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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DOK5-FASTKD1 (FusionGDB2 ID:23864)

Fusion Gene Summary for DOK5-FASTKD1

Fusion gene summary

Fusion gene information	Fusion gene name: DOK5-FASTKD1
	Fusion gene ID: 23864
		Hgene	Tgene
	Gene symbol	DOK5	FASTKD1
	Gene ID	55816	79675
	Gene name	docking protein 5	FAST kinase domains 1
	Synonyms	C20orf180\|IRS-6\|IRS6	-
	Cytomap	20q13.2	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	docking protein 5downstream of tyrosine kinase 5insulin receptor substrate 6	FAST kinase domain-containing protein 1, mitochondrial
	Modification date	20200320	20200313
	UniProtAcc	Q9P104	Q53R41
	Ensembl transtripts involved in fusion gene	ENST00000262593, ENST00000395939, ENST00000491469,	ENST00000495505, ENST00000453153, ENST00000453929,
Fusion gene scores	* DoF score	6 X 3 X 3=54	5 X 5 X 6=150
	# samples	8	6
	** MAII score	log2(8/54*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DOK5 [Title/Abstract] AND FASTKD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DOK5(53205345)-FASTKD1(170393850), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DOK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FASTKD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-2565-01A	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-

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Fusion Gene ORF analysis for DOK5-FASTKD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262593	ENST00000495505	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
5CDS-intron	ENST00000395939	ENST00000495505	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
In-frame	ENST00000262593	ENST00000453153	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
In-frame	ENST00000262593	ENST00000453929	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
In-frame	ENST00000395939	ENST00000453153	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
In-frame	ENST00000395939	ENST00000453929	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
intron-3CDS	ENST00000491469	ENST00000453153	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
intron-3CDS	ENST00000491469	ENST00000453929	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-
intron-intron	ENST00000491469	ENST00000495505	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262593	DOK5	chr20	53205345	+	ENST00000453153	FASTKD1	chr2	170393850	-	1305	759	341	1228	295
ENST00000262593	DOK5	chr20	53205345	+	ENST00000453929	FASTKD1	chr2	170393850	-	1299	759	341	1228	295
ENST00000395939	DOK5	chr20	53205345	+	ENST00000453153	FASTKD1	chr2	170393850	-	1076	530	244	999	251
ENST00000395939	DOK5	chr20	53205345	+	ENST00000453929	FASTKD1	chr2	170393850	-	1070	530	244	999	251

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262593	ENST00000453153	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-	0.003242204	0.9967578
ENST00000262593	ENST00000453929	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-	0.003481389	0.9965186
ENST00000395939	ENST00000453153	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-	0.002702163	0.9972978
ENST00000395939	ENST00000453929	DOK5	chr20	53205345	+	FASTKD1	chr2	170393850	-	0.002823074	0.9971769

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Fusion Genomic Features for DOK5-FASTKD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DOK5-FASTKD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:53205345/chr2:170393850)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DOK5 Q9P104	FASTKD1 Q53R41
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.	FUNCTION: Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity. {ECO:0000269\|PubMed:28238724, ECO:0000269\|PubMed:28335001}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000262593

8_112

136

307.0

Domain

Note=PH

Tgene

FASTKD1

chr20:53205345

chr2:170393850

ENST00000453153

777_837

691

848.0

Domain

RAP

Tgene

FASTKD1

chr20:53205345

chr2:170393850

ENST00000453929

777_837

648

805.0

Domain

RAP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000262593

132_237

136

307.0

Domain

IRS-type PTB

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000395939

132_237

199.0

Domain

IRS-type PTB

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000395939

8_112

199.0

Domain

Note=PH

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000262593

263_273

136

307.0

Motif

Note=DKFBH motif

Hgene

DOK5

chr20:53205345

chr2:170393850

ENST00000395939

263_273

199.0

Motif

Note=DKFBH motif

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Fusion Gene Sequence for DOK5-FASTKD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>23864_23864_1_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000262593_FASTKD1_chr2_170393850_ENST00000453153_length(transcript)=1305nt_BP=759nt
TTCTCCTCCTTCTCGGCCGGGAGGAGGCAGGGCTGGATCCCTCAGCCGCCGCCGCTCCTCCTCCTGGCAGGCCGGCCGCGGAGTCAGCTG
ACGCCGGCGCTCCAGCCTCGCCTCCCCGCGCCGCGCTCTGCGCTCCCCGAAAGTGGCTGCAAGCCGGCCGCCCACTGTCAGGGTTGGGGG
GACAGAGAAAGTGATGTGCGCCTTCTAAAGCCTCGCCCAGCGCCGCCGAAGCAGCTTCACCTCTCCAACTTTCTCCCACCGACTGCTTGT
CTTGACCCTGCCCTCCACCCTCCCCAGAGCCACTTCGGGTGCGCGCTCTTGGGTAAAGGGGGGGTCACCGGCTGTCTGGGATGGCTTCCA
ATTTTAATGACATAGTGAAGCAAGGGTACGTGAGGATCCGGAGCAGACGCCTCGGGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAG
CTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATA
ATGTGAAGAACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTT
GCGAATCAGATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGC
CTGACTTACTGGCCACTGGGGTTGAGAGAGAACAGAGTGGTATTGGTGGCATGGATGGAACACAACAGCAGATTTTTAAAATGTTAGCAG
AGGTACTAGGAGGAATCAATTGTGTAAAAGCCTCGGTTCTTACGCCTTATTACCACAAAGTAGATTTTGAGTGTATCTTGGATAAAAGAA
AAAAACCTCTTCCGTATGGAAGCCATAATATAGCATTGGGACAACTACCAGAAATGCCCTGGGAATCAAATATCGAAATAGTTGGATCAA
GGCTGCCACCAGGGGCTGAAAGGATTGCTTTGGAATTTTTGGATTCAAAAGCACTTTGTAGAAATATCCCTCACATGAAAGGAAAATCTG
CTATGAAAAAACGACATTTGGAAATTCTGGGGTATCGTGTAATTCAGATTTCCCAGTTTGAATGGAACTCTATGGCACTGTCAACAAAGG
ATGCTCGGATGGACTACCTGAGAGAATGTATATTTGGAGAAGTCAAGTCATGTTTGTAGTTTTTATTTAAAATGAATGTTATCGTGTGTT

>23864_23864_1_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000262593_FASTKD1_chr2_170393850_ENST00000453153_length(amino acids)=295AA_BP=139
MSGMASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDD
TSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFE
CILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNS

--------------------------------------------------------------
>23864_23864_2_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000262593_FASTKD1_chr2_170393850_ENST00000453929_length(transcript)=1299nt_BP=759nt
TTCTCCTCCTTCTCGGCCGGGAGGAGGCAGGGCTGGATCCCTCAGCCGCCGCCGCTCCTCCTCCTGGCAGGCCGGCCGCGGAGTCAGCTG
ACGCCGGCGCTCCAGCCTCGCCTCCCCGCGCCGCGCTCTGCGCTCCCCGAAAGTGGCTGCAAGCCGGCCGCCCACTGTCAGGGTTGGGGG
GACAGAGAAAGTGATGTGCGCCTTCTAAAGCCTCGCCCAGCGCCGCCGAAGCAGCTTCACCTCTCCAACTTTCTCCCACCGACTGCTTGT
CTTGACCCTGCCCTCCACCCTCCCCAGAGCCACTTCGGGTGCGCGCTCTTGGGTAAAGGGGGGGTCACCGGCTGTCTGGGATGGCTTCCA
ATTTTAATGACATAGTGAAGCAAGGGTACGTGAGGATCCGGAGCAGACGCCTCGGGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAG
CTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGCTGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATA
ATGTGAAGAACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCATAGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTT
GCGAATCAGATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGAGTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGC
CTGACTTACTGGCCACTGGGGTTGAGAGAGAACAGAGTGGTATTGGTGGCATGGATGGAACACAACAGCAGATTTTTAAAATGTTAGCAG
AGGTACTAGGAGGAATCAATTGTGTAAAAGCCTCGGTTCTTACGCCTTATTACCACAAAGTAGATTTTGAGTGTATCTTGGATAAAAGAA
AAAAACCTCTTCCGTATGGAAGCCATAATATAGCATTGGGACAACTACCAGAAATGCCCTGGGAATCAAATATCGAAATAGTTGGATCAA
GGCTGCCACCAGGGGCTGAAAGGATTGCTTTGGAATTTTTGGATTCAAAAGCACTTTGTAGAAATATCCCTCACATGAAAGGAAAATCTG
CTATGAAAAAACGACATTTGGAAATTCTGGGGTATCGTGTAATTCAGATTTCCCAGTTTGAATGGAACTCTATGGCACTGTCAACAAAGG
ATGCTCGGATGGACTACCTGAGAGAATGTATATTTGGAGAAGTCAAGTCATGTTTGTAGTTTTTATTTAAAATGAATGTTATCGTGTGTT

>23864_23864_2_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000262593_FASTKD1_chr2_170393850_ENST00000453929_length(amino acids)=295AA_BP=139
MSGMASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDD
TSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFE
CILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKSAMKKRHLEILGYRVIQISQFEWNS

--------------------------------------------------------------
>23864_23864_3_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000395939_FASTKD1_chr2_170393850_ENST00000453153_length(transcript)=1076nt_BP=530nt
CGCGCTCTGCGCTCCCCGAAAGTGGCTGCAAGCCGGCCGCCCACTGTCAGGGTTGGGGGGACAGAGAAAGTGATGTGCGCCTTCTAAAGC
CTCGCCCAGCGCCGCCGAAGCAGCTTCACCTCTCCAACTTTCTCCCACCGACTGCTTGTCTTGACCCTGCCCTCCACCCTCCCCAGAGCC
ACTTCGGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAGCTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGC
TGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATAATGTGAAGAACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCAT
AGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTTGCGAATCAGATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGA
GTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGCCTGACTTACTGGCCACTGGGGTTGAGAGAGAACAGAGTGGTATTGGTGG
CATGGATGGAACACAACAGCAGATTTTTAAAATGTTAGCAGAGGTACTAGGAGGAATCAATTGTGTAAAAGCCTCGGTTCTTACGCCTTA
TTACCACAAAGTAGATTTTGAGTGTATCTTGGATAAAAGAAAAAAACCTCTTCCGTATGGAAGCCATAATATAGCATTGGGACAACTACC
AGAAATGCCCTGGGAATCAAATATCGAAATAGTTGGATCAAGGCTGCCACCAGGGGCTGAAAGGATTGCTTTGGAATTTTTGGATTCAAA
AGCACTTTGTAGAAATATCCCTCACATGAAAGGAAAATCTGCTATGAAAAAACGACATTTGGAAATTCTGGGGTATCGTGTAATTCAGAT
TTCCCAGTTTGAATGGAACTCTATGGCACTGTCAACAAAGGATGCTCGGATGGACTACCTGAGAGAATGTATATTTGGAGAAGTCAAGTC

>23864_23864_3_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000395939_FASTKD1_chr2_170393850_ENST00000453153_length(amino acids)=251AA_BP=95
MEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGV
EREQSGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAER

--------------------------------------------------------------
>23864_23864_4_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000395939_FASTKD1_chr2_170393850_ENST00000453929_length(transcript)=1070nt_BP=530nt
CGCGCTCTGCGCTCCCCGAAAGTGGCTGCAAGCCGGCCGCCCACTGTCAGGGTTGGGGGGACAGAGAAAGTGATGTGCGCCTTCTAAAGC
CTCGCCCAGCGCCGCCGAAGCAGCTTCACCTCTCCAACTTTCTCCCACCGACTGCTTGTCTTGACCCTGCCCTCCACCCTCCCCAGAGCC
ACTTCGGATTTATCAGCGATGCTGGTTAGTATTCAAGAAAGCTTCAAGCAAAGGTCCAAAAAGACTGGAGAAATTTTCTGATGAACGTGC
TGCATATTTCAGGTGTTATCATAAGGTTACAGAACTCAATAATGTGAAGAACGTAGCTCGATTGCCAAAAAGCACCAAGAAACATGCCAT
AGGGATTTATTTCAATGACGATACCTCCAAGACTTTTGCTTGCGAATCAGATCTTGAGGCTGATGAGTGGTGCAAAGTACTCCAGATGGA
GTGTGTAGGAACACGGATCAATGACATCAGCCTTGGAGAGCCTGACTTACTGGCCACTGGGGTTGAGAGAGAACAGAGTGGTATTGGTGG
CATGGATGGAACACAACAGCAGATTTTTAAAATGTTAGCAGAGGTACTAGGAGGAATCAATTGTGTAAAAGCCTCGGTTCTTACGCCTTA
TTACCACAAAGTAGATTTTGAGTGTATCTTGGATAAAAGAAAAAAACCTCTTCCGTATGGAAGCCATAATATAGCATTGGGACAACTACC
AGAAATGCCCTGGGAATCAAATATCGAAATAGTTGGATCAAGGCTGCCACCAGGGGCTGAAAGGATTGCTTTGGAATTTTTGGATTCAAA
AGCACTTTGTAGAAATATCCCTCACATGAAAGGAAAATCTGCTATGAAAAAACGACATTTGGAAATTCTGGGGTATCGTGTAATTCAGAT
TTCCCAGTTTGAATGGAACTCTATGGCACTGTCAACAAAGGATGCTCGGATGGACTACCTGAGAGAATGTATATTTGGAGAAGTCAAGTC

>23864_23864_4_DOK5-FASTKD1_DOK5_chr20_53205345_ENST00000395939_FASTKD1_chr2_170393850_ENST00000453929_length(amino acids)=251AA_BP=95
MEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGV
EREQSGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPPGAER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DOK5-FASTKD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DOK5-FASTKD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DOK5-FASTKD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source