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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DOPEY1-CYB5R4 (FusionGDB2 ID:23877)

Fusion Gene Summary for DOPEY1-CYB5R4

check button Fusion gene summary
Fusion gene informationFusion gene name: DOPEY1-CYB5R4
Fusion gene ID: 23877
HgeneTgene
Gene symbol

DOPEY1

CYB5R4

Gene ID

23033

51167

Gene nameDOP1 leucine zipper like protein Acytochrome b5 reductase 4
SynonymsDOP1|DOPEY1|KIAA1117|dJ202D23.2NCB5OR|cb5/cb5R|dJ676J13.1
Cytomap

6q14.1

6q14.2

Type of geneprotein-codingprotein-coding
Descriptionprotein dopey-1dopey family member 1homolog of yeast DOP1cytochrome b5 reductase 4N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing proteinNADPH cytochrome B5 oxidoreductasecytochrome b-type NAD(P)H oxidoreductaseflavohemoprotein b5+b5Rflavohemoprotein b5/b5R
Modification date2020031320200313
UniProtAcc.

Q7L1T6

Ensembl transtripts involved in fusion geneENST00000237163, ENST00000349129, 
ENST00000536812, ENST00000369739, 
ENST00000484282, 		ENST00000369679, 
ENST00000369681, ENST00000479164, 
Fusion gene scores* DoF score5 X 2 X 4=403 X 4 X 3=36
# samples 85
** MAII scorelog2(8/40*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DOPEY1 [Title/Abstract] AND CYB5R4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOPEY1(83777498)-CYB5R4(84603240), # samples:1
DOPEY1(83777498)-CYB5R4(84665017), # samples:1
DOPEY1(83777498)-CYB5R4(84603241), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCYB5R4

GO:0006091

generation of precursor metabolites and energy

10611283

TgeneCYB5R4

GO:0006801

superoxide metabolic process

10611283

TgeneCYB5R4

GO:0055114

oxidation-reduction process

15131110


check buttonFusion gene breakpoints across DOPEY1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CYB5R4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8366-01ADOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
ChimerDB4STADTCGA-CD-8531-01ADOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
ChimerDB4STADTCGA-CD-8531DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+


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Fusion Gene ORF analysis for DOPEY1-CYB5R4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000237163ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000237163ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3CDSENST00000237163ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-3CDSENST00000237163ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000237163ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3CDSENST00000349129ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000349129ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3CDSENST00000349129ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-3CDSENST00000349129ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000349129ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3CDSENST00000536812ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000536812ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3CDSENST00000536812ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-3CDSENST00000536812ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-3CDSENST00000536812ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-3UTRENST00000237163ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-3UTRENST00000349129ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-3UTRENST00000536812ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-intronENST00000237163ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-intronENST00000237163ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-intronENST00000237163ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-intronENST00000349129ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-intronENST00000349129ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-intronENST00000349129ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
5UTR-intronENST00000536812ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
5UTR-intronENST00000536812ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
5UTR-intronENST00000536812ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-3CDSENST00000369739ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-3CDSENST00000369739ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-3CDSENST00000369739ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-3CDSENST00000369739ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-3CDSENST00000369739ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-3CDSENST00000484282ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-3CDSENST00000484282ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-3CDSENST00000484282ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-3CDSENST00000484282ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-3CDSENST00000484282ENST00000369681DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-3UTRENST00000369739ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-3UTRENST00000484282ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-intronENST00000369739ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-intronENST00000369739ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-intronENST00000369739ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+
intron-intronENST00000484282ENST00000369679DOPEY1chr6

83777498

+CYB5R4chr6

84665017

+
intron-intronENST00000484282ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603241

+
intron-intronENST00000484282ENST00000479164DOPEY1chr6

83777498

+CYB5R4chr6

84603240

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DOPEY1-CYB5R4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DOPEY1chr683777498+CYB5R4chr684665016+3.77E-070.99999964
DOPEY1chr683777498+CYB5R4chr684603240+2.54E-101
DOPEY1chr683777498+CYB5R4chr684603240+2.54E-101
DOPEY1chr683777498+CYB5R4chr684665016+3.77E-070.99999964
DOPEY1chr683777498+CYB5R4chr684603240+2.54E-101
DOPEY1chr683777498+CYB5R4chr684603240+2.54E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DOPEY1-CYB5R4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:83777498/:84603240)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYB5R4

Q7L1T6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DOPEY1-CYB5R4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DOPEY1-CYB5R4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DOPEY1-CYB5R4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DOPEY1-CYB5R4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource