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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DROSHA-DNAH5 (FusionGDB2 ID:24169)

Fusion Gene Summary for DROSHA-DNAH5

check button Fusion gene summary
Fusion gene informationFusion gene name: DROSHA-DNAH5
Fusion gene ID: 24169
HgeneTgene
Gene symbol

DROSHA

DNAH5

Gene ID

29102

1767

Gene namedrosha ribonuclease IIIdynein axonemal heavy chain 5
SynonymsETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASENCILD3|DNAHC5|HL1|KTGNR|PCD
Cytomap

5p13.3

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nucleardynein heavy chain 5, axonemalaxonemal beta dynein heavy chain 5ciliary dynein heavy chain 5dynein, axonemal, heavy polypeptide 5
Modification date2020031320200327
UniProtAcc

Q9NRR4

Q8TE73

Ensembl transtripts involved in fusion geneENST00000344624, ENST00000442743, 
ENST00000511367, ENST00000513349, 
ENST00000504361, 		ENST00000504001, 
ENST00000265104, 
Fusion gene scores* DoF score7 X 7 X 4=1969 X 7 X 6=378
# samples 78
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/378*10)=-2.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DROSHA [Title/Abstract] AND DNAH5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDROSHA(31448654)-DNAH5(13931353), # samples:1
Anticipated loss of major functional domain due to fusion event.DROSHA-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DROSHA-DNAH5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DROSHA-DNAH5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDROSHA

GO:0031053

primary miRNA processing

14508493|15574589

HgeneDROSHA

GO:0050829

defense response to Gram-negative bacterium

20180804

HgeneDROSHA

GO:0050830

defense response to Gram-positive bacterium

20180804


check buttonFusion gene breakpoints across DROSHA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAH5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3CC-06ADROSHAchr5

31448654

-DNAH5chr5

13931353

-


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Fusion Gene ORF analysis for DROSHA-DNAH5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344624ENST00000504001DROSHAchr5

31448654

-DNAH5chr5

13931353

-
5CDS-intronENST00000442743ENST00000504001DROSHAchr5

31448654

-DNAH5chr5

13931353

-
5CDS-intronENST00000511367ENST00000504001DROSHAchr5

31448654

-DNAH5chr5

13931353

-
5CDS-intronENST00000513349ENST00000504001DROSHAchr5

31448654

-DNAH5chr5

13931353

-
Frame-shiftENST00000344624ENST00000265104DROSHAchr5

31448654

-DNAH5chr5

13931353

-
Frame-shiftENST00000442743ENST00000265104DROSHAchr5

31448654

-DNAH5chr5

13931353

-
Frame-shiftENST00000511367ENST00000265104DROSHAchr5

31448654

-DNAH5chr5

13931353

-
In-frameENST00000513349ENST00000265104DROSHAchr5

31448654

-DNAH5chr5

13931353

-
intron-3CDSENST00000504361ENST00000265104DROSHAchr5

31448654

-DNAH5chr5

13931353

-
intron-intronENST00000504361ENST00000504001DROSHAchr5

31448654

-DNAH5chr5

13931353

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000513349DROSHAchr531448654-ENST00000265104DNAH5chr513931353-1861131403146169574603

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000513349ENST00000265104DROSHAchr531448654-DNAH5chr513931353-0.0039012990.99609864

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Fusion Genomic Features for DROSHA-DNAH5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DROSHA-DNAH5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:31448654/chr5:13931353)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DROSHA

Q9NRR4

DNAH5

Q8TE73

FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31448654chr5:13931353ENST00000344624-20331_2129601375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000344624-2033219_3169601375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000442743-19321_2129231338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000442743-1932219_3169231338.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000511367-22351_2129601375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000511367-2235219_3169601375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000513349-22351_2129231338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31448654chr5:13931353ENST00000513349-2235219_3169231338.0Compositional biasNote=Arg-rich
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040791435_1465194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST00000265104079284_305194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040793195_3302194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040793426_3491194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040793732_3817194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040794392_4420194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST00000265104079740_825194625.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040791980_1987194625.0Nucleotide bindingATP
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040792262_2269194625.0Nucleotide bindingATP
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040791942_2164194625.0RegionAAA 1
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040792224_2443194625.0RegionAAA 2
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040792550_2803194625.0RegionAAA 3
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040792916_3170194625.0RegionAAA 4
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040793185_3482194625.0RegionStalk
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040793567_3797194625.0RegionAAA 5
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040794012_4226194625.0RegionAAA 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31448654chr5:13931353ENST00000344624-20331107_12339601375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31448654chr5:13931353ENST00000344624-20331260_13349601375.0DomainNote=DRBM
HgeneDROSHAchr5:31448654chr5:13931353ENST00000344624-2033876_10569601375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31448654chr5:13931353ENST00000442743-19321107_12339231338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31448654chr5:13931353ENST00000442743-19321260_13349231338.0DomainNote=DRBM
HgeneDROSHAchr5:31448654chr5:13931353ENST00000442743-1932876_10569231338.0DomainNote=RNase III 1
HgeneDROSHAchr5:31448654chr5:13931353ENST00000511367-22351107_12339601375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31448654chr5:13931353ENST00000511367-22351260_13349601375.0DomainNote=DRBM
HgeneDROSHAchr5:31448654chr5:13931353ENST00000511367-2235876_10569601375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31448654chr5:13931353ENST00000513349-22351107_12339231338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31448654chr5:13931353ENST00000513349-22351260_13349231338.0DomainNote=DRBM
HgeneDROSHAchr5:31448654chr5:13931353ENST00000513349-2235876_10569231338.0DomainNote=RNase III 1
TgeneDNAH5chr5:31448654chr5:13931353ENST000002651040791_1941194625.0RegionStem


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Fusion Gene Sequence for DROSHA-DNAH5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24169_24169_1_DROSHA-DNAH5_DROSHA_chr5_31448654_ENST00000513349_DNAH5_chr5_13931353_ENST00000265104_length(transcript)=18611nt_BP=3140nt
GCTTTTTAATTCCCTCGGTTTCCTGTTCCGGAGGCGCGGGCGGTGCCACTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACG
GCGATCTCGCGGCCCGAGAGCCTTTTATAGACAGCTCCTTCAGTGTCTCTGTTTCCAAACCGCAACCGAGAAGAGACAGACGGAGAAAAG
AGAGTTACTTTTCCAGGTTGCTTTTCCCGGGGATGTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATC
TAGTGGAAGAGTTAGACGTGTGCATACTTCACTATGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGG
CGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCC
AGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGT
GCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCG
TCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTT
CCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCC
CCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTC
CCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTC
CCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGT
CATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCT
GATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAAC
CGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTGGAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGT
TGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAG
ACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGT
GACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGC
AGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAG
TGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCAC
CCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGC
ACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTAC
CGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTT
TCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAG
ATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTT
AAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAG
GAAGTGCTGTCCATGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAG
TGGGAGGAGCTGGAGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATC
GATCAACTGGATCGTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTAT
GCAGGAGACCCACAGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGAC
AAACAGAAGCTGGCACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGC
CAAGGATTCTGGAAAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAA
TGCCTAATGCATTTGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTA
AATTTTGGAATGAATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCAC
ATGCACATGCGGAAGAAAGGGATTAACACCTTGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGCAAAGACTGA
AGGGAGAGAAGGAAGCCAAGCGGGCTCTTTTGGATGCGAGGCATAACTACTTATTTGCAATTGTGGCTTCCTGTTTGGACCTGAACAAAA
CCGAAGTGGAGGATGCCATTCTTGAAGGGAATCAGATTGAAAGAATTGATCAACTTTTTGCTGTTGGAGGTCTCCGACACCTCATGTTTT
ACTATCAAGATGTGGAGGAAGCAGAAACAGGACAACTTGGCTCTCTAGGAGGGGTAAATCTTGTTTCTGGAAAGATTAAAAAACCTAAGG
TGTTCGTGACCGAGGGAAACGATGTGGCTCTTACTGGGGTATGTGTGTTCTTCATCAGGACTGACCCTTCCAAAGCCATCACCCCTGACA
ACATCCACCAGGAGGTGAGTTTTAACATGTTAGATGCGGCAGATGGAGGCCTGCTCAACAGTGTGAGACGTTTGCTGTCGGACATCTTCA
TTCCTGCTCTCAGAGCCACGAGCCATGGCTGGGGCGAGCTCGAGGGCCTTCAGGACGCAGCTAACATTCGCCAGGAGTTCTTGAGCTCCC
TGGAAGGCTTTGTGAACGTCCTGTCGGGTGCACAGGAGAGTCTGAAGGAGAAGGTGAACCTTCGAAAGTGTGACATACTTGAACTGAAAA
CCCTAAAGGAACCTACGGACTACTTGACTCTAGCAAATAACCCTGAGACTTTGGGAAAAATAGAGGATTGCATGAAAGTATGGATCAAAC
AGACAGAACAGGTTCTTGCTGAAAACAATCAGCTGCTGAAGGAAGCGGATGACGTTGGGCCACGAGCGGAGCTGGAGCACTGGAAAAAAA
GACTCTCCAAGTTTAACTACCTTTTGGAACAATTGAAAAGCCCGGATGTGAAGGCTGTGCTGGCAGTGCTTGCGGCGGCCAAGTCGAAAC
TGCTGAAGACTTGGCGGGAGATGGATATTCGAATCACTGATGCAACTAATGAAGCAAAGGACAATGTGAAATACTTGTATACACTTGAAA
AATGTTGTGACCCTTTGTACAGCAGTGATCCCCTATCCATGATGGATGCTATTCCTACACTTATAAATGCAATTAAAATGATCTATAGTA
TCTCTCATTACTATAATACCTCTGAGAAGATCACATCTCTGTTTGTAAAGGTGACAAATCAGATTATATCTGCATGTAAAGCCTATATTA
CCAATAATGGAACCGCTTCCATCTGGAACCAGCCACAGGATGTTGTTGAAGAAAAAATACTATCTGCGATTAAACTGAAACAGGAATACC
AGCTCTGCTTTCACAAGACAAAACAAAAGCTTAAACAAAATCCAAATGCAAAACAATTTGATTTTAGCGAGATGTATATTTTTGGAAAAT
TCGAAACTTTTCACCGACGCCTTGCCAAGATAATAGACATCTTTACAACCCTCAAGACGTATTCAGTCCTGCAAGATTCCACAATTGAAG
GGCTGGAAGACATGGCCACTAAATACCAGGGCATTGTGGCAACCATAAAGAAAAAGGAATACAATTTCCTAGACCAGCGGAAAATGGATT
TTGACCAAGATTACGAAGAGTTTTGCAAGCAGACTAATGACCTTCATAACGAGTTGCGGAAGTTCATGGATGTTACATTTGCAAAGATTC
AAAACACAAATCAAGCTCTAAGAATGTTGAAGAAATTTGAAAGATTGAATATACCTAATCTTGGTATTGATGACAAATATCAACTTATCC
TTGAGAACTATGGGGCTGACATTGATATGATTTCAAAGCTGTATACAAAGCAGAAATACGATCCTCCTCTGGCTCGAAACCAGCCTCCCA
TCGCTGGAAAGATTTTGTGGGCCCGCCAGCTCTTCCATAGGATTCAGCAGCCCATGCAGCTTTTCCAGCAGCACCCAGCTGTGCTAAGCA
CGGCAGAAGCCAAACCTATAATTCGCAGTTACAACAGGATGGCCAAGGTCCTCCTGGAGTTTGAGGTCCTCTTCCACAGGGCGTGGCTTC
GGCAAATTGAAGAAATTCATGTAGGTCTTGAGGCTTCATTATTGGTGAAGGCTCCAGGCACAGGGGAATTGTTTGTAAACTTTGACCCTC
AGATATTAATCTTATTTAGAGAAACAGAGTGCATGGCCCAGATGGGTCTGGAAGTCTCTCCACTGGCAACTTCCCTCTTCCAGAAACGAG
ATAGATACAAAAGGAACTTCAGTAACATGAAGATGATGCTAGCTGAATATCAGAGAGTGAAGTCAAAAATACCTGCTGCCATTGAGCAAT
TGATTGTCCCTCACTTGGCCAAAGTGGATGAAGCTCTCCAACCTGGCTTGGCTGCACTGACCTGGACATCACTGAATATTGAGGCTTATT
TAGAAAACACTTTTGCAAAGATCAAGGACCTGGAGTTGCTGCTTGACAGGGTCAATGATTTGATTGAGTTCCGCATTGATGCCATTCTAG
AAGAAATGAGCAGCACGCCTCTTTGTCAGCTTCCCCAGGAGGAGCCACTAACCTGTGAAGAGTTTCTCCAAATGACAAAGGATCTTTGTG
TAAATGGTGCACAAATACTACATTTTAAAAGCTCATTAGTGGAGGAGGCAGTCAATGAGCTTGTAAATATGTTGCTGGATGTGGAAGTTT
TATCTGAAGAAGAAAGTGAAAAAATATCCAATGAGAATAGTGTTAATTACAAAAATGAAAGTTCAGCAAAAAGAGAAGAAGGAAATTTTG
ACACCTTGACATCATCTATTAATGCCAGGGCCAATGCCCTGCTTTTGACGACAGTCACGAGGAAAAAGAAAGAAACTGAGATGTTAGGGG
AAGAAGCCCGCGAGTTACTCTCTCATTTCAACCATCAGAACATGGATGCTCTTCTGAAAGTTACAAGGAATACACTAGAGGCCATTCGCA
AACGTATTCATTCCTCTCACACAATTAACTTCCGGGACAGTAACAGTGCCTCTAACATGAAGCAGAACAGTTTGCCCATTTTCCGGGCAA
GCGTCACTCTGGCCATTCCCAACATCGTCATGGCCCCTGCCCTGGAAGATGTACAGCAGACCCTGAACAAAGCCGTGGAGTGCATCATCA
GTGTCCCTAAGGGGGTCAGACAGTGGAGCAGTGAACTGTTGTCCAAGAAAAAGATACAAGAAAGAAAAATGGCTGCTTTGCAGAGTAATG
AAGACAGTGATTCTGATGTTGAAATGGGAGAAAATGAACTTCAAGATACCTTGGAGATAGCATCTGTAAATTTACCCATTCCCGTGCAAA
CCAAGAACTATTATAAGAATGTTTCTGAAAACAAAGAGATTGTAAAATTAGTTTCTGTGCTTAGCACAATTATCAACTCCACCAAAAAGG
AAGTTATTACATCCATGGATTGCTTCAAACGCTACAATCACATTTGGCAAAAGGGAAAAGAAGAAGCCATTAAGACATTTATTACACAGA
GCCCCTTGCTTTCTGAATTTGAGTCCCAGATTCTCTATTTCCAAAACCTAGAGCAGGAAATTAATGCTGAGCCTGAATATGTCTGTGTGG
GTTCCATTGCTCTGTACACAGCTGACTTGAAGTTCGCCCTGACTGCTGAGACAAAGGCCTGGATGGTTGTCATTGGACGCCACTGTAACA
AAAAATACCGGAGTGAGATGGAAAACATTTTTATGCTTATTGAAGAATTCAATAAGAAACTAAATCGTCCAATTAAGGACCTAGATGATA
TTCGGATTGCAATGGCAGCGCTGAAAGAAATAAGGGAGGAGCAAATCTCCATTGACTTTCAAGTAGGACCTATTGAGGAATCTTATGCCC
TGCTTAACAGATATGGACTTCTGATAGCAAGGGAAGAGATAGACAAAGTTGATACACTGCACTATGCTTGGGAGAAGCTGCTGGCACGTG
CTGGCGAAGTCCAGAATAAATTAGTCTCACTGCAGCCCAGTTTCAAGAAAGAGCTTATTAGTGCTGTGGAGGTATTCCTCCAAGATTGTC
ACCAGTTTTATCTGGACTATGATTTGAATGGTCCAATGGCTAGCGGCTTGAAGCCCCAGGAAGCCAGTGACAGGCTTATCATGTTTCAGA
ATCAATTTGATAATATCTATCGGAAATACATCACATATACTGGAGGAGAGGAGCTTTTTGGCCTGCCAGCTACACAGTATCCTCAGCTTC
TTGAAATAAAGAAGCAACTAAATCTTCTACAGAAAATATATACTCTGTACAACAGTGTCATAGAAACTGTAAATAGCTATTATGATATTC
TTTGGTCAGAGGTGAATATTGAAAAAATTAACAATGAACTCTTAGAATTCCAGAACAGATGTCGAAAGCTTCCCCGGGCCTTGAAGGACT
GGCAGGCTTTTTTGGACCTGAAGAAGATCATTGATGATTTCAGCGAGTGTTGCCCGCTGCTGGAATACATGGCCAGTAAAGCCATGATGG
AGCGGCACTGGGAAAGGATAACCACCCTCACCGGGCACAGTCTGGATGTGGGGAATGAAAGCTTTAAGTTAAGAAATATCATGGAGGCAC
CTCTTCTGAAATATAAAGAGGAAATAGAGGACATCTGTATCAGTGCGGTGAAAGAGAGAGACATTGAGCAAAAGCTGAAGCAAGTGATTA
ATGAATGGGACAATAAAACATTCACCTTCGGCAGCTTTAAAACCCGTGGAGAGCTCCTCTTGAGAGGAGACAGTACCTCGGAAATCATCG
CCAACATGGAGGACAGCTTGATGTTGCTGGGATCCCTACTGAGCAACAGGTACAATATGCCATTCAAAGCCCAGATTCAAAAATGGGTGC
AGTACCTTTCCAACTCAACAGACATCATCGAGAGCTGGATGACGGTGCAAAACCTGTGGATTTATTTAGAAGCTGTCTTTGTGGGAGGAG
ACATTGCCAAGCAGCTGCCCAAGGAAGCCAAGCGGTTTTCTAACATAGATAAATCTTGGGTGAAGATCATGACTCGGGCACATGAAGTGC
CCAGTGTAGTCCAGTGCTGTGTTGGAGATGAGACCCTGGGGCAGCTGTTACCACACTTGCTGGACCAGTTGGAAATATGCCAGAAATCCC
TTACTGGGTACTTGGAGAAAAAACGACTGTGCTTTCCTCGGTTTTTCTTCGTCTCAGATCCTGCCCTTCTAGAGATTCTGGGGCAGGCGT
CGGACTCCCACACTATACAGGCCCATTTGCTGAATGTGTTTGACAACATTAAATCTGTCAAGTTCCACGAAAAGATCTATGATCGAATTC
TGTCAATTTCCTCTCAAGAGGGTGAGACGATTGAATTGGATAAACCTGTCATGGCAGAGGGCAATGTGGAAGTTTGGCTTAATTCTCTTT
TGGAAGAATCTCAGTCCTCATTGCATCTTGTGATTCGCCAGGCAGCCGCAAATATTCAAGAAACAGGTTTCCAACTAACTGAATTTCTTT
CATCCTTCCCTGCTCAGGTTGGATTATTAGGAATTCAGATGATATGGACACGGGATTCAGAAGAAGCCCTTAGAAATGCCAAGTTTGATA
AAAAAATCATGCAGAAAACTAATCAGGCTTTCCTGGAGCTACTCAATACATTGATAGACGTCACCACGAGGGATCTGAGTTCCACGGAAC
GAGTGAAATACGAGACTCTGATTACTATTCATGTGCACCAAAGGGATATCTTTGATGACCTGTGTCATATGCATATCAAGAGTCCCATGG
ACTTTGAGTGGCTGAAACAGTGCAGATTTTACTTTAACGAAGATTCTGACAAGATGATGATTCACATCACAGATGTGGCGTTCATATACC
AGAATGAATTTTTAGGCTGCACTGACAGGCTTGTAATAACTCCACTTACAGACAGATGTTACATCACGCTGGCTCAAGCTCTGGGAATGA
GCATGGGGGGAGCCCCTGCTGGACCTGCAGGCACAGGCAAAACAGAAACCACTAAAGACATGGGACGATGCCTCGGGAAATACGTCGTGG
TTTTCAATTGTTCAGACCAGATGGATTTCCGAGGACTTGGACGGATTTTTAAGGGACTGGCACAGTCTGGATCCTGGGGTTGTTTTGATG
AATTTAACCGTATTGATCTACCAGTTCTCTCGGTTGCAGCCCAGCAAATTTCCATTATTCTGACATGTAAAAAGGAGCACAAAAAGTCTT
TTATCTTTACTGATGGAGATAATGTGACTATGAACCCTGAATTTGGGCTTTTCTTAACCATGAATCCTGGCTATGCCGGACGGCAGGAAC
TCCCTGAAAACTTGAAGATTAATTTCCGCTCAGTGGCCATGATGGTGCCTGACCGTCAGATTATCATAAGGGTGAAGTTGGCTAGTTGTG
GCTTCATTGACAACGTTGTTTTGGCCAGGAAGTTTTTCACGCTCTACAAACTGTGTGAGGAGCAGCTTTCTAAGCAGGTTCATTATGACT
TTGGCCTGCGTAACATTCTGTCAGTTCTTCGGACCTTGGGAGCAGCAAAAAGAGCCAATCCAATGGATACGGAGTCCACGATTGTCATGC
GTGTACTACGGGACATGAATCTTTCTAAACTGATTGATGAGGATGAACCCTTGTTTTTGAGTTTGATTGAAGATCTCTTTCCAAATATTC
TTCTGGACAAGGCAGGTTACCCTGAACTGGAAGCAGCAATTAGTAGACAGGTTGAAGAAGCTGGTTTAATCAACCATCCTCCTTGGAAAC
TGAAGGTCATCCAGCTATTCGAAACGCAGAGAGTGCGACATGGGATGATGACTCTGGGGCCCAGTGGGGCTGGGAAGACCACCTGCATCC
ACACCTTGATGAGAGCCATGACAGATTGTGGAAAACCACATCGGGAAATGAGGATGAATCCCAAAGCGATTACTGCCCCACAGATGTTTG
GTCGGCTGGACGTTGCCACAAATGACTGGACTGATGGGATATTTTCTACGCTTTGGAGGAAAACATTAAGAGCAAAGAAAGGGGAACATA
TCTGGATAATTCTTGATGGTCCAGTAGATGCCATCTGGATTGAAAATCTGAATTCTGTTTTGGATGATAACAAAACTCTAACCCTTGCCA
ATGGTGATCGGATTCCCATGGCTCCAAACTGCAAGATCATTTTCGAGCCTCATAACATTGACAATGCTTCTCCTGCCACCGTCTCAAGAA
ATGGAATGGTTTTCATGAGCTCTTCTATCCTTGATTGGAGTCCTATTCTTGAGGGTTTTCTTAAGAAACGCTCACCTCAAGAAGCAGAAA
TTCTTCGTCAGCTGTACACCGAGTCTTTCCCAGACTTGTATCGCTTCTGTATCCAGAACTTAGAATACAAGATGGAGGTGCTGGAGGCCT
TTGTCATCACACAGAGCATTAACATGCTTCAAGGCCTGATTCCTCTGAAGGAGCAAGGCGGGGAGGTGAGCCAGGCTCACCTGGGGCGGC
TGTTCGTGTTCGCGCTGCTGTGGAGCGCGGGGGCGGCGCTGGAGCTGGACGGACGGCGCCGCCTGGAGCTCTGGCTGCGCTCTCGGCCCA
CAGGGACGCTGGAGCTGCCGCCGCCAGCGGGGCCCGGGGACACCGCCTTCGACTACTATGTGGCGCCCGATGGTACATGGACGCACTGGA
ACACGCGTACCCAGGAATACCTGTATCCGTCTGATACCACCCCAGAGTATGGTTCTATTCTGGTGCCAAATGTTGACAATGTGAGGACTG
ACTTTCTAATTCAAACCATTGCTAAACAGGGCAAGGCTGTGCTATTAATTGGTGAACAAGGAACAGCCAAAACAGTAATAATTAAAGGAT
TTATGTCAAAATATGATCCTGAATGTCACATGATCAAGAGTCTGAATTTTTCTTCTGCAACCACCCCACTGATGTTCCAGAGGACGATAG
AGAGCTATGTGGATAAACGAATGGGTACAACATATGGCCCTCCTGCGGGAAAGAAGATGACTGTTTTTATTGATGATGTGAATATGCCAA
TAATCAATGAGTGGGGAGATCAGGTTACGAATGAGATAGTGCGACAGCTGATGGAACAAAATGGATTCTATAATCTAGAGAAGCCTGGGG
AGTTCACCAGCATCGTGGACATCCAGTTTTTGGCAGCCATGATCCATCCTGGTGGTGGACGCAATGACATACCCCAAAGACTCAAGAGGC
AGTTCTCTATATTTAATTGCACGTTGCCCTCTGAAGCTTCTGTGGACAAGATCTTTGGTGTGATTGGGGTAGGCCACTACTGTACTCAGA
GGGGTTTCTCAGAAGAAGTGAGAGATTCTGTGACAAAATTGGTGCCTCTGACACGCCGACTATGGCAGATGACCAAGATTAAAATGCTTC
CTACCCCTGCAAAATTCCATTATGTGTTTAACCTACGAGATCTTTCTCGGGTCTGGCAGGGAATGCTGAACACTACTTCAGAGGTCATCA
AGGAACCAAATGATCTGTTAAAGCTGTGGAAGCATGAGTGTAAACGTGTTATAGCTGACCGTTTCACAGTGTCCAGTGATGTGACCTGGT
TTGATAAGGCTTTAGTAAGTTTGGTAGAGGAGGAGTTTGGTGAAGAGAAAAAACTCTTGGTGGATTGTGGAATTGACACATATTTTGTGG
ATTTCTTGAGAGATGCACCTGAAGCTGCAGGTGAAACATCTGAAGAGGCTGATGCTGAAACACCTAAAATTTATGAGCCAATTGAATCTT
TTAGTCACCTAAAAGAGCGTCTGAATATGTTCCTGCAGCTCTATAATGAGAGCATCCGTGGCGCCGGCATGGACATGGTGTTCTTTGCAG
ATGCCATGGTTCACTTAGTCAAGATCTCTCGTGTCATTCGTACTCCTCAGGGAAATGCCCTCCTGGTCGGGGTGGGCGGATCAGGAAAGC
AGAGCCTGACGAGGTTGGCTTCATTCATTGCTGGCTACGTTTCCTTCCAGATCACTCTGACGAGATCCTACAACACATCAAATCTGATGG
AAGATCTGAAGGTTTTGTATCGAACAGCTGGTCAGCAAGGCAAAGGAATCACTTTTATTTTCACAGACAATGAGATTAAAGATGAGTCAT
TTTTGGAATATATGAACAATGTTTTATCATCAGGTGAGGTCTCTAACCTATTTGCTCGAGATGAAATTGATGAAATTAATAGCGACCTGG
CATCAGTCATGAAAAAAGAATTCCCCAGGTGCCTTCCTACCAATGAGAACCTGCACGACTACTTCATGAGTCGGGTCCGACAGAACCTTC
ATATTGTGCTCTGCTTCTCGCCAGTGGGGGAGAAATTTCGAAACAGAGCTTTGAAGTTCCCTGCCCTAATTTCAGGATGCACAATTGACT
GGTTCAGCCGATGGCCCAAAGATGCTTTAGTTGCTGTGTCTGAACACTTCCTCACTTCCTATGATATTGACTGCAGTTTGGAAATCAAGA
AGGAGGTGGTCCAATGCATGGGCTCCTTCCAGGATGGGGTGGCTGAGAAGTGTGTTGATTATTTTCAGAGATTCCGACGTTCTACCCACG
TGACGCCCAAATCATACCTCTCCTTTATTCAGGGCTATAAGTTCATATATGGAGAAAAGCATGTGGAGGTGCGGACCCTGGCCAACAGAA
TGAATACTGGATTGGAAAAGCTCAAAGAAGCTTCAGAGTCTGTTGCAGCCTTGAGTAAAGAACTGGAAGCGAAAGAAAAGGAGCTACAAG
TGGCCAACGATAAAGCCGACATGGTCTTAAAAGAAGTGACAATGAAAGCACAGGCTGCTGAAAAGGTCAAGGCTGAGGTACAGAAGGTGA
AGGACAGGGCCCAGGCCATTGTGGACAGCATCTCTAAAGACAAAGCCATTGCTGAAGAAAAACTGGAAGCAGCAAAACCAGCTTTAGAAG
AGGCAGAAGCTGCATTGCAGACCATCAGGCCTTCGGACATCGCCACTGTTCGCACGTTGGGCCGCCCCCCTCACCTCATCATGCGGATCA
TGGATTGCGTACTGCTGCTGTTTCAAAGGAAAGTCAGTGCTGTGAAAATTGACCTGGAAAAAAGCTGTACCATGCCCTCCTGGCAGGAAT
CCTTAAAATTGATGACTGCAGGGAACTTTTTACAGAACTTACAGCAATTCCCAAAAGACACAATCAATGAAGAGGTGATAGAATTTTTGA
GTCCTTACTTTGAAATGCCTGACTATAACATCGAAACTGCTAAACGCGTATGTGGAAATGTAGCTGGTCTTTGTTCCTGGACGAAAGCTA
TGGCTTCCTTCTTTTCTATAAACAAAGAAGTACTGCCTCTGAAGGCCAACTTGGTGGTGCAAGAGAATCGCCATCTCCTGGCCATGCAGG
ATCTGCAGAAAGCCCAGGCCGAGTTGGATGACAAGCAGGCGGAACTTGACGTGGTGCAGGCTGAGTATGAACAGGCCATGACTGAAAAGC
AGACCTTGCTTGAAGATGCAGAGCGATGCAGACACAAGATGCAGACAGCTTCCACGCTCATCAGTGGCTTGGCAGGTGAAAAAGAAAGAT
GGACAGAGCAAAGCCAAGAGTTTGCTGCACAAACTAAAAGACTTGTAGGGGATGTACTGTTGGCTACAGCTTTTCTATCTTATTCTGGTC
CATTTAACCAAGAGTTTCGTGATCTTCTGTTAAATGACTGGCGGAAGGAAATGAAAGCCCGGAAAATTCCATTTGGAAAGAACCTAAATC
TCAGTGAGATGTTGATTGATGCTCCTACTATTAGTGAATGGAACCTCCAAGGTCTGCCAAATGATGACTTGTCCATTCAAAATGGAATTA
TTGTCACGAAGGCATCTCGTTACCCTTTGTTAATTGATCCACAGACTCAAGGCAAGATCTGGATTAAAAATAAAGAAAGCCGAAATGAAC
TCCAGATCACGTCTTTAAATCACAAGTACTTCAGAAACCACCTGGAAGACAGCCTTTCTCTTGGAAGGCCTTTGCTTATTGAAGATGTTG
GAGAGGAACTAGATCCAGCACTAGATAATGTTTTGGAAAGAAACTTCATTAAAACTGGGTCTACCTTTAAGGTGAAAGTTGGTGACAAGG
AAGTAGATGTGTTGGATGGCTTTAGACTCTACATTACCACCAAATTGCCTAACCCAGCCTACACCCCTGAGATAAGTGCCCGTACCTCCA
TCATTGACTTCACTGTCACCATGAAAGGTCTAGAAGATCAGTTACTGGGGAGGGTCATTCTCACAGAGAAGCAGGAATTGGAGAAAGAAA
GAACTCATCTGATGGAAGATGTAACTGCAAACAAAAGAAGGATGAAGGAACTAGAAGATAACTTGCTTTACCGCCTGACAAGTACCCAGG
GGTCCCTGGTAGAAGATGAAAGTCTCATTGTCGTGCTGAGTAACACAAAAAGGACAGCCGAGGAGGTGACACAGAAGCTAGAAATTTCTG
CTGAGACAGAAGTTCAAATTAACTCAGCCCGGGAGGAATACAGACCTGTGGCTACGCGGGGCAGCATCCTCTACTTCCTCATTACTGAGA
TGCGCTTGGTTAATGAGATGTATCAGACTTCGCTTCGCCAGTTTCTGGGCTTATTTGACCTTTCCTTAGCCAGGTCTGTCAAGAGCCCGA
TTACAAGCAAGAGGATTGCTAATATCATCGAGCACATGACCTACGAGGTTTATAAGTATGCTGCCCGAGGGCTGTACGAGGAGCACAAAT
TCCTGTTCACCTTGTTGCTTACCCTAAAGATTGACATCCAGAGGAACCGAGTCAAGCATGAAGAGTTTCTCACTCTTATTAAAGGAGGTG
CCTCATTAGACCTTAAAGCTTGTCCTCCAAAACCATCAAAATGGATCCTGGACATAACATGGCTGAATTTGGTGGAACTTAGCAAACTCA
GACAGTTTTCAGATGTCCTTGACCAGATATCGAGAAATGAGAAAATGTGGAAAATTTGGTTTGATAAGGAAAACCCGGAGGAGGAACCTC
TTCCAAATGCCTATGATAAATCTCTTGACTGCTTCAGACGTCTTCTCCTTATTAGATCCTGGTGTCCTGACAGAACCATCGCCCAGGCCC
GCAAGTACATCGTGGACTCCATGGGAGAAAAATATGCCGAAGGTGTTATTTTAGACTTGGAGAAGACGTGGGAGGAATCTGATCCACGGA
CGCCACTCATCTGTCTCCTGTCTATGGGCTCAGACCCCACAGATTCCATCATTGCCTTGGGGAAGAGATTAAAAATAGAAACCCGTTATG
TGTCCATGGGCCAGGGCCAGGAAGTCCATGCTCGGAAGCTCTTGCAGCAGACCATGGCGAACGGAGGATGGGCACTTCTGCAGAACTGCC
ATCTGGGACTTGATTTCATGGATGAGCTGATGGACATAATCATAGAAACTGAGCTTGTACATGATGCGTTCCGCCTCTGGATGACCACCG
AGGCTCATAAGCAGTTTCCCATTACACTCCTTCAGATGTCCATTAAATTTGCCAACGATCCTCCACAAGGACTCCGGGCAGGACTGAAAA
GAACATATAGTGGTGTCAGCCAAGACCTGCTGGACGTGAGCTCTGGGTCCCAGTGGAAGCCCATGCTGTACGCAGTGGCTTTCCTGCACT
CCACTGTCCAGGAGAGGCGCAAGTTCGGTGCCCTGGGGTGGAATATCCCCTACGAATTTAACCAAGCGGACTTTAATGCCACTGTGCAGT
TCATCCAAAACCACTTGGATGACATGGATGTCAAAAAGGGTGTCTCCTGGACCACCATCCGCTACATGATAGGAGAGATTCAATATGGAG
GCAGAGTCACTGACGACTATGATAAGAGATTGTTGAACACATTTGCTAAGGTTTGGTTCAGTGAAAATATGTTTGGACCAGATTTCAGTT
TTTACCAAGGATACAATATTCCAAAATGCAGCACAGTGGATAACTATCTTCAGTATATCCAGAGTTTGCCTGCCTATGACAGCCCTGAGG
TGTTTGGGCTGCACCCCAATGCTGACATCACCTACCAGAGCAAGCTGGCCAAGGACGTGCTGGACACCATCCTAGGCATCCAACCCAAGG
ACACCTCTGGTGGAGGGGATGAGACCCGGGAGGCGGTGGTGGCCCGGCTGGCTGATGATATGCTGGAGAAGCTGCCCCCAGACTATGTCC
CCTTTGAAGTAAAAGAGAGGCTGCAGAAGATGGGGCCATTCCAGCCTATGAACATTTTCCTCAGGCAGGAAATAGACAGAATGCAAAGGG
TACTCAGCCTTGTCCGCAGCACCCTCACTGAGCTGAAACTTGCTATTGATGGCACCATCATCATGAGCGAAAATCTGCGAGATGCATTGG
ATTGCATGTTTGATGCTAGAATCCCTGCTTGGTGGAAAAAAGCTTCTTGGATTTCTAGTACACTGGGTTTCTGGTTTACTGAACTTATAG
AAAGAAACAGCCAGTTTACCTCGTGGGTTTTCAATGGCCGACCTCACTGCTTTTGGATGACGGGTTTTTTTAACCCCCAGGGATTTTTAA
CTGCAATGCGACAGGAAATAACTCGGGCCAACAAAGGCTGGGCTCTGGACAATATGGTGCTTTGCAATGAAGTCACCAAATGGATGAAGG
ACGACATTTCTGCCCCTCCCACAGAGGGTGTCTATGTCTATGGCTTATATCTTGAAGGTGCTGGCTGGGACAAGAGGAACATGAAACTCA
TTGAATCAAAGCCAAAAGTGCTCTTTGAGTTGATGCCTGTCATAAGGATTTATGCAGAAAACAATACTTTACGAGATCCTCGGTTTTACT
CCTGTCCCATCTATAAGAAGCCAGTTCGAACGGACTTGAACTACATTGCCGCTGTGGATCTCAGGACAGCCCAGACCCCTGAACACTGGG
TGCTCCGTGGGGTTGCCCTTCTGTGTGATGTCAAGTAACATGTGGGGAGTGTCCCCACCCAATGCTTTGGAAAATGCAAGATCTAAATTA
TTGTAACCTTTATTTCTGTATGACTGCTGGACAGTGTATGTTAGGTCGTTTATGCAATTAATGAGCTGCATAGGTTTTCCCCACTCCTTA
ATTGGATGCTTATATTTTACTTGTTTCATCATTAGTGACCAATGTCTGAGTTTGTTGAAAATGTTATTTAGTGATATAAAAGTAAATTTA
CAGCATCCTAATGAAGTGTGGCCCTCAAATCCACAGTAGTATATTTTCTTCTTACTTCGCTCCGAAGACTGACTAGGGTAAGCAGACAGT
ATTTCTCTGGGAGGAATTATTCTTCTGTTAACGTGGCCTGGTAACAGCCAAGTTCTTGAAGGTAACAGGGCAAGTCTGTGCTGATTTTGC
TTCTATTGCCTTTCGTATTTAGGTCAAGTTAAGAGACTTATTTTCAGGGTTTCAAGCAGCCAATTAAAAATACCTTTTAAAAAATAGAAG
GAAATAGAAGAATGGATTAAGAATGTAAATAGAAAATTTATGTAAACATAGAGAATAAACGTAGAACAATGCTTAAGCCTACTTATAATT
AATAATGAAATACTAATTGATAATTCTTATAATAAAAATTAAAGCTAAAAGTAAATGATAGCATGCTCTCAGTAAAACTGATCCACTCAC
AAATTGCTGGAGCAATGTAAATCAACCCAACCTTTTTGTAAAATGATTAAATACAGAAAGAGCCATAAAAATATTCACACCCTTGGATCT
TTGTTTTCTCTACATCAAGGAAACAATTTAAAAGACTGAAAACAGTCTATATAAAATTGCATTTAATAACAGAAAAAAATGGAAAAATCA
TAAATATTCAATAGTCAGGCTATGGTTAAGGAAATTAAGAGATATTTGGCAACCATAAAAAACAATTTTGAAGATTCCATAATATGAAAT
GGTAGACCCAGACTGTTAAGTGAAAGATTTAGTTTACAAAATATTGAGCACACTGTGATTATAACAGCAAATATATTTGCATGTGGACAA
AGATTAGATGGCAAGATAGAAAAATAAGAACAGATGTGATAGCAAGAATTATAGTTGGCTTGAAAAAATGTGATGATCAGGAGAAAAAAT
AAAAAAAGGGTAGAAATATTAGACGGTGCGTAGGGACTTTCTATGGACTTTTATTAATTAGGAAACATTATCAAAGGAACTTTTCACGTA
TTTTTCTTTAAATTCTGGTTAGATGTTATTAATAATTCTTCATCTAACCTACTGACTAGAAAATATAGTCAGTACTAAATTAGAATTGTG
GTTTATAAACTTTTGGTTAGCTCTGGATCTGTATAACTGCATTTTTTTGGATAAACAGTTTTTGGTAGGTGGATACCGGGAGACAAGTGT
GGGTCCCTCTCACTGGGCTTCATTCTGTGGACCAGGATCATTATTTCATGCTCATGATCATGAGAGTTAGGACTGAGTGGCTCCTGTGAC
TCCCACCATCTTAGATGATACTGTTTTCTTGTGAGTTCTTTCTTTTGGTGTGGATTAGTATATCAGTTGATTTGTGTGAATTGTGGTGAA

>24169_24169_1_DROSHA-DNAH5_DROSHA_chr5_31448654_ENST00000513349_DNAH5_chr5_13931353_ENST00000265104_length(amino acids)=4603AA_BP=
MKGEKEAKRALLDARHNYLFAIVASCLDLNKTEVEDAILEGNQIERIDQLFAVGGLRHLMFYYQDVEEAETGQLGSLGGVNLVSGKIKKP
KVFVTEGNDVALTGVCVFFIRTDPSKAITPDNIHQEVSFNMLDAADGGLLNSVRRLLSDIFIPALRATSHGWGELEGLQDAANIRQEFLS
SLEGFVNVLSGAQESLKEKVNLRKCDILELKTLKEPTDYLTLANNPETLGKIEDCMKVWIKQTEQVLAENNQLLKEADDVGPRAELEHWK
KRLSKFNYLLEQLKSPDVKAVLAVLAAAKSKLLKTWREMDIRITDATNEAKDNVKYLYTLEKCCDPLYSSDPLSMMDAIPTLINAIKMIY
SISHYYNTSEKITSLFVKVTNQIISACKAYITNNGTASIWNQPQDVVEEKILSAIKLKQEYQLCFHKTKQKLKQNPNAKQFDFSEMYIFG
KFETFHRRLAKIIDIFTTLKTYSVLQDSTIEGLEDMATKYQGIVATIKKKEYNFLDQRKMDFDQDYEEFCKQTNDLHNELRKFMDVTFAK
IQNTNQALRMLKKFERLNIPNLGIDDKYQLILENYGADIDMISKLYTKQKYDPPLARNQPPIAGKILWARQLFHRIQQPMQLFQQHPAVL
STAEAKPIIRSYNRMAKVLLEFEVLFHRAWLRQIEEIHVGLEASLLVKAPGTGELFVNFDPQILILFRETECMAQMGLEVSPLATSLFQK
RDRYKRNFSNMKMMLAEYQRVKSKIPAAIEQLIVPHLAKVDEALQPGLAALTWTSLNIEAYLENTFAKIKDLELLLDRVNDLIEFRIDAI
LEEMSSTPLCQLPQEEPLTCEEFLQMTKDLCVNGAQILHFKSSLVEEAVNELVNMLLDVEVLSEEESEKISNENSVNYKNESSAKREEGN
FDTLTSSINARANALLLTTVTRKKKETEMLGEEARELLSHFNHQNMDALLKVTRNTLEAIRKRIHSSHTINFRDSNSASNMKQNSLPIFR
ASVTLAIPNIVMAPALEDVQQTLNKAVECIISVPKGVRQWSSELLSKKKIQERKMAALQSNEDSDSDVEMGENELQDTLEIASVNLPIPV
QTKNYYKNVSENKEIVKLVSVLSTIINSTKKEVITSMDCFKRYNHIWQKGKEEAIKTFITQSPLLSEFESQILYFQNLEQEINAEPEYVC
VGSIALYTADLKFALTAETKAWMVVIGRHCNKKYRSEMENIFMLIEEFNKKLNRPIKDLDDIRIAMAALKEIREEQISIDFQVGPIEESY
ALLNRYGLLIAREEIDKVDTLHYAWEKLLARAGEVQNKLVSLQPSFKKELISAVEVFLQDCHQFYLDYDLNGPMASGLKPQEASDRLIMF
QNQFDNIYRKYITYTGGEELFGLPATQYPQLLEIKKQLNLLQKIYTLYNSVIETVNSYYDILWSEVNIEKINNELLEFQNRCRKLPRALK
DWQAFLDLKKIIDDFSECCPLLEYMASKAMMERHWERITTLTGHSLDVGNESFKLRNIMEAPLLKYKEEIEDICISAVKERDIEQKLKQV
INEWDNKTFTFGSFKTRGELLLRGDSTSEIIANMEDSLMLLGSLLSNRYNMPFKAQIQKWVQYLSNSTDIIESWMTVQNLWIYLEAVFVG
GDIAKQLPKEAKRFSNIDKSWVKIMTRAHEVPSVVQCCVGDETLGQLLPHLLDQLEICQKSLTGYLEKKRLCFPRFFFVSDPALLEILGQ
ASDSHTIQAHLLNVFDNIKSVKFHEKIYDRILSISSQEGETIELDKPVMAEGNVEVWLNSLLEESQSSLHLVIRQAAANIQETGFQLTEF
LSSFPAQVGLLGIQMIWTRDSEEALRNAKFDKKIMQKTNQAFLELLNTLIDVTTRDLSSTERVKYETLITIHVHQRDIFDDLCHMHIKSP
MDFEWLKQCRFYFNEDSDKMMIHITDVAFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMSMGGAPAGPAGTGKTETTKDMGRCLGKYV
VVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQISIILTCKKEHKKSFIFTDGDNVTMNPEFGLFLTMNPGYAGRQ
ELPENLKINFRSVAMMVPDRQIIIRVKLASCGFIDNVVLARKFFTLYKLCEEQLSKQVHYDFGLRNILSVLRTLGAAKRANPMDTESTIV
MRVLRDMNLSKLIDEDEPLFLSLIEDLFPNILLDKAGYPELEAAISRQVEEAGLINHPPWKLKVIQLFETQRVRHGMMTLGPSGAGKTTC
IHTLMRAMTDCGKPHREMRMNPKAITAPQMFGRLDVATNDWTDGIFSTLWRKTLRAKKGEHIWIILDGPVDAIWIENLNSVLDDNKTLTL
ANGDRIPMAPNCKIIFEPHNIDNASPATVSRNGMVFMSSSILDWSPILEGFLKKRSPQEAEILRQLYTESFPDLYRFCIQNLEYKMEVLE
AFVITQSINMLQGLIPLKEQGGEVSQAHLGRLFVFALLWSAGAALELDGRRRLELWLRSRPTGTLELPPPAGPGDTAFDYYVAPDGTWTH
WNTRTQEYLYPSDTTPEYGSILVPNVDNVRTDFLIQTIAKQGKAVLLIGEQGTAKTVIIKGFMSKYDPECHMIKSLNFSSATTPLMFQRT
IESYVDKRMGTTYGPPAGKKMTVFIDDVNMPIINEWGDQVTNEIVRQLMEQNGFYNLEKPGEFTSIVDIQFLAAMIHPGGGRNDIPQRLK
RQFSIFNCTLPSEASVDKIFGVIGVGHYCTQRGFSEEVRDSVTKLVPLTRRLWQMTKIKMLPTPAKFHYVFNLRDLSRVWQGMLNTTSEV
IKEPNDLLKLWKHECKRVIADRFTVSSDVTWFDKALVSLVEEEFGEEKKLLVDCGIDTYFVDFLRDAPEAAGETSEEADAETPKIYEPIE
SFSHLKERLNMFLQLYNESIRGAGMDMVFFADAMVHLVKISRVIRTPQGNALLVGVGGSGKQSLTRLASFIAGYVSFQITLTRSYNTSNL
MEDLKVLYRTAGQQGKGITFIFTDNEIKDESFLEYMNNVLSSGEVSNLFARDEIDEINSDLASVMKKEFPRCLPTNENLHDYFMSRVRQN
LHIVLCFSPVGEKFRNRALKFPALISGCTIDWFSRWPKDALVAVSEHFLTSYDIDCSLEIKKEVVQCMGSFQDGVAEKCVDYFQRFRRST
HVTPKSYLSFIQGYKFIYGEKHVEVRTLANRMNTGLEKLKEASESVAALSKELEAKEKELQVANDKADMVLKEVTMKAQAAEKVKAEVQK
VKDRAQAIVDSISKDKAIAEEKLEAAKPALEEAEAALQTIRPSDIATVRTLGRPPHLIMRIMDCVLLLFQRKVSAVKIDLEKSCTMPSWQ
ESLKLMTAGNFLQNLQQFPKDTINEEVIEFLSPYFEMPDYNIETAKRVCGNVAGLCSWTKAMASFFSINKEVLPLKANLVVQENRHLLAM
QDLQKAQAELDDKQAELDVVQAEYEQAMTEKQTLLEDAERCRHKMQTASTLISGLAGEKERWTEQSQEFAAQTKRLVGDVLLATAFLSYS
GPFNQEFRDLLLNDWRKEMKARKIPFGKNLNLSEMLIDAPTISEWNLQGLPNDDLSIQNGIIVTKASRYPLLIDPQTQGKIWIKNKESRN
ELQITSLNHKYFRNHLEDSLSLGRPLLIEDVGEELDPALDNVLERNFIKTGSTFKVKVGDKEVDVLDGFRLYITTKLPNPAYTPEISART
SIIDFTVTMKGLEDQLLGRVILTEKQELEKERTHLMEDVTANKRRMKELEDNLLYRLTSTQGSLVEDESLIVVLSNTKRTAEEVTQKLEI
SAETEVQINSAREEYRPVATRGSILYFLITEMRLVNEMYQTSLRQFLGLFDLSLARSVKSPITSKRIANIIEHMTYEVYKYAARGLYEEH
KFLFTLLLTLKIDIQRNRVKHEEFLTLIKGGASLDLKACPPKPSKWILDITWLNLVELSKLRQFSDVLDQISRNEKMWKIWFDKENPEEE
PLPNAYDKSLDCFRRLLLIRSWCPDRTIAQARKYIVDSMGEKYAEGVILDLEKTWEESDPRTPLICLLSMGSDPTDSIIALGKRLKIETR
YVSMGQGQEVHARKLLQQTMANGGWALLQNCHLGLDFMDELMDIIIETELVHDAFRLWMTTEAHKQFPITLLQMSIKFANDPPQGLRAGL
KRTYSGVSQDLLDVSSGSQWKPMLYAVAFLHSTVQERRKFGALGWNIPYEFNQADFNATVQFIQNHLDDMDVKKGVSWTTIRYMIGEIQY
GGRVTDDYDKRLLNTFAKVWFSENMFGPDFSFYQGYNIPKCSTVDNYLQYIQSLPAYDSPEVFGLHPNADITYQSKLAKDVLDTILGIQP
KDTSGGGDETREAVVARLADDMLEKLPPDYVPFEVKERLQKMGPFQPMNIFLRQEIDRMQRVLSLVRSTLTELKLAIDGTIIMSENLRDA
LDCMFDARIPAWWKKASWISSTLGFWFTELIERNSQFTSWVFNGRPHCFWMTGFFNPQGFLTAMRQEITRANKGWALDNMVLCNEVTKWM
KDDISAPPTEGVYVYGLYLEGAGWDKRNMKLIESKPKVLFELMPVIRIYAENNTLRDPRFYSCPIYKKPVRTDLNYIAAVDLRTAQTPEH

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Fusion Gene PPI Analysis for DROSHA-DNAH5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DROSHA-DNAH5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DROSHA-DNAH5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource