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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DROSHA-SPEF2 (FusionGDB2 ID:24171)

Fusion Gene Summary for DROSHA-SPEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: DROSHA-SPEF2
Fusion gene ID: 24171
HgeneTgene
Gene symbol

DROSHA

SPEF2

Gene ID

29102

79925

Gene namedrosha ribonuclease IIIsperm flagellar 2
SynonymsETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASENCT122|KPL2|SPGF43
Cytomap

5p13.3

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclearsperm flagellar protein 2cancer/testis antigen 122testis tissue sperm-binding protein Li 47a
Modification date2020031320200313
UniProtAcc

Q9NRR4

.
Ensembl transtripts involved in fusion geneENST00000344624, ENST00000442743, 
ENST00000511367, ENST00000513349, 
ENST00000504361, 		ENST00000303129, 
ENST00000282469, ENST00000356031, 
ENST00000440995, ENST00000509059, 
Fusion gene scores* DoF score7 X 7 X 4=1968 X 10 X 12=960
# samples 716
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/960*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DROSHA [Title/Abstract] AND SPEF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDROSHA(31483661)-SPEF2(35628562), # samples:2
Anticipated loss of major functional domain due to fusion event.DROSHA-SPEF2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DROSHA-SPEF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DROSHA-SPEF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDROSHA

GO:0031053

primary miRNA processing

14508493|15574589

HgeneDROSHA

GO:0050829

defense response to Gram-negative bacterium

20180804

HgeneDROSHA

GO:0050830

defense response to Gram-positive bacterium

20180804


check buttonFusion gene breakpoints across DROSHA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPEF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-5715-01ADROSHAchr5

31483661

-SPEF2chr5

35628562

+


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Fusion Gene ORF analysis for DROSHA-SPEF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344624ENST00000303129DROSHAchr5

31483661

-SPEF2chr5

35628562

+
5CDS-intronENST00000442743ENST00000303129DROSHAchr5

31483661

-SPEF2chr5

35628562

+
5CDS-intronENST00000511367ENST00000303129DROSHAchr5

31483661

-SPEF2chr5

35628562

+
5CDS-intronENST00000513349ENST00000303129DROSHAchr5

31483661

-SPEF2chr5

35628562

+
Frame-shiftENST00000513349ENST00000282469DROSHAchr5

31483661

-SPEF2chr5

35628562

+
Frame-shiftENST00000513349ENST00000356031DROSHAchr5

31483661

-SPEF2chr5

35628562

+
Frame-shiftENST00000513349ENST00000440995DROSHAchr5

31483661

-SPEF2chr5

35628562

+
Frame-shiftENST00000513349ENST00000509059DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000344624ENST00000282469DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000344624ENST00000356031DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000344624ENST00000440995DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000344624ENST00000509059DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000442743ENST00000282469DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000442743ENST00000356031DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000442743ENST00000440995DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000442743ENST00000509059DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000511367ENST00000282469DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000511367ENST00000356031DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000511367ENST00000440995DROSHAchr5

31483661

-SPEF2chr5

35628562

+
In-frameENST00000511367ENST00000509059DROSHAchr5

31483661

-SPEF2chr5

35628562

+
intron-3CDSENST00000504361ENST00000282469DROSHAchr5

31483661

-SPEF2chr5

35628562

+
intron-3CDSENST00000504361ENST00000356031DROSHAchr5

31483661

-SPEF2chr5

35628562

+
intron-3CDSENST00000504361ENST00000440995DROSHAchr5

31483661

-SPEF2chr5

35628562

+
intron-3CDSENST00000504361ENST00000509059DROSHAchr5

31483661

-SPEF2chr5

35628562

+
intron-intronENST00000504361ENST00000303129DROSHAchr5

31483661

-SPEF2chr5

35628562

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000511367DROSHAchr531483661-ENST00000282469SPEF2chr535628562+5130231624538021185
ENST00000511367DROSHAchr531483661-ENST00000509059SPEF2chr535628562+6811231624550891614
ENST00000511367DROSHAchr531483661-ENST00000356031SPEF2chr535628562+7785231624577262493
ENST00000511367DROSHAchr531483661-ENST00000440995SPEF2chr535628562+8222231624577142489
ENST00000442743DROSHAchr531483661-ENST00000282469SPEF2chr535628562+482120074734931148
ENST00000442743DROSHAchr531483661-ENST00000509059SPEF2chr535628562+650220074747801577
ENST00000442743DROSHAchr531483661-ENST00000356031SPEF2chr535628562+747620074774172456
ENST00000442743DROSHAchr531483661-ENST00000440995SPEF2chr535628562+791320074774052452
ENST00000344624DROSHAchr531483661-ENST00000282469SPEF2chr535628562+493221184736041185
ENST00000344624DROSHAchr531483661-ENST00000509059SPEF2chr535628562+661321184748911614
ENST00000344624DROSHAchr531483661-ENST00000356031SPEF2chr535628562+758721184775282493
ENST00000344624DROSHAchr531483661-ENST00000440995SPEF2chr535628562+802421184775162489

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000511367ENST00000282469DROSHAchr531483661-SPEF2chr535628562+0.0002499440.9997501
ENST00000511367ENST00000509059DROSHAchr531483661-SPEF2chr535628562+0.0007445380.9992555
ENST00000511367ENST00000356031DROSHAchr531483661-SPEF2chr535628562+0.000619210.9993807
ENST00000511367ENST00000440995DROSHAchr531483661-SPEF2chr535628562+0.0007314540.9992686
ENST00000442743ENST00000282469DROSHAchr531483661-SPEF2chr535628562+0.0001568830.9998431
ENST00000442743ENST00000509059DROSHAchr531483661-SPEF2chr535628562+0.0006261690.99937385
ENST00000442743ENST00000356031DROSHAchr531483661-SPEF2chr535628562+0.0005628030.99943715
ENST00000442743ENST00000440995DROSHAchr531483661-SPEF2chr535628562+0.00064130.9993587
ENST00000344624ENST00000282469DROSHAchr531483661-SPEF2chr535628562+0.0002121070.99978787
ENST00000344624ENST00000509059DROSHAchr531483661-SPEF2chr535628562+0.0006061710.9993938
ENST00000344624ENST00000356031DROSHAchr531483661-SPEF2chr535628562+0.0005273610.9994727
ENST00000344624ENST00000440995DROSHAchr531483661-SPEF2chr535628562+0.0006061710.9993938

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Fusion Genomic Features for DROSHA-SPEF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DROSHAchr531483660-SPEF2chr535628561+7.25E-050.9999275
DROSHAchr531483660-SPEF2chr535628561+7.25E-050.9999275

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DROSHA-SPEF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:31483661/chr5:35628562)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DROSHA

Q9NRR4

.
FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31483661chr5:35628562ENST00000344624-13331_2126901375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000344624-1333219_3166901375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000442743-12321_2126531338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000442743-1232219_3166531338.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000511367-15351_2126901375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000511367-1535219_3166901375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000513349-15351_2126531338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31483661chr5:35628562ENST00000513349-1535219_3166531338.0Compositional biasNote=Arg-rich
TgeneSPEF2chr5:31483661chr5:35628562ENST000002824690101686_171219515.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000282469010227_26019515.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000282469010321_39619515.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000282469010732_75819515.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000282469010871_90919515.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST000003031290131686_17120620.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000303129013227_2600620.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000303129013321_3960620.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000303129013732_7580620.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000303129013871_9090620.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST000003560310371686_1712191823.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000356031037227_260191823.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000356031037321_396191823.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000356031037732_758191823.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000356031037871_909191823.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST000004409950371686_1712191819.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000440995037227_260191819.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000440995037321_396191819.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000440995037732_758191819.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST00000440995037871_909191819.0Coiled coilOntology_term=ECO:0000255
TgeneSPEF2chr5:31483661chr5:35628562ENST000003031290131_1050620.0DomainCalponin-homology (CH)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31483661chr5:35628562ENST00000344624-13331107_12336901375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31483661chr5:35628562ENST00000344624-13331260_13346901375.0DomainNote=DRBM
HgeneDROSHAchr5:31483661chr5:35628562ENST00000344624-1333876_10566901375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31483661chr5:35628562ENST00000442743-12321107_12336531338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31483661chr5:35628562ENST00000442743-12321260_13346531338.0DomainNote=DRBM
HgeneDROSHAchr5:31483661chr5:35628562ENST00000442743-1232876_10566531338.0DomainNote=RNase III 1
HgeneDROSHAchr5:31483661chr5:35628562ENST00000511367-15351107_12336901375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31483661chr5:35628562ENST00000511367-15351260_13346901375.0DomainNote=DRBM
HgeneDROSHAchr5:31483661chr5:35628562ENST00000511367-1535876_10566901375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31483661chr5:35628562ENST00000513349-15351107_12336531338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31483661chr5:35628562ENST00000513349-15351260_13346531338.0DomainNote=DRBM
HgeneDROSHAchr5:31483661chr5:35628562ENST00000513349-1535876_10566531338.0DomainNote=RNase III 1
TgeneSPEF2chr5:31483661chr5:35628562ENST000002824690101_10519515.0DomainCalponin-homology (CH)
TgeneSPEF2chr5:31483661chr5:35628562ENST000003560310371_105191823.0DomainCalponin-homology (CH)
TgeneSPEF2chr5:31483661chr5:35628562ENST000004409950371_105191819.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for DROSHA-SPEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24171_24171_1_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000282469_length(transcript)=4932nt_BP=2118nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTAAAAATACAGATTCTTGGG
CCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACA
ACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAG
AAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAG
TGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTC
CGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTA
GCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACA
ACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAG
AAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTT
TAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATA
TTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGC
TTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCT
GCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTAC
TTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTT
CTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAA
CAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGA
CAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGC
GGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAAC
TCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTA
TTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATG
TGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAG
GCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCAC
GAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGC
TGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGC
AAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAAC
AAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAA
AGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGA
TTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTA
ACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGGTACCTACTGATATGA
AATAATTAGAATGCTACATAATAAATCCTTTTTCTTTAACATTAATTTTGTGATATTCCTTATTTCATTTCTACTAATAAAAATAGACAT
GTTTTGTTTGCATTTTCCCTTGTTTTAATTTGTATGTTTGTACTACTTTTTAGATGCTTAAACTATACATAAGCTATTATCTATTGTTCC
TAGTAATCTTAGGGGAGTGGTCTGAAAAAACATCAAGCATAGTAATTGTCTGGGTAGACAGATTTCAGAATTTTTAAAATGCTTTAATTT
ATTTATTAGCATTTTTCTTTGTATGGGCTGTGTACTTTTGCTTCAAAAACCATTGTTAAAAAGTATTTCTTTTGTAATCAATCTAAATAA
TAGACTTTTTTTACAGGCAAAATGAAAGAGGAGGAAGTCTGGGTTTTATGAATAGCATAGATTCAAACAATCTTTTATTCAAAGATTGAA
ATAAAAAGTATCGGGTGCCAACTGTGATTTTTAGAAGAACTGTTGTAAAGCCTTTGAGATTAGACAGACTAGAGCTACATTACTGAAATT
GCCAACTACTAACTGTGTGACCTTAGGTGACCAGTTCATTAAGGGCTAATAGATTTCCATTTTTCAATTAATGGAAAGGGAATGCTACTA
TACCTACTTCATTTAAAATAACATGAGTTAAACACTTAGCTGAGTGCACTTCATGTTGGATGCATATAATACATATCCATTTCTTTCCTC
ACCATCCTACTCTCCCCATCCCACTCCATCTCACCCTTAGAAGTAAAGGTGTAACAATCATAGCTTTTGGATAGAAATTTTGAGTGGATC
AACAGCAATGGAATGAGGAGTGAGGCTTTTTATTAGAAAAATTACAAAATGAGTCCCGGAAGGTCAGTAAGTGCAACATGAAAAAAATCT
ATGAAAAGATTATTTGACCTAATTATTCACTGATAGTACATACTCAACAAAGGTTTGTGGGACAAAGGGTGAATAAAATGAATGAATTAC
AATGAACAAAGAAAAGTGCAAAATAACACTAACAAGTAAATATTACAAGAAGATAACCTTGTGGTTAAAAGATAAGGAAAAATATGAGAT
TATGAGAAATTAAATGTATACTATATTTTAATTAAATGAATCTGTATTTGTAGCACTAAGAGAATTATTATTAAGGATTGACTAGAACCT
TAAAAGATATATGTGGATGTTTGTTTTGTACGGTTGTAAAATATACTAGACCTATTACATCCACCTAAAGTATAATGCCATGTAAGAAAA

>24171_24171_1_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000282469_length(amino acids)=1185AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL

--------------------------------------------------------------
>24171_24171_2_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000356031_length(transcript)=7587nt_BP=2118nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTAAAAATACAGATTCTTGGG
CCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACA
ACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAG
AAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAG
TGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTC
CGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTA
GCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACA
ACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAG
AAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTT
TAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATA
TTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGC
TTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCT
GCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTAC
TTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTT
CTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAA
CAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGA
CAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGC
GGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAAC
TCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTA
TTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATG
TGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAG
GCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCAC
GAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGC
TGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGC
AAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAAC
AAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAA
AGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGA
TTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTA
ACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGT
GGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTC
TTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTA
CCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACA
ATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGG
ATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGAAACAATGCTTAGTGCTAATGCTGATA
AAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGC
TGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCC
TAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAA
AAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTAT
TAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTC
AACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACT
GGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAG
TAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAG
CTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGG
CTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAG
GTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAG
ATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGC
CTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGC
ATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAAT
GGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGCGAG
ACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACACTC
TTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATTACT
GGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAA
GCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCA
AGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAG
TATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTC
AGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGGCAG
AAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTG
CTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAA
AGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACGTAG
CTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCT
TCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAG
ATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTGGCA
CAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGG
ACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTG
TGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAG
AAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCAC
CCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTG
GAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTG
AACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATG
CAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACC
TAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTC
TCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGATATTAAAATAATTCTCCAAAGGAGTGAAC
ATGTACAAGGAAGTGATGGAGAGAGATCACCTTCAAGACATACAGAGGAAAAGAAATGAAGACAAAAGAGTGTGATTTTTTTAATTCTGC

>24171_24171_2_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000356031_length(amino acids)=2493AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLK
LTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSK
EIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILI
KINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAP
HGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYI
NTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQ
ERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLE
TVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKK
QEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGER
YLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKA
FTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQ
AGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAE
KTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQ

--------------------------------------------------------------
>24171_24171_3_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000440995_length(transcript)=8024nt_BP=2118nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTAAAAATACAGATTCTTGGG
CCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACA
ACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAG
AAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAG
TGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTC
CGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTA
GCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACA
ACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAG
AAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTT
TAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATA
TTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGC
TTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCT
GCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTAC
TTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTT
CTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAA
CAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGA
CAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGC
GGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAAC
TCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTA
TTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATG
TGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAG
GCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCAC
GAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGC
TGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGC
AAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAAC
AAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAA
AGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGA
TTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTA
ACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGT
GGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTC
TTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTA
CCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACA
ATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGG
ATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTG
AAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGA
GCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAA
TGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAAT
CCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATA
CTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTG
AAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGC
AATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTA
CGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGC
TTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTA
CTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCA
AAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAGATACATCACCTGTTG
CAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTAC
CTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGCATACTGTGCTTGCTT
ACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCA
ACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGCGAGACCGCCTGTGGGACA
TTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACACTCTTGGAATGACAATGA
ACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATTACTGGGGAATGGAAAGTA
AAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTC
CTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCAAGATGGATAACTCCC
TAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGG
CTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATA
AAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGGCAGAAGCAACTCCTGTCA
TAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTGCTGCCTTGCAATTTG
AAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAAAGGTGGTTGATGTAT
ATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACGTAGCTCGCTATCACATTG
AAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCTTCCCAGATCCTCCCC
CATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATA
TGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTGGCACAAACAACTTTCCTA
GTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCC
TGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGT
TGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAGAAAATCCTCTTGAAC
CCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCACCCCAGCTTGACTACA
CACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCC
AACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATG
CTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATGCAAACAATGAAAAGA
TGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACCTAAAGATAGAGAACA
TTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTT
TTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGTACACATCATCTATGTAGTGGAAATGATAGTGTGTGCAAAAGGTT
GGGCACCACTTCCATCAGGAAAACAGTGTGCAAGATGGAGAAACTAAGGACAAACCCCAGAGAAACTGGACAAACCCAGCAGAAGAAAGG
AAGAACTGCAACTCAGAAATCACATAACCACCAAGCAGGTCTGGACCACACATGCTAAATGTGCATCCACTATGGCGAGTCCCAGGCCTT
TAACAGCAGGGACTAAGGAGGGCAGAGGCTGACACCAACCCCCTTTCATACTGTAGCACTACATCCCTCTCAGATACCAGTTTAACACGA
AGTCTCCCTGTTTGACTCCTGTGAGTTGTGTATTGAACTACAAAGTGTTTGCTGAGTTGAAAATAAAAGCGCTTTCACTTTGATAGAATG
TAGATTGTGTATCTTGACTTCTCAATGATAGCAAGTTACATTTTGCAGTTTTCTTCCTATACCCACAAATGAAACTATTCAGACTTAAAT
ATCTTCCTGTGTGCCTAAACGTTTTTGTTCTAAGTTGCTGATCCTTTTAAATATTAAATTATTAATTAATATTAAAATTAATTTTATTGC

>24171_24171_3_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000440995_length(amino acids)=2489AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRA
QLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLP
SPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAE
IDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQE
SLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKT
VLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDI
INESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPK
PKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKK
PKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEM
ASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDIL
IDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWF
TGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSST
DAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAK

--------------------------------------------------------------
>24171_24171_4_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000509059_length(transcript)=6613nt_BP=2118nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTAAAAATACAGATTCTTGGG
CCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACA
ACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAG
AAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAG
TGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTC
CGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTA
GCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACA
ACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAG
AAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTT
TAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATA
TTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGC
TTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCT
GCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTAC
TTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTT
CTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAA
CAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGA
CAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGC
GGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAAC
TCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTA
TTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATG
TGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAG
GCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCAC
GAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGC
TGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGC
AAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAAC
AAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAA
AGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGA
TTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTA
ACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGT
GGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTC
TTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTA
CCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACA
ATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGG
ATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTG
AAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGA
GCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAA
TGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAAT
CCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATA
CTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTG
AAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGC
AATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTA
CGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGC
TTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTA
CTGCAAAAGGAAAACCTCAATCAGGTGATTGACAGAATGATTTATAATCCTGTTTTCAGTTTCTTATTTTTACTCAGTAAAGAATTATAA
ATTATAGTCTATCTACATTCAGACTTTGGGCAACTTCAATCATATGAAACAAGGCTTTACACTCAGATGGAAGTGGAAAAGCCCTCGGAG
TAGCTAAAAGCGTAGTTGTTACAAAGCCCAACTTCTTTGCCATGTAGGAGGAGACATGGAGTCATCACACCTAGGTCTACTGATTAGAGT
AAGACCACAGACGAGAAGAGGAAAAGGCACAGAGTAACAGGTAACTTCAGGCAGATCAAGAGGATACACGTCTGTGTGCTGAACTATAGA
GTTACATTTATGTAATGAGTAAGAACATCTTAATAAAATAAGAATGAGTATAGCTGGTTTTCCACCAGAATAAGGGAACAAATTAACAGC
AACCATTAGAACTAGAATTTATATGTAATTGTAAATCTTCAGGACTATGTGATTATAAAAGTATAGAAACAAGCTCCTGCCATCTCAGTA
AACATATATTTATGGACACAGAGATAAAGAGCCTAGATAGAGAACACTTTTAGTTTAAGTTTGTTCTAGATCCTTAACCGCTATGGACCA
TAAGTCTAGCATTAAGTGGCAGACAATGAATATAATGACAAAAGTGAAGTGCTTAATTGTTGTAATGCATGATATTGGTAGAGTGTCAGT
ATCCATTTGTGTGTGTATATAAAACAAATGAGGCTCTGGTTTCTAGTTTCAGCTTTATAAATGGCTGACTGTGCAGTTACACCATGTCTA
CCTAAGTATCTTTGATACTGTGTCATGACCACATTTCTAAACTCTATAGTCTTTCTGCCTCACGGAGATTTGAGATAGGTCTTAATTTTT
AAAATTAAACTTATTCATATTAAACAAAGACATATGAAGACTTTAGTAAGATATATTATGATATATTAAAGACCATTCTGCTCCAGGAAA
TTAGAAATTAACTACAGGCAAAATACACACATCCTAAAAAATGTTTTTATCATGTCAACAATAAAACACAAAGACATGAATTAAACATAC
ACCCTTTTCCCGCTGTCTCATTAGGAAATTAAAAAACAATTCAGAGGTCTGGAGGAAAATGGAAATATTTAAAATGCTTTTTAGAACTGG
GGAAGACAGGCCAAGCATGGTGGCTCATCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCAGAAATCAGGAGTTCGA
GACCCCGCTGGCCAACAGGGCAAAACCCATCTCTACCAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCACCTGTAATCCCAGCTGC
TTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCGAGATTGCCCCACTGCACTCTAGCCTGGGGGA
TAGAGTGAAACTCTACCTCCAAAAAAAAGAAAAGAAAAATAACTGAGGAAGACAGTTTTCACAGTGGGTCAGGTGAGCCTAGAATTATCG
AATATCGTCCTTTAACCTATAGCTATGACTCTAGGTTAAAGCTCCTCCTCAGCTTGCTCCAGTCAAGAGTATCTATGTATTTGAGCCATT
TCCTGAAACCAGACTCTAGTGTTTCTGATCAGACCAGCTCAGTCTTTAAGTTTCTGAAGTTTGTTTGCTATTTTATAATTATATTCTTGA

>24171_24171_4_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000344624_SPEF2_chr5_35628562_ENST00000509059_length(amino acids)=1614AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRA
QLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLP
SPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAE

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>24171_24171_5_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000282469_length(transcript)=4821nt_BP=2007nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACA
AGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGT
GGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTC
GTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGA
AGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTT
TTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATG
ATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTC
GTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTA
TAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTA
GATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCC
TATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCA
TGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGT
TTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTA
ACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGT
ACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACA
TGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAG
AAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTT
TTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTG
CATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGT
TCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGT
TAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGAC
GGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGC
AGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAA
AACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAG
AACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAG
AAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATG
ATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTA
CAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGGTACCTACTGATATGAAATAATTAGAATGCTACATAA
TAAATCCTTTTTCTTTAACATTAATTTTGTGATATTCCTTATTTCATTTCTACTAATAAAAATAGACATGTTTTGTTTGCATTTTCCCTT
GTTTTAATTTGTATGTTTGTACTACTTTTTAGATGCTTAAACTATACATAAGCTATTATCTATTGTTCCTAGTAATCTTAGGGGAGTGGT
CTGAAAAAACATCAAGCATAGTAATTGTCTGGGTAGACAGATTTCAGAATTTTTAAAATGCTTTAATTTATTTATTAGCATTTTTCTTTG
TATGGGCTGTGTACTTTTGCTTCAAAAACCATTGTTAAAAAGTATTTCTTTTGTAATCAATCTAAATAATAGACTTTTTTTACAGGCAAA
ATGAAAGAGGAGGAAGTCTGGGTTTTATGAATAGCATAGATTCAAACAATCTTTTATTCAAAGATTGAAATAAAAAGTATCGGGTGCCAA
CTGTGATTTTTAGAAGAACTGTTGTAAAGCCTTTGAGATTAGACAGACTAGAGCTACATTACTGAAATTGCCAACTACTAACTGTGTGAC
CTTAGGTGACCAGTTCATTAAGGGCTAATAGATTTCCATTTTTCAATTAATGGAAAGGGAATGCTACTATACCTACTTCATTTAAAATAA
CATGAGTTAAACACTTAGCTGAGTGCACTTCATGTTGGATGCATATAATACATATCCATTTCTTTCCTCACCATCCTACTCTCCCCATCC
CACTCCATCTCACCCTTAGAAGTAAAGGTGTAACAATCATAGCTTTTGGATAGAAATTTTGAGTGGATCAACAGCAATGGAATGAGGAGT
GAGGCTTTTTATTAGAAAAATTACAAAATGAGTCCCGGAAGGTCAGTAAGTGCAACATGAAAAAAATCTATGAAAAGATTATTTGACCTA
ATTATTCACTGATAGTACATACTCAACAAAGGTTTGTGGGACAAAGGGTGAATAAAATGAATGAATTACAATGAACAAAGAAAAGTGCAA
AATAACACTAACAAGTAAATATTACAAGAAGATAACCTTGTGGTTAAAAGATAAGGAAAAATATGAGATTATGAGAAATTAAATGTATAC
TATATTTTAATTAAATGAATCTGTATTTGTAGCACTAAGAGAATTATTATTAAGGATTGACTAGAACCTTAAAAGATATATGTGGATGTT
TGTTTTGTACGGTTGTAAAATATACTAGACCTATTACATCCACCTAAAGTATAATGCCATGTAAGAAAATGCTTTGACAGTATCAACCTG

>24171_24171_5_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000282469_length(amino acids)=1148AA_BP=653
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGII
TEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFE
KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESAS
KTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVR
HEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADY

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>24171_24171_6_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000356031_length(transcript)=7476nt_BP=2007nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACA
AGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGT
GGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTC
GTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGA
AGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTT
TTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATG
ATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTC
GTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTA
TAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTA
GATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCC
TATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCA
TGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGT
TTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTA
ACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGT
ACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACA
TGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAG
AAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTT
TTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTG
CATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGT
TCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGT
TAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGAC
GGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGC
AGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAA
AACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAG
AACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAG
AAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATG
ATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTA
CAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGG
TTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAA
CAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAA
AAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTC
TACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAG
CTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGAAACAATGCTTAGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAG
TCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTC
CTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTT
TAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACAT
TGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCT
CAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACC
AAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGT
TTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTG
AAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCAC
TTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAA
AAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAA
AAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAGATACATCACCTGTTGCAATAG
TGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACT
GGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTAT
ATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCC
TTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTG
ATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACACTCTTGGAATGACAATGAACCATT
TCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCC
CAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAG
TTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAA
ACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTG
AAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAG
TCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAA
CAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAA
TAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAAC
TCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACGTAGCTCGCTATCACATTGAAACAT
CTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAA
TACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCAC
CTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATT
GGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAG
TAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCA
CCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTC
CATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGA
TGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAG
TCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAA
GAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCA
TGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATG
CAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTC
AAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGATATTAAAATAATTCTCCAAAGGAGTGAACATGTACAAGGAAGTGATGGAG
AGAGATCACCTTCAAGACATACAGAGGAAAAGAAATGAAGACAAAAGAGTGTGATTTTTTTAATTCTGCAATAAATCTTCCAAAAATTAA

>24171_24171_6_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000356031_length(amino acids)=2456AA_BP=653
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGII
TEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFE
KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESAS
KTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVR
HEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADY
RMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHIL
HRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQ
EEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEI
PVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYK
TAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEK
EAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVK
KSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDH
KQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTK
RLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDT
WQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRV
KIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFF
INGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLL
TVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLF
ADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQK
DEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIK

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>24171_24171_7_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000440995_length(transcript)=7913nt_BP=2007nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACA
AGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGT
GGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTC
GTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGA
AGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTT
TTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATG
ATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTC
GTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTA
TAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTA
GATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCC
TATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCA
TGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGT
TTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTA
ACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGT
ACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACA
TGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAG
AAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTT
TTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTG
CATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGT
TCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGT
TAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGAC
GGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGC
AGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAA
AACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAG
AACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAG
AAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATG
ATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTA
CAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGG
TTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAA
CAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAA
AAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTC
TACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAG
CTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATA
GTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTG
TTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGC
TTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTG
CGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGA
ATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAG
ACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAA
ATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAA
AGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTC
CTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAAT
CAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAG
GAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTA
AGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAA
ATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAA
GTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGT
GGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAG
AGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGC
AGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACA
AGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCA
TTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACT
TTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGC
TTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCAC
CCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTG
CTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTC
GACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGC
TTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGA
ATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTG
TAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAG
GAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCC
AACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTT
GGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGC
AGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGG
AGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTG
CTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTC
CAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAAT
TAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCA
AAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAA
AAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAA
ATTATTCAGACTATAAGTTTCCTGTACACATCATCTATGTAGTGGAAATGATAGTGTGTGCAAAAGGTTGGGCACCACTTCCATCAGGAA
AACAGTGTGCAAGATGGAGAAACTAAGGACAAACCCCAGAGAAACTGGACAAACCCAGCAGAAGAAAGGAAGAACTGCAACTCAGAAATC
ACATAACCACCAAGCAGGTCTGGACCACACATGCTAAATGTGCATCCACTATGGCGAGTCCCAGGCCTTTAACAGCAGGGACTAAGGAGG
GCAGAGGCTGACACCAACCCCCTTTCATACTGTAGCACTACATCCCTCTCAGATACCAGTTTAACACGAAGTCTCCCTGTTTGACTCCTG
TGAGTTGTGTATTGAACTACAAAGTGTTTGCTGAGTTGAAAATAAAAGCGCTTTCACTTTGATAGAATGTAGATTGTGTATCTTGACTTC
TCAATGATAGCAAGTTACATTTTGCAGTTTTCTTCCTATACCCACAAATGAAACTATTCAGACTTAAATATCTTCCTGTGTGCCTAAACG

>24171_24171_7_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000440995_length(amino acids)=2452AA_BP=653
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGII
TEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFE
KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESAS
KTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVR
HEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADY
RMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHIL
HRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQ
EEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQD
CILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHED
ISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKK
AAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPAD
STDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFV
AQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQD
YYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQAS
LAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEE
HLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNI
KVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSE
FVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEK
DPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIP
ENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPVHIIYVVE

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>24171_24171_8_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000509059_length(transcript)=6502nt_BP=2007nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACA
AGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGT
GGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTC
GTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGA
AGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTT
TTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATG
ATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTC
GTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTA
TAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTA
GATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCC
TATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCA
TGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCATTTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGT
TTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTGCCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTA
ACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAGAAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGT
ACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGCAAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACA
TGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAACTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAG
AAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAACTTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTT
TTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGGCCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTG
CATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGAAAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGT
TCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGACTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGT
TAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTGAAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGAC
GGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGGCTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGC
AGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATGAAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAA
AACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAGAAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAG
AACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAGCTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAG
AAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAATGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATG
ATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTGTTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTA
CAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATAAGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGG
TTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACAGGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAA
CAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAACATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAA
AAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTATCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTC
TACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGGAGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAG
CTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATA
GTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTG
TTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGC
TTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTG
CGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGA
ATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAG
ACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAA
ATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAA
AGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTC
CTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAAT
CAGGTGATTGACAGAATGATTTATAATCCTGTTTTCAGTTTCTTATTTTTACTCAGTAAAGAATTATAAATTATAGTCTATCTACATTCA
GACTTTGGGCAACTTCAATCATATGAAACAAGGCTTTACACTCAGATGGAAGTGGAAAAGCCCTCGGAGTAGCTAAAAGCGTAGTTGTTA
CAAAGCCCAACTTCTTTGCCATGTAGGAGGAGACATGGAGTCATCACACCTAGGTCTACTGATTAGAGTAAGACCACAGACGAGAAGAGG
AAAAGGCACAGAGTAACAGGTAACTTCAGGCAGATCAAGAGGATACACGTCTGTGTGCTGAACTATAGAGTTACATTTATGTAATGAGTA
AGAACATCTTAATAAAATAAGAATGAGTATAGCTGGTTTTCCACCAGAATAAGGGAACAAATTAACAGCAACCATTAGAACTAGAATTTA
TATGTAATTGTAAATCTTCAGGACTATGTGATTATAAAAGTATAGAAACAAGCTCCTGCCATCTCAGTAAACATATATTTATGGACACAG
AGATAAAGAGCCTAGATAGAGAACACTTTTAGTTTAAGTTTGTTCTAGATCCTTAACCGCTATGGACCATAAGTCTAGCATTAAGTGGCA
GACAATGAATATAATGACAAAAGTGAAGTGCTTAATTGTTGTAATGCATGATATTGGTAGAGTGTCAGTATCCATTTGTGTGTGTATATA
AAACAAATGAGGCTCTGGTTTCTAGTTTCAGCTTTATAAATGGCTGACTGTGCAGTTACACCATGTCTACCTAAGTATCTTTGATACTGT
GTCATGACCACATTTCTAAACTCTATAGTCTTTCTGCCTCACGGAGATTTGAGATAGGTCTTAATTTTTAAAATTAAACTTATTCATATT
AAACAAAGACATATGAAGACTTTAGTAAGATATATTATGATATATTAAAGACCATTCTGCTCCAGGAAATTAGAAATTAACTACAGGCAA
AATACACACATCCTAAAAAATGTTTTTATCATGTCAACAATAAAACACAAAGACATGAATTAAACATACACCCTTTTCCCGCTGTCTCAT
TAGGAAATTAAAAAACAATTCAGAGGTCTGGAGGAAAATGGAAATATTTAAAATGCTTTTTAGAACTGGGGAAGACAGGCCAAGCATGGT
GGCTCATCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACCAGAAATCAGGAGTTCGAGACCCCGCTGGCCAACAGGGC
AAAACCCATCTCTACCAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCACCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGA
ATTGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCGAGATTGCCCCACTGCACTCTAGCCTGGGGGATAGAGTGAAACTCTACCTCCA
AAAAAAAGAAAAGAAAAATAACTGAGGAAGACAGTTTTCACAGTGGGTCAGGTGAGCCTAGAATTATCGAATATCGTCCTTTAACCTATA
GCTATGACTCTAGGTTAAAGCTCCTCCTCAGCTTGCTCCAGTCAAGAGTATCTATGTATTTGAGCCATTTCCTGAAACCAGACTCTAGTG
TTTCTGATCAGACCAGCTCAGTCTTTAAGTTTCTGAAGTTTGTTTGCTATTTTATAATTATATTCTTGAATACTGTGCATTGAAGAAATA

>24171_24171_8_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000442743_SPEF2_chr5_35628562_ENST00000509059_length(amino acids)=1577AA_BP=653
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGII
TEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFE
KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESAS
KTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVR
HEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADY
RMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHIL
HRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQ
EEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQD
CILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHED
ISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKK

--------------------------------------------------------------
>24171_24171_9_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000282469_length(transcript)=5130nt_BP=2316nt
CTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACGGCGATCTCGCGGCCCGAGAGCCTTTTATAGGTTGCTTTTCCCGGGGAT
GTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATCTAGTGGAAGAGTTAGACGTGTGCATACTTCACTA
TGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACA
GAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATC
TGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCC
CCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCA
GGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATA
ACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAG
TCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACC
CTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGA
GAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATC
GGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACC
GCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAA
AAGAGTATAAGAGATCTGGAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTA
AAAATACAGATTCTTGGGCCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAA
AAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACA
AGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATC
AGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGG
CCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATG
AGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTC
ATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGC
ACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCT
CCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCAC
ATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGA
ATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGT
TTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCAT
TTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTG
CCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAG
AAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGC
AAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAA
CTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAAC
TTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGG
CCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGA
AAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGA
CTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTG
AAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGG
CTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATG
AAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAG
AAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAG
CTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAA
TGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTG
TTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATA
AGGTACCTACTGATATGAAATAATTAGAATGCTACATAATAAATCCTTTTTCTTTAACATTAATTTTGTGATATTCCTTATTTCATTTCT
ACTAATAAAAATAGACATGTTTTGTTTGCATTTTCCCTTGTTTTAATTTGTATGTTTGTACTACTTTTTAGATGCTTAAACTATACATAA
GCTATTATCTATTGTTCCTAGTAATCTTAGGGGAGTGGTCTGAAAAAACATCAAGCATAGTAATTGTCTGGGTAGACAGATTTCAGAATT
TTTAAAATGCTTTAATTTATTTATTAGCATTTTTCTTTGTATGGGCTGTGTACTTTTGCTTCAAAAACCATTGTTAAAAAGTATTTCTTT
TGTAATCAATCTAAATAATAGACTTTTTTTACAGGCAAAATGAAAGAGGAGGAAGTCTGGGTTTTATGAATAGCATAGATTCAAACAATC
TTTTATTCAAAGATTGAAATAAAAAGTATCGGGTGCCAACTGTGATTTTTAGAAGAACTGTTGTAAAGCCTTTGAGATTAGACAGACTAG
AGCTACATTACTGAAATTGCCAACTACTAACTGTGTGACCTTAGGTGACCAGTTCATTAAGGGCTAATAGATTTCCATTTTTCAATTAAT
GGAAAGGGAATGCTACTATACCTACTTCATTTAAAATAACATGAGTTAAACACTTAGCTGAGTGCACTTCATGTTGGATGCATATAATAC
ATATCCATTTCTTTCCTCACCATCCTACTCTCCCCATCCCACTCCATCTCACCCTTAGAAGTAAAGGTGTAACAATCATAGCTTTTGGAT
AGAAATTTTGAGTGGATCAACAGCAATGGAATGAGGAGTGAGGCTTTTTATTAGAAAAATTACAAAATGAGTCCCGGAAGGTCAGTAAGT
GCAACATGAAAAAAATCTATGAAAAGATTATTTGACCTAATTATTCACTGATAGTACATACTCAACAAAGGTTTGTGGGACAAAGGGTGA
ATAAAATGAATGAATTACAATGAACAAAGAAAAGTGCAAAATAACACTAACAAGTAAATATTACAAGAAGATAACCTTGTGGTTAAAAGA
TAAGGAAAAATATGAGATTATGAGAAATTAAATGTATACTATATTTTAATTAAATGAATCTGTATTTGTAGCACTAAGAGAATTATTATT
AAGGATTGACTAGAACCTTAAAAGATATATGTGGATGTTTGTTTTGTACGGTTGTAAAATATACTAGACCTATTACATCCACCTAAAGTA
TAATGCCATGTAAGAAAATGCTTTGACAGTATCAACCTGTGTTAAGGTATTTCTTTCCATTGTAAATTAAAAGTCATTTTATTTGACAGA

>24171_24171_9_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000282469_length(amino acids)=1185AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL

--------------------------------------------------------------
>24171_24171_10_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000356031_length(transcript)=7785nt_BP=2316nt
CTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACGGCGATCTCGCGGCCCGAGAGCCTTTTATAGGTTGCTTTTCCCGGGGAT
GTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATCTAGTGGAAGAGTTAGACGTGTGCATACTTCACTA
TGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACA
GAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATC
TGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCC
CCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCA
GGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATA
ACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAG
TCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACC
CTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGA
GAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATC
GGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACC
GCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAA
AAGAGTATAAGAGATCTGGAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTA
AAAATACAGATTCTTGGGCCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAA
AAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACA
AGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATC
AGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGG
CCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATG
AGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTC
ATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGC
ACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCT
CCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCAC
ATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGA
ATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGT
TTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCAT
TTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTG
CCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAG
AAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGC
AAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAA
CTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAAC
TTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGG
CCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGA
AAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGA
CTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTG
AAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGG
CTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATG
AAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAG
AAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAG
CTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAA
TGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTG
TTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATA
AGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACA
GGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAA
CATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTA
TCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGG
AGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGAAACAATGC
TTAGTGCTAATGCTGATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTG
CAAAATCAGAACAGTTGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTG
TGAATCAAGACTGTATCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACC
TCACAGAAGTGGAAAGAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCAT
TTGATTTTGTCATATTATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTG
CTCACGAAGATATCAGTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTA
TAGGCTTCTTGGACAACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGG
AATCTTTATGTGAAAAAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAG
CTGAGAAAAAAGCAGCAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAA
TTCATCAAAGCCATGTGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGG
AAGGAAAAGGGAAGAAAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAAT
CACCTGCTGACTCTACAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAAC
CAGTTCCTGAGGAAATGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGC
ATCTGAGGGAAGACCAGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGC
AAGATTTTGTAGCTCAATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAAC
GAGTGAATGATCTGCGAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGA
GCTGGTTACAGGACACTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGAC
TCCTTCAAGATTATTACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATA
GTAAAGACAATTCTGAAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAA
AATCAGTACTGAAGGGCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGC
AGCAGGCTTCTTTAGCAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACC
CCAAAGAAAAATCTCCTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTA
AATCACCACCTATGGCAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAA
TAAAAGAAGAACACCTTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTC
TTGAAGATTTAGTAACAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAG
AAAAATTAACTGACGTAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTA
ATGGCAATATAAAAGTCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAAC
AGCTTGACAGTCTTCGAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGG
TGACCCTGAACCTTGGCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAG
TCAACTCCGAGTTCGTGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCC
TTCAGAAGTTCAAGGCTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATG
AAGATATAAAAATTCCAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTG
ACTATGAGAAGGATCCACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGG
CCCTCAGTGTGGCTGTTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTC
CAGCTGAGGAATTTCCTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATG
AAGAAATCCCTGAAAATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCA
ATAGATTTGCCAGCCACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGC
CAATTGAAGTCGCTGTTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGATATTAAAATAA
TTCTCCAAAGGAGTGAACATGTACAAGGAAGTGATGGAGAGAGATCACCTTCAAGACATACAGAGGAAAAGAAATGAAGACAAAAGAGTG

>24171_24171_10_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000356031_length(amino acids)=2493AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLK
LTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSK
EIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILI
KINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAP
HGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYI
NTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQ
ERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLE
TVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKK
QEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGER
YLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKA
FTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQ
AGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAE
KTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQ

--------------------------------------------------------------
>24171_24171_11_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000440995_length(transcript)=8222nt_BP=2316nt
CTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACGGCGATCTCGCGGCCCGAGAGCCTTTTATAGGTTGCTTTTCCCGGGGAT
GTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATCTAGTGGAAGAGTTAGACGTGTGCATACTTCACTA
TGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACA
GAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATC
TGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCC
CCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCA
GGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATA
ACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAG
TCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACC
CTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGA
GAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATC
GGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACC
GCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAA
AAGAGTATAAGAGATCTGGAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTA
AAAATACAGATTCTTGGGCCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAA
AAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACA
AGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATC
AGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGG
CCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATG
AGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTC
ATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGC
ACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCT
CCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCAC
ATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGA
ATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGT
TTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCAT
TTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTG
CCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAG
AAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGC
AAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAA
CTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAAC
TTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGG
CCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGA
AAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGA
CTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTG
AAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGG
CTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATG
AAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAG
AAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAG
CTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAA
TGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTG
TTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATA
AGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACA
GGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAA
CATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTA
TCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGG
AGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTG
ATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGT
TGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTA
TCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAA
GAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATAT
TATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCA
GTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACA
ACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAA
AAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAG
CAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATG
TGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGAAGCCCCGCATGGTAAGCAAGAATCTCTTCAGGAAGGAAAAGGGAAGA
AAGGTGAGACCGCACTCAAAAGAAAAGGTTCTCCTAAAGGAAAATCATCAGGAGGAAAAGTACCAGTAAAGAAATCACCTGCTGACTCTA
CAGATACATCACCTGTTGCAATAGTGCCACAGCCACCTAAGCCAGGATCAGAAGAATGGGTCTATGTGAATGAACCAGTTCCTGAGGAAA
TGCCTTTGTTTTTAGTACCTTACTGGGAACTAATAGAAAATTCCTATATAAACACCATCAAAACAGTACTCAGGCATCTGAGGGAAGACC
AGCATACTGTGCTTGCTTACTTATATGAGATTAGAACAAGTTTCCAGGAGTTTCTAAAGCGTCCGGATCACAAGCAAGATTTTGTAGCTC
AATGGCAGGCTGATTTCAACTCCCTTCCTGATGACCTGTGGGATGATGAGGAAACAAAGGCTGAACTACATCAACGAGTGAATGATCTGC
GAGACCGCCTGTGGGACATTTGTGATGCCCGGAAGGAAGAGGCGGAGCAGGAGCGGCTTGACATCATTAATGAGAGCTGGTTACAGGACA
CTCTTGGAATGACAATGAACCATTTCTTTTCCCTGATGCAGGCAGAGCTGAACCGTTTCCAAGATACAAAGAGACTCCTTCAAGATTATT
ACTGGGGAATGGAAAGTAAAATCCCAGTAGAGGACAACAAGAGATTTACTCGAATCCCTTTGGTCCAACTGGATAGTAAAGACAATTCTG
AAAGCCAGCTTAGAATTCCTCTAGTTCCTCGAATATCCATTTCTCTGGAAACAGTTACACCCAAACCAAAAACAAAATCAGTACTGAAGG
GCAAGATGGATAACTCCCTAGAAAACGTTGAGTCCAACTTTGAGGCCGATGAAAAGTTGGTCATGGACACCTGGCAGCAGGCTTCTTTAG
CAGTATCTCACATGGTGGCTGCTGAAATTCATCAGAGGCTTATGGAAGAAGAAAAAGAAAACCAGCCAGCAGACCCCAAAGAAAAATCTC
CTCAGATGGGTGCAAATAAAAAAGTCAAAAAGGAGCCACCCAAGAAAAAACAGGAAGACAAAAAACCCAAAGGTAAATCACCACCTATGG
CAGAAGCAACTCCTGTCATAGTAACAACAGAGGAAATTGCTGAAATCAAAAGGAAAAATGAACTGAGGGTCAAAATAAAAGAAGAACACC
TTGCTGCCTTGCAATTTGAAGAAATAGCCACGCAATTTCGACTTGAACTGATAAAGACAAAAGCATTGGCTCTTCTTGAAGATTTAGTAA
CAAAGGTGGTTGATGTATATAAACTCATGGAAAAATGGCTTGGTGAGAGGTATTTGAATGAAATGGCCAGTACAGAAAAATTAACTGACG
TAGCTCGCTATCACATTGAAACATCTACAAAAATTCAGAATGAACTTTATTTAAGCCAAGAAGACTTCTTCATTAATGGCAATATAAAAG
TCTTCCCAGATCCTCCCCCATCAATACGTCCTCCACCTGTAGAAAAGGAAGAAGATGGTACCCTGACCATTGAACAGCTTGACAGTCTTC
GAGATCAGTTCTTAGATATGGCACCTAAAGGCATAATAGGAAATAAAGCATTTACTGACATTCTGATCGATTTGGTGACCCTGAACCTTG
GCACAAACAACTTTCCTAGTAATTGGATGCACCTTACCCAACCTGAATTACAGGAATTAACATCTTTATTAACAGTCAACTCCGAGTTCG
TGGACTGGCGGAAGTTCCTGTTAGTAACCTCAATGCCTTGGCCCATTCCCTTGGAGGAGGAGCTCCTTGAGACCCTTCAGAAGTTCAAGG
CTGTGGATAAGGAGCAGTTGGGCACCATCACTTTTGAGCAGTATATGCAGGCTGGTCTGTGGTTTACAGGAGATGAAGATATAAAAATTC
CAGAAAATCCTCTTGAACCCCTTCCATTTAATAGGCAGGAGCATCTTATAGAGTTTTTCTTTAGGCTATTTGCTGACTATGAGAAGGATC
CACCCCAGCTTGACTACACACAGATGCTGCTTTACTTTGCTTGCCACCCAGACACCGTGGAAGGAGTCTACAGGGCCCTCAGTGTGGCTG
TTGGAACTCATGTCTTCCAACAAGTCAAAGCTTCCATTCCAAGTGCAGAAAAGACCTCCTCAACTGATGCAGGTCCAGCTGAGGAATTTC
CTGAACCTGAGGAAAATGCTGCAAGAGAAGAAAGGAAATTAAAAGACGACACGGAGAAAAGGGAACAGAAGGATGAAGAAATCCCTGAAA
ATGCAAACAATGAAAAGATGTCCATGGAAACACTACTCAAAGTGTTCAAAGGGGGAAGTGAAGCACAGGACTCCAATAGATTTGCCAGCC
ACCTAAAGATAGAGAACATTTATGCAGAGGGCTTCATAAAAACATTTCAAGACCTAGGTGCCAAGAACCTGGAGCCAATTGAAGTCGCTG
TTCTCTTGAAGCATCCTTTTATTCAAGACCTGATTTCAAATTATTCAGACTATAAGTTTCCTGTACACATCATCTATGTAGTGGAAATGA
TAGTGTGTGCAAAAGGTTGGGCACCACTTCCATCAGGAAAACAGTGTGCAAGATGGAGAAACTAAGGACAAACCCCAGAGAAACTGGACA
AACCCAGCAGAAGAAAGGAAGAACTGCAACTCAGAAATCACATAACCACCAAGCAGGTCTGGACCACACATGCTAAATGTGCATCCACTA
TGGCGAGTCCCAGGCCTTTAACAGCAGGGACTAAGGAGGGCAGAGGCTGACACCAACCCCCTTTCATACTGTAGCACTACATCCCTCTCA
GATACCAGTTTAACACGAAGTCTCCCTGTTTGACTCCTGTGAGTTGTGTATTGAACTACAAAGTGTTTGCTGAGTTGAAAATAAAAGCGC
TTTCACTTTGATAGAATGTAGATTGTGTATCTTGACTTCTCAATGATAGCAAGTTACATTTTGCAGTTTTCTTCCTATACCCACAAATGA
AACTATTCAGACTTAAATATCTTCCTGTGTGCCTAAACGTTTTTGTTCTAAGTTGCTGATCCTTTTAAATATTAAATTATTAATTAATAT

>24171_24171_11_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000440995_length(amino acids)=2489AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRA
QLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLP
SPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAE
IDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQE
SLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKT
VLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDI
INESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPK
PKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKK
PKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEM
ASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDIL
IDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWF
TGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSST
DAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAK

--------------------------------------------------------------
>24171_24171_12_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000509059_length(transcript)=6811nt_BP=2316nt
CTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACGGCGATCTCGCGGCCCGAGAGCCTTTTATAGGTTGCTTTTCCCGGGGAT
GTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATCTAGTGGAAGAGTTAGACGTGTGCATACTTCACTA
TGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACA
GAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATC
TGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCC
CCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCA
GGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATA
ACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAG
TCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACC
CTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGA
GAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATC
GGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACC
GCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAA
AAGAGTATAAGAGATCTGGAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTA
AAAATACAGATTCTTGGGCCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAA
AAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACA
AGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATC
AGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGG
CCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATG
AGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTC
ATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGC
ACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCT
CCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCAC
ATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGA
ATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGT
TTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGGTCCCAAGTCATTTGCAAAGGCAT
TTTCCAGTGGCTATCTACTTGGAGAAGTTCTACACAAGTTTGAACTTCAGGATGATTTTTCAGAATTTTTGGACAGCAGGGTTTCAAGTG
CCAAACTTAATAATTTTTCTCGCTTGGAGCCAACACTTAACCTTCTGGGTGTGCAGTTTGATCAGAATGTGGCCCATGGCATCATCACAG
AAAAGCCTGGGGTGGCAACAAAGCTGTTATATCAATTGTACATTGCTCTTCAGAAAAAGAAGAAAAGTGGACTGACTGGAGTGGAGATGC
AAACCATGCAACGTCTGACAAATTTAAGACTTCAAAACATGAAAAGTGATACTTTTCAAGAGAGACTTAGACACATGATACCACGTCAAA
CTGATTTCAATCTGATGCGGATTACATACAGGTTTCAAGAAAAATATAAACACGTGAAAGAAGATCTTGCCCATTTGCATTTTGAGAAAC
TTGAAAGATTTCAAAAACTCAAGGAAGAGCAAAGATGTTTTGATATTGAAAAGCAATACTTAAACAGAAGACGACAAAATGAAATAATGG
CCAAAATCCAAGCAGCTATTATACAGATTCCTAAACCTGCATCAAATCGTACTTTGAAAGCACTCGAGGCCCAAAAAATGATGAAAAAGA
AAAAAGAGGCAGAAGATGTGGCTGATGAAATTAAGAAGTTCGAAGCATTAATAAAAAAGGATCTCCAAGCAAAAGAAAGTGCATCCAAGA
CTTCTTTAGATACAGCAGGCCAGACAACCACCGATTTGTTAAATACTTACTCAGATGACGAGTACATTAAAAAAATCCAGAAGCGCCTTG
AAGAAGATGCTTTTGCACGAGAGCAAAGGGAGAAAAGACGGCGGAAATTGTTAATGGACCAGTTAATAGCCCACGAAGCACAAGAGGAGG
CTTATCGGGAGGAACAGCTGATTAACCGGCTGATGCGGCAGTCCCAGCAGGAGCGCAGGATTGCCGTGCAGCTCATGCATGTTCGGCATG
AAAAGGAAGTTTTATGGCAAAACAGAATTTTCAGAGAAAAACAACATGAGGAAAGACGACTTAAAGATTTCCAGGATGCTCTTGATCGAG
AAGCGGCTTTGGCAAAACAAGCCAAGATTGACTTTGAAGAACAATTCCTTAAAGAAAAGAGATTTCATGATCAGATTGCTGTGGAAAGAG
CTCAAGCTCGTTATGAAAAGCATTATTCAGTATGTGCAGAAATTTTGGATCAAATAGTTGATTTGTCCACTAAAGTGGCAGACTATCGAA
TGTTGACAAATAATCTGATTCCGTATAAGTTGATGCATGATTGGAAGGAACTATTTTTTAATGCAAAACCCATATATGAACAAGCCTCTG
TTAAGACACTACCTGCTAACCCCTCAAGAGAACAACTTACAGAACTGGAGAAAAGGGACTTGCTAGATACCAATGATTATGAAGAATATA
AGAACATGGTTGGAGAGTGGGCCTTACCAGAAGAAATGGTTGACAATTTACCACCCTCCAACAATTGCATACTGGGCCATATTCTTCACA
GGCTAGCTGAAAAATCTCTTCCTCCTCGAGCGGAATCAACAACACCTGAATTACCTTCATTTGCTGTTAAAGGATGCTTATTGGGGAAAA
CATTAAGTGGAAAAACTACCATTTTAAGGTCTCTACAAAAAGACTTTCCTATACAGATACTTTCTATTGACACTCTTGTCCAAGAAGCTA
TCCAAGCATTTCATGACAATGAAAAAGTCAGTGAGGTTCTACCAATTCAGAAAAATGATGAAGAAGATGCTCTACCAGTTCTGCAAGAGG
AGATTAAAGAAAGCCAGGATCCACAACATGTATTTTCAGCTGGTCCAGTTTCAGATGAAGTATTACCAGAAACAGAAGGTGCTAATGCTG
ATAAAACACCAAAAGCTGAAGAAGTCAAATCAAGTGATAGTTTCTTAAAACTCACTACACGTGCTCAGCTTGGTGCAAAATCAGAACAGT
TGCTGAAGAAAGGAAAGAGCATTCCTGATGTGCTGCTTGTTGACATCATAGTAAATGCTATTAATGAGATACCTGTGAATCAAGACTGTA
TCCTAGATGGTTTTCCAATGACTTTAAACCAAGCACAGCTTCTGGAAGAAGCTCTTACAGGCTGCAATAGAAACCTCACAGAAGTGGAAA
GAAAAAAAGCACAAAAATCCACATTGGCTATTGATCCTGCGACTTCCAAAGAAATACCTCTTCCCTCTCCTGCATTTGATTTTGTCATAT
TATTAGATGTTTCAGATACTTCCTCAATGAGTCGCATGAATGATATTATAGCTGAAGAATTGTCCTATAAAACTGCTCACGAAGATATCA
GTCAACGTGTAGCTGCTGAAAACCAAGATAAGGATGGAGACCAAAATTTAAGAGACCAGATACAACATAGAATTATAGGCTTCTTGGACA
ACTGGCCTTTATTGGAGCAATGGTTTTCAGAGCCAGAAAATATTTTGATAAAAATCAATGCTGAAATAGATAAGGAATCTTTATGTGAAA
AAGTAAAAGAAATTCTTACGACTGAAATAGCAAAAAAAAAGAATAAAGTTGAGAAGAAATTAGAAGAAAAGGAAGCTGAGAAAAAAGCAG
CAGCTTCCCTGGCTGAGCTTCCACTTCCTACACCTCCTCCTGCTCCTCCTCCTGAACCAGAAAAAGAGAAGGAAATTCATCAAAGCCATG
TGGCTTCAAAAACTCCTACTGCAAAAGGAAAACCTCAATCAGGTGATTGACAGAATGATTTATAATCCTGTTTTCAGTTTCTTATTTTTA
CTCAGTAAAGAATTATAAATTATAGTCTATCTACATTCAGACTTTGGGCAACTTCAATCATATGAAACAAGGCTTTACACTCAGATGGAA
GTGGAAAAGCCCTCGGAGTAGCTAAAAGCGTAGTTGTTACAAAGCCCAACTTCTTTGCCATGTAGGAGGAGACATGGAGTCATCACACCT
AGGTCTACTGATTAGAGTAAGACCACAGACGAGAAGAGGAAAAGGCACAGAGTAACAGGTAACTTCAGGCAGATCAAGAGGATACACGTC
TGTGTGCTGAACTATAGAGTTACATTTATGTAATGAGTAAGAACATCTTAATAAAATAAGAATGAGTATAGCTGGTTTTCCACCAGAATA
AGGGAACAAATTAACAGCAACCATTAGAACTAGAATTTATATGTAATTGTAAATCTTCAGGACTATGTGATTATAAAAGTATAGAAACAA
GCTCCTGCCATCTCAGTAAACATATATTTATGGACACAGAGATAAAGAGCCTAGATAGAGAACACTTTTAGTTTAAGTTTGTTCTAGATC
CTTAACCGCTATGGACCATAAGTCTAGCATTAAGTGGCAGACAATGAATATAATGACAAAAGTGAAGTGCTTAATTGTTGTAATGCATGA
TATTGGTAGAGTGTCAGTATCCATTTGTGTGTGTATATAAAACAAATGAGGCTCTGGTTTCTAGTTTCAGCTTTATAAATGGCTGACTGT
GCAGTTACACCATGTCTACCTAAGTATCTTTGATACTGTGTCATGACCACATTTCTAAACTCTATAGTCTTTCTGCCTCACGGAGATTTG
AGATAGGTCTTAATTTTTAAAATTAAACTTATTCATATTAAACAAAGACATATGAAGACTTTAGTAAGATATATTATGATATATTAAAGA
CCATTCTGCTCCAGGAAATTAGAAATTAACTACAGGCAAAATACACACATCCTAAAAAATGTTTTTATCATGTCAACAATAAAACACAAA
GACATGAATTAAACATACACCCTTTTCCCGCTGTCTCATTAGGAAATTAAAAAACAATTCAGAGGTCTGGAGGAAAATGGAAATATTTAA
AATGCTTTTTAGAACTGGGGAAGACAGGCCAAGCATGGTGGCTCATCCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCAC
CAGAAATCAGGAGTTCGAGACCCCGCTGGCCAACAGGGCAAAACCCATCTCTACCAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGC
ACCTGTAATCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCGAGATTGCCCCACT
GCACTCTAGCCTGGGGGATAGAGTGAAACTCTACCTCCAAAAAAAAGAAAAGAAAAATAACTGAGGAAGACAGTTTTCACAGTGGGTCAG
GTGAGCCTAGAATTATCGAATATCGTCCTTTAACCTATAGCTATGACTCTAGGTTAAAGCTCCTCCTCAGCTTGCTCCAGTCAAGAGTAT
CTATGTATTTGAGCCATTTCCTGAAACCAGACTCTAGTGTTTCTGATCAGACCAGCTCAGTCTTTAAGTTTCTGAAGTTTGTTTGCTATT

>24171_24171_12_DROSHA-SPEF2_DROSHA_chr5_31483661_ENST00000511367_SPEF2_chr5_35628562_ENST00000509059_length(amino acids)=1614AA_BP=690
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPGPKSFAKAFSSGYLLGEVLHKFELQDDFSE
FLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER
LRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKAL
EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQL
IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRF
HDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLL
DTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILS
IDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGANADKTPKAEEVKSSDSFLKLTTRA
QLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLP
SPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAE

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Fusion Gene PPI Analysis for DROSHA-SPEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSPEF2chr5:31483661chr5:35628562ENST000002824690101324_167619.333333333333332515.0IFT20
TgeneSPEF2chr5:31483661chr5:35628562ENST000003031290131324_16760620.0IFT20
TgeneSPEF2chr5:31483661chr5:35628562ENST000003560310371324_167619.3333333333333321823.0IFT20
TgeneSPEF2chr5:31483661chr5:35628562ENST000004409950371324_167619.3333333333333321819.0IFT20


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DROSHA-SPEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DROSHA-SPEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource