Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DSC3-RPS6 (FusionGDB2 ID:24188)

Fusion Gene Summary for DSC3-RPS6

Fusion gene summary

Fusion gene information	Fusion gene name: DSC3-RPS6
	Fusion gene ID: 24188
		Hgene	Tgene
	Gene symbol	DSC3	RPS6
	Gene ID	1825	6194
	Gene name	desmocollin 3	ribosomal protein S6
	Synonyms	CDHF3\|DSC\|DSC1\|DSC2\|DSC4\|HT-CP	S6
	Cytomap	18q12.1	9p22.1
	Type of gene	protein-coding	protein-coding
	Description	desmocollin-3cadherin family member 3desmocollin-4	40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6
	Modification date	20200313	20200313
	UniProtAcc	Q14574	.
	Ensembl transtripts involved in fusion gene	ENST00000360428, ENST00000434452,	ENST00000380381, ENST00000315377, ENST00000380384, ENST00000498815, ENST00000380394,
Fusion gene scores	* DoF score	6 X 7 X 4=168	15 X 15 X 4=900
	# samples	6	17
	** MAII score	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DSC3 [Title/Abstract] AND RPS6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DSC3(28576756)-RPS6(19378916), # samples:1 DSC3(28576757)-RPS6(19378916), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RPS6	GO:0031929	TOR signaling	16428328
Tgene	RPS6	GO:0043065	positive regulation of apoptotic process	18362888

Fusion gene breakpoints across DSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPS6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
ChimerDB4	Non-Cancer	TCGA-IP-7968-11A	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-

Top

Fusion Gene ORF analysis for DSC3-RPS6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000360428	ENST00000380381	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-3UTR	ENST00000360428	ENST00000380381	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-3UTR	ENST00000434452	ENST00000380381	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-3UTR	ENST00000434452	ENST00000380381	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000315377	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000315377	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000380384	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000380384	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000498815	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000360428	ENST00000498815	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000315377	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000315377	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000380384	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000380384	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000498815	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
5CDS-intron	ENST00000434452	ENST00000498815	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
In-frame	ENST00000360428	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
In-frame	ENST00000360428	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-
In-frame	ENST00000434452	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-
In-frame	ENST00000434452	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360428	DSC3	chr18	28576756	-	ENST00000380394	RPS6	chr9	19378916	-	3764	2574	9	3185	1058
ENST00000434452	DSC3	chr18	28576756	-	ENST00000380394	RPS6	chr9	19378916	-	3838	2648	83	3259	1058
ENST00000360428	DSC3	chr18	28576757	-	ENST00000380394	RPS6	chr9	19378916	-	3764	2574	9	3185	1058
ENST00000434452	DSC3	chr18	28576757	-	ENST00000380394	RPS6	chr9	19378916	-	3838	2648	83	3259	1058

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360428	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-	0.00031629	0.99968374
ENST00000434452	ENST00000380394	DSC3	chr18	28576756	-	RPS6	chr9	19378916	-	0.000378398	0.9996216
ENST00000360428	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-	0.00031629	0.99968374
ENST00000434452	ENST00000380394	DSC3	chr18	28576757	-	RPS6	chr9	19378916	-	0.000378398	0.9996216

Top

Fusion Genomic Features for DSC3-RPS6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DSC3-RPS6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28576756/chr9:19378916)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSC3 Q14574	.
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

136_243

831

897.0

Domain

Cadherin 1

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

244_355

831

897.0

Domain

Cadherin 2

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

356_471

831

897.0

Domain

Cadherin 3

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

472_579

831

897.0

Domain

Cadherin 4

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

580_690

831

897.0

Domain

Cadherin 5

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

136_243

831

2180.3333333333335

Domain

Cadherin 1

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

244_355

831

2180.3333333333335

Domain

Cadherin 2

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

356_471

831

2180.3333333333335

Domain

Cadherin 3

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

472_579

831

2180.3333333333335

Domain

Cadherin 4

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

580_690

831

2180.3333333333335

Domain

Cadherin 5

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

136_243

831

897.0

Domain

Cadherin 1

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

244_355

831

897.0

Domain

Cadherin 2

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

356_471

831

897.0

Domain

Cadherin 3

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

472_579

831

897.0

Domain

Cadherin 4

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

580_690

831

897.0

Domain

Cadherin 5

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

136_243

831

2180.3333333333335

Domain

Cadherin 1

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

244_355

831

2180.3333333333335

Domain

Cadherin 2

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

356_471

831

2180.3333333333335

Domain

Cadherin 3

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

472_579

831

2180.3333333333335

Domain

Cadherin 4

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

580_690

831

2180.3333333333335

Domain

Cadherin 5

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

136_690

831

897.0

Topological domain

Extracellular

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

136_690

831

2180.3333333333335

Topological domain

Extracellular

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

136_690

831

897.0

Topological domain

Extracellular

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

136_690

831

2180.3333333333335

Topological domain

Extracellular

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

691_711

831

897.0

Transmembrane

Helical

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

691_711

831

2180.3333333333335

Transmembrane

Helical

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

691_711

831

897.0

Transmembrane

Helical

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

691_711

831

2180.3333333333335

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000360428

712_896

831

897.0

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576756

chr9:19378916

ENST00000434452

712_896

831

2180.3333333333335

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000360428

712_896

831

897.0

Topological domain

Cytoplasmic

Hgene

DSC3

chr18:28576757

chr9:19378916

ENST00000434452

712_896

831

2180.3333333333335

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for DSC3-RPS6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24188_24188_1_DSC3-RPS6_DSC3_chr18_28576756_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3764nt_BP=2574nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTG
AATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTG
AACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAAC
TTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGAT
CCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAG
TTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAAT
CCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTC
CATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCC
CGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTA
TTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATC
CTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTT
CCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACC
CAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAA
GGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAAC
TGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAA
CAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGA
ACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAG
AAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCT
AAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGT
CTTGTTACTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAA
TATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGA
GCTTCTACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTC
ATTGCTGATAGAAAACTACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATA
AAGTCAGACCTATTGTGTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGA
GCATAAGACACCTGCCTCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGA
ATATAGCTCTTTAAAGCACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAA
GGCATAGTTTTAGTGGATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTC

>24188_24188_1_DSC3-RPS6_DSC3_chr18_28576756_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------
>24188_24188_2_DSC3-RPS6_DSC3_chr18_28576756_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3838nt_BP=2648nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACC
GTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTA
CAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAA
AGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCA
CCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAG
TCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTC
AAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTT
ATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGA
AAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGT
GTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGG
GTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCAC
AGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACT
CTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCT
TGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACT
CGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGA
AGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGA
GAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGAC
TGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCC
GCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTACTCCACGTG
TCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGG
CCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGT
CTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTCATTGCTGATAGAAAAC
TACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATAAAGTCAGACCTATTGT
GTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGAGCATAAGACACCTGCC
TCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGAATATAGCTCTTTAAAG
CACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAAGGCATAGTTTTAGTGG
ATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTCAACTCCAGTGAATTGT

>24188_24188_2_DSC3-RPS6_DSC3_chr18_28576756_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------
>24188_24188_3_DSC3-RPS6_DSC3_chr18_28576757_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3764nt_BP=2574nt
TCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCC
GCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAA
AAGGTGATACTTAATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTC
ATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCA
TTTACCATATGGCTTTCTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGA
CACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCA
TTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTA
AATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCT
TATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTC
ACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCG
GACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTA
ATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTT
GGATTGATAGGCACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTT
GTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTT
ACCATTTTAAAGGGAAATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTG
AATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTG
AACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAAC
TTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGAT
CCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAG
TTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAAT
CCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTC
CATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCC
CGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTA
TTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATC
CTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTT
CCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACC
CAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAA
GGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAAC
TGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAA
CAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGA
ACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAG
AAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCT
AAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGT
CTTGTTACTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAA
TATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGA
GCTTCTACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTC
ATTGCTGATAGAAAACTACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATA
AAGTCAGACCTATTGTGTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGA
GCATAAGACACCTGCCTCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGA
ATATAGCTCTTTAAAGCACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAA
GGCATAGTTTTAGTGGATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTC

>24188_24188_3_DSC3-RPS6_DSC3_chr18_28576757_ENST00000360428_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------
>24188_24188_4_DSC3-RPS6_DSC3_chr18_28576757_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(transcript)=3838nt_BP=2648nt
GAAGTTGCTCCCGGGCAGGCAAGCCTGAGAGAGGCCAAATACACTTAAAAACAAGCAGCGGCGAGAAAAGCACCTCCCGCGCCCTGCACC
TCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGCTGGGCCCCGGCGCT
CCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTTAATG
TACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATC
CTGATTTCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTT
CTGACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTG
TTCTCAGGCGTGCCAAGAGGAGATGGGCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAG
TTGAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAG
AAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAG
ATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAACCACCCTGTTTTCACAGAAGCAATTTATA
ATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGC
GCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAATCACCACAGTCTCTC
ATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACAT
CAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCAT
TCAATGTGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAA
ATGAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACC
GTCAAGTGAACCTGGAAATTGGAGTAAACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTA
CAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAA
AGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCA
CCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAG
TCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTC
AAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTT
ATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGA
AAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGT
GTGAATGTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGG
GTATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCAC
AGCAAAACTTAATTATATCAAACACAGAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACT
CTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCT
TGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACT
CGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGA
AGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGA
GAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGAC
TGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCC
GCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTACTCCACGTG
TCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGG
CCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGT
CTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTCATTGCTGATAGAAAAC
TACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATAAAGTCAGACCTATTGT
GTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGAGCATAAGACACCTGCC
TCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGAATATAGCTCTTTAAAG
CACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAAGGCATAGTTTTAGTGG
ATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTCAACTCCAGTGAATTGT

>24188_24188_4_DSC3-RPS6_DSC3_chr18_28576757_ENST00000434452_RPS6_chr9_19378916_ENST00000380394_length(amino acids)=1058AA_BP=855
MHLGRSRSRHPPGARVLLALPGIPMAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRS
SDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFL
QQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEA
IYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLI
GTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYE
ENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKG
WITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGA
PFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAI
LLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGN
QTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGE
RKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DSC3-RPS6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DSC3-RPS6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DSC3-RPS6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source