FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DSG2-DSG4 (FusionGDB2 ID:24247)

Fusion Gene Summary for DSG2-DSG4

check button Fusion gene summary
Fusion gene informationFusion gene name: DSG2-DSG4
Fusion gene ID: 24247
HgeneTgene
Gene symbol

DSG2

DSG4

Gene ID

1829

147409

Gene namedesmoglein 2desmoglein 4
SynonymsCDHF5|HDGCCDGF13|CDHF13|HYPT6|LAH
Cytomap

18q12.1

18q12.1

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-2cadherin family member 5desmoglein-4cadherin family member 13
Modification date2020031320200313
UniProtAcc

Q14126

Q86SJ6

Ensembl transtripts involved in fusion geneENST00000261590, ENST00000585206, 
ENST00000308128, ENST00000359747, 
Fusion gene scores* DoF score3 X 4 X 3=361 X 1 X 1=1
# samples 41
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: DSG2 [Title/Abstract] AND DSG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSG2(29121277)-DSG4(28979235), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSG2

GO:0007155

cell adhesion

17559062

HgeneDSG2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

17559062


check buttonFusion gene breakpoints across DSG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-7402-01ADSG2chr18

29121277

+DSG4chr18

28979235

+


Top

Fusion Gene ORF analysis for DSG2-DSG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261590ENST00000308128DSG2chr18

29121277

+DSG4chr18

28979235

+
In-frameENST00000261590ENST00000359747DSG2chr18

29121277

+DSG4chr18

28979235

+
intron-3CDSENST00000585206ENST00000308128DSG2chr18

29121277

+DSG4chr18

28979235

+
intron-3CDSENST00000585206ENST00000359747DSG2chr18

29121277

+DSG4chr18

28979235

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261590DSG2chr1829121277+ENST00000308128DSG4chr1828979235+464922103543271430
ENST00000261590DSG2chr1829121277+ENST00000359747DSG4chr1828979235+570222103543841449

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261590ENST00000308128DSG2chr1829121277+DSG4chr1828979235+0.0004869560.99951303
ENST00000261590ENST00000359747DSG2chr1829121277+DSG4chr1828979235+0.0003689960.9996309

Top

Fusion Genomic Features for DSG2-DSG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DSG2chr1829121277+DSG4chr1828979234+0.0003689780.99963105
DSG2chr1829121277+DSG4chr1828979234+0.0003689780.99963105

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DSG2-DSG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:29121277/chr18:28979235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSG2

Q14126

DSG4

Q86SJ6

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315161_2736671119.0DomainCadherin 2
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315274_3886671119.0DomainCadherin 3
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315389_5036671119.0DomainCadherin 4
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+131550_1606671119.0DomainCadherin 1
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+131550_6096671119.0Topological domainExtracellular
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315610_6346671119.0TransmembraneHelical
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716386_4973351041.0DomainCadherin 4
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715386_4973351060.0DomainCadherin 4
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716884_9093351041.0RepeatNote=Desmoglein repeat 1
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716910_9403351041.0RepeatNote=Desmoglein repeat 2
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715884_9093351060.0RepeatNote=Desmoglein repeat 1
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715910_9403351060.0RepeatNote=Desmoglein repeat 2
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716653_10403351041.0Topological domainCytoplasmic
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715653_10403351060.0Topological domainCytoplasmic
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716632_6523351041.0TransmembraneHelical
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715632_6523351060.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+13151022_10516671119.0RepeatNote=Desmoglein repeat 6
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315881_9126671119.0RepeatNote=Desmoglein repeat 1
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315913_9426671119.0RepeatNote=Desmoglein repeat 2
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315943_9686671119.0RepeatNote=Desmoglein repeat 3
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315969_9926671119.0RepeatNote=Desmoglein repeat 4
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315993_10216671119.0RepeatNote=Desmoglein repeat 5
HgeneDSG2chr18:29121277chr18:28979235ENST00000261590+1315635_11186671119.0Topological domainCytoplasmic
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716158_2693351041.0DomainCadherin 2
TgeneDSG4chr18:29121277chr18:28979235ENST00000308128716270_3853351041.0DomainCadherin 3
TgeneDSG4chr18:29121277chr18:28979235ENST0000030812871650_1573351041.0DomainCadherin 1
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715158_2693351060.0DomainCadherin 2
TgeneDSG4chr18:29121277chr18:28979235ENST00000359747715270_3853351060.0DomainCadherin 3
TgeneDSG4chr18:29121277chr18:28979235ENST0000035974771550_1573351060.0DomainCadherin 1
TgeneDSG4chr18:29121277chr18:28979235ENST0000030812871650_6313351041.0Topological domainExtracellular
TgeneDSG4chr18:29121277chr18:28979235ENST0000035974771550_6313351060.0Topological domainExtracellular


Top

Fusion Gene Sequence for DSG2-DSG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24247_24247_1_DSG2-DSG4_DSG2_chr18_29121277_ENST00000261590_DSG4_chr18_28979235_ENST00000308128_length(transcript)=4649nt_BP=2210nt
ATTTTCTCGCGGCGGCCACACCTGGAGCCGCGCCTTTGGGTTGGGCTGGGCTGGGCCGCGCAACCGCCACGGGAAGACAGCCCTCGGGGC
GGGGAGGGAGAGGGTGGCCGGGCCGGGGGGAGGCCGGGGCCAGGGAGGAGCCGAGTGCGCGCTCGGGGCAGGCGGCGGCGCGGAGCGGTG
CGGCGGCGGGAGGCGGAGGCGAGGGTGCGATGGCGCGGAGCCCGGGACGCGCGTACGCCCTGCTGCTTCTCCTGATCTGCTTTAACGTTG
GAAGTGGACTTCACTTACAGGTCTTAAGCACAAGAAATGAAAATAAGCTGCTTCCTAAACATCCTCATTTAGTGCGGCAAAAGCGCGCCT
GGATCACCGCCCCCGTGGCTCTTCGGGAGGGAGAGGATCTGTCCAAGAAGAATCCAATTGCCAAGATACATTCTGATCTTGCAGAAGAAA
GAGGACTCAAAATTACTTACAAATACACTGGAAAAGGGATTACAGAGCCACCTTTTGGTATATTTGTCTTTAACAAAGATACTGGAGAAC
TGAATGTTACCAGCATTCTTGATCGAGAAGAAACACCATTTTTTCTGCTAACAGGTTACGCTTTGGATGCAAGAGGAAACAATGTAGAGA
AACCCTTAGAGCTACGCATTAAGGTTCTTGATATCAATGACAACGAACCAGTGTTCACACAGGATGTCTTTGTTGGGTCTGTTGAAGAGT
TGAGTGCAGCACATACTCTTGTGATGAAAATCAATGCAACAGATGCAGATGAGCCCAATACCCTGAATTCGAAAATTTCCTATAGAATCG
TATCTCTGGAGCCTGCTTATCCTCCAGTGTTCTACCTAAATAAAGATACAGGAGAGATTTATACAACCAGTGTTACCTTGGACAGAGAGG
AACACAGCAGCTACACTTTGACAGTAGAAGCAAGAGATGGCAATGGAGAAGTTACAGACAAACCTGTAAAACAAGCTCAAGTTCAGATTC
GTATTTTGGATGTCAATGACAATATACCTGTAGTAGAAAATAAAGTGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTA
CGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATT
TCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCA
GTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAA
ATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTG
GAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGG
ATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGG
CCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAG
AGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTT
TCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGA
AAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTT
GTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGG
CCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCA
TAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGATGCTGGATTATGAACAAGCACCTAACATTCAGCTTAGTA
TCGGAGTTAAAAACCAAGCTGATTTTCACTACTCCGTTGCTTCTCAATTCCAAATGCACCCAACCCCTGTGAGAATTCAAGTTGTTGATG
TGAGAGAAGGACCTGCATTTCATCCAAGTACTATGGCTTTTAGTGTGCGGGAAGGAATAAAAGGAAGTTCCTTATTGAATTATGTGCTTG
GCACATATACAGCCATAGATTTGGACACAGGAAACCCTGCAACAGATGTCAGATATATCATAGGGCATGATGCAGGCAGCTGGTTAAAAA
TTGATTCAAGAACTGGTGAGATACAATTTTCTAGAGAATTTGATAAGAAGTCAAAATATATTATCAATGGGATATACACAGCAGAGATCC
TGGCTATAGATGATGGCTCTGGAAAAACAGCTACAGGAACCATATGTATTGAGGTTCCTGATATCAATGATTATTGTCCAAACATTTTTC
CTGAAAGAAGAACCATCTGCATTGACTCTCCATCAGTCCTTATCTCTGTTAATGAACATTCTTATGGGTCTCCGTTTACTTTCTGTGTTG
TTGATGAGCCACCAGGAATAGCTGACATGTGGGATGTCAGATCAACAAATGCTACCTCGGCAATCCTTACGGCTAAGCAGGTTTTATCTC
CAGGATTTTATGAAATCCCAATCCTGGTGAAGGACAGCTATAACAGAGCATGTGAATTGGCACAAATGGTGCAGTTATATGCCTGTGATT
GCGATGACAACCACATGTGCCTGGACTCTGGTGCCGCGGGCATCTACACAGAGGACATAACTGGTGACACGTATGGGCCTGTCACTGAAG
ACCAAGCTGGAGTTTCAAATGTTGGTCTTGGACCAGCAGGGATTGGCATGATGGTTCTGGGCATCCTGCTACTGATTTTGGCTCCACTCT
TGCTGCTCCTGTGTTGCTGCAAACAGAGACAGCCAGAAGGCCTGGGAACAAGATTTGCTCCTGTGCCTGAGGGCGGAGAAGGAGTGATGC
AGTCTTGGAGAATTGAAGGGGCCCATCCCGAGGACAGGGATGTGTCAAATATATGTGCACCCATGACAGCCTCAAATACCCAGGATCGGA
TGGATTCCTCTGAAATCTACACCAACACCTATGCAGCCGGGGGCACGGTGGAAGGAGGTGTATCGGGAGTGGAGCTCAACACAGGTATGG
GGACAGCCGTTGGCCTCATGGCCGCAGGGGCCGCAGGAGCCTCAGGGGCCGCAAGGAAGAGGAGCTCTACCATGGGAACCCTGCGGGACT
ACGCTGACGCAGACATCAACATGGCTTTCTTGGACAGCTACTTCTCGGAGAAAGCGTATGCTTATGCAGATGAAGATGAAGGTCGACCAG
CCAATGACTGCTTGCTCATTTATGACCACGAGGGAGTCGGGTCTCCCGTAGGCTCTATTGGTTGTTGCAGTTGGATTGTGGATGACTTAG
ATGAAAGCTGCATGGAAACTTTAGATCCAAAATTTAGGACTCTTGCTGAGATCTGCTTAAACACAGAAATTGAACCATTTCCTTCACACC
AGGCTTGTATACCAATCAGTACTGACCTCCCTTTGCTCGGACCTAATTACTTTGTTAATGAATCTTCAGGATTGACTCCCTCAGAAGTTG
AATTCCAAGAAGAAATGGCAGCATCTGAACCCGTGGTCCATGGGGATATTATTGTGACTGAGACTTACGGTAATGCTGATCCATGTGTGC
AACCCACTACAATTATTTTTGATCCTCAGCTTGCACCCAATGTTGTAGTAACCGAAGCAGTAATGGCACCTGTCTATGATATTCAAGGGA
ATATTTGTGTACCTGCTGAGTTAGCAGATTACAACAATGTAATCTATGCTGAGAGAGTACTGGCTAGTCCTGGTGTGCCTGACATGAGCA
ATAGTAGCACGACTGAGGGTTGTATGGGACCTGTGATGAGCGGCAATATTTTAGTAGGGCCAGAAATTCAAGTGATGCAAATGATGAGTC
CAGACCTTCCCATAGGCCAAACCGTTGGCTCCACATCCCCCATGACATCTCGACACAGAGTAACACGATACAGTAACATACATTACACCC
AACAGTAAGTGCTTTATGGTCAGTATTCTATGTGGAGACCTTGCACCTTGTAATCATCAATACATCCACCAAAAATATATAATGTACCAT
ATATATTAATAGTCAACAAATACTCAGATATTCTAAGGTCAATGCCATTATTTGATTATACCATTTTGAGGGTGAATATGGCTAGGCACT
TTAGATAAGCCTTTTTAAAATTCTTTCTGATTTTAAATAATGCGTCAAAAAATGTGCAGAAAATGTATTGCATCCCTTGATACTGTCTAA

>24247_24247_1_DSG2-DSG4_DSG2_chr18_29121277_ENST00000261590_DSG4_chr18_28979235_ENST00000308128_length(amino acids)=1430AA_BP=103
MGWAGLGRATATGRQPSGRGGRGWPGRGEAGAREEPSARSGQAAARSGAAAGGGGEGAMARSPGRAYALLLLLICFNVGSGLHLQVLSTR
NENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREET
PFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFY
LNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIG
SDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSV
ISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTIT
GTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLI
SDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGA
PPEDKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS
VLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPED
RDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD
SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPL
LGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN

--------------------------------------------------------------
>24247_24247_2_DSG2-DSG4_DSG2_chr18_29121277_ENST00000261590_DSG4_chr18_28979235_ENST00000359747_length(transcript)=5702nt_BP=2210nt
ATTTTCTCGCGGCGGCCACACCTGGAGCCGCGCCTTTGGGTTGGGCTGGGCTGGGCCGCGCAACCGCCACGGGAAGACAGCCCTCGGGGC
GGGGAGGGAGAGGGTGGCCGGGCCGGGGGGAGGCCGGGGCCAGGGAGGAGCCGAGTGCGCGCTCGGGGCAGGCGGCGGCGCGGAGCGGTG
CGGCGGCGGGAGGCGGAGGCGAGGGTGCGATGGCGCGGAGCCCGGGACGCGCGTACGCCCTGCTGCTTCTCCTGATCTGCTTTAACGTTG
GAAGTGGACTTCACTTACAGGTCTTAAGCACAAGAAATGAAAATAAGCTGCTTCCTAAACATCCTCATTTAGTGCGGCAAAAGCGCGCCT
GGATCACCGCCCCCGTGGCTCTTCGGGAGGGAGAGGATCTGTCCAAGAAGAATCCAATTGCCAAGATACATTCTGATCTTGCAGAAGAAA
GAGGACTCAAAATTACTTACAAATACACTGGAAAAGGGATTACAGAGCCACCTTTTGGTATATTTGTCTTTAACAAAGATACTGGAGAAC
TGAATGTTACCAGCATTCTTGATCGAGAAGAAACACCATTTTTTCTGCTAACAGGTTACGCTTTGGATGCAAGAGGAAACAATGTAGAGA
AACCCTTAGAGCTACGCATTAAGGTTCTTGATATCAATGACAACGAACCAGTGTTCACACAGGATGTCTTTGTTGGGTCTGTTGAAGAGT
TGAGTGCAGCACATACTCTTGTGATGAAAATCAATGCAACAGATGCAGATGAGCCCAATACCCTGAATTCGAAAATTTCCTATAGAATCG
TATCTCTGGAGCCTGCTTATCCTCCAGTGTTCTACCTAAATAAAGATACAGGAGAGATTTATACAACCAGTGTTACCTTGGACAGAGAGG
AACACAGCAGCTACACTTTGACAGTAGAAGCAAGAGATGGCAATGGAGAAGTTACAGACAAACCTGTAAAACAAGCTCAAGTTCAGATTC
GTATTTTGGATGTCAATGACAATATACCTGTAGTAGAAAATAAAGTGCTTGAAGGGATGGTTGAAGAAAATCAAGTCAACGTAGAAGTTA
CGCGCATAAAAGTGTTCGATGCAGATGAAATAGGTTCTGATAATTGGCTGGCAAATTTTACATTTGCATCAGGAAATGAAGGAGGTTATT
TCCACATAGAAACAGATGCTCAAACTAACGAAGGAATTGTGACCCTTATTAAGGAAGTAGATTATGAAGAAATGAAGAATCTTGACTTCA
GTGTTATTGTCGCTAATAAAGCAGCTTTTCACAAGTCGATTAGGAGTAAATACAAGCCTACACCCATTCCCATCAAGGTCAAAGTGAAAA
ATGTGAAAGAAGGCATTCATTTTAAAAGCAGCGTCATCTCAATTTATGTTAGCGAGAGCATGGATAGATCAAGCAAAGGCCAAATAATTG
GAAATTTTCAAGCTTTTGATGAGGACACTGGACTACCAGCCCATGCAAGATATGTAAAATTAGAAGATAGAGATAATTGGATCTCTGTGG
ATTCTGTCACATCTGAAATTAAACTTGCAAAACTTCCTGATTTTGAATCTAGATATGTTCAAAATGGCACATACACTGTAAAGATTGTGG
CCATATCAGAAGATTATCCTAGAAAAACCATCACTGGCACAGTCCTTATCAATGTTGAAGACATCAACGACAACTGTCCCACACTGATAG
AGCCTGTGCAGACAATCTGTCACGATGCAGAGTATGTGAATGTTACTGCAGAGGACCTGGATGGACACCCAAACAGTGGCCCTTTCAGTT
TCTCCGTCATTGACAAACCACCTGGCATGGCAGAAAAATGGAAAATAGCACGCCAAGAAAGTACCAGTGTGCTGCTGCAACAAAGTGAGA
AAAAGCTTGGGAGAAGTGAAATTCAGTTCCTGATTTCAGACAATCAGGGTTTTAGTTGTCCTGAAAAGCAGGTCCTTACACTCACAGTTT
GTGAGTGTCTGCATGGCAGCGGCTGCAGGGAAGCACAGCATGACTCCTATGTGGGCCTGGGACCCGCAGCAATTGCGCTCATGATTTTGG
CCTTTCTGCTCCTGCTATTGGTACCACTTTTACTGCTGATGTGCCATTGCGGAAAGGGCGCCAAAGGCTTTACCCCCATACCTGGCACCA
TAGAGATGCTGCATCCTTGGAATAATGAAGGAGCACCACCTGAAGACAAGATGCTGGATTATGAACAAGCACCTAACATTCAGCTTAGTA
TCGGAGTTAAAAACCAAGCTGATTTTCACTACTCCGTTGCTTCTCAATTCCAAATGCACCCAACCCCTGTGAGAATTCAAGTTGTTGATG
TGAGAGAAGGACCTGCATTTCATCCAAGTACTATGGCTTTTAGTGTGCGGGAAGGAATAAAAGGAAGTTCCTTATTGAATTATGTGCTTG
GCACATATACAGCCATAGATTTGGACACAGGAAACCCTGCAACAGATGTCAGATATATCATAGGGCATGATGCAGGCAGCTGGTTAAAAA
TTGATTCAAGAACTGGTGAGATACAATTTTCTAGAGAATTTGATAAGAAGTCAAAATATATTATCAATGGGATATACACAGCAGAGATCC
TGGCTATAGATGATGGCTCTGGAAAAACAGCTACAGGAACCATATGTATTGAGGTTCCTGATATCAATGATTATTGTCCAAACATTTTTC
CTGAAAGAAGAACCATCTGCATTGACTCTCCATCAGTCCTTATCTCTGTTAATGAACATTCTTATGGGTCTCCGTTTACTTTCTGTGTTG
TTGATGAGCCACCAGGAATAGCTGACATGTGGGATGTCAGATCAACAAATGCTACCTCGGCAATCCTTACGGCTAAGCAGGTTTTATCTC
CAGGATTTTATGAAATCCCAATCCTGGTGAAGGACAGCTATAACAGAGCATGTGAATTGGCACAAATGGTGCAGTTATATGCCTGTGATT
GCGATGACAACCACATGTGCCTGGACTCTGGTGCCGCGGGCATCTACACAGAGGACATAACTGGTGACACGTATGGGCCTGTCACTGAAG
ACCAAGCTGGAGTTTCAAATGTTGGTCTTGGACCAGCAGGGATTGGCATGATGGTTCTGGGCATCCTGCTACTGATTTTGGCTCCACTCT
TGCTGCTCCTGTGTTGCTGCAAACAGAGACAGCCAGAAGGCCTGGGAACAAGATTTGCTCCTGTGCCTGAGGGCGGAGAAGGAGTGATGC
AGTCTTGGAGAATTGAAGGGGCCCATCCCGAGGACAGGCTTTTTAGCGCCTACGCCTTGCCGGGTGGTGGTGGCACCGCAGACGGCGGCG
GCAGCGTTTTAGGCAGATGCGCGCTGCAGGCAACTCCAGCGCTGTTAAACCAACATCCTCCCTTTTCAGAAATCTACACCAACACCTATG
CAGCCGGGGGCACGGTGGAAGGAGGTGTATCGGGAGTGGAGCTCAACACAGGTATGGGGACAGCCGTTGGCCTCATGGCCGCAGGGGCCG
CAGGAGCCTCAGGGGCCGCAAGGAAGAGGAGCTCTACCATGGGAACCCTGCGGGACTACGCTGACGCAGACATCAACATGGCTTTCTTGG
ACAGCTACTTCTCGGAGAAAGCGTATGCTTATGCAGATGAAGATGAAGGTCGACCAGCCAATGACTGCTTGCTCATTTATGACCACGAGG
GAGTCGGGTCTCCCGTAGGCTCTATTGGTTGTTGCAGTTGGATTGTGGATGACTTAGATGAAAGCTGCATGGAAACTTTAGATCCAAAAT
TTAGGACTCTTGCTGAGATCTGCTTAAACACAGAAATTGAACCATTTCCTTCACACCAGGCTTGTATACCAATCAGTACTGACCTCCCTT
TGCTCGGACCTAATTACTTTGTTAATGAATCTTCAGGATTGACTCCCTCAGAAGTTGAATTCCAAGAAGAAATGGCAGCATCTGAACCCG
TGGTCCATGGGGATATTATTGTGACTGAGACTTACGGTAATGCTGATCCATGTGTGCAACCCACTACAATTATTTTTGATCCTCAGCTTG
CACCCAATGTTGTAGTAACCGAAGCAGTAATGGCACCTGTCTATGATATTCAAGGGAATATTTGTGTACCTGCTGAGTTAGCAGATTACA
ACAATGTAATCTATGCTGAGAGAGTACTGGCTAGTCCTGGTGTGCCTGACATGAGCAATAGTAGCACGACTGAGGGTTGTATGGGACCTG
TGATGAGCGGCAATATTTTAGTAGGGCCAGAAATTCAAGTGATGCAAATGATGAGTCCAGACCTTCCCATAGGCCAAACCGTTGGCTCCA
CATCCCCCATGACATCTCGACACAGAGTAACACGATACAGTAACATACATTACACCCAACAGTAAGTGCTTTATGGTCAGTATTCTATGT
GGAGACCTTGCACCTTGTAATCATCAATACATCCACCAAAAATATATAATGTACCATATATATTAATAGTCAACAAATACTCAGATATTC
TAAGGTCAATGCCATTATTTGATTATACCATTTTGAGGGTGAATATGGCTAGGCACTTTAGATAAGCCTTTTTAAAATTCTTTCTGATTT
TAAATAATGCGTCAAAAAATGTGCAGAAAATGTATTGCATCCCTTGATACTGTCTAACGAATAGCACATAACTCATATTGTGAATCCTAT
GGGTCTTGAGGCCTGTAGAACCAATCTTGTAAACCAAGATGCCTTGTTCTTGGAAGTTACAAAAGAAGCCCTGTCTACATCCACCAGCCA
TATTTTTCGTTAGGGAAATATTTATATTAAAATTTTTAATTGAAAAGTTGAATGAAATGTACATTCTGAAAGGAAATTGAAAAGGAACGT
AGAGTATCTGTCAATATCTTTAGATATCTGAAGTCATTTGTCTCTTCAAAAGATTTTTCAATATTATGCGCTATTAAGCAATAGGAGATG
CTTAATATAATAAGAAAAGAGTTTGCCAACTGAAAGCATGGCTGGAAATGGTTCATCAAAGAAAAATATATATTTTTATTGAACTTTATT
GATTTATATGATTAACTGTAAATTAATCTAGAATAGCAAAAAAAAATGACAATCCTAAAGTAGAAAGAGTTATTGGGGAAATATTAGAGT
TTTCCCCACTTACAGGGAATTTTTTCCCTACTGTTGCCAATTATGTCAGAAAAATACATGAAATATGGCTTAACCAATTTCATTGACCTG
AATCGTAGAGCTTTCAATTGGCAACCAGATATTCTCCAAAAGCACTCTGTAGTTATTCATATATTCTACAATATTTACTTAGAAGCAACT
AGGTGTTGGGTGCTAGTCTTGGCTCTGTGAATATACAGGTAAAGAAGACAGACATGGTTTCTGCCTTCATAGAGCTTCTATTCATTTCTA
GACTTAAAATAAAACTCTGGGATATGGCTTTAAGTTCCTAACAACAATAATTAACCAACTACTTAAGTCCATTACCAAGTTGTGTTTCTC
TTTGCAACACTACTGTTTATGTTGAATAAATAAAATGGAAACACATTGCTTACTTTTCGTAGGCATAAAGCTGACTTGAGAAAAAGAATC
TCTAGCCAGGTAATTTTACTTAATTCTGTAAAATATGTATACAGTAGCAGCAATAATGTGACTGAGATAATGTAAATGAAATAAACTTAT

>24247_24247_2_DSG2-DSG4_DSG2_chr18_29121277_ENST00000261590_DSG4_chr18_28979235_ENST00000359747_length(amino acids)=1449AA_BP=103
MGWAGLGRATATGRQPSGRGGRGWPGRGEAGAREEPSARSGQAAARSGAAAGGGGEGAMARSPGRAYALLLLLICFNVGSGLHLQVLSTR
NENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREET
PFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFY
LNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIG
SDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSV
ISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTIT
GTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLI
SDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGA
PPEDKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPS
VLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPED
RLFSAYALPGGGGTADGGGSVLGRCALQATPALLNQHPPFSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSS
TMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTE
IEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMA
PVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVTR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DSG2-DSG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DSG2-DSG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DSG2-DSG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource