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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPH7-PPP2R4 (FusionGDB2 ID:23968)

Fusion Gene Summary for DPH7-PPP2R4

check button Fusion gene summary
Fusion gene informationFusion gene name: DPH7-PPP2R4
Fusion gene ID: 23968
HgeneTgene
Gene symbol

DPH7

PPP2R4

Gene ID

92715

5524

Gene namediphthamide biosynthesis 7protein phosphatase 2 phosphatase activator
SynonymsC9orf112|RRT2|WDR85PP2A|PPP2R4|PR53
Cytomap

9q34.3

9q34.11

Type of geneprotein-codingprotein-coding
Descriptiondiphthine methyltransferaseWD repeat-containing protein 85serine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosph
Modification date2020031320200329
UniProtAcc

Q9BTV6

.
Ensembl transtripts involved in fusion geneENST00000277540, ENST00000479650, 
ENST00000347048, ENST00000355007, 
ENST00000357197, ENST00000414510, 
ENST00000419582, ENST00000423100, 
ENST00000432124, ENST00000432651, 
ENST00000434095, ENST00000435132, 
ENST00000435305, ENST00000436883, 
ENST00000524946, ENST00000337738, 
ENST00000348141, ENST00000358994, 
ENST00000393370, ENST00000452489, 
Fusion gene scores* DoF score5 X 7 X 6=2103 X 4 X 2=24
# samples 74
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DPH7 [Title/Abstract] AND PPP2R4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPH7(140468660)-PPP2R4(131885331), # samples:1
DPH7(140470532)-PPP2R4(131885331), # samples:1
Anticipated loss of major functional domain due to fusion event.DPH7-PPP2R4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DPH7-PPP2R4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP2R4

GO:0032515

negative regulation of phosphoprotein phosphatase activity

16916641

TgenePPP2R4

GO:0032516

positive regulation of phosphoprotein phosphatase activity

16916641

TgenePPP2R4

GO:0035307

positive regulation of protein dephosphorylation

16916641

TgenePPP2R4

GO:0035308

negative regulation of protein dephosphorylation

16916641

TgenePPP2R4

GO:0043065

positive regulation of apoptotic process

17333320

TgenePPP2R4

GO:0043666

regulation of phosphoprotein phosphatase activity

16916641


check buttonFusion gene breakpoints across DPH7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A159-01ADPH7chr9

140468660

-PPP2R4chr9

131885331

+
ChimerDB4BRCATCGA-E2-A159-01ADPH7chr9

140470532

-PPP2R4chr9

131885331

+


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Fusion Gene ORF analysis for DPH7-PPP2R4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000277540ENST00000347048DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000347048DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000355007DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000355007DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000357197DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000357197DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000414510DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000414510DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000419582DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000419582DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000423100DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000423100DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000432124DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000432124DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000432651DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000432651DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000434095DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000434095DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000435132DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000435132DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000435305DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000435305DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000436883DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000436883DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000524946DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5CDS-intronENST00000277540ENST00000524946DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000337738DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000337738DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000348141DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000348141DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000358994DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000358994DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000393370DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000393370DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000452489DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-3CDSENST00000479650ENST00000452489DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000347048DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000347048DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000355007DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000355007DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000357197DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000357197DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000414510DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000414510DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000419582DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000419582DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000423100DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000423100DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000432124DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000432124DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000432651DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000432651DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000434095DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000434095DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000435132DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000435132DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000435305DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000435305DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000436883DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000436883DPH7chr9

140470532

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000524946DPH7chr9

140468660

-PPP2R4chr9

131885331

+
5UTR-intronENST00000479650ENST00000524946DPH7chr9

140470532

-PPP2R4chr9

131885331

+
Frame-shiftENST00000277540ENST00000337738DPH7chr9

140468660

-PPP2R4chr9

131885331

+
Frame-shiftENST00000277540ENST00000348141DPH7chr9

140468660

-PPP2R4chr9

131885331

+
Frame-shiftENST00000277540ENST00000358994DPH7chr9

140468660

-PPP2R4chr9

131885331

+
Frame-shiftENST00000277540ENST00000393370DPH7chr9

140468660

-PPP2R4chr9

131885331

+
Frame-shiftENST00000277540ENST00000452489DPH7chr9

140468660

-PPP2R4chr9

131885331

+
In-frameENST00000277540ENST00000337738DPH7chr9

140470532

-PPP2R4chr9

131885331

+
In-frameENST00000277540ENST00000348141DPH7chr9

140470532

-PPP2R4chr9

131885331

+
In-frameENST00000277540ENST00000358994DPH7chr9

140470532

-PPP2R4chr9

131885331

+
In-frameENST00000277540ENST00000393370DPH7chr9

140470532

-PPP2R4chr9

131885331

+
In-frameENST00000277540ENST00000452489DPH7chr9

140470532

-PPP2R4chr9

131885331

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277540DPH7chr9140470532-ENST00000358994PPP2R4chr9131885331+2856533531375440
ENST00000277540DPH7chr9140470532-ENST00000393370PPP2R4chr9131885331+2858533531375440
ENST00000277540DPH7chr9140470532-ENST00000337738PPP2R4chr9131885331+2961533531480475
ENST00000277540DPH7chr9140470532-ENST00000348141PPP2R4chr9131885331+2858533531375440
ENST00000277540DPH7chr9140470532-ENST00000452489PPP2R4chr9131885331+2028533531528491

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277540ENST00000358994DPH7chr9140470532-PPP2R4chr9131885331+0.0016584180.99834156
ENST00000277540ENST00000393370DPH7chr9140470532-PPP2R4chr9131885331+0.0016490940.998351
ENST00000277540ENST00000337738DPH7chr9140470532-PPP2R4chr9131885331+0.0016095160.99839056
ENST00000277540ENST00000348141DPH7chr9140470532-PPP2R4chr9131885331+0.0016490940.998351
ENST00000277540ENST00000452489DPH7chr9140470532-PPP2R4chr9131885331+0.0026959380.9973041

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Fusion Genomic Features for DPH7-PPP2R4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DPH7chr9140468659-PPP2R4chr9131885330+5.84E-101
DPH7chr9140470531-PPP2R4chr9131885330+1.56E-081
DPH7chr9140468659-PPP2R4chr9131885330+5.84E-101
DPH7chr9140470531-PPP2R4chr9131885330+1.56E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DPH7-PPP2R4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140468660/chr9:131885331)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPH7

Q9BTV6

.
FUNCTION: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250|UniProtKB:P38332, ECO:0000269|PubMed:19965467, ECO:0000269|PubMed:23486472}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R4chr9:140470532chr9:131885331ENST00000337738111183_18943359.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000337738111240_24243359.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000337738111342_34343359.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035500719183_18943282.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035500719240_24243282.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035500719342_34343282.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035719709183_1890295.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035719709240_2420295.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST0000035719709342_3430295.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000358994211183_18943324.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000358994211240_24243324.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000358994211342_34343324.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000393370110183_18943324.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000393370110240_24243324.0Nucleotide bindingNote=ATP
TgenePPP2R4chr9:140470532chr9:131885331ENST00000393370110342_34343324.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39131_185125453.0RepeatNote=WD 2
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39186_229125453.0RepeatNote=WD 3
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39230_273125453.0RepeatNote=WD 4
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39274_313125453.0RepeatNote=WD 5
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39314_403125453.0RepeatNote=WD 6
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-39404_448125453.0RepeatNote=WD 7
HgeneDPH7chr9:140470532chr9:131885331ENST00000277540-3979_130125453.0RepeatNote=WD 1


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Fusion Gene Sequence for DPH7-PPP2R4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23968_23968_1_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000337738_length(transcript)=2961nt_BP=533nt
CCCCGGAAGGAGTCGCGAGAGAGGCGGCCCGCGCTGACGGTGTCCCTGGGGCTCTGCGCTCGTCCGGCCGGCCCCGGCCTCGCCGCCCCG
CGCAGTACCCAGCCCGGCCCCGCCGACCCGCCTCTACTGCCGGCTCCGCGCCCTTCCCCGAGGGCTGGATGATGGGCTGTTTCGCCCTGC
AAACGGTGGACACCGAGCTGACCGCGGACTCGGTGGAGTGGTGCCCGCTGCAAGGCTGCAGGCACCTGCTGGCGTGCGGGACCTACCAGC
TGCGGCGGCCGGAGGACCGGCCTGCCGGCCCCCAGAACAAGGGTGGAATGGAAGTTAAGGAGCCTCAGGTCCGTTTAGGCCGTCTCTTCC
TGTACAGTTTCAATGACAACAACTCTATTCACCCTCTGGTCGAGGTCCAAAGAAAAGATACTTCTGCAATCCTGGACATGAAATGGTGTC
ACATCCCGGTGGCTGGACATGCCCTCTTGGGCTTGGCAGATGCCAGTGGATCCATACAACTGCTCCGCCTGGTGGAATCTGAGGCATACG
CTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGATGTGGAATG
AGGTTCATGAGGAAAAGGAGCAGGCTGCAAAGCAGAGTGTGTCCTGCGATGAATGCATACCATTACCCCGCGCCGGGCACTGTGCACCTT
CGGAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTG
GGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTG
CTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTG
CTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGG
TTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCA
TCTGGGGCAGTTCGCAGCTGATAGACCACCCATACCTGGAGCCCAGACACTTTGTGGATGAGAAGGCCGTGAATGAGAACCACAAGGACT
ACATGTTCCTGGAGTGTATCCTGTTTATTACCGAGATGAAGACTGGCCCATTTGCAGAGCACTCCAACCAGCTGTGGAACATCAGCGCCG
TCCCTTCCTGGTCCAAAGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGTGCCTGGAGAAGTTCCCTGTGATCCAGCACTTCAAGT
TCGGGAGCCTGCTGCCCATCCATCCTGTCACGTCGGGCTAGGAGGGGCCAAGCCGAAGAGCCACCCAGGCCACAGTTCCTGTGCCTGCCT
TCCCCACCCCAGCAGTGGCCCCTCCCCATCCCCTCCCTCTGTTCGTCCCGTTTGATGAGAGGCTGTTTACTGGGGTGGGGTGGCGAGATG
GGCTTGAGGGGGCTCAGAGCATAAGGCTTCAGGGCCCAAGTTGGGAGAAGTGACCAAAGTGTAGCCAGTTTTCTGAGTTCCCGTGTGCTA
GACTGGCCAGAAGAGAGGGTCTGGGGCCTGGTCACTCGGCCACTCTCTCCTGTTTCTGGCCTCTTCTCCCTTCACTCCCGTCCAGTCTGG
TTTTGAGAGCAGGGGCTGTTCTGCAGCACCGCAGGGAAGGGAGGAGAGATACCTGCTGCTTCCATTGCTTTTCCCTTCCTGGAGTCGATG
CCTTTCTAAGGGTTGGAGCTGCTCCTTGCAGGGGCGGGTCAGTTTCCCAGGCCATGCCGGGGTGGCCATCTATGGTAGGGCTGGAAGCTG
AGGCTGGCCGCCAGCTGTGGGCTGGGGTGGGGTGGGTGGGGTCGGGTGGTGGAGAGGCCTTAGCTGTCCTGGCTGGTGCCCCTCCCAGGC
TCCTTTTCACCCTGCCCCCTGGGCCTGAGGCCCCCTGTGTCCAAGCCTCCCCCTGGCTCTTCAGTTCTCTAGCCCTTGGCTCTGCTGGGT
TTCCTGACTGTAGCCACATCTCTCCCGCTCCCTAAGGGTAACCTAGCCAATGGAAGCTGCCCTTTGGGTAGGTGCTGGGCTCCTGGGAGG
GCCCAGATGATGGGGTGAGGCATGTCTTTCCAGAACTTTCCCTGGCAGGGAGGGGATGGCAGAAACTCAGGGAGGGGCTTGGGGCCCATT
GTATCTGGAGAGCCTGGATTCCTCTTGGCAGTCTTAGGCCCGGCCACTTCTGCTACCTTTGCGCTGCTGTGAGCCTCACCCTGGGCCCCT
GGGCCCTGCTTCTCTGCTCCCCTGGGTGATGGGTGGGCCCAGAAGGTGGCAGTCCCACACCTTGTCCTCCCACCTCCCTGAACTGTCCAT
TGCTTTTATAGGGTGAGGTAAGAGACAGCCTCCCAAGCCCAGGCTTTGGCACTCAGAATGGGCCCAGTGGGGGCTGGGCAGGCCCATTGA
GGGCCACCGCCGAGGTTTCTCCTAGGGCTGTTCCTGGGCCTGGCTCTTACAGGCTCGTCCCCCAGGCCTGCCCTTCTCCACTGCCCCCTC
CTGTGTCTGGGTCCACACACCCTTCAGGAAGGGGGAGCACTGAGAAGCACAGCACAGGGGCTCAGCCTGGGATCCGGTGATGGTCTGGGC
AGAGGCTGGGTCAGGAGTCCCAAAGGTCAGTGACAGTTTCTCAGAAGAGGCCCAGCGTCCACCTCTCTCCCAGGGCCAGACAGCCCTTCC

>23968_23968_1_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000337738_length(amino acids)=475AA_BP=160
MRSSGRPRPRRPAQYPARPRRPASTAGSAPFPEGWMMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGME
VKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEAYADYIGFILTLNEGVKGKK
LTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAEN
LVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQG
VWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAE

--------------------------------------------------------------
>23968_23968_2_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000348141_length(transcript)=2858nt_BP=533nt
CCCCGGAAGGAGTCGCGAGAGAGGCGGCCCGCGCTGACGGTGTCCCTGGGGCTCTGCGCTCGTCCGGCCGGCCCCGGCCTCGCCGCCCCG
CGCAGTACCCAGCCCGGCCCCGCCGACCCGCCTCTACTGCCGGCTCCGCGCCCTTCCCCGAGGGCTGGATGATGGGCTGTTTCGCCCTGC
AAACGGTGGACACCGAGCTGACCGCGGACTCGGTGGAGTGGTGCCCGCTGCAAGGCTGCAGGCACCTGCTGGCGTGCGGGACCTACCAGC
TGCGGCGGCCGGAGGACCGGCCTGCCGGCCCCCAGAACAAGGGTGGAATGGAAGTTAAGGAGCCTCAGGTCCGTTTAGGCCGTCTCTTCC
TGTACAGTTTCAATGACAACAACTCTATTCACCCTCTGGTCGAGGTCCAAAGAAAAGATACTTCTGCAATCCTGGACATGAAATGGTGTC
ACATCCCGGTGGCTGGACATGCCCTCTTGGGCTTGGCAGATGCCAGTGGATCCATACAACTGCTCCGCCTGGTGGAATCTGAGGCATACG
CTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGA
AACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACA
GGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGG
CTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTC
TCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCC
AGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGC
AGCTGATAGACCACCCATACCTGGAGCCCAGACACTTTGTGGATGAGAAGGCCGTGAATGAGAACCACAAGGACTACATGTTCCTGGAGT
GTATCCTGTTTATTACCGAGATGAAGACTGGCCCATTTGCAGAGCACTCCAACCAGCTGTGGAACATCAGCGCCGTCCCTTCCTGGTCCA
AAGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGTGCCTGGAGAAGTTCCCTGTGATCCAGCACTTCAAGTTCGGGAGCCTGCTGC
CCATCCATCCTGTCACGTCGGGCTAGGAGGGGCCAAGCCGAAGAGCCACCCAGGCCACAGTTCCTGTGCCTGCCTTCCCCACCCCAGCAG
TGGCCCCTCCCCATCCCCTCCCTCTGTTCGTCCCGTTTGATGAGAGGCTGTTTACTGGGGTGGGGTGGCGAGATGGGCTTGAGGGGGCTC
AGAGCATAAGGCTTCAGGGCCCAAGTTGGGAGAAGTGACCAAAGTGTAGCCAGTTTTCTGAGTTCCCGTGTGCTAGACTGGCCAGAAGAG
AGGGTCTGGGGCCTGGTCACTCGGCCACTCTCTCCTGTTTCTGGCCTCTTCTCCCTTCACTCCCGTCCAGTCTGGTTTTGAGAGCAGGGG
CTGTTCTGCAGCACCGCAGGGAAGGGAGGAGAGATACCTGCTGCTTCCATTGCTTTTCCCTTCCTGGAGTCGATGCCTTTCTAAGGGTTG
GAGCTGCTCCTTGCAGGGGCGGGTCAGTTTCCCAGGCCATGCCGGGGTGGCCATCTATGGTAGGGCTGGAAGCTGAGGCTGGCCGCCAGC
TGTGGGCTGGGGTGGGGTGGGTGGGGTCGGGTGGTGGAGAGGCCTTAGCTGTCCTGGCTGGTGCCCCTCCCAGGCTCCTTTTCACCCTGC
CCCCTGGGCCTGAGGCCCCCTGTGTCCAAGCCTCCCCCTGGCTCTTCAGTTCTCTAGCCCTTGGCTCTGCTGGGTTTCCTGACTGTAGCC
ACATCTCTCCCGCTCCCTAAGGGTAACCTAGCCAATGGAAGCTGCCCTTTGGGTAGGTGCTGGGCTCCTGGGAGGGCCCAGATGATGGGG
TGAGGCATGTCTTTCCAGAACTTTCCCTGGCAGGGAGGGGATGGCAGAAACTCAGGGAGGGGCTTGGGGCCCATTGTATCTGGAGAGCCT
GGATTCCTCTTGGCAGTCTTAGGCCCGGCCACTTCTGCTACCTTTGCGCTGCTGTGAGCCTCACCCTGGGCCCCTGGGCCCTGCTTCTCT
GCTCCCCTGGGTGATGGGTGGGCCCAGAAGGTGGCAGTCCCACACCTTGTCCTCCCACCTCCCTGAACTGTCCATTGCTTTTATAGGGTG
AGGTAAGAGACAGCCTCCCAAGCCCAGGCTTTGGCACTCAGAATGGGCCCAGTGGGGGCTGGGCAGGCCCATTGAGGGCCACCGCCGAGG
TTTCTCCTAGGGCTGTTCCTGGGCCTGGCTCTTACAGGCTCGTCCCCCAGGCCTGCCCTTCTCCACTGCCCCCTCCTGTGTCTGGGTCCA
CACACCCTTCAGGAAGGGGGAGCACTGAGAAGCACAGCACAGGGGCTCAGCCTGGGATCCGGTGATGGTCTGGGCAGAGGCTGGGTCAGG
AGTCCCAAAGGTCAGTGACAGTTTCTCAGAAGAGGCCCAGCGTCCACCTCTCTCCCAGGGCCAGACAGCCCTTCCTGGCTCCCCCATCCC

>23968_23968_2_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000348141_length(amino acids)=440AA_BP=160
MRSSGRPRPRRPAQYPARPRRPASTAGSAPFPEGWMMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGME
VKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEAYADYIGFILTLNEGVKGKK
LTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGT
GHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKA

--------------------------------------------------------------
>23968_23968_3_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000358994_length(transcript)=2856nt_BP=533nt
CCCCGGAAGGAGTCGCGAGAGAGGCGGCCCGCGCTGACGGTGTCCCTGGGGCTCTGCGCTCGTCCGGCCGGCCCCGGCCTCGCCGCCCCG
CGCAGTACCCAGCCCGGCCCCGCCGACCCGCCTCTACTGCCGGCTCCGCGCCCTTCCCCGAGGGCTGGATGATGGGCTGTTTCGCCCTGC
AAACGGTGGACACCGAGCTGACCGCGGACTCGGTGGAGTGGTGCCCGCTGCAAGGCTGCAGGCACCTGCTGGCGTGCGGGACCTACCAGC
TGCGGCGGCCGGAGGACCGGCCTGCCGGCCCCCAGAACAAGGGTGGAATGGAAGTTAAGGAGCCTCAGGTCCGTTTAGGCCGTCTCTTCC
TGTACAGTTTCAATGACAACAACTCTATTCACCCTCTGGTCGAGGTCCAAAGAAAAGATACTTCTGCAATCCTGGACATGAAATGGTGTC
ACATCCCGGTGGCTGGACATGCCCTCTTGGGCTTGGCAGATGCCAGTGGATCCATACAACTGCTCCGCCTGGTGGAATCTGAGGCATACG
CTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGA
AACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACA
GGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGG
CTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTC
TCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCC
AGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGC
AGCTGATAGACCACCCATACCTGGAGCCCAGACACTTTGTGGATGAGAAGGCCGTGAATGAGAACCACAAGGACTACATGTTCCTGGAGT
GTATCCTGTTTATTACCGAGATGAAGACTGGCCCATTTGCAGAGCACTCCAACCAGCTGTGGAACATCAGCGCCGTCCCTTCCTGGTCCA
AAGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGTGCCTGGAGAAGTTCCCTGTGATCCAGCACTTCAAGTTCGGGAGCCTGCTGC
CCATCCATCCTGTCACGTCGGGCTAGGAGGGGCCAAGCCGAAGAGCCACCCAGGCCACAGTTCCTGTGCCTGCCTTCCCCACCCCAGCAG
TGGCCCCTCCCCATCCCCTCCCTCTGTTCGTCCCGTTTGATGAGAGGCTGTTTACTGGGGTGGGGTGGCGAGATGGGCTTGAGGGGGCTC
AGAGCATAAGGCTTCAGGGCCCAAGTTGGGAGAAGTGACCAAAGTGTAGCCAGTTTTCTGAGTTCCCGTGTGCTAGACTGGCCAGAAGAG
AGGGTCTGGGGCCTGGTCACTCGGCCACTCTCTCCTGTTTCTGGCCTCTTCTCCCTTCACTCCCGTCCAGTCTGGTTTTGAGAGCAGGGG
CTGTTCTGCAGCACCGCAGGGAAGGGAGGAGAGATACCTGCTGCTTCCATTGCTTTTCCCTTCCTGGAGTCGATGCCTTTCTAAGGGTTG
GAGCTGCTCCTTGCAGGGGCGGGTCAGTTTCCCAGGCCATGCCGGGGTGGCCATCTATGGTAGGGCTGGAAGCTGAGGCTGGCCGCCAGC
TGTGGGCTGGGGTGGGGTGGGTGGGGTCGGGTGGTGGAGAGGCCTTAGCTGTCCTGGCTGGTGCCCCTCCCAGGCTCCTTTTCACCCTGC
CCCCTGGGCCTGAGGCCCCCTGTGTCCAAGCCTCCCCCTGGCTCTTCAGTTCTCTAGCCCTTGGCTCTGCTGGGTTTCCTGACTGTAGCC
ACATCTCTCCCGCTCCCTAAGGGTAACCTAGCCAATGGAAGCTGCCCTTTGGGTAGGTGCTGGGCTCCTGGGAGGGCCCAGATGATGGGG
TGAGGCATGTCTTTCCAGAACTTTCCCTGGCAGGGAGGGGATGGCAGAAACTCAGGGAGGGGCTTGGGGCCCATTGTATCTGGAGAGCCT
GGATTCCTCTTGGCAGTCTTAGGCCCGGCCACTTCTGCTACCTTTGCGCTGCTGTGAGCCTCACCCTGGGCCCCTGGGCCCTGCTTCTCT
GCTCCCCTGGGTGATGGGTGGGCCCAGAAGGTGGCAGTCCCACACCTTGTCCTCCCACCTCCCTGAACTGTCCATTGCTTTTATAGGGTG
AGGTAAGAGACAGCCTCCCAAGCCCAGGCTTTGGCACTCAGAATGGGCCCAGTGGGGGCTGGGCAGGCCCATTGAGGGCCACCGCCGAGG
TTTCTCCTAGGGCTGTTCCTGGGCCTGGCTCTTACAGGCTCGTCCCCCAGGCCTGCCCTTCTCCACTGCCCCCTCCTGTGTCTGGGTCCA
CACACCCTTCAGGAAGGGGGAGCACTGAGAAGCACAGCACAGGGGCTCAGCCTGGGATCCGGTGATGGTCTGGGCAGAGGCTGGGTCAGG
AGTCCCAAAGGTCAGTGACAGTTTCTCAGAAGAGGCCCAGCGTCCACCTCTCTCCCAGGGCCAGACAGCCCTTCCTGGCTCCCCCATCCC

>23968_23968_3_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000358994_length(amino acids)=440AA_BP=160
MRSSGRPRPRRPAQYPARPRRPASTAGSAPFPEGWMMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGME
VKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEAYADYIGFILTLNEGVKGKK
LTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGT
GHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKA

--------------------------------------------------------------
>23968_23968_4_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000393370_length(transcript)=2858nt_BP=533nt
CCCCGGAAGGAGTCGCGAGAGAGGCGGCCCGCGCTGACGGTGTCCCTGGGGCTCTGCGCTCGTCCGGCCGGCCCCGGCCTCGCCGCCCCG
CGCAGTACCCAGCCCGGCCCCGCCGACCCGCCTCTACTGCCGGCTCCGCGCCCTTCCCCGAGGGCTGGATGATGGGCTGTTTCGCCCTGC
AAACGGTGGACACCGAGCTGACCGCGGACTCGGTGGAGTGGTGCCCGCTGCAAGGCTGCAGGCACCTGCTGGCGTGCGGGACCTACCAGC
TGCGGCGGCCGGAGGACCGGCCTGCCGGCCCCCAGAACAAGGGTGGAATGGAAGTTAAGGAGCCTCAGGTCCGTTTAGGCCGTCTCTTCC
TGTACAGTTTCAATGACAACAACTCTATTCACCCTCTGGTCGAGGTCCAAAGAAAAGATACTTCTGCAATCCTGGACATGAAATGGTGTC
ACATCCCGGTGGCTGGACATGCCCTCTTGGGCTTGGCAGATGCCAGTGGATCCATACAACTGCTCCGCCTGGTGGAATCTGAGGCATACG
CTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGGCCATTGAGA
AACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTGGGAATAAGGCATACA
GGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTGCTGTGCCTGAGGTGG
CTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTGCTTTCCTCTGCTGTC
TCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGGTTATGCGGAAACTCC
AGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCATCTGGGGCAGTTCGC
AGCTGATAGACCACCCATACCTGGAGCCCAGACACTTTGTGGATGAGAAGGCCGTGAATGAGAACCACAAGGACTACATGTTCCTGGAGT
GTATCCTGTTTATTACCGAGATGAAGACTGGCCCATTTGCAGAGCACTCCAACCAGCTGTGGAACATCAGCGCCGTCCCTTCCTGGTCCA
AAGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGTGCCTGGAGAAGTTCCCTGTGATCCAGCACTTCAAGTTCGGGAGCCTGCTGC
CCATCCATCCTGTCACGTCGGGCTAGGAGGGGCCAAGCCGAAGAGCCACCCAGGCCACAGTTCCTGTGCCTGCCTTCCCCACCCCAGCAG
TGGCCCCTCCCCATCCCCTCCCTCTGTTCGTCCCGTTTGATGAGAGGCTGTTTACTGGGGTGGGGTGGCGAGATGGGCTTGAGGGGGCTC
AGAGCATAAGGCTTCAGGGCCCAAGTTGGGAGAAGTGACCAAAGTGTAGCCAGTTTTCTGAGTTCCCGTGTGCTAGACTGGCCAGAAGAG
AGGGTCTGGGGCCTGGTCACTCGGCCACTCTCTCCTGTTTCTGGCCTCTTCTCCCTTCACTCCCGTCCAGTCTGGTTTTGAGAGCAGGGG
CTGTTCTGCAGCACCGCAGGGAAGGGAGGAGAGATACCTGCTGCTTCCATTGCTTTTCCCTTCCTGGAGTCGATGCCTTTCTAAGGGTTG
GAGCTGCTCCTTGCAGGGGCGGGTCAGTTTCCCAGGCCATGCCGGGGTGGCCATCTATGGTAGGGCTGGAAGCTGAGGCTGGCCGCCAGC
TGTGGGCTGGGGTGGGGTGGGTGGGGTCGGGTGGTGGAGAGGCCTTAGCTGTCCTGGCTGGTGCCCCTCCCAGGCTCCTTTTCACCCTGC
CCCCTGGGCCTGAGGCCCCCTGTGTCCAAGCCTCCCCCTGGCTCTTCAGTTCTCTAGCCCTTGGCTCTGCTGGGTTTCCTGACTGTAGCC
ACATCTCTCCCGCTCCCTAAGGGTAACCTAGCCAATGGAAGCTGCCCTTTGGGTAGGTGCTGGGCTCCTGGGAGGGCCCAGATGATGGGG
TGAGGCATGTCTTTCCAGAACTTTCCCTGGCAGGGAGGGGATGGCAGAAACTCAGGGAGGGGCTTGGGGCCCATTGTATCTGGAGAGCCT
GGATTCCTCTTGGCAGTCTTAGGCCCGGCCACTTCTGCTACCTTTGCGCTGCTGTGAGCCTCACCCTGGGCCCCTGGGCCCTGCTTCTCT
GCTCCCCTGGGTGATGGGTGGGCCCAGAAGGTGGCAGTCCCACACCTTGTCCTCCCACCTCCCTGAACTGTCCATTGCTTTTATAGGGTG
AGGTAAGAGACAGCCTCCCAAGCCCAGGCTTTGGCACTCAGAATGGGCCCAGTGGGGGCTGGGCAGGCCCATTGAGGGCCACCGCCGAGG
TTTCTCCTAGGGCTGTTCCTGGGCCTGGCTCTTACAGGCTCGTCCCCCAGGCCTGCCCTTCTCCACTGCCCCCTCCTGTGTCTGGGTCCA
CACACCCTTCAGGAAGGGGGAGCACTGAGAAGCACAGCACAGGGGCTCAGCCTGGGATCCGGTGATGGTCTGGGCAGAGGCTGGGTCAGG
AGTCCCAAAGGTCAGTGACAGTTTCTCAGAAGAGGCCCAGCGTCCACCTCTCTCCCAGGGCCAGACAGCCCTTCCTGGCTCCCCCATCCC

>23968_23968_4_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000393370_length(amino acids)=440AA_BP=160
MRSSGRPRPRRPAQYPARPRRPASTAGSAPFPEGWMMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGME
VKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEAYADYIGFILTLNEGVKGKK
LTFEYRVSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGT
GHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKA

--------------------------------------------------------------
>23968_23968_5_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000452489_length(transcript)=2028nt_BP=533nt
CCCCGGAAGGAGTCGCGAGAGAGGCGGCCCGCGCTGACGGTGTCCCTGGGGCTCTGCGCTCGTCCGGCCGGCCCCGGCCTCGCCGCCCCG
CGCAGTACCCAGCCCGGCCCCGCCGACCCGCCTCTACTGCCGGCTCCGCGCCCTTCCCCGAGGGCTGGATGATGGGCTGTTTCGCCCTGC
AAACGGTGGACACCGAGCTGACCGCGGACTCGGTGGAGTGGTGCCCGCTGCAAGGCTGCAGGCACCTGCTGGCGTGCGGGACCTACCAGC
TGCGGCGGCCGGAGGACCGGCCTGCCGGCCCCCAGAACAAGGGTGGAATGGAAGTTAAGGAGCCTCAGGTCCGTTTAGGCCGTCTCTTCC
TGTACAGTTTCAATGACAACAACTCTATTCACCCTCTGGTCGAGGTCCAAAGAAAAGATACTTCTGCAATCCTGGACATGAAATGGTGTC
ACATCCCGGTGGCTGGACATGCCCTCTTGGGCTTGGCAGATGCCAGTGGATCCATACAACTGCTCCGCCTGGTGGAATCTGAGGCATACG
CTGACTACATCGGATTCATCCTTACCCTCAACGAAGGTGTGAAGGGGAAGAAGCTGACCTTCGAGTACAGAGTCTCCGAGATGTGGAATG
AGGTTCATGAGGAAAAGGAGCAGGCTGCAAAGCAGAGTGTGTCCTGCGATGAATGCATACCATTACCCCGCGCCGGGCACTGTGCACCTT
CGGAGGCCATTGAGAAACTAGTCGCTCTTCTCAACACGCTGGACAGGTGGATTGATGAGACTCCTCCAGTGGACCAGCCCTCTCGGTTTG
GGAATAAGGCATACAGGACCTGGTATGCCAAACTTGATGAGGAAGCAGAAAACTTGGTGGCCACAGTGGTCCCTACCCATCTGGCAGCTG
CTGTGCCTGAGGTGGCTGTTTACCTAAAGGAGTCAGTGGGGAACTCCACGCGCATTGACTACGGCACAGGGCATGAGGCAGCCTTCGCTG
CTTTCCTCTGCTGTCTCTGCAAGATTGGGGTGCTCCGGGTGGATGACCAAATAGCTATTGTCTTCAAGGTGTTCAATCGGTACCTTGAGG
TTATGCGGAAACTCCAGAAAACATACAGGATGGAGCCAGCCGGCAGCCAGGGAGTGTGGGGTCTGGATGACTTCCAGTTTCTGCCCTTCA
TCTGGGGCAGTTCGCAGCTGATAGACCACCCATACCTGGAGCCCAGACACTTTGTGGATGAGAAGGCCGTGAATGAGAACCACAAGGACT
ACATGTTCCTGGAGTGTATCCTGTTTATTACCGAGATGAAGACTGGCCCATTTGCAGAGCACTCCAACCAGCTGTGGAACATCAGCGCCG
TCCCTTCCTGGTCCAAAGTGAACCAGGGTCTCATCCGCATGTATAAGGCCGAGGCCAGCCCCTCTGACACTTGGGGCCTCGGAATCTCCC
ATCTGGGGCATGGGCAGTCAGAGAAGCACCAGCCACCCCAGCCCCGAAAAGCTGCAGTCCAGCTCTGTCCTGATGAGCTTGGAGGCTGAG
GCAAGGACCTGCTGCATGGGGAGTGGGGGCGATGGGGGCCTCCCTTCTCCTTTATCAAGTGGCCAAAGGCTCCTCAAAGCTCGGGCAGTC
TGAGTCTGGCTCTCCCATGGCATACCTGGGAAGGGTCTTACCCTTTGGAGGCATCTCCAAAGTGCTGCCTTCAAATGTTAGTGTGTATGA
TCACTGAGTGGTGGGAGGTCTGAGGGTAGGCCGAGAATTGGCATTTTTATGGACCGCTTCAGGGATTTTGATGCAAATGGTTTTCCCTGC
TCTCAAATCAGATGCTGAGGAGAGGAGAGCTGAGGCTTCCTGGAGCTCCCCCTGCTGGCAGGCAGCCGAGGGTGTCTCCTGCCCTCTTGG
CACTGTTCTCCCAGCCAAGGAGGTGGCCTTTTCTCTCTTCCAAGTGGGGAGGAGACATTTTATTTCTACTCTGTCCCTTCTGCTAGCTCC

>23968_23968_5_DPH7-PPP2R4_DPH7_chr9_140470532_ENST00000277540_PPP2R4_chr9_131885331_ENST00000452489_length(amino acids)=491AA_BP=160
MRSSGRPRPRRPAQYPARPRRPASTAGSAPFPEGWMMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGME
VKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEAYADYIGFILTLNEGVKGKK
LTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAEN
LVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQG
VWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DPH7-PPP2R4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DPH7-PPP2R4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DPH7-PPP2R4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource