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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPF2-PPP1R10 (FusionGDB2 ID:23939)

Fusion Gene Summary for DPF2-PPP1R10

check button Fusion gene summary
Fusion gene informationFusion gene name: DPF2-PPP1R10
Fusion gene ID: 23939
HgeneTgene
Gene symbol

DPF2

PPP1R10

Gene ID

5977

5514

Gene namedouble PHD fingers 2protein phosphatase 1 regulatory subunit 10
SynonymsCSS7|REQ|UBID4|ubi-d4CAT53|FB19|PNUTS|PP1R10|R111|p99
Cytomap

11q13.1

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein ubi-d4BAF45DBRG1-associated factor 45DD4, zinc and double PHD fingers family 2apoptosis response zinc finger proteinprotein requiemrequiem, apoptosis response zinc fingerserine/threonine-protein phosphatase 1 regulatory subunit 10HLA-C associated transcript 53MHC class I region proline-rich protein CAT53PP1-binding protein of 114 kDaphosphatase 1 nuclear targeting subunitprotein phosphatase 1, regulatory (inhibitor)
Modification date2020031320200313
UniProtAcc

Q92785

.
Ensembl transtripts involved in fusion geneENST00000532264, ENST00000252268, 
ENST00000415073, ENST00000528416, 
ENST00000376511, ENST00000484449, 
ENST00000383586, ENST00000420949, 
ENST00000424446, ENST00000426299, 
ENST00000429597, ENST00000449113, 
ENST00000468706, ENST00000475926, 
ENST00000478528, ENST00000482076, 
ENST00000488513, ENST00000494003, 
ENST00000547333, ENST00000548899, 
ENST00000549281, ENST00000549865, 
ENST00000551493, ENST00000552146, 
Fusion gene scores* DoF score7 X 5 X 5=1758 X 7 X 5=280
# samples 107
** MAII scorelog2(10/175*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPF2 [Title/Abstract] AND PPP1R10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPF2(65101389)-PPP1R10(30577732), # samples:1
DPF2(65108016)-PPP1R10(30577732), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R10

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

23426265


check buttonFusion gene breakpoints across DPF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP1R10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A825-06ADPF2chr11

65101389

+PPP1R10chr6

30577732

-
ChimerDB4SKCMTCGA-W3-A825-06ADPF2chr11

65108016

-PPP1R10chr6

30577732

-


Top

Fusion Gene ORF analysis for DPF2-PPP1R10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000532264ENST00000376511DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-5UTRENST00000532264ENST00000484449DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000383586DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000420949DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000424446DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000426299DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000429597DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000449113DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000468706DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000475926DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000478528DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000482076DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000488513DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000494003DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000547333DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000548899DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000549281DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000549865DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000551493DPF2chr11

65101389

+PPP1R10chr6

30577732

-
3UTR-intronENST00000532264ENST00000552146DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000252268ENST00000376511DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000252268ENST00000376511DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-5UTRENST00000252268ENST00000484449DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000252268ENST00000484449DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-5UTRENST00000415073ENST00000376511DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000415073ENST00000376511DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-5UTRENST00000415073ENST00000484449DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000415073ENST00000484449DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-5UTRENST00000528416ENST00000376511DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000528416ENST00000376511DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-5UTRENST00000528416ENST00000484449DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-5UTRENST00000528416ENST00000484449DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000383586DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000383586DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000420949DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000420949DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000424446DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000424446DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000426299DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000426299DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000429597DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000429597DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000449113DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000449113DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000468706DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000468706DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000475926DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000475926DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000478528DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000478528DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000482076DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000482076DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000488513DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000488513DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000494003DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000494003DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000547333DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000547333DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000548899DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000548899DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000549281DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000549281DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000549865DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000549865DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000551493DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000551493DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000552146DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000252268ENST00000552146DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000383586DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000383586DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000420949DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000420949DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000424446DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000424446DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000426299DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000426299DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000429597DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000429597DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000449113DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000449113DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000468706DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000468706DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000475926DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000475926DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000478528DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000478528DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000482076DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000482076DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000488513DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000488513DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000494003DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000494003DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000547333DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000547333DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000548899DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000548899DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000549281DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000549281DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000549865DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000549865DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000551493DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000551493DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000552146DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000415073ENST00000552146DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000383586DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000383586DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000420949DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000420949DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000424446DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000424446DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000426299DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000426299DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000429597DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000429597DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000449113DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000449113DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000468706DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000468706DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000475926DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000475926DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000478528DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000478528DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000482076DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000482076DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000488513DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000488513DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000494003DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000494003DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000547333DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000547333DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000548899DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000548899DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000549281DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000549281DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000549865DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000549865DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000551493DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000551493DPF2chr11

65108016

-PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000552146DPF2chr11

65101389

+PPP1R10chr6

30577732

-
5CDS-intronENST00000528416ENST00000552146DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-5UTRENST00000532264ENST00000376511DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-5UTRENST00000532264ENST00000484449DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000383586DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000420949DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000424446DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000426299DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000429597DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000449113DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000468706DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000475926DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000478528DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000482076DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000488513DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000494003DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000547333DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000548899DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000549281DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000549865DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000551493DPF2chr11

65108016

-PPP1R10chr6

30577732

-
intron-intronENST00000532264ENST00000552146DPF2chr11

65108016

-PPP1R10chr6

30577732

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DPF2-PPP1R10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DPF2-PPP1R10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:65101389/:30577732)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPF2

Q92785

.
FUNCTION: Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DPF2-PPP1R10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DPF2-PPP1R10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DPF2-PPP1R10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DPF2-PPP1R10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource