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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSG3-DSC3 (FusionGDB2 ID:24251)

Fusion Gene Summary for DSG3-DSC3

check button Fusion gene summary
Fusion gene informationFusion gene name: DSG3-DSC3
Fusion gene ID: 24251
HgeneTgene
Gene symbol

DSG3

DSC3

Gene ID

1830

1825

Gene namedesmoglein 3desmocollin 3
SynonymsCDHF6|PVACDHF3|DSC|DSC1|DSC2|DSC4|HT-CP
Cytomap

18q12.1

18q12.1

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-3130 kDa pemphigus vulgaris antigencadherin family member 6desmocollin-3cadherin family member 3desmocollin-4
Modification date2020031320200313
UniProtAcc

P32926

Q14574

Ensembl transtripts involved in fusion geneENST00000257189, ENST00000360428, 
ENST00000434452, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: DSG3 [Title/Abstract] AND DSC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSG3(29027888)-DSC3(28588491), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DSG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NWDSG3chr18

29027888

+DSC3chr18

28588491

-


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Fusion Gene ORF analysis for DSG3-DSC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257189ENST00000360428DSG3chr18

29027888

+DSC3chr18

28588491

-
In-frameENST00000257189ENST00000434452DSG3chr18

29027888

+DSC3chr18

28588491

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257189DSG3chr1829027888+ENST00000360428DSC3chr1828588491-5726131831558491
ENST00000257189DSG3chr1829027888+ENST00000434452DSC3chr1828588491-5691131831387434

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257189ENST00000360428DSG3chr1829027888+DSC3chr1828588491-0.0001717670.9998282
ENST00000257189ENST00000434452DSG3chr1829027888+DSC3chr1828588491-0.0002467280.9997533

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Fusion Genomic Features for DSG3-DSC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSG3-DSC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:29027888/chr18:28588491)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSG3

P32926

DSC3

Q14574

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816472_579421897.0DomainCadherin 4
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816580_690421897.0DomainCadherin 5
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817472_5794212180.3333333333335DomainCadherin 4
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817580_6904212180.3333333333335DomainCadherin 5
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816712_896421897.0Topological domainCytoplasmic
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817712_8964212180.3333333333335Topological domainCytoplasmic
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816691_711421897.0TransmembraneHelical
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817691_7114212180.3333333333335TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116159_268161000.0DomainCadherin 2
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116269_383161000.0DomainCadherin 3
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116386_499161000.0DomainCadherin 4
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+11650_158161000.0DomainCadherin 1
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116910_935161000.0RepeatNote=Desmoglein repeat 1
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116936_966161000.0RepeatNote=Desmoglein repeat 2
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+11650_615161000.0Topological domainExtracellular
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116641_999161000.0Topological domainCytoplasmic
HgeneDSG3chr18:29027888chr18:28588491ENST00000257189+116616_640161000.0TransmembraneHelical
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816136_243421897.0DomainCadherin 1
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816244_355421897.0DomainCadherin 2
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816356_471421897.0DomainCadherin 3
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817136_2434212180.3333333333335DomainCadherin 1
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817244_3554212180.3333333333335DomainCadherin 2
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817356_4714212180.3333333333335DomainCadherin 3
TgeneDSC3chr18:29027888chr18:28588491ENST00000360428816136_690421897.0Topological domainExtracellular
TgeneDSC3chr18:29027888chr18:28588491ENST00000434452817136_6904212180.3333333333335Topological domainExtracellular


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Fusion Gene Sequence for DSG3-DSC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24251_24251_1_DSG3-DSC3_DSG3_chr18_29027888_ENST00000257189_DSC3_chr18_28588491_ENST00000360428_length(transcript)=5726nt_BP=131nt
TTTTCTTAGACATCAACTGCAGACGGCTGGCAGGATAGAAGCAGCGGCTCACTTGGACTTTTTCACCAGGGAAATCAGAGACAATGATGG
GGCTCTTCCCCAGAACTACAGGGGCTCTGGCCATCTTCGTGCCACTGAATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAA
ACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGG
GGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACC
CCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCA
TAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGAT
CATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAA
AAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAG
AAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCA
TTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTC
GTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGC
TAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAG
AAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGG
GATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATC
ATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCC
GTCTCGGTGAAAAATTGCATCGATGTAATCAGAATGAAGACCGCATGCCATCCCAAGATTATGTCCTCACTTATAACTATGAGGGAAGAG
GATCTCCAGCTGGTTCTGTGGGCTGCTGCAGTGAAAAGCAGGAAGAAGATGGCCTTGACTTTTTAAATAATTTGGAACCCAAATTTATTA
CATTAGCAGAAGCATGCACAAAGAGATAATGTCACAGTGCTACAATTAGGTCTTTGTCAGACATTCTGGAGGTTTCCAAAAATAATATTG
TAAAGTTCAATTTCAACATGTATGTATATGATGATTTTTTTCTCAATTTTGAATTATGCTACTCACCAATTTATATTTTTAAAGCAAGTT
GTTGCTTATCTTTTCCAAAAAGTGAAAAATGTTAAAACAGACAACTGGTAAATCTCAAACTCCAGCACTGGAATTAAGGTCTCTAAAGCA
TCTGCTCTTTTTTTTTTTTACGGATATTTTAGTAATAAATATGCTGGATAAATATTAGTCCAACAATAGCTAAGTTATGCTAATATCACA
TTATTATGTATTCACTTTAAGTGATAGTTTAAAAAATAAACAAGAAATATTGAGTATCACTATGTGAAGAAAGTTTTGGAAAAGAAACAA
TGAAGACTGAATTAAATTAAAAATGTTGCAGCTCATAAAGAATTGGGACTCACCCCTACTGCACTACCAAATTCATTTGACTTTGGAGGC
AAAATGTGTTGAAGTGCCCTATGAAGTAGCAATTTTCTATAGGAATATAGTTGGAAATAAATGTGTGTGTGTATATTATTATTAATCAAT
GCAATATTTAAAATGAAATGAGAACAAAGAGGAAAATGGTAAAAACTTGAAATGAGGCTGGGGTATAGTTTGTCCTACAATAGAAAAAAG
AGAGAGCTTCCTAGGCCTGGGCTCTTAAATGCTGCATTATAACTGAGTCTATGAGGAAATAGTTCCTGTCCAATTTGTGTAATTTGTTTA
AAATTGTAAATAAATTAAACTTTTCTGGTTTCTGTGGGAAGGAAATAGGGAATCCAATGGAACAGTAGCTTTGCTTTGCAGTCTGTTTCA
AGATTTCTGCATCCACAAGTTAGTAGCAAACTGGGGAATACTCGCTGCAGCTGGGGTTCCCTGCTTTTTGGTAGCAAGGGTCCAGAGATG
AGGTGTTTTTTTCGGGGAGCTAATAACAAAAACATTTTAAAACTTACCTTTACTGAAGTTAAATCCTCTATTGCTGTTTCTATTCTCTCT
TATAGTGACCAACATCTTTTTAATTTAGATCCAAATAACCATGTCCTCCTAGAGTTTAGAGGCTAGAGGGAGCTGAGGGGAGGATCTTAC
TGAAAGCACCCTGGGGAGATTGATTGTCCTTAAACCTAAGCCCCACAAACTTGACACCTGATCAGGTCTGGGAGCTACAAAATTTCATTT
TTCTCCTCACTGCCCTTCTTCTGAGTGGCATTGGCCTGAATCAAGGAAAGCCAGGCCTTGTGGGCCCCCTTCTTTCGGCTTTCTGCTAAA
GCAACACCTCCAGCAGAGATTCCCTTAAGTGACTCCAGGTTTTCCACCATCCTTCAGCGTGAATTAATTTTTAATCAGTTTGCTTTCTCC
AGAGAAATTTTAAAATAATAGAAGAAATAGAAATTTTGAATGTATAAAAGAAAAAGATCAAGTTGTCATTTTAGAACAGAGGGAACTTTG
GGAGAAAGCAGCCCAAGTAGGTTATTTGTACAGTCAGAGGGCAACAGGAAGATGCAGGCCTTCAAGGGCAAGGAGAGGCCACAAGGAATA
TGGGTGGGAGTAAAAGCAACATCGTCTGCTTCATACTTTTTCCTAGGCTTGGCACTGCCTTTTCCTTTCTCAGGCCAATGGCAACTGCCA
TTTGAGTCCGGTGAGGGATCAGCCAACCTCTTCTCTATGGCTCACCTTATTTGGAGTGAGAAATCAAGGAGACAGAGCTGACTGCATGAT
GAGTCTGAAGGCATTTGCAGGATGAGCCTGAACTGGTTGTGCAGAACAAACAAGGCATTCATGGGAATTGTTGTATTCCTTCTGCAGCCC
TCCTTCTGGGCACTAAGAAGGTCTATGAATTAAATGCCTATCTAAAATTCTGATTTATTCCTACATTTTCTGTTTTCTAATTTGACCCTA
AAATCTATGTGTTTTAGACTTAGACTTTTTATTGCCCCCCCCCCCCCCTTTTTTTTTTGAGACGGAGTCTCGCTCTGACGCACAGGCTGG
AGTGCAGTGGCTCCGATCTCTGCTCACTGAAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAATAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCT
GACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGACCCACCGCTCCCGGCCTTGTTTTCCGTTTAAAGTCG
TCTTCTTTTAATGTAATCATTTTGAACATGTGTGAAAGTTGATCATACGAATTGGATCAATCTTGAAATACTCAACCAAAAGACAGTCGA
GAAGCCAGGGGGAGAAAGAACTCAGGGCACAAAATATTGGTCTGAGAATGGAATTCTCTGTAAGCCTAGTTGCTGAAATTTCCTGCTGTA
TCCAGAAGCCAGTTTTATCTAACGGCTACTGAAACACCCACTGTGTTTTGCTCACTCCCTCACTCACCGATCAAAACCTGCTACCTCCCC
AAGACTTTACTAGTGCCGATAAACTTTCTCAAAGAGCAACCAGTATCACTTCCCTGTTTATAAAACCTCTAACCATCTCTTTGTTCTTTG
AACATGCTGAAAACCACCTGGTCTGCATGTATGCCCGAATTTGTAATTCTTTTCTCTCAAATGAAAATTTAATTTTAGGGATTCATTTCT
ATATTTTCACATATGTAGTATTATTATTTCCTTATATGTGTAAGGTGAAATTTATGGTATTTGAGTGTGCAAGAAAATATATTTTTAAAG
CTTTCATTTTTCCCCCAGTGAATGATTTAGAATTTTTTATGTAAATATACAGAATGTTTTTTCTTACTTTTATAAGGAAGCAGCTGTCTA
AAATGCAGTGGGGTTTGTTTTGCAATGTTTTAAACAGAGTTTTAGTATTGCTATTAAAAGAAGTTACTTTGCTTTTAAAGAAACTTGGCT
GCTTAAAATAAGCAAAAATTGGATGCGTAAAGTAATATTTACAGATGTGGGGAGATGTAATAAAACAATATTAACTTGGTTTCTTGTTTT
TGCTGTATTTAGAGATTAAATAATTCTAAGATGATCACTTTGCAAAATTATGCTTATGGCTGGCATGGAAATAGAAATAATTATGTCTTT
GTTGTATTAATGGGGAATATTTTGGACAATGTTTCATTATCAAATTGTCGACATCATTAATATATATTGTAATGTTGGGAAGAGATCACT
ATTTTGAAGCACAGCTTTACAGATGAGTATCTATGATACATATGTATAATAAATTTTGATTGGGTATTAAAAGTATTAGAAGGTGGTTAT
AATTGCAGAGTATTCCATGAATAGTACACTGACACAGGGGTTTTACTTTGAGGACCAGTGTAGTCAAGGGAAAACATGAGTTAAAAAGAA
AAGCAGGCGATATTGCAGTCTTGATTCTGCCACTTACAGGATAGATAACGCCTGAACTTTAATGACAAGATGATCCAACCATAAAGGTGC
TCTGTGCTTCACAGTGAATCTTTTCCCCATGCAGGAGTGTGCTCCCCTACAAACGTTAAGACTGATCATTTCAAAAATCTATTAGCTATA
TCAAAAGCCTTACATTTTAATATAGGTTGAACCAAAATTTCAATTCCAGTAACTTCTATTGTAACCATTATTTTTGTGTATGTCTTCAAG
AATGTTCATTGGATTTTTGTTTGTAATAGTAAAATACCGGATACATTTCACGTGTCCTTCAGTATTGATTTGGTTGAATATTGGGTCATA
ATGGTTGAGAAGCATGGACACTAGAGCCAGAATGCTTGGATATGAATCCTGGATCTGTCACTTACTTCTGTGTGACCTTTGAAAGGCTAC
TTATTTCCTCTCTTAGCTTTCTCATTAAAATCAATGAACAATGCCAGCCTCATGGGGTTGTTGAATGATTAAATGAGTTACTATACCTAA
AGTACATAGAACACTGCCTGCACATAGTAAAAGAATTATAAGTGTGAGGTAGTTGGTAAAATTATGTAGTTGGATATACTACCGAACAAT

>24251_24251_1_DSG3-DSC3_DSG3_chr18_29027888_ENST00000257189_DSC3_chr18_28588491_ENST00000360428_length(amino acids)=491AA_BP=16
MMGLFPRTTGALAIFVPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKA
YDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVIC
KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPT
QCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCG
TMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYE

--------------------------------------------------------------
>24251_24251_2_DSG3-DSC3_DSG3_chr18_29027888_ENST00000257189_DSC3_chr18_28588491_ENST00000434452_length(transcript)=5691nt_BP=131nt
TTTTCTTAGACATCAACTGCAGACGGCTGGCAGGATAGAAGCAGCGGCTCACTTGGACTTTTTCACCAGGGAAATCAGAGACAATGATGG
GGCTCTTCCCCAGAACTACAGGGGCTCTGGCCATCTTCGTGCCACTGAATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAA
ACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGG
GGCCTGAATGCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACC
CCGAAAATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCA
TAACTTCCAAAATCCTGGATAGGGAGGTTGAAACTCCCAAAAATGAGTTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGAT
CATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAA
AAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAG
AAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGAAAAATGCTGGATTTCAAGAATATACCA
TTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTC
GTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGGGTATAGCACTGCTCTTTTCTGTATTGC
TAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAG
AAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGG
GATCAGGAATGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATC
ATCATACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCC
GTCTCGGTGAAGAATCCATTAGAGGACACACTGGTTAAAAATTAAACATAAAAGAAATTGCATCGATGTAATCAGAATGAAGACCGCATG
CCATCCCAAGATTATGTCCTCACTTATAACTATGAGGGAAGAGGATCTCCAGCTGGTTCTGTGGGCTGCTGCAGTGAAAAGCAGGAAGAA
GATGGCCTTGACTTTTTAAATAATTTGGAACCCAAATTTATTACATTAGCAGAAGCATGCACAAAGAGATAATGTCACAGTGCTACAATT
AGGTCTTTGTCAGACATTCTGGAGGTTTCCAAAAATAATATTGTAAAGTTCAATTTCAACATGTATGTATATGATGATTTTTTTCTCAAT
TTTGAATTATGCTACTCACCAATTTATATTTTTAAAGCAAGTTGTTGCTTATCTTTTCCAAAAAGTGAAAAATGTTAAAACAGACAACTG
GTAAATCTCAAACTCCAGCACTGGAATTAAGGTCTCTAAAGCATCTGCTCTTTTTTTTTTTTACGGATATTTTAGTAATAAATATGCTGG
ATAAATATTAGTCCAACAATAGCTAAGTTATGCTAATATCACATTATTATGTATTCACTTTAAGTGATAGTTTAAAAAATAAACAAGAAA
TATTGAGTATCACTATGTGAAGAAAGTTTTGGAAAAGAAACAATGAAGACTGAATTAAATTAAAAATGTTGCAGCTCATAAAGAATTGGG
ACTCACCCCTACTGCACTACCAAATTCATTTGACTTTGGAGGCAAAATGTGTTGAAGTGCCCTATGAAGTAGCAATTTTCTATAGGAATA
TAGTTGGAAATAAATGTGTGTGTGTATATTATTATTAATCAATGCAATATTTAAAATGAAATGAGAACAAAGAGGAAAATGGTAAAAACT
TGAAATGAGGCTGGGGTATAGTTTGTCCTACAATAGAAAAAAGAGAGAGCTTCCTAGGCCTGGGCTCTTAAATGCTGCATTATAACTGAG
TCTATGAGGAAATAGTTCCTGTCCAATTTGTGTAATTTGTTTAAAATTGTAAATAAATTAAACTTTTCTGGTTTCTGTGGGAAGGAAATA
GGGAATCCAATGGAACAGTAGCTTTGCTTTGCAGTCTGTTTCAAGATTTCTGCATCCACAAGTTAGTAGCAAACTGGGGAATACTCGCTG
CAGCTGGGGTTCCCTGCTTTTTGGTAGCAAGGGTCCAGAGATGAGGTGTTTTTTTCGGGGAGCTAATAACAAAAACATTTTAAAACTTAC
CTTTACTGAAGTTAAATCCTCTATTGCTGTTTCTATTCTCTCTTATAGTGACCAACATCTTTTTAATTTAGATCCAAATAACCATGTCCT
CCTAGAGTTTAGAGGCTAGAGGGAGCTGAGGGGAGGATCTTACTGAAAGCACCCTGGGGAGATTGATTGTCCTTAAACCTAAGCCCCACA
AACTTGACACCTGATCAGGTCTGGGAGCTACAAAATTTCATTTTTCTCCTCACTGCCCTTCTTCTGAGTGGCATTGGCCTGAATCAAGGA
AAGCCAGGCCTTGTGGGCCCCCTTCTTTCGGCTTTCTGCTAAAGCAACACCTCCAGCAGAGATTCCCTTAAGTGACTCCAGGTTTTCCAC
CATCCTTCAGCGTGAATTAATTTTTAATCAGTTTGCTTTCTCCAGAGAAATTTTAAAATAATAGAAGAAATAGAAATTTTGAATGTATAA
AAGAAAAAGATCAAGTTGTCATTTTAGAACAGAGGGAACTTTGGGAGAAAGCAGCCCAAGTAGGTTATTTGTACAGTCAGAGGGCAACAG
GAAGATGCAGGCCTTCAAGGGCAAGGAGAGGCCACAAGGAATATGGGTGGGAGTAAAAGCAACATCGTCTGCTTCATACTTTTTCCTAGG
CTTGGCACTGCCTTTTCCTTTCTCAGGCCAATGGCAACTGCCATTTGAGTCCGGTGAGGGATCAGCCAACCTCTTCTCTATGGCTCACCT
TATTTGGAGTGAGAAATCAAGGAGACAGAGCTGACTGCATGATGAGTCTGAAGGCATTTGCAGGATGAGCCTGAACTGGTTGTGCAGAAC
AAACAAGGCATTCATGGGAATTGTTGTATTCCTTCTGCAGCCCTCCTTCTGGGCACTAAGAAGGTCTATGAATTAAATGCCTATCTAAAA
TTCTGATTTATTCCTACATTTTCTGTTTTCTAATTTGACCCTAAAATCTATGTGTTTTAGACTTAGACTTTTTATTGCCCCCCCCCCCCC
CTTTTTTTTTTGAGACGGAGTCTCGCTCTGACGCACAGGCTGGAGTGCAGTGGCTCCGATCTCTGCTCACTGAAAGCTCCGCCTCCCGGG
TTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAATAG
AGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACA
GGCATGACCCACCGCTCCCGGCCTTGTTTTCCGTTTAAAGTCGTCTTCTTTTAATGTAATCATTTTGAACATGTGTGAAAGTTGATCATA
CGAATTGGATCAATCTTGAAATACTCAACCAAAAGACAGTCGAGAAGCCAGGGGGAGAAAGAACTCAGGGCACAAAATATTGGTCTGAGA
ATGGAATTCTCTGTAAGCCTAGTTGCTGAAATTTCCTGCTGTATCCAGAAGCCAGTTTTATCTAACGGCTACTGAAACACCCACTGTGTT
TTGCTCACTCCCTCACTCACCGATCAAAACCTGCTACCTCCCCAAGACTTTACTAGTGCCGATAAACTTTCTCAAAGAGCAACCAGTATC
ACTTCCCTGTTTATAAAACCTCTAACCATCTCTTTGTTCTTTGAACATGCTGAAAACCACCTGGTCTGCATGTATGCCCGAATTTGTAAT
TCTTTTCTCTCAAATGAAAATTTAATTTTAGGGATTCATTTCTATATTTTCACATATGTAGTATTATTATTTCCTTATATGTGTAAGGTG
AAATTTATGGTATTTGAGTGTGCAAGAAAATATATTTTTAAAGCTTTCATTTTTCCCCCAGTGAATGATTTAGAATTTTTTATGTAAATA
TACAGAATGTTTTTTCTTACTTTTATAAGGAAGCAGCTGTCTAAAATGCAGTGGGGTTTGTTTTGCAATGTTTTAAACAGAGTTTTAGTA
TTGCTATTAAAAGAAGTTACTTTGCTTTTAAAGAAACTTGGCTGCTTAAAATAAGCAAAAATTGGATGCGTAAAGTAATATTTACAGATG
TGGGGAGATGTAATAAAACAATATTAACTTGGTTTCTTGTTTTTGCTGTATTTAGAGATTAAATAATTCTAAGATGATCACTTTGCAAAA
TTATGCTTATGGCTGGCATGGAAATAGAAATAATTATGTCTTTGTTGTATTAATGGGGAATATTTTGGACAATGTTTCATTATCAAATTG
TCGACATCATTAATATATATTGTAATGTTGGGAAGAGATCACTATTTTGAAGCACAGCTTTACAGATGAGTATCTATGATACATATGTAT
AATAAATTTTGATTGGGTATTAAAAGTATTAGAAGGTGGTTATAATTGCAGAGTATTCCATGAATAGTACACTGACACAGGGGTTTTACT
TTGAGGACCAGTGTAGTCAAGGGAAAACATGAGTTAAAAAGAAAAGCAGGCGATATTGCAGTCTTGATTCTGCCACTTACAGGATAGATA
ACGCCTGAACTTTAATGACAAGATGATCCAACCATAAAGGTGCTCTGTGCTTCACAGTGAATCTTTTCCCCATGCAGGAGTGTGCTCCCC
TACAAACGTTAAGACTGATCATTTCAAAAATCTATTAGCTATATCAAAAGCCTTACATTTTAATATAGGTTGAACCAAAATTTCAATTCC
AGTAACTTCTATTGTAACCATTATTTTTGTGTATGTCTTCAAGAATGTTCATTGGATTTTTGTTTGTAATAGTAAAATACCGGATACATT
TCACGTGTCCTTCAGTATTGATTTGGTTGAATATTGGGTCATAATGGTTGAGAAGCATGGACACTAGAGCCAGAATGCTTGGATATGAAT
CCTGGATCTGTCACTTACTTCTGTGTGACCTTTGAAAGGCTACTTATTTCCTCTCTTAGCTTTCTCATTAAAATCAATGAACAATGCCAG
CCTCATGGGGTTGTTGAATGATTAAATGAGTTACTATACCTAAAGTACATAGAACACTGCCTGCACATAGTAAAAGAATTATAAGTGTGA

>24251_24251_2_DSG3-DSC3_DSG3_chr18_29027888_ENST00000257189_DSC3_chr18_28588491_ENST00000434452_length(amino acids)=434AA_BP=16
MMGLFPRTTGALAIFVPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKA
YDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVIC
KPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPT
QCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCG

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Fusion Gene PPI Analysis for DSG3-DSC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSG3-DSC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSG3-DSC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource