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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DSC2-KRT4 (FusionGDB2 ID:24180) |
Fusion Gene Summary for DSC2-KRT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSC2-KRT4 | Fusion gene ID: 24180 | Hgene | Tgene | Gene symbol | DSC2 | KRT4 | Gene ID | 1825 | 3851 |
| Gene name | desmocollin 3 | keratin 4 | |
| Synonyms | CDHF3|DSC|DSC1|DSC2|DSC4|HT-CP | CK-4|CK4|CYK4|K4|WSN1 | |
| Cytomap | 18q12.1 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | desmocollin-3cadherin family member 3desmocollin-4 | keratin, type II cytoskeletal 4cytokeratin 4keratin 4, type IItype-II keratin Kb4 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q02487 | P19013 | |
| Ensembl transtripts involved in fusion gene | ENST00000251081, ENST00000280904, | ENST00000293774, ENST00000458244, ENST00000551956, | |
| Fusion gene scores | * DoF score | 7 X 9 X 5=315 | 10 X 16 X 5=800 |
| # samples | 9 | 15 | |
| ** MAII score | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/800*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DSC2 [Title/Abstract] AND KRT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DSC2(28648859)-KRT4(53202203), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DSC2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KRT4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CG-5717 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
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Fusion Gene ORF analysis for DSC2-KRT4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000251081 | ENST00000293774 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| In-frame | ENST00000251081 | ENST00000458244 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| In-frame | ENST00000251081 | ENST00000551956 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| In-frame | ENST00000280904 | ENST00000293774 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| In-frame | ENST00000280904 | ENST00000458244 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| In-frame | ENST00000280904 | ENST00000551956 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000251081 | DSC2 | chr18 | 28648859 | - | ENST00000458244 | KRT4 | chr12 | 53202203 | - | 3625 | 2541 | 15 | 3104 | 1029 |
| ENST00000251081 | DSC2 | chr18 | 28648859 | - | ENST00000293774 | KRT4 | chr12 | 53202203 | - | 3625 | 2541 | 15 | 3104 | 1029 |
| ENST00000251081 | DSC2 | chr18 | 28648859 | - | ENST00000551956 | KRT4 | chr12 | 53202203 | - | 3625 | 2541 | 15 | 3104 | 1029 |
| ENST00000280904 | DSC2 | chr18 | 28648859 | - | ENST00000458244 | KRT4 | chr12 | 53202203 | - | 4036 | 2952 | 426 | 3515 | 1029 |
| ENST00000280904 | DSC2 | chr18 | 28648859 | - | ENST00000293774 | KRT4 | chr12 | 53202203 | - | 4036 | 2952 | 426 | 3515 | 1029 |
| ENST00000280904 | DSC2 | chr18 | 28648859 | - | ENST00000551956 | KRT4 | chr12 | 53202203 | - | 4036 | 2952 | 426 | 3515 | 1029 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000251081 | ENST00000458244 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000471932 | 0.99952805 |
| ENST00000251081 | ENST00000293774 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000471932 | 0.99952805 |
| ENST00000251081 | ENST00000551956 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000471932 | 0.99952805 |
| ENST00000280904 | ENST00000458244 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000608703 | 0.9993913 |
| ENST00000280904 | ENST00000293774 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000608703 | 0.9993913 |
| ENST00000280904 | ENST00000551956 | DSC2 | chr18 | 28648859 | - | KRT4 | chr12 | 53202203 | - | 0.000608703 | 0.9993913 |
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Fusion Genomic Features for DSC2-KRT4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DSC2-KRT4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28648859/chr12:53202203) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSC2 | KRT4 |
| FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 136_243 | 836 | 1547.3333333333333 | Domain | Cadherin 1 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 244_355 | 836 | 1547.3333333333333 | Domain | Cadherin 2 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 356_471 | 836 | 1547.3333333333333 | Domain | Cadherin 3 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 472_579 | 836 | 1547.3333333333333 | Domain | Cadherin 4 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 580_694 | 836 | 1547.3333333333333 | Domain | Cadherin 5 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 136_243 | 836 | 902.0 | Domain | Cadherin 1 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 244_355 | 836 | 902.0 | Domain | Cadherin 2 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 356_471 | 836 | 902.0 | Domain | Cadherin 3 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 472_579 | 836 | 902.0 | Domain | Cadherin 4 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 580_694 | 836 | 902.0 | Domain | Cadherin 5 |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 136_694 | 836 | 1547.3333333333333 | Topological domain | Extracellular |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 136_694 | 836 | 902.0 | Topological domain | Extracellular |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 695_715 | 836 | 1547.3333333333333 | Transmembrane | Helical |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 695_715 | 836 | 902.0 | Transmembrane | Helical |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 456_512 | 407 | 595.0 | Compositional bias | Note=Ser-rich | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 456_512 | 333 | 521.0 | Compositional bias | Note=Ser-rich | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 448_520 | 407 | 595.0 | Region | Note=Tail | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 448_520 | 333 | 521.0 | Region | Note=Tail |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000251081 | - | 15 | 17 | 716_901 | 836 | 1547.3333333333333 | Topological domain | Cytoplasmic |
| Hgene | DSC2 | chr18:28648859 | chr12:53202203 | ENST00000280904 | - | 15 | 16 | 716_901 | 836 | 902.0 | Topological domain | Cytoplasmic |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 10_108 | 407 | 595.0 | Compositional bias | Note=Gly-rich | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 10_108 | 333 | 521.0 | Compositional bias | Note=Gly-rich | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 137_450 | 407 | 595.0 | Domain | IF rod | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 137_450 | 333 | 521.0 | Domain | IF rod | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 137_172 | 407 | 595.0 | Region | Note=Coil 1A | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 173_191 | 407 | 595.0 | Region | Note=Linker 1 | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 192_284 | 407 | 595.0 | Region | Note=Coil 1B | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 1_136 | 407 | 595.0 | Region | Note=Head | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 285_307 | 407 | 595.0 | Region | Note=Linker 12 | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000293774 | 4 | 9 | 308_447 | 407 | 595.0 | Region | Note=Coil 2 | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 137_172 | 333 | 521.0 | Region | Note=Coil 1A | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 173_191 | 333 | 521.0 | Region | Note=Linker 1 | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 192_284 | 333 | 521.0 | Region | Note=Coil 1B | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 1_136 | 333 | 521.0 | Region | Note=Head | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 285_307 | 333 | 521.0 | Region | Note=Linker 12 | |
| Tgene | KRT4 | chr18:28648859 | chr12:53202203 | ENST00000551956 | 4 | 9 | 308_447 | 333 | 521.0 | Region | Note=Coil 2 |
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Fusion Gene Sequence for DSC2-KRT4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >24180_24180_1_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000293774_length(transcript)=3625nt_BP=2541nt CGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTG CTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTT GGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTC TATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATA TTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCA ATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATA TACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGT CCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTA ATAATCAAAATAGAGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGC ACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCA CCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTAC CAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAAT GACCACTTGCCAACATTTACTCGTACTTCTTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAG GATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGAT GCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAAT GAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCT GAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAA ACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTT TTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGT ACGGGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATG TCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTA CAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCT ATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACAT CGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGC ATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTA TCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGT GGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGG GCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTT ACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCA GAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCA GAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCA CGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAG GAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTA GGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCC AGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGC ACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTC TCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCA CCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGT CACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCG GCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATC >24180_24180_1_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000293774_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- >24180_24180_2_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000458244_length(transcript)=3625nt_BP=2541nt CGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTG CTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTT GGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTC TATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATA TTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCA ATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATA TACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGT CCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTA ATAATCAAAATAGAGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGC ACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCA CCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTAC CAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAAT GACCACTTGCCAACATTTACTCGTACTTCTTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAG GATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGAT GCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAAT GAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCT GAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAA ACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTT TTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGT ACGGGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATG TCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTA CAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCT ATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACAT CGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGC ATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTA TCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGT GGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGG GCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTT ACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCA GAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCA GAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCA CGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAG GAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTA GGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCC AGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGC ACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTC TCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCA CCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGT CACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCG GCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATC >24180_24180_2_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000458244_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- >24180_24180_3_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000551956_length(transcript)=3625nt_BP=2541nt CGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTG CTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTT GGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTC TATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATA TTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCA ATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATA TACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGT CCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATTGCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTA ATAATCAAAATAGAGGATGAAAATGATAACTACCCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGC ACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCA CCATCACCCACCCTATTTTCTATGCATCCAACTACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTAC CAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAAT GACCACTTGCCAACATTTACTCGTACTTCTTATGTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAG GATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGAT GCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAAT GAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCT GAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAA ACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTT TTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGT ACGGGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATG TCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTA CAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCAGCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCT ATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACAT CGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGC ATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTA TCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGT GGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGG GCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTT ACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCA GAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCA GAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCA CGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAG GAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTA GGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCC AGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGC ACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTC TCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCA CCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGT CACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCG GCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATC >24180_24180_3_DSC2-KRT4_DSC2_chr18_28648859_ENST00000251081_KRT4_chr12_53202203_ENST00000551956_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- >24180_24180_4_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000293774_length(transcript)=4036nt_BP=2952nt GGCTTCTGCTGGGCAGGGCCGGCTGTTAATCTCGCCTGGCGGAGCGGACACCGGGGCGTGGTGGGGGAGATGGGCCTTATAGGTGGCGTC CGCTGGTGAGAAACACCTTGCGCAGGTAAAAGGGTGGCGGCGAGAGGGAGTTCCCACCCGTGGCTTTCTTAGAGAAATGAAGTCTTAAGT CTTAAATAGACAACAAGGAGGGGCCGATCGGTGTCTTTTGGACGCGTCTGGAGCCCCTCCCTCCGCCAAAGGAAAAGCCCCTTGGATGAG AGGCAGGCGCTTCAGAGAAGCTAAGAAAAGCACCTCTCCGCGCGCCCCACCTCCTCCGCCTCGCGCTCCTCCTGAGCAGCGGGCCCAGAC TGCGCTCCGGCCGCGGCCCTCGCCCCGCGGAGCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAG GCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGC AAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAAT CTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGA AGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAA AGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTT CCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCT CGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATT GCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTACCCAATT TTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAG CCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGC GTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTAT TTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTTATGTGACA TCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAAT TATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCT TTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCC ATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAA AATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACT GATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAAT GGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACGGGGACACTGGGCATTATACTTCAAGACGTGAATGAT AACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCT ATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCA GCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACT TCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTT GGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCT AAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCT GCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAG ACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGA CACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATC TCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATC GAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGC AAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAG CTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGC ATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGC TCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGA CGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCT CTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGAC TCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCC ATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTA GATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTT >24180_24180_4_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000293774_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- >24180_24180_5_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000458244_length(transcript)=4036nt_BP=2952nt GGCTTCTGCTGGGCAGGGCCGGCTGTTAATCTCGCCTGGCGGAGCGGACACCGGGGCGTGGTGGGGGAGATGGGCCTTATAGGTGGCGTC CGCTGGTGAGAAACACCTTGCGCAGGTAAAAGGGTGGCGGCGAGAGGGAGTTCCCACCCGTGGCTTTCTTAGAGAAATGAAGTCTTAAGT CTTAAATAGACAACAAGGAGGGGCCGATCGGTGTCTTTTGGACGCGTCTGGAGCCCCTCCCTCCGCCAAAGGAAAAGCCCCTTGGATGAG AGGCAGGCGCTTCAGAGAAGCTAAGAAAAGCACCTCTCCGCGCGCCCCACCTCCTCCGCCTCGCGCTCCTCCTGAGCAGCGGGCCCAGAC TGCGCTCCGGCCGCGGCCCTCGCCCCGCGGAGCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAG GCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGC AAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAAT CTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGA AGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAA AGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTT CCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCT CGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATT GCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTACCCAATT TTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAG CCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGC GTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTAT TTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTTATGTGACA TCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAAT TATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCT TTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCC ATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAA AATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACT GATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAAT GGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACGGGGACACTGGGCATTATACTTCAAGACGTGAATGAT AACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCT ATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCA GCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACT TCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTT GGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCT AAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCT GCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAG ACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGA CACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATC TCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATC GAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGC AAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAG CTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGC ATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGC TCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGA CGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCT CTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGAC TCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCC ATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTA GATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTT >24180_24180_5_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000458244_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- >24180_24180_6_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000551956_length(transcript)=4036nt_BP=2952nt GGCTTCTGCTGGGCAGGGCCGGCTGTTAATCTCGCCTGGCGGAGCGGACACCGGGGCGTGGTGGGGGAGATGGGCCTTATAGGTGGCGTC CGCTGGTGAGAAACACCTTGCGCAGGTAAAAGGGTGGCGGCGAGAGGGAGTTCCCACCCGTGGCTTTCTTAGAGAAATGAAGTCTTAAGT CTTAAATAGACAACAAGGAGGGGCCGATCGGTGTCTTTTGGACGCGTCTGGAGCCCCTCCCTCCGCCAAAGGAAAAGCCCCTTGGATGAG AGGCAGGCGCTTCAGAGAAGCTAAGAAAAGCACCTCTCCGCGCGCCCCACCTCCTCCGCCTCGCGCTCCTCCTGAGCAGCGGGCCCAGAC TGCGCTCCGGCCGCGGCCCTCGCCCCGCGGAGCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAG GCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGC AAAAATGTGACATTACATGTTCCCTCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAAT CTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAAATACTATTCTATTGTCCTCGGAGAAGAGA AGTTTTACCATATTACTTTCCAACACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAA AGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTT CCACTTTTCCTTCAACAGGTTCAATCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCT CGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCTGTAGATCGTGAGCAGTATGAATCTTTTGAGATAATT GCCTTTGCAACAACTCCAGATGGGTATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTACCCAATT TTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGCACTACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAG CCTGACACGATGCACACACGCCTGAAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACTACAGGC GTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAGTTGAAAATAAAAGTACAAGACATGGATGGTCAGTAT TTTGGTCTACAGACAACTTCAACTTGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTTATGTGACA TCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGATAAGGACTTAGTGAATACTGCTAACTGGAGAGCTAAT TATACCATTTTAAAGGGCAATGAAAATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTTAAGCCT TTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAAGCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCC ATGAGCACAGCAACAGTTACTGTTAATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATGAAAGAA AATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACAAGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACT GATCCAACAGGGTGGGTCACCATTGATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATCAAAAAT GGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACGGGGACACTGGGCATTATACTTCAAGACGTGAATGAT AACAGCCCATTCATACCTAAAAAGACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGATGAGCCT ATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAGAGAATGTGGAGACTGAAAGCAATTAATGATACAGCA GCACGTCTTTCCTATCAGAATGATCCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGTGTCACT TCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGTGTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTT GGAAAGTGGGCCATCCTTGCAATATTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGGACGTCT AAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCAAACACAGAAGCTCCTGGAGATGACAAAGTGTATTCT GCGAATGGCTTCACAACCCAAACTGTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGTCAGGAG ACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCTGGCCACCATCACACCCTGGACTCCTGCAGGGGAGGA CACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAGTCCAGCAGCTCCAGATC TCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATC GAGAACATCAAGAAGCAGTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGC AAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAG CTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGAATGTCTGGAGAATGCCAGAGTGCCGTGAGC ATCTCTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGC TCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGA CGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCT CTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGAC TCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCC ATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTA GATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTT >24180_24180_6_DSC2-KRT4_DSC2_chr18_28648859_ENST00000280904_KRT4_chr12_53202203_ENST00000551956_length(amino acids)=1029AA_BP=892 MPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNT ILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIR GPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQ VCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT FTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFS REASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD REAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWR LKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTL VCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHH TLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGE NALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DSC2-KRT4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DSC2-KRT4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DSC2-KRT4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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