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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DSCR3-NIPBL (FusionGDB2 ID:24212)

Fusion Gene Summary for DSCR3-NIPBL

Fusion gene summary

Fusion gene information	Fusion gene name: DSCR3-NIPBL
	Fusion gene ID: 24212
		Hgene	Tgene
	Gene symbol	DSCR3	NIPBL
	Gene ID	10311	25836
	Gene name	VPS26 endosomal protein sorting factor C	NIPBL cohesin loading factor
	Synonyms	DCRA\|DSCR3\|DSCRA	CDLS\|CDLS1\|IDN3\|IDN3-B\|Scc2
	Cytomap	21q22.13	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	vacuolar protein sorting-associated protein 26CDSCR3 arrestin fold containingDown syndrome critical region 3Down syndrome critical region gene 3Down syndrome critical region protein 3Down syndrome critical region protein A	nipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homolog
	Modification date	20200313	20200313
	UniProtAcc	.	Q6KC79
	Ensembl transtripts involved in fusion gene	ENST00000309117, ENST00000398998, ENST00000399001, ENST00000476950, ENST00000539844, ENST00000288304, ENST00000399000,	ENST00000504430, ENST00000282516, ENST00000448238,
Fusion gene scores	* DoF score	7 X 2 X 5=70	8 X 11 X 5=440
	# samples	9	9
	** MAII score	log2(9/70*10)=0.362570079384708 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/440*10)=-2.28950661719499 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DSCR3 [Title/Abstract] AND NIPBL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DSCR3(38639539)-NIPBL(37019413), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NIPBL	GO:0000122	negative regulation of transcription by RNA polymerase II	18854353
Tgene	NIPBL	GO:0031065	positive regulation of histone deacetylation	18854353
Tgene	NIPBL	GO:0045892	negative regulation of transcription, DNA-templated	18854353
Tgene	NIPBL	GO:0071921	cohesin loading	22628566

Fusion gene breakpoints across DSCR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NIPBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-6406-01A	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
ChimerDB4	LGG	TCGA-DU-6406	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+

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Fusion Gene ORF analysis for DSCR3-NIPBL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000309117	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5CDS-intron	ENST00000398998	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5CDS-intron	ENST00000399001	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5CDS-intron	ENST00000476950	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5CDS-intron	ENST00000539844	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-3CDS	ENST00000288304	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-3CDS	ENST00000288304	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-3CDS	ENST00000399000	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-3CDS	ENST00000399000	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-intron	ENST00000288304	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
5UTR-intron	ENST00000399000	ENST00000504430	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000309117	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000309117	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000398998	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000398998	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000399001	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000399001	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000476950	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000476950	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000539844	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+
In-frame	ENST00000539844	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309117	DSCR3	chr21	38639539	-	ENST00000282516	NIPBL	chr5	37019413	+	5311	295	190	3789	1199
ENST00000309117	DSCR3	chr21	38639539	-	ENST00000448238	NIPBL	chr5	37019413	+	3636	295	190	3468	1092
ENST00000539844	DSCR3	chr21	38639539	-	ENST00000282516	NIPBL	chr5	37019413	+	5101	85	22	3579	1185
ENST00000539844	DSCR3	chr21	38639539	-	ENST00000448238	NIPBL	chr5	37019413	+	3426	85	22	3258	1078
ENST00000399001	DSCR3	chr21	38639539	-	ENST00000282516	NIPBL	chr5	37019413	+	5130	114	9	3608	1199
ENST00000399001	DSCR3	chr21	38639539	-	ENST00000448238	NIPBL	chr5	37019413	+	3455	114	9	3287	1092
ENST00000476950	DSCR3	chr21	38639539	-	ENST00000282516	NIPBL	chr5	37019413	+	5125	109	4	3603	1199
ENST00000476950	DSCR3	chr21	38639539	-	ENST00000448238	NIPBL	chr5	37019413	+	3450	109	4	3282	1092
ENST00000398998	DSCR3	chr21	38639539	-	ENST00000282516	NIPBL	chr5	37019413	+	5311	295	190	3789	1199
ENST00000398998	DSCR3	chr21	38639539	-	ENST00000448238	NIPBL	chr5	37019413	+	3636	295	190	3468	1092

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309117	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000228079	0.9997719
ENST00000309117	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000394446	0.9996056
ENST00000539844	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000184954	0.99981505
ENST00000539844	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000343026	0.99965703
ENST00000399001	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000186199	0.99981385
ENST00000399001	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000339039	0.99966097
ENST00000476950	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000187285	0.9998128
ENST00000476950	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000344273	0.9996557
ENST00000398998	ENST00000282516	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000228079	0.9997719
ENST00000398998	ENST00000448238	DSCR3	chr21	38639539	-	NIPBL	chr5	37019413	+	0.000394446	0.9996056

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Fusion Genomic Features for DSCR3-NIPBL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DSCR3	chr21	38639538	-	NIPBL	chr5	37019412	+	0.005243608	0.99475646
DSCR3	chr21	38639538	-	NIPBL	chr5	37019412	+	0.005243608	0.99475646
DSCR3	chr21	38639538	-	NIPBL	chr5	37019412	+	0.005243608	0.99475646
DSCR3	chr21	38639538	-	NIPBL	chr5	37019412	+	0.005243608	0.99475646

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSCR3-NIPBL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:38639539/chr5:37019413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NIPBL Q6KC79
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250\|UniProtKB:Q6KCD5, ECO:0000269\|PubMed:22628566, ECO:0000269\|PubMed:28167679, ECO:0000269\|PubMed:28914604}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

1767_1805

1640

2805.0

Repeat

Note=HEAT 1

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

1843_1881

1640

2805.0

Repeat

Note=HEAT 2

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

1945_1984

1640

2805.0

Repeat

Note=HEAT 3

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

2227_2267

1640

2805.0

Repeat

Note=HEAT 4

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

2313_2351

1640

2805.0

Repeat

Note=HEAT 5

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

1767_1805

1640

2698.0

Repeat

Note=HEAT 1

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

1843_1881

1640

2698.0

Repeat

Note=HEAT 2

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

1945_1984

1640

2698.0

Repeat

Note=HEAT 3

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

2227_2267

1640

2698.0

Repeat

Note=HEAT 4

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

2313_2351

1640

2698.0

Repeat

Note=HEAT 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

418_462

1640

2805.0

Compositional bias

Note=Gln-rich

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

418_462

1640

2698.0

Compositional bias

Note=Gln-rich

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000282516

996_1009

1640

2805.0

Motif

PxVxL motif

Tgene

NIPBL

chr21:38639539

chr5:37019413

ENST00000448238

996_1009

1640

2698.0

Motif

PxVxL motif

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Fusion Gene Sequence for DSCR3-NIPBL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24212_24212_1_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000309117_NIPBL_chr5_37019413_ENST00000282516_length(transcript)=5311nt_BP=295nt
GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG
GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC
CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG
AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA
CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT
GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA
CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA
TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG
TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT
GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG
ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT
CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT
TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA
CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC
CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC
TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA
ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA
GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT
GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG
ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG
ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA
AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA
GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA
AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA
AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA
CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA
TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT
CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT
CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC
TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC
ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT
GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA
GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC
TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG
TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA
AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA
ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC
ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC
AGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGC
TATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGG
CTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTAT
TTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGAC
TTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAA
AAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTC
GCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAA
CTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGC
GGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTA
TTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACC
CTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTG
TTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGT
TTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAG
GGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTC
AAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATT
CTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTT
GAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGAT
GTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTG
ACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCT
GTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTG
GCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATA

>24212_24212_1_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000309117_NIPBL_chr5_37019413_ENST00000282516_length(amino acids)=1199AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSL
RRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKK

--------------------------------------------------------------
>24212_24212_2_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000309117_NIPBL_chr5_37019413_ENST00000448238_length(transcript)=3636nt_BP=295nt
GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG
GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC
CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG
AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA
CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT
GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA
CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA
TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG
TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT
GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG
ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT
CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT
TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA
CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC
CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC
TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA
ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA
GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT
GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG
ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG
ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA
AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA
GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA
AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA
AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA
CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA
TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT
CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT
CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC
TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC
ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT
GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA
GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC
TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG
TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA
AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA
ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC
ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC
AGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGT
ACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTT

>24212_24212_2_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000309117_NIPBL_chr5_37019413_ENST00000448238_length(amino acids)=1092AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVR

--------------------------------------------------------------
>24212_24212_3_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000398998_NIPBL_chr5_37019413_ENST00000282516_length(transcript)=5311nt_BP=295nt
GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG
GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC
CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG
AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA
CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT
GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA
CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA
TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG
TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT
GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG
ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT
CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT
TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA
CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC
CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC
TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA
ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA
GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT
GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG
ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG
ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA
AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA
GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA
AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA
AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA
CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA
TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT
CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT
CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC
TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC
ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT
GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA
GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC
TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG
TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA
AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA
ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC
ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC
AGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGC
TATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGG
CTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTAT
TTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGAC
TTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAA
AAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTC
GCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAA
CTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGC
GGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTA
TTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACC
CTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTG
TTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGT
TTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAG
GGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTC
AAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATT
CTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTT
GAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGAT
GTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTG
ACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCT
GTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTG
GCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATA

>24212_24212_3_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000398998_NIPBL_chr5_37019413_ENST00000282516_length(amino acids)=1199AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSL
RRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKK

--------------------------------------------------------------
>24212_24212_4_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000398998_NIPBL_chr5_37019413_ENST00000448238_length(transcript)=3636nt_BP=295nt
GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG
GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC
CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG
AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA
CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT
GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA
CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA
TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG
TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT
GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG
ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT
CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT
TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA
CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC
CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC
TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA
ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA
GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT
GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG
ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG
ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA
AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA
GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA
AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA
AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA
CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA
TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT
CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT
CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC
TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC
ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT
GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA
GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC
TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG
TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA
AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA
ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC
ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC
AGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGT
ACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTT

>24212_24212_4_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000398998_NIPBL_chr5_37019413_ENST00000448238_length(amino acids)=1092AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVR

--------------------------------------------------------------
>24212_24212_5_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000399001_NIPBL_chr5_37019413_ENST00000282516_length(transcript)=5130nt_BP=114nt
CTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGA
GCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAAC
ACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATG
AAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAAC
CGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGAT
GCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGT
GAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATG
CAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGA
CCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTC
AGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATT
AAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAAC
ATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCC
TCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCT
GACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAA
CATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAG
CTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATG
ACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGA
TACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGA
TCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAA
GTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAG
CATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAA
GTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAA
GACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCAC
ACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATAT
TTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTC
ATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTC
AGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCT
TTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACA
CAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATG
GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAG
TCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCT
TTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGT
AAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAA
ACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAA
CTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCA
CTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCA
GGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCT
ATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGC
TCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATT
TACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACT
TCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAA
AAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCG
CTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAAC
TTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCG
GATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTAT
TCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCC
TGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGT
TTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTT
TTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGG
GTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCA
AGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTC
TTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTG
AGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATG
TTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGA
CTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTG
TTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGG
CAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATAA

>24212_24212_5_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000399001_NIPBL_chr5_37019413_ENST00000282516_length(amino acids)=1199AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSL
RRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKK

--------------------------------------------------------------
>24212_24212_6_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000399001_NIPBL_chr5_37019413_ENST00000448238_length(transcript)=3455nt_BP=114nt
CTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGA
GCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAAC
ACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATG
AAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAAC
CGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGAT
GCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGT
GAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATG
CAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGA
CCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTC
AGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATT
AAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAAC
ATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCC
TCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCT
GACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAA
CATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAG
CTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATG
ACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGA
TACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGA
TCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAA
GTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAG
CATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAA
GTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAA
GACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCAC
ACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATAT
TTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTC
ATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTC
AGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCT
TTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACA
CAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATG
GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAG
TCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCT
TTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGT
AAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAA
ACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAA
CTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCA
CTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCA
GGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTA
CACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTA

>24212_24212_6_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000399001_NIPBL_chr5_37019413_ENST00000448238_length(amino acids)=1092AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVR

--------------------------------------------------------------
>24212_24212_7_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000476950_NIPBL_chr5_37019413_ENST00000282516_length(transcript)=5125nt_BP=109nt
TTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAA
TAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA
GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC
ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA
AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG
CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA
TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG
AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA
GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA
CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA
ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC
CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA
TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA
TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC
AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT
TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT
AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA
TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT
TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT
TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC
AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT
AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT
AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA
GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT
TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA
TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA
AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT
CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA
AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA
GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG
GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT
CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT
TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT
GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCT
CATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCT
TGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTC
ATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTG
CTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTA
CAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATTTACAA
AAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACTTCCAG
CTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAAAAATC
AGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCGCTGTT
GTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAACTTTCT
GTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCGGATGG
CTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTATTCTGT
TGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCCTGAAA
ACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGTTTCCA
TTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTTTTCAA
AGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGGGTGTA
AACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCAAGAGT
ACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTCTTTAA
ACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTGAGATG
AATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATGTTTAT
TCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGACTAAA
TCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTGTTTCA
AGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGGCAAAT

>24212_24212_7_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000476950_NIPBL_chr5_37019413_ENST00000282516_length(amino acids)=1199AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSL
RRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKK

--------------------------------------------------------------
>24212_24212_8_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000476950_NIPBL_chr5_37019413_ENST00000448238_length(transcript)=3450nt_BP=109nt
TTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAA
TAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA
GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC
ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA
AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG
CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA
TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG
AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA
GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA
CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA
ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC
CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA
TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA
TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC
AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT
TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT
AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA
TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT
TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT
TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC
AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT
AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT
AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA
GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT
TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA
TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA
AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT
CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA
AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA
GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG
GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT
CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT
TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT
GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCT
CATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCT
TGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGGT
GAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTACACCA
AGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTAACATA

>24212_24212_8_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000476950_NIPBL_chr5_37019413_ENST00000448238_length(amino acids)=1092AA_BP=35
MGSRAAGSGGCCGELEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQ
KDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENA
IAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDI
CIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVV
PLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLF
TVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLK
NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLN
LFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRK
RVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLD
FLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVR

--------------------------------------------------------------
>24212_24212_9_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000539844_NIPBL_chr5_37019413_ENST00000282516_length(transcript)=5101nt_BP=85nt
AAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTC
AGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTC
TCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGA
AGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAA
AACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTC
CATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGC
CATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGA
TAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATAT
GCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATT
TCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAA
ACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGA
TACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTAC
TCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATT
GGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTAC
CACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAG
TGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCT
TGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAG
TCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCG
GCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAA
ACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGT
GAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACA
AGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTC
AGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCT
AAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACC
TGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAA
GATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTG
TTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAA
AACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCA
TATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATC
ATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGA
TTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGG
TATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATC
TGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGC
TAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGA
AGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAA
TACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTC
AGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACC
ACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAA
GCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAA
TAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCA
AATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAAC
CTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGT
TCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAA
TGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTC
CAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTA
TCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCA
GGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATC
TGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTAT
ACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATT
GTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTA
TAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTA
TTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTGAGATGAATATGACACTTCATAATTACACT
CACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAG
CTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATT
TGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTT
TTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAG

>24212_24212_9_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000539844_NIPBL_chr5_37019413_ENST00000282516_length(amino acids)=1185AA_BP=21
MEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKE
IETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEV
VAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMC
VKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLV
EHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATI
EEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLE
DFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQ
QADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKAD
QQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLL
YIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDI
NSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEE
VKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAA
QMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVV

--------------------------------------------------------------
>24212_24212_10_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000539844_NIPBL_chr5_37019413_ENST00000448238_length(transcript)=3426nt_BP=85nt
AAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTC
AGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTC
TCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGA
AGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAA
AACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTC
CATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGC
CATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGA
TAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATAT
GCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATT
TCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAA
ACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGA
TACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTAC
TCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATT
GGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTAC
CACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAG
TGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCT
TGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAG
TCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCG
GCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAA
ACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGT
GAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACA
AGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTC
AGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCT
AAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACC
TGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAA
GATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTG
TTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAA
AACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCA
TATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATC
ATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGA
TTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGG
TATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATC
TGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGC
TAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGA
AGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAA
TACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGGTGAGGCGGAGGAGGAGTCAACGTAT
TTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTACACCAAGTAATGTAATACTTAAAAGAGAA
AACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTAACATAAAAGACAATAAAAAAACAGAAATG

>24212_24212_10_DSCR3-NIPBL_DSCR3_chr21_38639539_ENST00000539844_NIPBL_chr5_37019413_ENST00000448238_length(amino acids)=1078AA_BP=21
MEMGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKE
IETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEV
VAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMC
VKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLV
EHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATI
EEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLE
DFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQ
QADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKAD
QQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLL
YIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDI
NSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEE

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Top

Fusion Gene PPI Analysis for DSCR3-NIPBL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DSCR3-NIPBL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DSCR3-NIPBL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source