|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DOCK9-DPP4 (FusionGDB2 ID:23844) |
Fusion Gene Summary for DOCK9-DPP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOCK9-DPP4 | Fusion gene ID: 23844 | Hgene | Tgene | Gene symbol | DOCK9 | DPP4 | Gene ID | 23348 | 1803 |
| Gene name | dedicator of cytokinesis 9 | dipeptidyl peptidase 4 | |
| Synonyms | ZIZ1|ZIZIMIN1 | ADABP|ADCP2|CD26|DPPIV|TP103 | |
| Cytomap | 13q32.3 | 2q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dedicator of cytokinesis protein 9cdc42 guanine nucleotide exchange factor zizimin-1 | dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) | |
| Modification date | 20200313 | 20200322 | |
| UniProtAcc | Q9BZ29 | P27487 | |
| Ensembl transtripts involved in fusion gene | ENST00000339416, ENST00000376460, ENST00000442173, ENST00000448493, ENST00000461998, | ENST00000360534, ENST00000491591, | |
| Fusion gene scores | * DoF score | 13 X 11 X 7=1001 | 4 X 4 X 2=32 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/1001*10)=-2.73840756834011 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DOCK9 [Title/Abstract] AND DPP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DOCK9(99712347)-DPP4(162848758), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DPP4 | GO:0001666 | response to hypoxia | 16670267 |
| Tgene | DPP4 | GO:0006508 | proteolysis | 27198182 |
| Tgene | DPP4 | GO:0008284 | positive regulation of cell proliferation | 17549790 |
| Tgene | DPP4 | GO:0010716 | negative regulation of extracellular matrix disassembly | 16651416 |
| Tgene | DPP4 | GO:0031295 | T cell costimulation | 10900005|17287217 |
| Tgene | DPP4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 11772392 |
| Tgene | DPP4 | GO:0042110 | T cell activation | 7594462 |
| Tgene | DPP4 | GO:0043542 | endothelial cell migration | 16651416 |
| Fusion gene breakpoints across DOCK9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across DPP4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | AA503112 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
Top |
Fusion Gene ORF analysis for DOCK9-DPP4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000339416 | ENST00000360534 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-3UTR | ENST00000376460 | ENST00000360534 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-3UTR | ENST00000442173 | ENST00000360534 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-3UTR | ENST00000448493 | ENST00000360534 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-3UTR | ENST00000461998 | ENST00000360534 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-intron | ENST00000339416 | ENST00000491591 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-intron | ENST00000376460 | ENST00000491591 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-intron | ENST00000442173 | ENST00000491591 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-intron | ENST00000448493 | ENST00000491591 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| intron-intron | ENST00000461998 | ENST00000491591 | DOCK9 | chr13 | 99712347 | + | DPP4 | chr2 | 162848758 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for DOCK9-DPP4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for DOCK9-DPP4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:99712347/:162848758) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOCK9 | DPP4 |
| FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. | FUNCTION: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948). {ECO:0000269|PubMed:10570924, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16254193, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:18708048}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. {ECO:0000269|PubMed:23835475}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for DOCK9-DPP4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for DOCK9-DPP4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for DOCK9-DPP4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for DOCK9-DPP4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies