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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPP6-ACTR3B (FusionGDB2 ID:24024)

Fusion Gene Summary for DPP6-ACTR3B

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP6-ACTR3B
Fusion gene ID: 24024
HgeneTgene
Gene symbol

DPP6

ACTR3B

Gene ID

1804

57180

Gene namedipeptidyl peptidase like 6actin related protein 3B
SynonymsDPL1|DPPX|MRD33|VF2ARP11|ARP3BETA
Cytomap

7q36.2

7q36.1-q36.2

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6actin-related protein 3BARP3 actin related protein 3 homolog BARP3-betaactin-like protein 3Bactin-related protein 3-betaactin-related protein ARP4actin-related protein Arp11
Modification date2020031320200313
UniProtAcc.

Q9P1U1

Ensembl transtripts involved in fusion geneENST00000377770, ENST00000406326, 
ENST00000332007, ENST00000404039, 
ENST00000427557, ENST00000496611, 
ENST00000488782, ENST00000397282, 
ENST00000537264, ENST00000256001, 
ENST00000377776, 
Fusion gene scores* DoF score9 X 10 X 5=4505 X 7 X 6=210
# samples 128
** MAII scorelog2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPP6 [Title/Abstract] AND ACTR3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPP6(153750148)-ACTR3B(152498705), # samples:24
Anticipated loss of major functional domain due to fusion event.DPP6-ACTR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP6

GO:1901379

regulation of potassium ion transmembrane transport

18364354


check buttonFusion gene breakpoints across DPP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTR3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YBDPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4ESCATCGA-V5-AASVDPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-02-2485DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0125DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0184-01ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-06-0190-02ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-06-0190DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0210DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-0645DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2558DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2562DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2567DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-5408DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-5412DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-5414DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-5415DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-12-3653DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-14-0790DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-14-1823DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-15-0742DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-19-1390DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-19-5960DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-26-5134DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-27-2523DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-1747DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-2514DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-5204DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-5207DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-28-5215DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-32-1982-01ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-32-2638DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-41-2572DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-76-4928DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-09-2045DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-13-A5FTDPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-24-1419DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-24-1567DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-59-2363DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-61-1995DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-61-2110DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4STADTCGA-VQ-A8E2DPP6chr7

153750148

+ACTR3Bchr7

152498705

+


Top

Fusion Gene ORF analysis for DPP6-ACTR3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000377770ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-3UTRENST00000406326ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-5UTRENST00000377770ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-5UTRENST00000377770ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-5UTRENST00000377770ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-5UTRENST00000377770ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
5CDS-5UTRENST00000406326ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-5UTRENST00000406326ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
5CDS-5UTRENST00000406326ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-5UTRENST00000406326ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
5CDS-intronENST00000377770ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-intronENST00000377770ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
5CDS-intronENST00000377770ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-intronENST00000377770ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
5CDS-intronENST00000406326ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-intronENST00000406326ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
5CDS-intronENST00000406326ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
5CDS-intronENST00000406326ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
Frame-shiftENST00000377770ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
Frame-shiftENST00000377770ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
Frame-shiftENST00000377770ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
Frame-shiftENST00000377770ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
Frame-shiftENST00000406326ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
Frame-shiftENST00000406326ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
Frame-shiftENST00000406326ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
Frame-shiftENST00000406326ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
In-frameENST00000377770ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
In-frameENST00000377770ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
In-frameENST00000406326ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
In-frameENST00000406326ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000332007ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000332007ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000332007ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000332007ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000332007ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000332007ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000404039ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000404039ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000404039ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000404039ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000404039ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000404039ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000427557ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000427557ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000427557ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000427557ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000427557ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000427557ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000496611ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000496611ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000496611ENST00000256001DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3CDSENST00000496611ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3CDSENST00000496611ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-3CDSENST00000496611ENST00000377776DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-3UTRENST00000332007ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3UTRENST00000404039ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3UTRENST00000427557ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-3UTRENST00000496611ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000332007ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000332007ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000332007ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-5UTRENST00000332007ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-5UTRENST00000404039ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000404039ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000404039ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-5UTRENST00000404039ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-5UTRENST00000427557ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000427557ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000427557ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-5UTRENST00000427557ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-5UTRENST00000496611ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000496611ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
intron-5UTRENST00000496611ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-5UTRENST00000496611ENST00000537264DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000332007ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000332007ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000332007ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000332007ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000404039ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000404039ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000404039ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000404039ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000427557ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000427557ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000427557ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000427557ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000496611ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000496611ENST00000397282DPP6chr7

153750148

+ACTR3Bchr7

152480272

+
intron-intronENST00000496611ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
intron-intronENST00000496611ENST00000488782DPP6chr7

153750148

+ACTR3Bchr7

152480272

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406326DPP6chr7153750148+ENST00000377776ACTR3Bchr7152498705+18536461061467453
ENST00000406326DPP6chr7153750148+ENST00000256001ACTR3Bchr7152498705+25036461061677523
ENST00000377770DPP6chr7153750148+ENST00000377776ACTR3Bchr7152498705+1591384571205382
ENST00000377770DPP6chr7153750148+ENST00000256001ACTR3Bchr7152498705+2241384571415452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406326ENST00000377776DPP6chr7153750148+ACTR3Bchr7152498705+0.0010181450.9989818
ENST00000406326ENST00000256001DPP6chr7153750148+ACTR3Bchr7152498705+0.0004010460.9995989
ENST00000377770ENST00000377776DPP6chr7153750148+ACTR3Bchr7152498705+0.0009481910.99905175
ENST00000377770ENST00000256001DPP6chr7153750148+ACTR3Bchr7152498705+0.0003708850.99962914

Top

Fusion Genomic Features for DPP6-ACTR3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DPP6chr7153750148+ACTR3Bchr7152480271+0.198987950.80101204
DPP6chr7153750148+ACTR3Bchr7152480271+0.198987950.80101204
DPP6chr7153750148+ACTR3Bchr7152498705+0.0002001210.9997999
DPP6chr7153750148+ACTR3Bchr7152498705+0.0002001210.9997999
DPP6chr7153750148+ACTR3Bchr7152480271+0.198987950.80101204
DPP6chr7153750148+ACTR3Bchr7152480271+0.198987950.80101204
DPP6chr7153750148+ACTR3Bchr7152498705+0.0002001210.9997999
DPP6chr7153750148+ACTR3Bchr7152498705+0.0002001210.9997999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DPP6-ACTR3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:153750148/chr7:152498705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ACTR3B

Q9P1U1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+126117_8650804.0Topological domainExtracellular
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+1261_950804.0Topological domainCytoplasmic
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+126117_86581866.0Topological domainExtracellular
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+1261_9581866.0Topological domainCytoplasmic
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+12696_1160804.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+12696_11681866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for DPP6-ACTR3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24024_24024_1_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000256001_length(transcript)=2241nt_BP=384nt
GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA
AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC
ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC
CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG
CGGAGCGATGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTT
TTTAAATATCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCA
GAAATTATGTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAA
GTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGA
AGCTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCT
GAGCAGTCACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTG
GATCCCCGGAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTG
GGACCTGAAATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGC
CCCATCGATGTGCGGCGCCCGCTGTATAAGAATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCCGACTGCAGAGG
GATTTGAAGAGAGTGGTGGATGCTAGGCTGAGGCTCAGCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCCAGGTG
GTCACGCATCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTCCATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAG
AAGGACTATGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGA
TGGTGTCACGTTGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCG
TGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCC
TTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGA
CTTTGAAAATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCT
CCCAGCCTATTTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGT
ACAACTGGCTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGT
TTATAGGCAAACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGACATGAAGTTTGAAC
ACTAAACAGTAATGTATGAGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAAGATG

>24024_24024_1_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000256001_length(amino acids)=452AA_BP=109
MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG
AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV
LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP
DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGST
MFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGV

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>24024_24024_2_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000377776_length(transcript)=1591nt_BP=384nt
GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA
AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC
ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC
CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG
CGGAGCGATGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTT
TTTAAATATCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCA
GAAATTATGTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAA
GTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGA
AGCTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCT
GAGCAGTCACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTG
GATCCCCGGAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTG
GGACCTGAAATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGC
CCCATCGATGTGCGGCGCCCGCTGTATAAGCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACGGGCCCAGCATC
TGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCCTTC
AGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGC
GCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCC
TCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTA

>24024_24024_2_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000377776_length(amino acids)=382AA_BP=109
MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG
AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV
LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP
DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHT

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>24024_24024_3_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000256001_length(transcript)=2503nt_BP=646nt
GGTGGTGCCAAATTCTGGGGCCTAGGCATTTCCCTCGCTTTATGTTTTTGGTTTTTTTTCTTCCTTCAATCTCTTTGATTAGGCCGTACG
TGGCTGTGGCAAGGAGTTGGGGAAAAAAATTATAAAAACAGGAAAGAGAGAAAGCACAGCCAGAGCCCCGGCTTCGCGAGCCGCCGGGGA
GGGGGCGGAGGAGGCTGAGCCAGGCAGAGTCGCCAGCGGAGACTCGCGAGTGGCGCGCGGGAGGAGCGGCCGCCGGCGCTGGGCTTGCCT
TGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGAAAGCAAAA
TATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAACACCTCGAG
GTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCCCTCGGCCC
GCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCGCGGAGCGA
TGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTTTTTAAATA
TCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCAGAAATTAT
GTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAAGTGGGTGA
ACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAGCTGCAT
CAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTC
ACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCG
GAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTGGGACCTGA
AATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGCCCCATCGA
TGTGCGGCGCCCGCTGTATAAGAATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCCGACTGCAGAGGGATTTGAA
GAGAGTGGTGGATGCTAGGCTGAGGCTCAGCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCCAGGTGGTCACGCA
TCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTCCATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTA
TGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCA
CGTTGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCA
TTGCCGGTGCATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCG
CCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAA
ATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCTCCCAGCCT
ATTTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGTACAACTGG
CTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGTTTATAGGC
AAACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGACATGAAGTTTGAACACTAAACA
GTAATGTATGAGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAAGATGATGGTTTG

>24024_24024_3_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000256001_length(amino acids)=523AA_BP=180
MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ
RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED
WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ
YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDA

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>24024_24024_4_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000377776_length(transcript)=1853nt_BP=646nt
GGTGGTGCCAAATTCTGGGGCCTAGGCATTTCCCTCGCTTTATGTTTTTGGTTTTTTTTCTTCCTTCAATCTCTTTGATTAGGCCGTACG
TGGCTGTGGCAAGGAGTTGGGGAAAAAAATTATAAAAACAGGAAAGAGAGAAAGCACAGCCAGAGCCCCGGCTTCGCGAGCCGCCGGGGA
GGGGGCGGAGGAGGCTGAGCCAGGCAGAGTCGCCAGCGGAGACTCGCGAGTGGCGCGCGGGAGGAGCGGCCGCCGGCGCTGGGCTTGCCT
TGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGAAAGCAAAA
TATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAACACCTCGAG
GTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCCCTCGGCCC
GCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCGCGGAGCGA
TGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTTTTTAAATA
TCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCAGAAATTAT
GTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAAGTGGGTGA
ACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAGCTGCAT
CAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTC
ACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCG
GAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTGGGACCTGA
AATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGCCCCATCGA
TGTGCGGCGCCCGCTGTATAAGCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACGGGCCCAGCATCTGCCGCCA
CAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCCTTCAGAACCCA
GAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGGGCCC
TTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTC
CTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTAGAAAATGG

>24024_24024_4_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000377776_length(amino acids)=453AA_BP=180
MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ
RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED
WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ
YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHTKKDYEEYGPSICRHNPVFG

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Fusion Gene PPI Analysis for DPP6-ACTR3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DPP6-ACTR3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DPP6-ACTR3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource