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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPP4-THSD7B (FusionGDB2 ID:24023)

Fusion Gene Summary for DPP4-THSD7B

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP4-THSD7B
Fusion gene ID: 24023
HgeneTgene
Gene symbol

DPP4

THSD7B

Gene ID

1803

80731

Gene namedipeptidyl peptidase 4thrombospondin type 1 domain containing 7B
SynonymsADABP|ADCP2|CD26|DPPIV|TP103-
Cytomap

2q24.2

2q22.1

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)thrombospondin type-1 domain-containing protein 7Bthrombospondin, type I, domain containing 7B
Modification date2020032220200313
UniProtAcc

P27487

.
Ensembl transtripts involved in fusion geneENST00000360534, ENST00000491591, 
ENST00000485379, ENST00000543459, 
ENST00000272643, ENST00000409968, 
ENST00000413152, 
Fusion gene scores* DoF score5 X 5 X 4=1009 X 7 X 4=252
# samples 69
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPP4 [Title/Abstract] AND THSD7B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPP4(162929909)-THSD7B(137813990), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP4

GO:0001666

response to hypoxia

16670267

HgeneDPP4

GO:0006508

proteolysis

27198182

HgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

HgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

HgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

HgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

HgeneDPP4

GO:0042110

T cell activation

7594462

HgeneDPP4

GO:0043542

endothelial cell migration

16651416


check buttonFusion gene breakpoints across DPP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THSD7B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A3A5-01ADPP4chr2

162929909

-THSD7Bchr2

137813990

+


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Fusion Gene ORF analysis for DPP4-THSD7B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360534ENST00000485379DPP4chr2

162929909

-THSD7Bchr2

137813990

+
5CDS-intronENST00000360534ENST00000543459DPP4chr2

162929909

-THSD7Bchr2

137813990

+
In-frameENST00000360534ENST00000272643DPP4chr2

162929909

-THSD7Bchr2

137813990

+
In-frameENST00000360534ENST00000409968DPP4chr2

162929909

-THSD7Bchr2

137813990

+
In-frameENST00000360534ENST00000413152DPP4chr2

162929909

-THSD7Bchr2

137813990

+
intron-3CDSENST00000491591ENST00000272643DPP4chr2

162929909

-THSD7Bchr2

137813990

+
intron-3CDSENST00000491591ENST00000409968DPP4chr2

162929909

-THSD7Bchr2

137813990

+
intron-3CDSENST00000491591ENST00000413152DPP4chr2

162929909

-THSD7Bchr2

137813990

+
intron-intronENST00000491591ENST00000485379DPP4chr2

162929909

-THSD7Bchr2

137813990

+
intron-intronENST00000491591ENST00000543459DPP4chr2

162929909

-THSD7Bchr2

137813990

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360534DPP4chr2162929909-ENST00000409968THSD7Bchr2137813990+644965556153361591
ENST00000360534DPP4chr2162929909-ENST00000272643THSD7Bchr2137813990+645865556153451594
ENST00000360534DPP4chr2162929909-ENST00000413152THSD7Bchr2137813990+645865556153451594

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360534ENST00000409968DPP4chr2162929909-THSD7Bchr2137813990+0.0019816570.9980184
ENST00000360534ENST00000272643DPP4chr2162929909-THSD7Bchr2137813990+0.0018142770.9981857
ENST00000360534ENST00000413152DPP4chr2162929909-THSD7Bchr2137813990+0.0018142770.9981857

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Fusion Genomic Features for DPP4-THSD7B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DPP4chr2162929908-THSD7Bchr2137813989+0.0004697920.9995302
DPP4chr2162929908-THSD7Bchr2137813989+0.0004697920.9995302

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DPP4-THSD7B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:162929909/chr2:137813990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP4

P27487

.
FUNCTION: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948). {ECO:0000269|PubMed:10570924, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16254193, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:18708048}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. {ECO:0000269|PubMed:23835475}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP4chr2:162929909chr2:137813990ENST00000360534-2261_631767.0Topological domainCytoplasmic
HgeneDPP4chr2:162929909chr2:137813990ENST00000360534-2267_2831767.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028584_589461610.0Compositional biasNote=Poly-Pro
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281000_1125461610.0DomainTSP type-1 13
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028102_177461610.0DomainTSP type-1 2
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281127_1181461610.0DomainTSP type-1 14
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281182_1245461610.0DomainTSP type-1 15
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281247_1302461610.0DomainTSP type-1 16
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281303_1368461610.0DomainTSP type-1 17
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281370_1431461610.0DomainTSP type-1 18
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028179_233461610.0DomainTSP type-1 3
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028336_392461610.0DomainTSP type-1 4
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028399_482461610.0DomainTSP type-1 5
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028484_543461610.0DomainTSP type-1 6
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028601_661461610.0DomainTSP type-1 7
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028662_735461610.0DomainTSP type-1 8
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028737_796461610.0DomainTSP type-1 9
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028797_869461610.0DomainTSP type-1 10
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028871_924461610.0DomainTSP type-1 11
TgeneTHSD7Bchr2:162929909chr2:137813990ENST00000272643028925_998461610.0DomainTSP type-1 12
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281577_1606461610.0Topological domainCytoplasmic
TgeneTHSD7Bchr2:162929909chr2:137813990ENST000002726430281556_1576461610.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP4chr2:162929909chr2:137813990ENST00000360534-22629_76631767.0Topological domainExtracellular
TgeneTHSD7Bchr2:162929909chr2:137813990ENST0000027264302840_98461610.0DomainTSP type-1 1
TgeneTHSD7Bchr2:162929909chr2:137813990ENST0000027264302832_1555461610.0Topological domainExtracellular


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Fusion Gene Sequence for DPP4-THSD7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24023_24023_1_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000272643_length(transcript)=6458nt_BP=655nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCAGTCCGTGGGGAAGGTGTACAGGAGACTGTGGTCCCGGAGGAGTCCAGAGTCGGGCAGTGTGGTGT
TTTCATGTTGACGGGTGGACAAGTCACCTGTCTAACTGTGGTGAGAGCAACAGGCCTCCAAAGGAAAGAAGTTGTTTCCGAGTTTGTGAC
TGGCACAGTGACCTCTTTCAGTGGGAGGTTTCTGACTGGCACCACTGTGTGCTTGTTCCTTACGCTCGCGGTGAAGTCAAGCCTCGGACT
GCAGAGTGTGTGACGGCTCAGCATGGACTGCAGCACCGGATGGTGCGCTGCATTCAGAAGCTGAACCGAACTGTGGTTGCAAATGAAATA
TGCGAACACTTTGCCCTTCAGCCTCCTACAGAACAGGCTTGCCTCATTCCTTGTCCCCGGGATTGTGTAGTATCTGAGTTCTTACCATGG
TCCAACTGTAGCAAGGGATGTGGGAAGAAATTGCAGCATAGAACTCGCGCGGTCATAGCTCCCCCTCTCTTTGGTGGTTTGCAATGTCCA
AATCTGACTGAGTCAAGAGCCTGTGATGCTCCCATTTCCTGTCCTCTTGGGGAAGAGGAATATACATTTAGCCTTAAGGTTGGACCATGG
AGTAAATGCAGACTGCCTCATCTTAAAGAAATTAATCCAAGCGGAAGAACTGTTCTGGATTTTAACTCTGATTCAAATGAGCGAGTCACC
TTTAAACATCAAAGTTACAAAGCACATCATCATTCGAAGTCTTGGGCAATAGAGATAGGTTATCAAACCCGGCAGGTTTCGTGTACAAGA
AGTGATGGACAAAATGCTATGTTAAGCCTTTGCCTTCAAGATTCCTTCCCATTGACTGTTCAGTCCTGCATCATGCCCAAAGACTGTGAA
ACCTCCCAGTGGTCCTCCTGGAGCCCCTGCTCCAAGACATGCCGTTCAGGGAGTCTCTTGCCAGGATTTAGGAGCAGGAGCCGGAACGTG
AAGCACATGGCTATTGGAGGTGGAAAGGAGTGTCCTGAACTTCTTGAGAAAGAGGCCTGCATTGTTGAAGGAGAACTTCTGCAGCAATGT
CCCAGGTATTCCTGGAGAACTTCTGAATGGAAAGAATGCCAAGTCTCTCTCCTCCTCGAGCAGCAGGATCCCCACTGGCATGTGACGGGA
CCCGTGTGTGGCGGTGGGATCCAGACCCGGGAGGTGTACTGTGCCCAGAGCGTACCAGCAGCTGCCGCACTGAGGGCCAAGGAAGTCTCT
AGACCTGTGGAAAAGGCATTATGTGTGGGACCCGCCCCGTTGCCCTCTCAGCTCTGCAATATCCCTTGCTCTACGGACTGCATAGTATCT
TCCTGGTCAGCCTGGGGCCTGTGCATCCATGAAAACTGTCATGATCCTCAGGGGAAAAAAGGATTTAGAACGAGGCAGCGCCATGTCCTC
ATGGAATCTACAGGGCCTGCAGGGCATTGCCCTCATTTGGTGGAGTCTGTTCCTTGTGAGGATCCAATGTGCTACCGATGGCTGGCATCA
GAAGGGATCTGTTTCCCTGATCATGGAAAATGTGGCCTGGGACATCGTATTCTGAAGGCCGTCTGCCAGAATGACCGCGGAGAAGATGTA
TCAGGGAGTCTTTGCCCAGTTCCCCCTCCTCCTGAGAGGAAGTCTTGTGAAATTCCCTGCCGAATGGACTGTGTGCTGAGCGAGTGGACG
GAGTGGTCATCCTGTTCCCAGTCCTGTTCAAATAAAAACTCAGATGGGAAACAGACCAGGTCAAGAACTATCCTGGCACTGGCTGGGGAA
GGTGGAAAGCCATGTCCCCCTAGTCAGGCTCTCCAAGAGCATCGTTTGTGTAATGACCATTCCTGTATGCAGCTTCACTGGGAGACATCG
CCTTGGGGCCCTTGTTCTGAGGACACATTGGTAACTGCCCTTAATGCAACCATTGGCTGGAATGGAGAAGCCACGTGTGGTGTAGGCATT
CAGACTCGGAGAGTCTTCTGTGTCAAGAGTCACGTGGGACAAGTAATGACCAAAAGATGTCCAGATTCTACTCGACCTGAAACTGTGCGC
CCCTGTTTTCTCCCATGCAAAAAAGACTGTATTGTGACTGCTTTCAGTGAGTGGACACCCTGCCCAAGGATGTGCCAAGCAGGAAATGCC
ACAGTAAAACAGTCTCGATACAGAATCATCATCCAAGAAGCAGCCAATGGAGGCCAGGAATGCCCAGATACCTTATATGAGGAGAGAGAG
TGTGAAGATGTTTCCTTGTGTCCTGTATATCGGTGGAAGCCACAGAAATGGAGCCCTTGCATCTTAGTGCCAGAGTCTGTCTGGCAGGGA
ATAACGGGCAGCAGTGAAGCCTGTGGAAAGGGGTTACAAACAAGAGCTGTCTCATGCATCTCTGATGACAACCGGTCAGCAGAAATGATG
GAATGCCTCAAGCAGACAAACGGCATGCCTCTCCTTGTGCAAGAATGCACAGTCCCATGTCGAGAAGACTGCACCTTCACTGCTTGGTCC
AAGTTTACGCCCTGCTCCACGAACTGTGAAGCCACAAAAAGTAGGCGGCGACAGCTCACAGGGAAAAGCAGAAAGAAGGAGAAATGCCAG
GATTCTGACCTTTACCCTCTAGTGGAGACAGAACTATGTCCTTGTGATGAATTTATATCCCAACCTTATGGAAACTGGTCAGATTGCATT
CTTCCAGAAGGCAGAAGGGAGCCTCACCGAGGACTGCGGGTACAAGCAGACAGCAAAGAATGTGGAGAAGGCCTGCGCTTTCGAGCAGTA
GCCTGTTCTGATAAAAATGGAAGACCTGTTGACCCCTCCTTCTGCAGCAGCTCTGGTTACATTCAAGAAAAATGTGTCATTCCCTGCCCA
TTTGATTGCAAGTTAAGCGATTGGTCTAGTTGGGGGTCTTGCAGTTCATCTTGTGGAATTGGAGTGAGAATTCGATCCAAATGGCTAAAA
GAAAAACCTTACAATGGAGGACGACCATGTCCCAAACTGGATCTCAAGAATCAGAATGCTCAGGTACATGAGGCAGTCCCATGTTACAGT
GAGTGCAATCAGTATTCCTGGGTTGTAGAACACTGGTCTTCATGCAAAATCAACAATGAGCTGAGGTCCCTGCGCTGTGGAGGAGGAACA
CAATCTAGGAAAATCAGATGTGTGAATACTGCGGATGGTGAAGGTGGAGCAGTGGATAGCAACCTGTGCAACCAGGATGAAATTCCCCCA
GAAACCCAGTCCTGTTCTCTTATGTGTCCCAATGAGTGTGTCATGTCTGAGTGGGGACTTTGGAGCAAATGCCCACAGTCATGCGATCCC
CACACAATGCAGAGAAGAACTCGCCACCTGCTAAGACCATCACTGAACTCAAGGACTTGTGCTGAAGACTCACAGGTGCAGCCTTGCCTC
CTGAATGAAAATTGCTTCCAGTTCCAGTACAATCTAACAGAGTGGAGCACATGCCAGCTGAGTGAAAACGCACCCTGTGGTCAAGGCGTC
AGGACCCGCCTGCTAAGCTGTGTGTGCAGTGATGGCAAGCCAGTCAGCATGGACCAATGTGAGCAGCATAATTTGGAGAAGCCCCAGAGA
ATGAGCATTCCCTGCTTGGTGGAATGCGTGGTCAACTGTCAGCTCTCAGGGTGGACGGCTTGGACAGAGTGTTCACAGACCTGTGGCCAT
GGAGGTCGAATGAGCCGGACTCGATTTATCATTATGCCAACCCAAGGAGAAGGACGGCCATGCCCCACAGAGCTTACCCAGGAGAAAACC
TGCCCAGTGACCCCCTGCTACAGCTGGGTCCTTGGCAACTGGTCTGCATGTAAATTGGAGGGTGGAGACTGTGGGGAAGGAGTTCAGATC
CGCAGCCTTTCCTGCATGGTCCACAGTGGTTCAATATCTCATGCAGCTGGACGTGTCGAGGATGCACTGTGTGGAGAAATGCCCTTTCAG
GACAGCATCCTGAAGCAGCTGTGTTCTGTGCCTTGCCCAGGAGACTGCCATTTAACAGAATGGTCAGAGTGGAGCACATGTGAATTAACC
TGCATTGATGGAAGAAGCTTTGAGACTGTGGGCCGCCAGTCTAGATCAAGGACTTTTATAATTCAGTCTTTTGAGAACCAAGACAGCTGC
CCCCAACAGGTTCTAGAAACACGCCCTTGTACAGGAGGCAAATGTTATCACTACACATGGAAAGCAAGTCTTTGGAACAATAACGAACGA
ACTGTATGGTGCCAGCGTTCAGATGGCGTTAATGTCACAGGAGGCTGCTCCCCTCAGGCCCGTCCTGCTGCCATTCGGCAGTGCATTCCA
GCCTGCAGAAAACCTTTCTCCTACTGTACACAGGGTGGAGTCTGTGGTTGTGAGAAGGGCTATACAGAGATAATGAAATCAAATGGTTTC
CTGGATTACTGCATGAAAGTACCAGGCTCAGAGGATAAAAAAGCTGATGTGAAAAACCTTTCTGGGAAAAACAGACCTGTGAATTCAAAA
ATACATGATATTTTTAAAGGATGGTCTCTTCAACCACTTGATCCAGATGGCCGAGTAAAAATTTGGGTTTATGGCGTTTCAGGTGGCGCT
TTTCTCATCATGATTTTCCTAATATTTACTTCCTACCTTGTTTGCAAGAAGCCAAAACCACATCAAAGCACACCTCCCCAACAGAAGCCT
CTGACCTTAGCCTACGATGGAGACTTAGACATGTAATCTGAAAAAGAAATCCAAATGTAGACATCAACTGCCTTAACCGCTTTCTCTTTT
GTAGCTCTCAGACTTCTCAGTTTTTTGAGGAATCTCAAGATGTGATATATTGGGCAGAATACAAATATTGCAAAAGTAATATTGCCTCAA
CTTCATTTGGACATGGAGTCAAGGATTATTAGGTCTGCCATTTTGTTTTCAAGTTGTTTGTGGGTGTGTTTTATTTTTTTGGTTTTCCCA
AGGGACCTGAAAACCCTTCTCTTCCTGTTTGGAACTGGGAGGAAGAAAACATGATGGAATTCCCACAGACTTGAGTAAACTTGATCTTCA
GCAGCATAATGACAATCCAGAGGAAAATACAGTCAAGGCATTTACTCTAAATGACGAGTCTGACACTGCATTGTTACGCACTATATTAGT
GCAAAGTCTTTATTCTTCCCATACTTCAACACTGAGTTTTCTAGAGTTTACTTTGGTTTAAAGACTTTCAAATTGGATTGCCTATTTTTC
ATGAACACAGAGAGAATGGATTACCATTTCAGAAATTCTCTGAGTTTTTAACCTTTAAATATTGTATTTTGTTTTGTAGCCAGGGGATGA
TGGCGCTTCATGGGTTGCAGCTACTGAAAATAGCAGCGTGTGTGTAATTGCTGGACTAGATGAAAGCTAGGTCATTTCTGAAGGGAATGT
GTACTGAATGTTAGAGTGTACAAATGAAATATGTGGTTAAATTGGAGAATGAGGTAGATTATTTGATTACTAAAACTGTATTTTAACAAA
AACTTATCCATGTAGATATAGCATTAACCACACACAGTTGTAATTCAGTTTAATGATGACAAACTCTGCTTTTGTAATTTCAATTTTCTT
ATCTGAATATTTATAAATTCTTCTTTCAAATTTAATTATCTGACCTCATTTAATATACATCAAACACCGATCCTGTTTGTACAAAGTCTT
GCTTTTATAAGGTTTCAATAATATCTAAAACAACACATTAAAAAGCTGAGACCATTTTATGAAGATAATTGTTTGTAATCATAGGTGTTG

>24023_24023_1_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000272643_length(amino acids)=1594AA_BP=32
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGSPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ
WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGC
GKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYK
AHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG
GKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKAL
CVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPD
HGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPP
SQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCK
KDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEA
CGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPL
VETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSD
WSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQNAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC
VNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQ
FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRT
RFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQL
CSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRS
DGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKG

--------------------------------------------------------------
>24023_24023_2_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000409968_length(transcript)=6449nt_BP=655nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCAGTCCGTGGGGAAGGTGTACAGGAGACTGTGGTCCCGGAGGAGTCCAGAGTCGGGCAGTGTGGTGT
TTTCATGTTGACGGGTGGACAAGTCACCTGTCTAACTGTGGTGAGAGCAACAGGCCTCCAAAGGAAAGAAGTTGTTTCCGAGTTTGTGAC
TGGCACAGTGACCTCTTTCAGTGGGAGGTTTCTGACTGGCACCACTGTGTGCTTGTTCCTTACGCTCGCGGTGAAGTCAAGCCTCGGACT
GCAGAGTGTGTGACGGCTCAGCATGGACTGCAGCACCGGATGGTGCGCTGCATTCAGAAGCTGAACCGAACTGTGGTTGCAAATGAAATA
TGCGAACACTTTGCCCTTCAGCCTCCTACAGAACAGGCTTGCCTCATTCCTTGTCCCCGGGATTGTGTAGTATCTGAGTTCTTACCATGG
TCCAACTGTAGCAAGGGATGTGGGAAGAAATTGCAGCATAGAACTCGCGCGGTCATAGCTCCCCCTCTCTTTGGTGGTTTGCAATGTCCA
AATCTGACTGAGTCAAGAGCCTGTGATGCTCCCATTTCCTGTCCTCTTGGGGAAGAGGAATATACATTTAGCCTTAAGGTTGGACCATGG
AGTAAATGCAGACTGCCTCATCTTAAAGAAATTAATCCAAGCGGAAGAACTGTTCTGGATTTTAACTCTGATTCAAATGAGCGAGTCACC
TTTAAACATCAAAGTTACAAAGCACATCATCATTCGAAGTCTTGGGCAATAGAGATAGGTTATCAAACCCGGCAGGTTTCGTGTACAAGA
AGTGATGGACAAAATGCTATGTTAAGCCTTTGCCTTCAAGATTCCTTCCCATTGACTGTTCAGTCCTGCATCATGCCCAAAGACTGTGAA
ACCTCCCAGTGGTCCTCCTGGAGCCCCTGCTCCAAGACATGCCGTTCAGGGAGTCTCTTGCCAGGATTTAGGAGCAGGAGCCGGAACGTG
AAGCACATGGCTATTGGAGGTGGAAAGGAGTGTCCTGAACTTCTTGAGAAAGAGGCCTGCATTGTTGAAGGAGAACTTCTGCAGCAATGT
CCCAGGTATTCCTGGAGAACTTCTGAATGGAAAGAATGCCAAGTCTCTCTCCTCCTCGAGCAGCAGGATCCCCACTGGCATGTGACGGGA
CCCGTGTGTGGCGGTGGGATCCAGACCCGGGAGGTGTACTGTGCCCAGAGCGTACCAGCAGCTGCCGCACTGAGGGCCAAGGAAGTCTCT
AGACCTGTGGAAAAGGCATTATGTGTGGGACCCGCCCCGTTGCCCTCTCAGCTCTGCAATATCCCTTGCTCTACGGACTGCATAGTATCT
TCCTGGTCAGCCTGGGGCCTGTGCATCCATGAAAACTGTCATGATCCTCAGGGGAAAAAAGGATTTAGAACGAGGCAGCGCCATGTCCTC
ATGGAATCTACAGGGCCTGCAGGGCATTGCCCTCATTTGGTGGAGTCTGTTCCTTGTGAGGATCCAATGTGCTACCGATGGCTGGCATCA
GAAGGGATCTGTTTCCCTGATCATGGAAAATGTGGCCTGGGACATCGTATTCTGAAGGCCGTCTGCCAGAATGACCGCGGAGAAGATGTA
TCAGGGAGTCTTTGCCCAGTTCCCCCTCCTCCTGAGAGGAAGTCTTGTGAAATTCCCTGCCGAATGGACTGTGTGCTGAGCGAGTGGACG
GAGTGGTCATCCTGTTCCCAGTCCTGTTCAAATAAAAACTCAGATGGGAAACAGACCAGGTCAAGAACTATCCTGGCACTGGCTGGGGAA
GGTGGAAAGCCATGTCCCCCTAGTCAGGCTCTCCAAGAGCATCGTTTGTGTAATGACCATTCCTGTATGCAGCTTCACTGGGAGACATCG
CCTTGGGGCCCTTGTTCTGAGGACACATTGGTAACTGCCCTTAATGCAACCATTGGCTGGAATGGAGAAGCCACGTGTGGTGTAGGCATT
CAGACTCGGAGAGTCTTCTGTGTCAAGAGTCACGTGGGACAAGTAATGACCAAAAGATGTCCAGATTCTACTCGACCTGAAACTGTGCGC
CCCTGTTTTCTCCCATGCAAAAAAGACTGTATTGTGACTGCTTTCAGTGAGTGGACACCCTGCCCAAGGATGTGCCAAGCAGGAAATGCC
ACAGTAAAACAGTCTCGATACAGAATCATCATCCAAGAAGCAGCCAATGGAGGCCAGGAATGCCCAGATACCTTATATGAGGAGAGAGAG
TGTGAAGATGTTTCCTTGTGTCCTGTATATCGGTGGAAGCCACAGAAATGGAGCCCTTGCATCTTAGTGCCAGAGTCTGTCTGGCAGGGA
ATAACGGGCAGCAGTGAAGCCTGTGGAAAGGGGTTACAAACAAGAGCTGTCTCATGCATCTCTGATGACAACCGGTCAGCAGAAATGATG
GAATGCCTCAAGCAGACAAACGGCATGCCTCTCCTTGTGCAAGAATGCACAGTCCCATGTCGAGAAGACTGCACCTTCACTGCTTGGTCC
AAGTTTACGCCCTGCTCCACGAACTGTGAAGCCACAAAAAGTAGGCGGCGACAGCTCACAGGGAAAAGCAGAAAGAAGGAGAAATGCCAG
GATTCTGACCTTTACCCTCTAGTGGAGACAGAACTATGTCCTTGTGATGAATTTATATCCCAACCTTATGGAAACTGGTCAGATTGCATT
CTTCCAGAAGGCAGAAGGGAGCCTCACCGAGGACTGCGGGTACAAGCAGACAGCAAAGAATGTGGAGAAGGCCTGCGCTTTCGAGCAGTA
GCCTGTTCTGATAAAAATGGAAGACCTGTTGACCCCTCCTTCTGCAGCAGCTCTGGTTACATTCAAGAAAAATGTGTCATTCCCTGCCCA
TTTGATTGCAAGTTAAGCGATTGGTCTAGTTGGGGGTCTTGCAGTTCATCTTGTGGAATTGGAGTGAGAATTCGATCCAAATGGCTAAAA
GAAAAACCTTACAATGGAGGACGACCATGTCCCAAACTGGATCTCAAGAATCAGGTACATGAGGCAGTCCCATGTTACAGTGAGTGCAAT
CAGTATTCCTGGGTTGTAGAACACTGGTCTTCATGCAAAATCAACAATGAGCTGAGGTCCCTGCGCTGTGGAGGAGGAACACAATCTAGG
AAAATCAGATGTGTGAATACTGCGGATGGTGAAGGTGGAGCAGTGGATAGCAACCTGTGCAACCAGGATGAAATTCCCCCAGAAACCCAG
TCCTGTTCTCTTATGTGTCCCAATGAGTGTGTCATGTCTGAGTGGGGACTTTGGAGCAAATGCCCACAGTCATGCGATCCCCACACAATG
CAGAGAAGAACTCGCCACCTGCTAAGACCATCACTGAACTCAAGGACTTGTGCTGAAGACTCACAGGTGCAGCCTTGCCTCCTGAATGAA
AATTGCTTCCAGTTCCAGTACAATCTAACAGAGTGGAGCACATGCCAGCTGAGTGAAAACGCACCCTGTGGTCAAGGCGTCAGGACCCGC
CTGCTAAGCTGTGTGTGCAGTGATGGCAAGCCAGTCAGCATGGACCAATGTGAGCAGCATAATTTGGAGAAGCCCCAGAGAATGAGCATT
CCCTGCTTGGTGGAATGCGTGGTCAACTGTCAGCTCTCAGGGTGGACGGCTTGGACAGAGTGTTCACAGACCTGTGGCCATGGAGGTCGA
ATGAGCCGGACTCGATTTATCATTATGCCAACCCAAGGAGAAGGACGGCCATGCCCCACAGAGCTTACCCAGGAGAAAACCTGCCCAGTG
ACCCCCTGCTACAGCTGGGTCCTTGGCAACTGGTCTGCATGTAAATTGGAGGGTGGAGACTGTGGGGAAGGAGTTCAGATCCGCAGCCTT
TCCTGCATGGTCCACAGTGGTTCAATATCTCATGCAGCTGGACGTGTCGAGGATGCACTGTGTGGAGAAATGCCCTTTCAGGACAGCATC
CTGAAGCAGCTGTGTTCTGTGCCTTGCCCAGGAGACTGCCATTTAACAGAATGGTCAGAGTGGAGCACATGTGAATTAACCTGCATTGAT
GGAAGAAGCTTTGAGACTGTGGGCCGCCAGTCTAGATCAAGGACTTTTATAATTCAGTCTTTTGAGAACCAAGACAGCTGCCCCCAACAG
GTTCTAGAAACACGCCCTTGTACAGGAGGCAAATGTTATCACTACACATGGAAAGCAAGTCTTTGGAACAATAACGAACGAACTGTATGG
TGCCAGCGTTCAGATGGCGTTAATGTCACAGGAGGCTGCTCCCCTCAGGCCCGTCCTGCTGCCATTCGGCAGTGCATTCCAGCCTGCAGA
AAACCTTTCTCCTACTGTACACAGGGTGGAGTCTGTGGTTGTGAGAAGGGCTATACAGAGATAATGAAATCAAATGGTTTCCTGGATTAC
TGCATGAAAGTACCAGGCTCAGAGGATAAAAAAGCTGATGTGAAAAACCTTTCTGGGAAAAACAGACCTGTGAATTCAAAAATACATGAT
ATTTTTAAAGGATGGTCTCTTCAACCACTTGATCCAGATGGCCGAGTAAAAATTTGGGTTTATGGCGTTTCAGGTGGCGCTTTTCTCATC
ATGATTTTCCTAATATTTACTTCCTACCTTGTTTGCAAGAAGCCAAAACCACATCAAAGCACACCTCCCCAACAGAAGCCTCTGACCTTA
GCCTACGATGGAGACTTAGACATGTAATCTGAAAAAGAAATCCAAATGTAGACATCAACTGCCTTAACCGCTTTCTCTTTTGTAGCTCTC
AGACTTCTCAGTTTTTTGAGGAATCTCAAGATGTGATATATTGGGCAGAATACAAATATTGCAAAAGTAATATTGCCTCAACTTCATTTG
GACATGGAGTCAAGGATTATTAGGTCTGCCATTTTGTTTTCAAGTTGTTTGTGGGTGTGTTTTATTTTTTTGGTTTTCCCAAGGGACCTG
AAAACCCTTCTCTTCCTGTTTGGAACTGGGAGGAAGAAAACATGATGGAATTCCCACAGACTTGAGTAAACTTGATCTTCAGCAGCATAA
TGACAATCCAGAGGAAAATACAGTCAAGGCATTTACTCTAAATGACGAGTCTGACACTGCATTGTTACGCACTATATTAGTGCAAAGTCT
TTATTCTTCCCATACTTCAACACTGAGTTTTCTAGAGTTTACTTTGGTTTAAAGACTTTCAAATTGGATTGCCTATTTTTCATGAACACA
GAGAGAATGGATTACCATTTCAGAAATTCTCTGAGTTTTTAACCTTTAAATATTGTATTTTGTTTTGTAGCCAGGGGATGATGGCGCTTC
ATGGGTTGCAGCTACTGAAAATAGCAGCGTGTGTGTAATTGCTGGACTAGATGAAAGCTAGGTCATTTCTGAAGGGAATGTGTACTGAAT
GTTAGAGTGTACAAATGAAATATGTGGTTAAATTGGAGAATGAGGTAGATTATTTGATTACTAAAACTGTATTTTAACAAAAACTTATCC
ATGTAGATATAGCATTAACCACACACAGTTGTAATTCAGTTTAATGATGACAAACTCTGCTTTTGTAATTTCAATTTTCTTATCTGAATA
TTTATAAATTCTTCTTTCAAATTTAATTATCTGACCTCATTTAATATACATCAAACACCGATCCTGTTTGTACAAAGTCTTGCTTTTATA
AGGTTTCAATAATATCTAAAACAACACATTAAAAAGCTGAGACCATTTTATGAAGATAATTGTTTGTAATCATAGGTGTTGAAAGTAAAA

>24023_24023_2_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000409968_length(amino acids)=1591AA_BP=32
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGSPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ
WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGC
GKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYK
AHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG
GKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKAL
CVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPD
HGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPP
SQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCK
KDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEA
CGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPL
VETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSD
WSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT
ADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQY
NLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFI
IMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQLCSV
PCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRSDGV
NVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKGWSL

--------------------------------------------------------------
>24023_24023_3_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000413152_length(transcript)=6458nt_BP=655nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCAGTCCGTGGGGAAGGTGTACAGGAGACTGTGGTCCCGGAGGAGTCCAGAGTCGGGCAGTGTGGTGT
TTTCATGTTGACGGGTGGACAAGTCACCTGTCTAACTGTGGTGAGAGCAACAGGCCTCCAAAGGAAAGAAGTTGTTTCCGAGTTTGTGAC
TGGCACAGTGACCTCTTTCAGTGGGAGGTTTCTGACTGGCACCACTGTGTGCTTGTTCCTTACGCTCGCGGTGAAGTCAAGCCTCGGACT
GCAGAGTGTGTGACGGCTCAGCATGGACTGCAGCACCGGATGGTGCGCTGCATTCAGAAGCTGAACCGAACTGTGGTTGCAAATGAAATA
TGCGAACACTTTGCCCTTCAGCCTCCTACAGAACAGGCTTGCCTCATTCCTTGTCCCCGGGATTGTGTAGTATCTGAGTTCTTACCATGG
TCCAACTGTAGCAAGGGATGTGGGAAGAAATTGCAGCATAGAACTCGCGCGGTCATAGCTCCCCCTCTCTTTGGTGGTTTGCAATGTCCA
AATCTGACTGAGTCAAGAGCCTGTGATGCTCCCATTTCCTGTCCTCTTGGGGAAGAGGAATATACATTTAGCCTTAAGGTTGGACCATGG
AGTAAATGCAGACTGCCTCATCTTAAAGAAATTAATCCAAGCGGAAGAACTGTTCTGGATTTTAACTCTGATTCAAATGAGCGAGTCACC
TTTAAACATCAAAGTTACAAAGCACATCATCATTCGAAGTCTTGGGCAATAGAGATAGGTTATCAAACCCGGCAGGTTTCGTGTACAAGA
AGTGATGGACAAAATGCTATGTTAAGCCTTTGCCTTCAAGATTCCTTCCCATTGACTGTTCAGTCCTGCATCATGCCCAAAGACTGTGAA
ACCTCCCAGTGGTCCTCCTGGAGCCCCTGCTCCAAGACATGCCGTTCAGGGAGTCTCTTGCCAGGATTTAGGAGCAGGAGCCGGAACGTG
AAGCACATGGCTATTGGAGGTGGAAAGGAGTGTCCTGAACTTCTTGAGAAAGAGGCCTGCATTGTTGAAGGAGAACTTCTGCAGCAATGT
CCCAGGTATTCCTGGAGAACTTCTGAATGGAAAGAATGCCAAGTCTCTCTCCTCCTCGAGCAGCAGGATCCCCACTGGCATGTGACGGGA
CCCGTGTGTGGCGGTGGGATCCAGACCCGGGAGGTGTACTGTGCCCAGAGCGTACCAGCAGCTGCCGCACTGAGGGCCAAGGAAGTCTCT
AGACCTGTGGAAAAGGCATTATGTGTGGGACCCGCCCCGTTGCCCTCTCAGCTCTGCAATATCCCTTGCTCTACGGACTGCATAGTATCT
TCCTGGTCAGCCTGGGGCCTGTGCATCCATGAAAACTGTCATGATCCTCAGGGGAAAAAAGGATTTAGAACGAGGCAGCGCCATGTCCTC
ATGGAATCTACAGGGCCTGCAGGGCATTGCCCTCATTTGGTGGAGTCTGTTCCTTGTGAGGATCCAATGTGCTACCGATGGCTGGCATCA
GAAGGGATCTGTTTCCCTGATCATGGAAAATGTGGCCTGGGACATCGTATTCTGAAGGCCGTCTGCCAGAATGACCGCGGAGAAGATGTA
TCAGGGAGTCTTTGCCCAGTTCCCCCTCCTCCTGAGAGGAAGTCTTGTGAAATTCCCTGCCGAATGGACTGTGTGCTGAGCGAGTGGACG
GAGTGGTCATCCTGTTCCCAGTCCTGTTCAAATAAAAACTCAGATGGGAAACAGACCAGGTCAAGAACTATCCTGGCACTGGCTGGGGAA
GGTGGAAAGCCATGTCCCCCTAGTCAGGCTCTCCAAGAGCATCGTTTGTGTAATGACCATTCCTGTATGCAGCTTCACTGGGAGACATCG
CCTTGGGGCCCTTGTTCTGAGGACACATTGGTAACTGCCCTTAATGCAACCATTGGCTGGAATGGAGAAGCCACGTGTGGTGTAGGCATT
CAGACTCGGAGAGTCTTCTGTGTCAAGAGTCACGTGGGACAAGTAATGACCAAAAGATGTCCAGATTCTACTCGACCTGAAACTGTGCGC
CCCTGTTTTCTCCCATGCAAAAAAGACTGTATTGTGACTGCTTTCAGTGAGTGGACACCCTGCCCAAGGATGTGCCAAGCAGGAAATGCC
ACAGTAAAACAGTCTCGATACAGAATCATCATCCAAGAAGCAGCCAATGGAGGCCAGGAATGCCCAGATACCTTATATGAGGAGAGAGAG
TGTGAAGATGTTTCCTTGTGTCCTGTATATCGGTGGAAGCCACAGAAATGGAGCCCTTGCATCTTAGTGCCAGAGTCTGTCTGGCAGGGA
ATAACGGGCAGCAGTGAAGCCTGTGGAAAGGGGTTACAAACAAGAGCTGTCTCATGCATCTCTGATGACAACCGGTCAGCAGAAATGATG
GAATGCCTCAAGCAGACAAACGGCATGCCTCTCCTTGTGCAAGAATGCACAGTCCCATGTCGAGAAGACTGCACCTTCACTGCTTGGTCC
AAGTTTACGCCCTGCTCCACGAACTGTGAAGCCACAAAAAGTAGGCGGCGACAGCTCACAGGGAAAAGCAGAAAGAAGGAGAAATGCCAG
GATTCTGACCTTTACCCTCTAGTGGAGACAGAACTATGTCCTTGTGATGAATTTATATCCCAACCTTATGGAAACTGGTCAGATTGCATT
CTTCCAGAAGGCAGAAGGGAGCCTCACCGAGGACTGCGGGTACAAGCAGACAGCAAAGAATGTGGAGAAGGCCTGCGCTTTCGAGCAGTA
GCCTGTTCTGATAAAAATGGAAGACCTGTTGACCCCTCCTTCTGCAGCAGCTCTGGTTACATTCAAGAAAAATGTGTCATTCCCTGCCCA
TTTGATTGCAAGTTAAGCGATTGGTCTAGTTGGGGGTCTTGCAGTTCATCTTGTGGAATTGGAGTGAGAATTCGATCCAAATGGCTAAAA
GAAAAACCTTACAATGGAGGACGACCATGTCCCAAACTGGATCTCAAGAATCAGAATGCTCAGGTACATGAGGCAGTCCCATGTTACAGT
GAGTGCAATCAGTATTCCTGGGTTGTAGAACACTGGTCTTCATGCAAAATCAACAATGAGCTGAGGTCCCTGCGCTGTGGAGGAGGAACA
CAATCTAGGAAAATCAGATGTGTGAATACTGCGGATGGTGAAGGTGGAGCAGTGGATAGCAACCTGTGCAACCAGGATGAAATTCCCCCA
GAAACCCAGTCCTGTTCTCTTATGTGTCCCAATGAGTGTGTCATGTCTGAGTGGGGACTTTGGAGCAAATGCCCACAGTCATGCGATCCC
CACACAATGCAGAGAAGAACTCGCCACCTGCTAAGACCATCACTGAACTCAAGGACTTGTGCTGAAGACTCACAGGTGCAGCCTTGCCTC
CTGAATGAAAATTGCTTCCAGTTCCAGTACAATCTAACAGAGTGGAGCACATGCCAGCTGAGTGAAAACGCACCCTGTGGTCAAGGCGTC
AGGACCCGCCTGCTAAGCTGTGTGTGCAGTGATGGCAAGCCAGTCAGCATGGACCAATGTGAGCAGCATAATTTGGAGAAGCCCCAGAGA
ATGAGCATTCCCTGCTTGGTGGAATGCGTGGTCAACTGTCAGCTCTCAGGGTGGACGGCTTGGACAGAGTGTTCACAGACCTGTGGCCAT
GGAGGTCGAATGAGCCGGACTCGATTTATCATTATGCCAACCCAAGGAGAAGGACGGCCATGCCCCACAGAGCTTACCCAGGAGAAAACC
TGCCCAGTGACCCCCTGCTACAGCTGGGTCCTTGGCAACTGGTCTGCATGTAAATTGGAGGGTGGAGACTGTGGGGAAGGAGTTCAGATC
CGCAGCCTTTCCTGCATGGTCCACAGTGGTTCAATATCTCATGCAGCTGGACGTGTCGAGGATGCACTGTGTGGAGAAATGCCCTTTCAG
GACAGCATCCTGAAGCAGCTGTGTTCTGTGCCTTGCCCAGGAGACTGCCATTTAACAGAATGGTCAGAGTGGAGCACATGTGAATTAACC
TGCATTGATGGAAGAAGCTTTGAGACTGTGGGCCGCCAGTCTAGATCAAGGACTTTTATAATTCAGTCTTTTGAGAACCAAGACAGCTGC
CCCCAACAGGTTCTAGAAACACGCCCTTGTACAGGAGGCAAATGTTATCACTACACATGGAAAGCAAGTCTTTGGAACAATAACGAACGA
ACTGTATGGTGCCAGCGTTCAGATGGCGTTAATGTCACAGGAGGCTGCTCCCCTCAGGCCCGTCCTGCTGCCATTCGGCAGTGCATTCCA
GCCTGCAGAAAACCTTTCTCCTACTGTACACAGGGTGGAGTCTGTGGTTGTGAGAAGGGCTATACAGAGATAATGAAATCAAATGGTTTC
CTGGATTACTGCATGAAAGTACCAGGCTCAGAGGATAAAAAAGCTGATGTGAAAAACCTTTCTGGGAAAAACAGACCTGTGAATTCAAAA
ATACATGATATTTTTAAAGGATGGTCTCTTCAACCACTTGATCCAGATGGCCGAGTAAAAATTTGGGTTTATGGCGTTTCAGGTGGCGCT
TTTCTCATCATGATTTTCCTAATATTTACTTCCTACCTTGTTTGCAAGAAGCCAAAACCACATCAAAGCACACCTCCCCAACAGAAGCCT
CTGACCTTAGCCTACGATGGAGACTTAGACATGTAATCTGAAAAAGAAATCCAAATGTAGACATCAACTGCCTTAACCGCTTTCTCTTTT
GTAGCTCTCAGACTTCTCAGTTTTTTGAGGAATCTCAAGATGTGATATATTGGGCAGAATACAAATATTGCAAAAGTAATATTGCCTCAA
CTTCATTTGGACATGGAGTCAAGGATTATTAGGTCTGCCATTTTGTTTTCAAGTTGTTTGTGGGTGTGTTTTATTTTTTTGGTTTTCCCA
AGGGACCTGAAAACCCTTCTCTTCCTGTTTGGAACTGGGAGGAAGAAAACATGATGGAATTCCCACAGACTTGAGTAAACTTGATCTTCA
GCAGCATAATGACAATCCAGAGGAAAATACAGTCAAGGCATTTACTCTAAATGACGAGTCTGACACTGCATTGTTACGCACTATATTAGT
GCAAAGTCTTTATTCTTCCCATACTTCAACACTGAGTTTTCTAGAGTTTACTTTGGTTTAAAGACTTTCAAATTGGATTGCCTATTTTTC
ATGAACACAGAGAGAATGGATTACCATTTCAGAAATTCTCTGAGTTTTTAACCTTTAAATATTGTATTTTGTTTTGTAGCCAGGGGATGA
TGGCGCTTCATGGGTTGCAGCTACTGAAAATAGCAGCGTGTGTGTAATTGCTGGACTAGATGAAAGCTAGGTCATTTCTGAAGGGAATGT
GTACTGAATGTTAGAGTGTACAAATGAAATATGTGGTTAAATTGGAGAATGAGGTAGATTATTTGATTACTAAAACTGTATTTTAACAAA
AACTTATCCATGTAGATATAGCATTAACCACACACAGTTGTAATTCAGTTTAATGATGACAAACTCTGCTTTTGTAATTTCAATTTTCTT
ATCTGAATATTTATAAATTCTTCTTTCAAATTTAATTATCTGACCTCATTTAATATACATCAAACACCGATCCTGTTTGTACAAAGTCTT
GCTTTTATAAGGTTTCAATAATATCTAAAACAACACATTAAAAAGCTGAGACCATTTTATGAAGATAATTGTTTGTAATCATAGGTGTTG

>24023_24023_3_DPP4-THSD7B_DPP4_chr2_162929909_ENST00000360534_THSD7B_chr2_137813990_ENST00000413152_length(amino acids)=1594AA_BP=32
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGSPWGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ
WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGC
GKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYK
AHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGG
GKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAKEVSRPVEKAL
CVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYRWLASEGICFPD
HGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPP
SQALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFLPCK
KDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQEAANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEA
CGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSDLYPL
VETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSD
WSSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQNAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRC
VNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQ
FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRT
RFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQL
CSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNNNERTVWCQRS
DGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKSNGFLDYCMKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKG

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Fusion Gene PPI Analysis for DPP4-THSD7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DPP4-THSD7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DPP4-THSD7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource