATGTTGCAGCTTTCACCGTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACTGCTTGGGGAGACC TTTGAGCTGGACCGATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTGAGTCATCATCCCCCTGCTGCTGCGCACCATGCTGAG TCCAAAAATGGCTGGACATTGCGTCAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCCCCTCGGTACCATT CATTGTATTTTCCATGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACAACTGTACACAACATTATTGTGGGCAAGTTGTGGATA GATCAGTCTGGCGAAATTGATATTGTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTACTTCTCTCGGGAT GTAGCAAGAAAGGTGACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTTGCTCTTCTGGGGACGTGGGATGAGAAAATGGAATGT TTCAAAGTACAGCCAGTCATTGGGGAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGTCATGCTGTGGAAA AGGAATCCTTTACCGAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCTCTGACTCTCAATGCTTGGGAAAGTGGCACTGCCCCC ACAGACAGCCGGTTACGACCTGACCAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCGCCTGGAGGAAAAA CAAAGACTTTCCAGAAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGATGGCACACCATATGATCCCTATAAGGCACTGTGGTTT GAGCGGAAGAAGGACCCTGTTACCAAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACAGGACTGGAGCTCA TGCCCGGACATTTTCTGAAACGGCAGTAACAAAAAAGAGGAGCATATAATGGAGAAGAGGACAGAGGATGTGTGGGAAAGCTGGAAGTTG TGACTCTCTTACCAAGTGCTTTCCTCAAGTTTGTCTCTCTTGACCAATCATTTTTTCCAAATCAATCACCAGAAGGAGACACCAGTGGTG GTGATTGGCTGGTTGCCTTAGCTGATTGAAACTGAAATCGACATAGGAGATACTATGTCTGTAAGGGAGAGGTTTAGTGGCCGAAGGTTA GTGTTATTCCACATCCACGAAGTCAAGTATTCTTGGCTCTTCTTTCTCCCTCTGCCCCCATTTAAGACAATGTCACTCACCCTCCCCTTG TAGTATCCTGCTCAGCCAAGATCTGCCTAAGATTATGATTCAGGGGCATTTTGGTGCTGTTAAAAGCAAGAGCCGAATTTAGAAGTTCCC TTAAAAAGAAACACATAAGACTTACCAATGGAGGCATTGTGAATGGTTGCAGTGGAGCTTAGGTATAACATCATCAAGTGTGTTCACACG CGGGGTCGGTTTAATGGAGTGTCCACGCGGAGATAACTGCGATATTGGAACACCTGTGAGAGAGATTGTTCTATAGGGCTGGAATATTCA GAGTTACATTCTTGGAAGTTTCTGTTTTTACTTGCATCAAACACCCCTCTGTTGTTCTCCATCATCTTTAATAGCAACTGGAGACCACTT TGGTCATTGGTAAGGGGGTGCATTCTCCTCACAAAGGGGTTTTATGGACTTCCTCAGGCGGAGAGCTTCTGAGAACACAGGCAGGATGGA AAAAGACTACTAGCCACTTTTGCTTTCCCAACCCCCCTTAATGCCATCCTTCATTGTCTTTCTGGCTTCTCTTCTTCTGGCACAGTACCA TTTTGGGTCTGTGCCCCAGTGTGGAGCAAAACATTGCCTGTCCCATTCTGATATACTTCAGAATTTGAGAGCAGAAGTTAATGTGGAACA AAAGTTTTCACCATCTCTCAAGCCCCAAGGACTGGAGCCACCTCTGGAATAATGTGTTAAATATCTGTATATTATATATATGTAGAGAAA AATCTAATTTTTTGGTTTGATTTCCTTCCCATTAAGAATCTTGTTTTTTGATACCCTTGTCTCCCTGAGACTCTTTCTTGGACACGTGTT GATGTGGATGGCACTCCTGCTCTCCATCTTTTATGGGCAGAGAGATTTCAAAACCTGAGCAGGATCATGTCTGGCAGTTACTAAACAGGG ACTTTGTCCATGGTTTGTATCATGGGGTGCCTACTGCTGTCTAAACTCTGCTCTCCTAATTAGCTGACTCTTGAAAATGAAATCCTAACC TCTTTCCTGCCTCTTTTCTTTCTCTTTTCAGGAAGAGTGTGGGTAGAAAGTCCGGAGGGCAACTTCCAATTTAATTCTGCTCTGTCCGGC GCATAGGCTGAATTCCAAAAGAACTTTCTTCCTAGGATGTGGGGCTTAAAGCACCGTCATGTGGGGTGGATCAGATAATTGCTCCTGTGG GGCCCTGGCTTCCTTCTCTGTTTGTGCAGTATTTGTTTTTGTTGTCTTGTTGAGAAATATCCCCTGTGCAACCCACCCTTGGTTGAGGAT CACAAATTGAGGTGCCTTCCTTGTATGCTTTTTGTTAGTATTTTTTGTTTTTGTTCCTTAACTGCTGAGCCTCAGCCAGCGTGGGTCCTG GGGGAAATACCATTCCAAAGGAAGCCATCCCTATGGGGAAATTGGTTTTACTGGGTAAATTAATACTTTTATTTCTTCCCCTATCCCTTC CTTCCTAGTTGTGATAAACATGGGAGAGGAGTGACTTTGACTGCTGGGGAATTTCCTCCTAAGAACCTTATTCCCAAAATAAGCCAGGGA TTATGTCAAGGCTTCTTTCAAGGAGGCTCATAAAAGCAGTGACCTCATCCGGGGCTTTGGATAGAGTGAGAATTCCCCAACTAAATTGGA CTTCTCTGCTTTATCCCCTTCTCTTCCTTCACCATCTGCACTACATTTCTGGCTGATCCCAATCAGATTCCCGCTAATGGAAGAAGTTTA GAATCTTTCAGGTGGAATAAAGTCACATGAAAACAAAACACAACTATATATATTTTCAGTTTTTTTGCCTTATTGATTTTTTTCCAAAAA >23840_23840_2_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000382331_OSBP_chr11_59369311_ENST00000263847_length(amino acids)=853AA_BP=320 MPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVL DQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLAS YVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCS GSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFELLACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQ HNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKE KRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKP FNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHN IIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAE ESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPY -------------------------------------------------------------- >23840_23840_3_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000432829_OSBP_chr11_59369311_ENST00000263847_length(transcript)=6863nt_BP=3082nt GACAGACGAGGTTTGCGCTTGGCTGGGCATGTTCCGCGGCTACTCTGCGGCGCGCCAGGCCCCCGCTTTCCGCACCCCGCGACCCTAGAA GCCACCGAACCGCCGGCGGGCCATGGCCACTCTGCCGAGCGCAGAGCGCCGCGCGTTCGCGCTCAAGATCAACAGGTATTCTTCAGCGGA AATAAGGAAACAGTTTACTCTCCCACCAAACCTTGGCCAGTACCATCGACAGAGCATAAGTACCTCTGGCTTCCCCTCTCTTCAACTACC TCAGTTTTATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCTGAACAGCCTGGATGTGCAGCTTGCCCAGGAGCT CGGGGACTTCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGACTTTGCAGCCCTCTTTGCCGGAGGAAGGGGTTGA ACTGGACCCTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGTGAACCGGAAAAACCAAGGAAGTCCAGAAATCTG TGGCTTTAAAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGACGTTTGAGTCGGAAACCTTGGAGTGCAGTGAACC CGCTGCTCAGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGGCCCCGTCACTGCCTGTGACTTTGACCTCCGCAG CCTGCAGCCTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTTTGAGAAGCAGAACGAGGAGGCCCGGAGGACCAA TAGGCAGGCCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGAAATACGTCCAGTACCAGAATGTCCCAAGGAACA CCTGGGCAACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGAGCCCCTGTTTGCCAGCATTGCCCTCTACGATGT TAAAGAAAGGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTTCAAAGGATTTCTGCGAGCTCACACGCCTTCAGT GGCCGCATCAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGACATCTACCTGGTAGTCAAGATTGAAAAAGTCCT GCAGCAGGGAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGATGGTGGAAAGAGTAAAGAAAAGATTGAAAAACT AAAACTCCAAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGCCTGGGCACCCATAAGCTTATCAAGCTTCTTCAA TGTCTCCACCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTCAGTGGGTGAACGGAGGACATTGGCCCAATCTAG AAGGCTTTCTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAAAACCTCCACTCTGAGCGTTAGCAGCTTTTTCAA GCAGGAAGGAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAAAAGATCATCATCCTTACAGAGACGAGTCAAGTC AATTCCAGGCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTGTCTGACTCCTGAAATGCTGCCCGTGAAACCCTT TCCTGAAAACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGTATATGTCCCTCACACTGTGTACAGAAACCTTCT CTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAGA TGCTAGCAATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACACAGCTGTTACATACCATAATAA GTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCACCTCCTGTTCACCTTCTACCATATCAG CTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTCTTAAATGAACGTCTTCAAACTGGATC CTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCCCATTACAGAATCCTCCCATTAA GTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGGACAACCACCTGGAGAAGTTCTT CACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCGAGATGGCGCTGGAGCATGAGCT GAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGCTGGACAAGCTCTTCCAGCTGTC CGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGGCCATCGCCAACAGTCTGCACAA CAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCTTCCGCCTGCCAGAGGTGCAAAG GGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCACATCAGCTGCTGCTGTGAGTTC AAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAGACGAGGAAGTGAAGAACATCAT GTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTCCAAGTTCACCTGCAGCCCCAAG GCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGAGAGAAACAGTCTTCAAGTATGC CTGGTTCTTCTTTGAGCTTCTGGCCTGCAGAGATTTCCTCATGTTAGCCCAGACCCATAGTAAAAAATGGCAAAAGTCACTACAGTATGA AAGAGACCAGCGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCTGGAGAGGGCCTTCCGAGGAGCCACGGT GCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAAGATCAGTGCTGCTCTGGCAAAGGGGACATGAGCGATGAAGATGATGAGAA TGAATTTTTTGATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGGCAGCAATATCAGTGGAGCCAGCAGTGA CATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAGACCAAAAAGGAAAAGAGAACCAGAATACCATACAAGCCAAACTATAGCCT CAATTTATGGAGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGTAAACTTTAATGAGCCCTTGTCCATGCT TCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTAGACCGAGCTGCAAAATGTGAGAATTCTCTAGAACAGCTCTGTTATGTTGC AGCTTTCACCGTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACTGCTTGGGGAGACCTTTGAGCTGGACCG ATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTGAGTCATCATCCCCCTGCTGCTGCGCACCATGCTGAGTCCAAAAATGGCTG GACATTGCGTCAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCCCCTCGGTACCATTCATTGTATTTTCCA TGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACAACTGTACACAACATTATTGTGGGCAAGTTGTGGATAGATCAGTCTGGCGA AATTGATATTGTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTACTTCTCTCGGGATGTAGCAAGAAAGGT GACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTTGCTCTTCTGGGGACGTGGGATGAGAAAATGGAATGTTTCAAAGTACAGCC AGTCATTGGGGAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGTCATGCTGTGGAAAAGGAATCCTTTACC GAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCTCTGACTCTCAATGCTTGGGAAAGTGGCACTGCCCCCACAGACAGCCGGTT ACGACCTGACCAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCGCCTGGAGGAAAAACAAAGACTTTCCAG AAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGATGGCACACCATATGATCCCTATAAGGCACTGTGGTTTGAGCGGAAGAAGGA CCCTGTTACCAAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACAGGACTGGAGCTCATGCCCGGACATTTT CTGAAACGGCAGTAACAAAAAAGAGGAGCATATAATGGAGAAGAGGACAGAGGATGTGTGGGAAAGCTGGAAGTTGTGACTCTCTTACCA AGTGCTTTCCTCAAGTTTGTCTCTCTTGACCAATCATTTTTTCCAAATCAATCACCAGAAGGAGACACCAGTGGTGGTGATTGGCTGGTT GCCTTAGCTGATTGAAACTGAAATCGACATAGGAGATACTATGTCTGTAAGGGAGAGGTTTAGTGGCCGAAGGTTAGTGTTATTCCACAT CCACGAAGTCAAGTATTCTTGGCTCTTCTTTCTCCCTCTGCCCCCATTTAAGACAATGTCACTCACCCTCCCCTTGTAGTATCCTGCTCA GCCAAGATCTGCCTAAGATTATGATTCAGGGGCATTTTGGTGCTGTTAAAAGCAAGAGCCGAATTTAGAAGTTCCCTTAAAAAGAAACAC ATAAGACTTACCAATGGAGGCATTGTGAATGGTTGCAGTGGAGCTTAGGTATAACATCATCAAGTGTGTTCACACGCGGGGTCGGTTTAA TGGAGTGTCCACGCGGAGATAACTGCGATATTGGAACACCTGTGAGAGAGATTGTTCTATAGGGCTGGAATATTCAGAGTTACATTCTTG GAAGTTTCTGTTTTTACTTGCATCAAACACCCCTCTGTTGTTCTCCATCATCTTTAATAGCAACTGGAGACCACTTTGGTCATTGGTAAG GGGGTGCATTCTCCTCACAAAGGGGTTTTATGGACTTCCTCAGGCGGAGAGCTTCTGAGAACACAGGCAGGATGGAAAAAGACTACTAGC CACTTTTGCTTTCCCAACCCCCCTTAATGCCATCCTTCATTGTCTTTCTGGCTTCTCTTCTTCTGGCACAGTACCATTTTGGGTCTGTGC CCCAGTGTGGAGCAAAACATTGCCTGTCCCATTCTGATATACTTCAGAATTTGAGAGCAGAAGTTAATGTGGAACAAAAGTTTTCACCAT CTCTCAAGCCCCAAGGACTGGAGCCACCTCTGGAATAATGTGTTAAATATCTGTATATTATATATATGTAGAGAAAAATCTAATTTTTTG GTTTGATTTCCTTCCCATTAAGAATCTTGTTTTTTGATACCCTTGTCTCCCTGAGACTCTTTCTTGGACACGTGTTGATGTGGATGGCAC TCCTGCTCTCCATCTTTTATGGGCAGAGAGATTTCAAAACCTGAGCAGGATCATGTCTGGCAGTTACTAAACAGGGACTTTGTCCATGGT TTGTATCATGGGGTGCCTACTGCTGTCTAAACTCTGCTCTCCTAATTAGCTGACTCTTGAAAATGAAATCCTAACCTCTTTCCTGCCTCT TTTCTTTCTCTTTTCAGGAAGAGTGTGGGTAGAAAGTCCGGAGGGCAACTTCCAATTTAATTCTGCTCTGTCCGGCGCATAGGCTGAATT CCAAAAGAACTTTCTTCCTAGGATGTGGGGCTTAAAGCACCGTCATGTGGGGTGGATCAGATAATTGCTCCTGTGGGGCCCTGGCTTCCT TCTCTGTTTGTGCAGTATTTGTTTTTGTTGTCTTGTTGAGAAATATCCCCTGTGCAACCCACCCTTGGTTGAGGATCACAAATTGAGGTG CCTTCCTTGTATGCTTTTTGTTAGTATTTTTTGTTTTTGTTCCTTAACTGCTGAGCCTCAGCCAGCGTGGGTCCTGGGGGAAATACCATT CCAAAGGAAGCCATCCCTATGGGGAAATTGGTTTTACTGGGTAAATTAATACTTTTATTTCTTCCCCTATCCCTTCCTTCCTAGTTGTGA TAAACATGGGAGAGGAGTGACTTTGACTGCTGGGGAATTTCCTCCTAAGAACCTTATTCCCAAAATAAGCCAGGGATTATGTCAAGGCTT CTTTCAAGGAGGCTCATAAAAGCAGTGACCTCATCCGGGGCTTTGGATAGAGTGAGAATTCCCCAACTAAATTGGACTTCTCTGCTTTAT CCCCTTCTCTTCCTTCACCATCTGCACTACATTTCTGGCTGATCCCAATCAGATTCCCGCTAATGGAAGAAGTTTAGAATCTTTCAGGTG GAATAAAGTCACATGAAAACAAAACACAACTATATATATTTTCAGTTTTTTTGCCTTATTGATTTTTTTCCAAAAAAAAAAAACTACTAA >23840_23840_3_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000432829_OSBP_chr11_59369311_ENST00000263847_length(amino acids)=1523AA_BP=990 MATLPSAERRAFALKINRYSSAEIRKQFTLPPNLGQYHRQSISTSGFPSLQLPQFYDPVEPVDFEGLLMTHLNSLDVQLAQELGDFTDDD LDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQAGPR HLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILV KLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGD CAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGERRTLAQSRRLSERAL SLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRP HKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHNKSPDFYEE VKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKG VFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIA GQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARV MSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFELL ACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPE IITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDL EYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIK ITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDP SGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLM -------------------------------------------------------------- >23840_23840_4_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000453981_OSBP_chr11_59369311_ENST00000263847_length(transcript)=6863nt_BP=3082nt GACAGACGAGGTTTGCGCTTGGCTGGGCATGTTCCGCGGCTACTCTGCGGCGCGCCAGGCCCCCGCTTTCCGCACCCCGCGACCCTAGAA GCCACCGAACCGCCGGCGGGCCATGGCCACTCTGCCGAGCGCAGAGCGCCGCGCGTTCGCGCTCAAGATCAACAGGTATTCTTCAGCGGA AATAAGGAAACAGTTTACTCTCCCACCAAACCTTGGCCAGTACCATCGACAGAGCATAAGTACCTCTGGCTTCCCCTCTCTTCAACTACC TCAGTTTTATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCTGAACAGCCTGGATGTGCAGCTTGCCCAGGAGCT CGGGGACTTCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGACTTTGCAGCCCTCTTTGCCGGAGGAAGGGGTTGA ACTGGACCCTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGTGAACCGGAAAAACCAAGGAAGTCCAGAAATCTG TGGCTTTAAAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGACGTTTGAGTCGGAAACCTTGGAGTGCAGTGAACC CGCTGCTCAGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGGCCCCGTCACTGCCTGTGACTTTGACCTCCGCAG CCTGCAGCCTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTTTGAGAAGCAGAACGAGGAGGCCCGGAGGACCAA TAGGCAGGCCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGAAATACGTCCAGTACCAGAATGTCCCAAGGAACA CCTGGGCAACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGAGCCCCTGTTTGCCAGCATTGCCCTCTACGATGT TAAAGAAAGGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTTCAAAGGATTTCTGCGAGCTCACACGCCTTCAGT GGCCGCATCAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGACATCTACCTGGTAGTCAAGATTGAAAAAGTCCT GCAGCAGGGAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGATGGTGGAAAGAGTAAAGAAAAGATTGAAAAACT AAAACTCCAAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGCCTGGGCACCCATAAGCTTATCAAGCTTCTTCAA TGTCTCCACCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTCAGTGGGTGAACGGAGGACATTGGCCCAATCTAG AAGGCTTTCTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAAAACCTCCACTCTGAGCGTTAGCAGCTTTTTCAA GCAGGAAGGAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAAAAGATCATCATCCTTACAGAGACGAGTCAAGTC AATTCCAGGCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTGTCTGACTCCTGAAATGCTGCCCGTGAAACCCTT TCCTGAAAACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGTATATGTCCCTCACACTGTGTACAGAAACCTTCT CTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACATTACAATAAAGATCCAGTTTATGTGTGGAGAAGA TGCTAGCAATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCAGGAAGTGTACACAGCTGTTACATACCATAATAA GTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAATCACCACCTCCTGTTCACCTTCTACCATATCAG CTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCCAATTCTCTTAAATGAACGTCTTCAAACTGGATC CTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGCTGAGAAAGTCCCATTACAGAATCCTCCCATTAA GTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGTACACACCCAGGACAACCACCTGGAGAAGTTCTT CACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCAGAAAATCAGCGAGATGGCGCTGGAGCATGAGCT GAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCTGCACCTGGTGCTGGACAAGCTCTTCCAGCTGTC CGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGAGTCCGTGGTGGCCATCGCCAACAGTCTGCACAA CAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGTGCACTACGTCTTCCGCCTGCCAGAGGTGCAAAG GGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACACGTATGGCCGCACATCAGCTGCTGCTGTGAGTTC AAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACACTCCGCAGCAGACGAGGAAGTGAAGAACATCAT GTCTTCAAAGATCGCCGATCGCAACTGCAGCCGAATGTCTTACTATTGCTCTGGCAGTAGTGATGCTCCAAGTTCACCTGCAGCCCCAAG GCCAGCCAGCAAAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAATGGTGAGAGAAACAGTCTTCAAGTATGC CTGGTTCTTCTTTGAGCTTCTGGCCTGCAGAGATTTCCTCATGTTAGCCCAGACCCATAGTAAAAAATGGCAAAAGTCACTACAGTATGA AAGAGACCAGCGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCTGGAGAGGGCCTTCCGAGGAGCCACGGT GCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAAGATCAGTGCTGCTCTGGCAAAGGGGACATGAGCGATGAAGATGATGAGAA TGAATTTTTTGATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGGCAGCAATATCAGTGGAGCCAGCAGTGA CATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAGACCAAAAAGGAAAAGAGAACCAGAATACCATACAAGCCAAACTATAGCCT CAATTTATGGAGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGTAAACTTTAATGAGCCCTTGTCCATGCT TCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTAGACCGAGCTGCAAAATGTGAGAATTCTCTAGAACAGCTCTGTTATGTTGC AGCTTTCACCGTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACTGCTTGGGGAGACCTTTGAGCTGGACCG ATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTGAGTCATCATCCCCCTGCTGCTGCGCACCATGCTGAGTCCAAAAATGGCTG GACATTGCGTCAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCCCCTCGGTACCATTCATTGTATTTTCCA TGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACAACTGTACACAACATTATTGTGGGCAAGTTGTGGATAGATCAGTCTGGCGA AATTGATATTGTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTACTTCTCTCGGGATGTAGCAAGAAAGGT GACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTTGCTCTTCTGGGGACGTGGGATGAGAAAATGGAATGTTTCAAAGTACAGCC AGTCATTGGGGAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGTCATGCTGTGGAAAAGGAATCCTTTACC GAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCTCTGACTCTCAATGCTTGGGAAAGTGGCACTGCCCCCACAGACAGCCGGTT ACGACCTGACCAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCGCCTGGAGGAAAAACAAAGACTTTCCAG AAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGATGGCACACCATATGATCCCTATAAGGCACTGTGGTTTGAGCGGAAGAAGGA CCCTGTTACCAAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACAGGACTGGAGCTCATGCCCGGACATTTT CTGAAACGGCAGTAACAAAAAAGAGGAGCATATAATGGAGAAGAGGACAGAGGATGTGTGGGAAAGCTGGAAGTTGTGACTCTCTTACCA AGTGCTTTCCTCAAGTTTGTCTCTCTTGACCAATCATTTTTTCCAAATCAATCACCAGAAGGAGACACCAGTGGTGGTGATTGGCTGGTT GCCTTAGCTGATTGAAACTGAAATCGACATAGGAGATACTATGTCTGTAAGGGAGAGGTTTAGTGGCCGAAGGTTAGTGTTATTCCACAT CCACGAAGTCAAGTATTCTTGGCTCTTCTTTCTCCCTCTGCCCCCATTTAAGACAATGTCACTCACCCTCCCCTTGTAGTATCCTGCTCA GCCAAGATCTGCCTAAGATTATGATTCAGGGGCATTTTGGTGCTGTTAAAAGCAAGAGCCGAATTTAGAAGTTCCCTTAAAAAGAAACAC ATAAGACTTACCAATGGAGGCATTGTGAATGGTTGCAGTGGAGCTTAGGTATAACATCATCAAGTGTGTTCACACGCGGGGTCGGTTTAA TGGAGTGTCCACGCGGAGATAACTGCGATATTGGAACACCTGTGAGAGAGATTGTTCTATAGGGCTGGAATATTCAGAGTTACATTCTTG GAAGTTTCTGTTTTTACTTGCATCAAACACCCCTCTGTTGTTCTCCATCATCTTTAATAGCAACTGGAGACCACTTTGGTCATTGGTAAG GGGGTGCATTCTCCTCACAAAGGGGTTTTATGGACTTCCTCAGGCGGAGAGCTTCTGAGAACACAGGCAGGATGGAAAAAGACTACTAGC CACTTTTGCTTTCCCAACCCCCCTTAATGCCATCCTTCATTGTCTTTCTGGCTTCTCTTCTTCTGGCACAGTACCATTTTGGGTCTGTGC CCCAGTGTGGAGCAAAACATTGCCTGTCCCATTCTGATATACTTCAGAATTTGAGAGCAGAAGTTAATGTGGAACAAAAGTTTTCACCAT CTCTCAAGCCCCAAGGACTGGAGCCACCTCTGGAATAATGTGTTAAATATCTGTATATTATATATATGTAGAGAAAAATCTAATTTTTTG GTTTGATTTCCTTCCCATTAAGAATCTTGTTTTTTGATACCCTTGTCTCCCTGAGACTCTTTCTTGGACACGTGTTGATGTGGATGGCAC TCCTGCTCTCCATCTTTTATGGGCAGAGAGATTTCAAAACCTGAGCAGGATCATGTCTGGCAGTTACTAAACAGGGACTTTGTCCATGGT TTGTATCATGGGGTGCCTACTGCTGTCTAAACTCTGCTCTCCTAATTAGCTGACTCTTGAAAATGAAATCCTAACCTCTTTCCTGCCTCT TTTCTTTCTCTTTTCAGGAAGAGTGTGGGTAGAAAGTCCGGAGGGCAACTTCCAATTTAATTCTGCTCTGTCCGGCGCATAGGCTGAATT CCAAAAGAACTTTCTTCCTAGGATGTGGGGCTTAAAGCACCGTCATGTGGGGTGGATCAGATAATTGCTCCTGTGGGGCCCTGGCTTCCT TCTCTGTTTGTGCAGTATTTGTTTTTGTTGTCTTGTTGAGAAATATCCCCTGTGCAACCCACCCTTGGTTGAGGATCACAAATTGAGGTG CCTTCCTTGTATGCTTTTTGTTAGTATTTTTTGTTTTTGTTCCTTAACTGCTGAGCCTCAGCCAGCGTGGGTCCTGGGGGAAATACCATT CCAAAGGAAGCCATCCCTATGGGGAAATTGGTTTTACTGGGTAAATTAATACTTTTATTTCTTCCCCTATCCCTTCCTTCCTAGTTGTGA TAAACATGGGAGAGGAGTGACTTTGACTGCTGGGGAATTTCCTCCTAAGAACCTTATTCCCAAAATAAGCCAGGGATTATGTCAAGGCTT CTTTCAAGGAGGCTCATAAAAGCAGTGACCTCATCCGGGGCTTTGGATAGAGTGAGAATTCCCCAACTAAATTGGACTTCTCTGCTTTAT CCCCTTCTCTTCCTTCACCATCTGCACTACATTTCTGGCTGATCCCAATCAGATTCCCGCTAATGGAAGAAGTTTAGAATCTTTCAGGTG GAATAAAGTCACATGAAAACAAAACACAACTATATATATTTTCAGTTTTTTTGCCTTATTGATTTTTTTCCAAAAAAAAAAAACTACTAA >23840_23840_4_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000453981_OSBP_chr11_59369311_ENST00000263847_length(amino acids)=1523AA_BP=990 MATLPSAERRAFALKINRYSSAEIRKQFTLPPNLGQYHRQSISTSGFPSLQLPQFYDPVEPVDFEGLLMTHLNSLDVQLAQELGDFTDDD LDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQAGPR HLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILV KLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGD CAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGERRTLAQSRRLSERAL SLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRP HKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHNKSPDFYEE VKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKG VFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIA GQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARV MSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFELL ACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPE IITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDL EYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIK ITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDP SGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLM -------------------------------------------------------------- >23840_23840_5_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000469391_OSBP_chr11_59369311_ENST00000263847_length(transcript)=6530nt_BP=2749nt TACGCGCCGTGTAACTGTGAATCTTTCAAAGCCTCAGTTTTATGACCCTGTGGAGCCAGTGGACTTTGAAGGACTTCTGATGACACACCT GAACAGCCTGGATGTGCAGCTTGCCCAGGAGCTCGGGGACTTCACTGATGACGACTTGGACGTGGTGTTCACGCCAAAGGAATGTAGGAC TTTGCAGCCCTCTTTGCCGGAGGAAGGGGTTGAACTGGACCCTCATGTCAGGGACTGTGTTCAGACCTACATCCGTGAGTGGCTAATCGT GAACCGGAAAAACCAAGGAAGTCCAGAAATCTGTGGCTTTAAAAAGACTGGATCTCGAAAAGATTTTCACAAGACGCTTCCGAAACAGAC GTTTGAGTCGGAAACCTTGGAGTGCAGTGAACCCGCTGCTCAGGCAGGCCCCCGCCACTTAAACGTGCTGTGCGACGTGTCTGGGAAAGG CCCCGTCACTGCCTGTGACTTTGACCTCCGCAGCCTGCAGCCTGACAAGCGGCTAGAAAACCTCCTGCAGCAAGTGAGTGCCGAGGACTT TGAGAAGCAGAACGAGGAGGCCCGGAGGACCAATAGGCAGGCCGAGCTCTTTGCCCTTTACCCATCAGTGGACGAGGAGGATGCTGTGGA AATACGTCCAGTACCAGAATGTCCCAAGGAACACCTGGGCAACAGAATATTGGTCAAGTTGCTGACCTTGAAGTTCGAGATTGAAATTGA GCCCCTGTTTGCCAGCATTGCCCTCTACGATGTTAAAGAAAGGAAAAAGATCTCAGAAAATTTTCACTGTGACCTGAACTCTGACCAGTT CAAAGGATTTCTGCGAGCTCACACGCCTTCAGTGGCCGCATCAAGTCAGGCGAGATCTGCAGTCTTCTCAGTCACCTACCCGTCCTCAGA CATCTACCTGGTAGTCAAGATTGAAAAAGTCCTGCAGCAGGGAGAGATTGGAGACTGTGCAGAGCCCTACACGGTTATCAAAGAAAGTGA TGGTGGAAAGAGTAAAGAAAAGATTGAAAAACTAAAACTCCAAGCTGAATCCTTCTGCCAGCGTTTGGGGAAATACCGGATGCCCTTTGC CTGGGCACCCATAAGCTTATCAAGCTTCTTCAATGTCTCCACCCTTGAGAGGGAGGTAACTGATGTGGACTCTGTGGTTGGGAGAAGCTC AGTGGGTGAACGGAGGACATTGGCCCAATCTAGAAGGCTTTCTGAAAGAGCCCTCTCCTTGGAGGAAAATGGGGTTGGATCCAACTTCAA AACCTCCACTCTGAGCGTTAGCAGCTTTTTCAAGCAGGAAGGAGATCGCCTTAGCGATGAAGACTTATTCAAGTTTTTAGCTGACTACAA AAGATCATCATCCTTACAGAGACGAGTCAAGTCAATTCCAGGCTTGCTAAGACTGGAGATTTCTACAGCTCCAGAGATCATCAATTGCTG TCTGACTCCTGAAATGCTGCCCGTGAAACCCTTTCCTGAAAACCGGACACGCCCGCACAAAGAGATTTTGGAATTTCCAACACGAGAAGT ATATGTCCCTCACACTGTGTACAGAAACCTTCTCTATGTCTACCCACAGAGGCTGAACTTTGTAAACAAACTAGCATCAGCCCGGAACAT TACAATAAAGATCCAGTTTATGTGTGGAGAAGATGCTAGCAATGCGATGCCGGTCATCTTTGGAAAATCCAGCGGGCCTGAATTTCTGCA GGAAGTGTACACAGCTGTTACATACCATAATAAGTCTCCTGACTTTTATGAAGAAGTGAAAATTAAGCTCCCCGCTAAGCTCACAGTAAA TCACCACCTCCTGTTCACCTTCTACCATATCAGCTGTCAGCAGAAGCAAGGAGCCTCCGTGGAAACTCTCCTGGGATATTCATGGCTGCC AATTCTCTTAAATGAACGTCTTCAAACTGGATCCTACTGTCTCCCAGTTGCCTTGGAAAAATTGCCACCCAACTACTCCATGCATTCTGC TGAGAAAGTCCCATTACAGAATCCTCCCATTAAGTGGGCTGAAGGACATAAGGGAGTATTTAATATTGAAGTGCAAGCTGTTTCTTCTGT ACACACCCAGGACAACCACCTGGAGAAGTTCTTCACCCTCTGCCACTCCCTGGAGAGCCAGGTGACCTTCCCCATCCGCGTGCTGGATCA GAAAATCAGCGAGATGGCGCTGGAGCATGAGCTGAAGCTCAGCATCATCTGCCTGAACTCCTCCCGCCTGGAGCCGCTCGTGCTCTTCCT GCACCTGGTGCTGGACAAGCTCTTCCAGCTGTCCGTGCAGCCCATGGTCATCGCTGGCCAGACAGCCAACTTCTCCCAGTTTGCCTTCGA GTCCGTGGTGGCCATCGCCAACAGTCTGCACAACAGCAAGGACCTGAGCAAGGACCAGCATGGGAGGAACTGCCTGCTGGCTTCCTACGT GCACTACGTCTTCCGCCTGCCAGAGGTGCAAAGGGATGTGCCCAAGTCAGGCGCTCCCACTGCCCTCCTAGACCCTCGGAGCTACCACAC GTATGGCCGCACATCAGCTGCTGCTGTGAGTTCAAAGCTGCTGCAGGCCCGGGTGATGAGCAGCAGTAACCCAGACCTCGCGGGGACACA CTCCGCAGCAGACGAGGAAGTGAAGAACATCATGTCTTCAAAGCATTTCCATGAGGAGCTTGCCCTTCAGATGGTGGTCAGCACCGGAAT GGTGAGAGAAACAGTCTTCAAGTATGCCTGGTTCTTCTTTGAGCTTCTGGCCTGCAGAGATTTCCTCATGTTAGCCCAGACCCATAGTAA AAAATGGCAAAAGTCACTACAGTATGAAAGAGACCAGCGTATCCGACTGGAAGAAACCCTCGAGCAGCTGGCGAAGCAGCATAATCACCT GGAGAGGGCCTTCCGAGGAGCCACGGTGCTGCCGGCAAACACTCCTGGCAATGTGGGTTCTGGTAAAGATCAGTGCTGCTCTGGCAAAGG GGACATGAGCGATGAAGATGATGAGAATGAATTTTTTGATGCACCTGAGATCATCACCATGCCTGAAAATTTGGGCCACAAACGTACTGG CAGCAATATCAGTGGAGCCAGCAGTGACATCAGCCTTGATGAACAGTACAAGCATCAGCTGGAGGAGACCAAAAAGGAAAAGAGAACCAG AATACCATACAAGCCAAACTATAGCCTCAATTTATGGAGCATCATGAAGAACTGCATTGGAAAAGAACTCTCTAAGATCCCCATGCCGGT AAACTTTAATGAGCCCTTGTCCATGCTTCAGCGCCTTACTGAAGATCTGGAATACCATGAGCTGTTAGACCGAGCTGCAAAATGTGAGAA TTCTCTAGAACAGCTCTGTTATGTTGCAGCTTTCACCGTGTCCTCCTACTCCACTACTGTCTTCCGCACCAGTAAGCCATTCAACCCACT GCTTGGGGAGACCTTTGAGCTGGACCGATTAGAGGAGAATGGGTACCGATCCCTCTGTGAACAGGTGAGTCATCATCCCCCTGCTGCTGC GCACCATGCTGAGTCCAAAAATGGCTGGACATTGCGTCAGGAAATCAAAATCACCAGCAAGTTTCGAGGCAAATACCTCTCCATTATGCC CCTCGGTACCATTCATTGTATTTTCCATGCAACTGGGCACCACTACACTTGGAAGAAAGTTACCACAACTGTACACAACATTATTGTGGG CAAGTTGTGGATAGATCAGTCTGGCGAAATTGATATTGTGAATCACAAGACAGGAGACAAGTGTAATCTTAAATTTGTTCCTTATAGCTA CTTCTCTCGGGATGTAGCAAGAAAGGTGACGGGGGAAGTGACAGATCCATCAGGAAAAGTCCACTTTGCTCTTCTGGGGACGTGGGATGA GAAAATGGAATGTTTCAAAGTACAGCCAGTCATTGGGGAAAATGGGGGTGATGCTCGACAGAGAGGCCATGAAGCAGAGGAAAGCAGGGT CATGCTGTGGAAAAGGAATCCTTTACCGAAGAATGCAGAAAACATGTACTACTTCTCAGAGCTTGCTCTGACTCTCAATGCTTGGGAAAG TGGCACTGCCCCCACAGACAGCCGGTTACGACCTGACCAGAGACTGATGGAAAATGGACGCTGGGATGAAGCAAATGCGGAGAAGCAGCG CCTGGAGGAAAAACAAAGACTTTCCAGAAAGAAGAGAGAAGCGGAAGCTATGAAAGCCACAGAGGATGGCACACCATATGATCCCTATAA GGCACTGTGGTTTGAGCGGAAGAAGGACCCTGTTACCAAGGAGTTAACCCATATTTATAGGGGAGAATACTGGGAGTGTAAAGAAAAACA GGACTGGAGCTCATGCCCGGACATTTTCTGAAACGGCAGTAACAAAAAAGAGGAGCATATAATGGAGAAGAGGACAGAGGATGTGTGGGA AAGCTGGAAGTTGTGACTCTCTTACCAAGTGCTTTCCTCAAGTTTGTCTCTCTTGACCAATCATTTTTTCCAAATCAATCACCAGAAGGA GACACCAGTGGTGGTGATTGGCTGGTTGCCTTAGCTGATTGAAACTGAAATCGACATAGGAGATACTATGTCTGTAAGGGAGAGGTTTAG TGGCCGAAGGTTAGTGTTATTCCACATCCACGAAGTCAAGTATTCTTGGCTCTTCTTTCTCCCTCTGCCCCCATTTAAGACAATGTCACT CACCCTCCCCTTGTAGTATCCTGCTCAGCCAAGATCTGCCTAAGATTATGATTCAGGGGCATTTTGGTGCTGTTAAAAGCAAGAGCCGAA TTTAGAAGTTCCCTTAAAAAGAAACACATAAGACTTACCAATGGAGGCATTGTGAATGGTTGCAGTGGAGCTTAGGTATAACATCATCAA GTGTGTTCACACGCGGGGTCGGTTTAATGGAGTGTCCACGCGGAGATAACTGCGATATTGGAACACCTGTGAGAGAGATTGTTCTATAGG GCTGGAATATTCAGAGTTACATTCTTGGAAGTTTCTGTTTTTACTTGCATCAAACACCCCTCTGTTGTTCTCCATCATCTTTAATAGCAA CTGGAGACCACTTTGGTCATTGGTAAGGGGGTGCATTCTCCTCACAAAGGGGTTTTATGGACTTCCTCAGGCGGAGAGCTTCTGAGAACA CAGGCAGGATGGAAAAAGACTACTAGCCACTTTTGCTTTCCCAACCCCCCTTAATGCCATCCTTCATTGTCTTTCTGGCTTCTCTTCTTC TGGCACAGTACCATTTTGGGTCTGTGCCCCAGTGTGGAGCAAAACATTGCCTGTCCCATTCTGATATACTTCAGAATTTGAGAGCAGAAG TTAATGTGGAACAAAAGTTTTCACCATCTCTCAAGCCCCAAGGACTGGAGCCACCTCTGGAATAATGTGTTAAATATCTGTATATTATAT ATATGTAGAGAAAAATCTAATTTTTTGGTTTGATTTCCTTCCCATTAAGAATCTTGTTTTTTGATACCCTTGTCTCCCTGAGACTCTTTC TTGGACACGTGTTGATGTGGATGGCACTCCTGCTCTCCATCTTTTATGGGCAGAGAGATTTCAAAACCTGAGCAGGATCATGTCTGGCAG TTACTAAACAGGGACTTTGTCCATGGTTTGTATCATGGGGTGCCTACTGCTGTCTAAACTCTGCTCTCCTAATTAGCTGACTCTTGAAAA TGAAATCCTAACCTCTTTCCTGCCTCTTTTCTTTCTCTTTTCAGGAAGAGTGTGGGTAGAAAGTCCGGAGGGCAACTTCCAATTTAATTC TGCTCTGTCCGGCGCATAGGCTGAATTCCAAAAGAACTTTCTTCCTAGGATGTGGGGCTTAAAGCACCGTCATGTGGGGTGGATCAGATA ATTGCTCCTGTGGGGCCCTGGCTTCCTTCTCTGTTTGTGCAGTATTTGTTTTTGTTGTCTTGTTGAGAAATATCCCCTGTGCAACCCACC CTTGGTTGAGGATCACAAATTGAGGTGCCTTCCTTGTATGCTTTTTGTTAGTATTTTTTGTTTTTGTTCCTTAACTGCTGAGCCTCAGCC AGCGTGGGTCCTGGGGGAAATACCATTCCAAAGGAAGCCATCCCTATGGGGAAATTGGTTTTACTGGGTAAATTAATACTTTTATTTCTT CCCCTATCCCTTCCTTCCTAGTTGTGATAAACATGGGAGAGGAGTGACTTTGACTGCTGGGGAATTTCCTCCTAAGAACCTTATTCCCAA AATAAGCCAGGGATTATGTCAAGGCTTCTTTCAAGGAGGCTCATAAAAGCAGTGACCTCATCCGGGGCTTTGGATAGAGTGAGAATTCCC CAACTAAATTGGACTTCTCTGCTTTATCCCCTTCTCTTCCTTCACCATCTGCACTACATTTCTGGCTGATCCCAATCAGATTCCCGCTAA TGGAAGAAGTTTAGAATCTTTCAGGTGGAATAAAGTCACATGAAAACAAAACACAACTATATATATTTTCAGTTTTTTTGCCTTATTGAT >23840_23840_5_DOCK8-OSBP_DOCK8_chr9_390566_ENST00000469391_OSBP_chr11_59369311_ENST00000263847_length(amino acids)=1424AA_BP=891 MMTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKT LPKQTFESETLECSEPAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDE EDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVT YPSSDIYLVVKIEKVLQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSV VGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPE IINCCLTPEMLPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSG PEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNY SMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEP LVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDP RSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKHFHEELALQMVVSTGMVRETVFKYAWFFFELLACRDFLMLA QTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLG HKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRA AKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKY LSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALL GTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEAN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DOCK8-OSBP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DOCK8-OSBP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DOCK8-OSBP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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