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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DPP6-DTNA (FusionGDB2 ID:24026)

Fusion Gene Summary for DPP6-DTNA

Fusion gene summary

Fusion gene information	Fusion gene name: DPP6-DTNA
	Fusion gene ID: 24026
		Hgene	Tgene
	Gene symbol	DPP6	DTNA
	Gene ID	1804	1837
	Gene name	dipeptidyl peptidase like 6	dystrobrevin alpha
	Synonyms	DPL1\|DPPX\|MRD33\|VF2	D18S892E\|DRP3\|DTN\|DTN-A\|LVNC1
	Cytomap	7q36.2	18q12.1
	Type of gene	protein-coding	protein-coding
	Description	dipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6	dystrobrevin alphadystrophin-related protein 3
	Modification date	20200313	20200313
	UniProtAcc	.	Q9Y4J8
	Ensembl transtripts involved in fusion gene	ENST00000332007, ENST00000377770, ENST00000404039, ENST00000406326, ENST00000427557, ENST00000496611,	ENST00000269190, ENST00000283365, ENST00000399097, ENST00000399121, ENST00000444659, ENST00000592449, ENST00000595022, ENST00000598334, ENST00000269191, ENST00000269192, ENST00000315456, ENST00000348997, ENST00000399113, ENST00000554864, ENST00000556414, ENST00000590831, ENST00000591182, ENST00000596745, ENST00000597599, ENST00000597674, ENST00000598142, ENST00000598774, ENST00000599844, ENST00000601125,
Fusion gene scores	* DoF score	9 X 10 X 5=450	7 X 7 X 3=147
	# samples	12	7
	** MAII score	log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DPP6 [Title/Abstract] AND DTNA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DPP6(154685096)-DTNA(32470629), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DPP6	GO:1901379	regulation of potassium ion transmembrane transport	18364354

Fusion gene breakpoints across DPP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DTNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AI500195	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+

Top

Fusion Gene ORF analysis for DPP6-DTNA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000332007	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000332007	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000377770	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-3UTR	ENST00000404039	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000332007	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000377770	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
3UTR-intron	ENST00000404039	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000406326	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000427557	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000269190	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000283365	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000399097	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000399121	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000444659	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000592449	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000595022	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-3UTR	ENST00000496611	ENST00000598334	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000406326	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000427557	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000269191	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000269192	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000315456	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000348997	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000399113	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000554864	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000556414	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000590831	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000591182	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000596745	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000597599	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000597674	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000598142	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000598774	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000599844	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+
intron-intron	ENST00000496611	ENST00000601125	DPP6	chr7	154685096	-	DTNA	chr18	32470629	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DPP6-DTNA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DPP6-DTNA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:154685096/:32470629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DTNA Q9Y4J8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DPP6-DTNA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DPP6-DTNA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DPP6-DTNA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DPP6-DTNA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source