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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSN1-MROH8 (FusionGDB2 ID:24258)

Fusion Gene Summary for DSN1-MROH8

check button Fusion gene summary
Fusion gene informationFusion gene name: DSN1-MROH8
Fusion gene ID: 24258
HgeneTgene
Gene symbol

DSN1

MROH8

Gene ID

79980

140699

Gene nameDSN1 component of MIS12 kinetochore complexmaestro heat like repeat family member 8
SynonymsC20orf172|KNL3|MIS13|dJ469A13.2|hKNL-3C20orf131|C20orf132
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionkinetochore-associated protein DSN1 homologDSN1 homolog, MIS12 kinetochore complex componentDSN1, MIND kinetochore complex component, homologDSN1, MIS12 kinetochore complex componentkinetochore null 3 homologprotein MROH8maestro heat-like repeat-containing protein family member 8
Modification date2020032020200313
UniProtAcc

Q9H410

Q9H579

Ensembl transtripts involved in fusion geneENST00000373734, ENST00000373740, 
ENST00000373745, ENST00000373750, 
ENST00000426836, ENST00000448110, 
ENST00000473615, 		ENST00000217333, 
ENST00000400441, ENST00000466091, 
ENST00000441008, 
Fusion gene scores* DoF score5 X 5 X 4=10010 X 9 X 7=630
# samples 610
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSN1 [Title/Abstract] AND MROH8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSN1(35383166)-MROH8(35769717), # samples:1
Anticipated loss of major functional domain due to fusion event.DSN1-MROH8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DSN1-MROH8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DSN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MROH8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L1-01ADSN1chr20

35383166

-MROH8chr20

35769717

-


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Fusion Gene ORF analysis for DSN1-MROH8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373734ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373734ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373734ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373740ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373740ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373740ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373745ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373745ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373745ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373750ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373750ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000373750ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000426836ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000426836ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000426836ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000448110ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000448110ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5CDS-intronENST00000448110ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
5UTR-3CDSENST00000473615ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
5UTR-intronENST00000473615ENST00000217333DSN1chr20

35383166

-MROH8chr20

35769717

-
5UTR-intronENST00000473615ENST00000400441DSN1chr20

35383166

-MROH8chr20

35769717

-
5UTR-intronENST00000473615ENST00000466091DSN1chr20

35383166

-MROH8chr20

35769717

-
Frame-shiftENST00000373745ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
Frame-shiftENST00000426836ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
Frame-shiftENST00000448110ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
In-frameENST00000373734ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
In-frameENST00000373740ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-
In-frameENST00000373750ENST00000441008DSN1chr20

35383166

-MROH8chr20

35769717

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373740DSN1chr2035383166-ENST00000441008MROH8chr2035769717-28298197772324515
ENST00000373750DSN1chr2035383166-ENST00000441008MROH8chr2035769717-3140113010882635515
ENST00000373734DSN1chr2035383166-ENST00000441008MROH8chr2035769717-28228127702317515

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373740ENST00000441008DSN1chr2035383166-MROH8chr2035769717-0.0102230470.98977697
ENST00000373750ENST00000441008DSN1chr2035383166-MROH8chr2035769717-0.0090255160.9909745
ENST00000373734ENST00000441008DSN1chr2035383166-MROH8chr2035769717-0.0093055270.9906944

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Fusion Genomic Features for DSN1-MROH8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSN1-MROH8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35383166/chr20:35769717)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSN1

Q9H410

MROH8

Q9H579

FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DSN1-MROH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24258_24258_1_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373734_MROH8_chr20_35769717_ENST00000441008_length(transcript)=2822nt_BP=812nt
GCATGCGCCCTTGGTTGGCGGGAGTTTCGGAGGCGGTGACCGTGACGTAGAAGGTGGAGACCGCTTCACCCTGATCAGGGAGTATCGGCT
GCGGGTGCGCAAGGCGTCCAGGAGTGACCTGGGGCTGTGGAGAGCGACCCGTGGCCTTGTGTTTCAGAGTTTACCACCTAGGATGACTTC
AGTGACTAGATCAGAGATCATAGATGAGCTCAGCCGGTCTATCAGTGTCGATTTAGCAGAAAGCAAACGGCTTGGCTGTCTCCTGCTTTC
CAGTTTCCAGTTCTCTATTCAGAAACTTGAACCTTTCCTAAGGGACACTAAGGGCTTCAGTCTTGAAAGTTTTAGAGCCAAAGCATCTTC
TCTTTCTGAAGAATTGAAACATTTTGCAGACGGACTGGAAACTGATGGAACTCTACAAAAATGTTTTGAAGATTCAAATGGAAAAGCATC
AGATTTTTCTTTGGAAGCATCTGTGGCTGAGATGAAGGAATACATAACAAAGTTTTCTTTAGAACGTCAGACTTGGGATCAGCTCTTGCT
TCACTACCAGCAGGAGGCTAAAGAGATATTGTCCAGAGGATCAACTGAGGCCAAAATTACTGAGGTCAAAGTGGAACCTATGACATATCT
TGGGTCTTCTCAGAATGAAGTTCTTAATACAAAACCTGACTACCAGAAAATATTACAGAACCAGAGCAAAGTCTTTGACTGTATGGAGTT
GGTGATGGATGAACTGCAAGGATCAGTGAAACAGCTGCAGGCCTTTATGGATGAAAGTACCCAGTGCTTCCAGAAGGTGTCAGTACAGCT
CGGTCTTTGAAGGTTTTCTTGATTCAAATGAGCTCTGCCAGTTTATAATGACTACATTTGATACCCTGAAAACCCTGAAACATCCCTGCA
TCCAGCGATCAGCAGGAGAATTACTGCTAACTTTGGCAAAAAATACAGAGTCCCAATTTGAGAAGGTGCCAGAAATTATGGGAGTTATCT
GTGCCCAGTTATCCATAATCAGCCAGCCTAGAGTCCGCCAACAAATCATAAATACCGTGAGTTTATTTATATCCAGACCCAAGTACACAG
ATATAGTGCTCAGCTTCCTTCTGTGTCATCCAGTGCCGTATAACAGGCACCTGGCTGAGGTGTGGAGAATGCTGTCGGTGGAGCTTCCCA
GCACGACCTGGATTCTGTGGAGGCTCCTGAGGAAGCTGCAGAAATGCCATAATGAGCCTGCACAGGAGAAGATGGCATATGTGGCTGTGG
CTGCAACAGATGCCCTTTATGAGGTGTTTTTGGGAAACAGGCTTCGAGCAGCTACGTTCCGACTCTTTCCTCAGCTTCTCATGACACTGC
TTATCCAGATTCATCACAGCATCGGCCTCACCATGTCTGATGTCGACATCCCAAGTGGCCTGTACACAGAACAGGAAGTGCCTTCAGAGG
TCACCCCTTTGTGCTTTGCCATGCAGGCTACAAAGACTCTCCTCCTCAGAACATGCTGCTTGCAGGAATTCAACATCATGGAAAAGAATA
AAGGATGGGCTCTCCTGGGAGGAAAAGATGGCCATCTTCAGGGACTATTTCTCCTTGCCAACGCATTGCTGGAAAGAAATCAGCTCCTTG
CACAGAAGGTCATGTACTTATTAGTCCCTCTTCTTAACCGAGGGAATGATAAACATAAACTCACATCTGCAGGCTTTTTTGTGGAGCTTC
TCCGGAGTCCAGTGGCCAAGAGACTGCCCAGCATATACTCTGTTGCCCGCTTTAAAGACTGGCTACAAGATGGAAATCATCTCTTTAGAA
TTCTCGGCCTGAGGGGACTGTACAATCTTGTTGGACACCAGGAGATGAGAGAAGACATCAAGAGCCTGTTGCCATACATTGTAGACAGCT
TGCGTGAAACCGATGAGAAGATCGTTCTGTCAGCCATCCAGATACTCCTGCAACTTGTTAGAACAATGGATTTCACTACCCTGGCTGCCA
TGATGAGGACCCTGTTCTCCTTATTTGGTGATGTGAGATCTGATGTTCATCGTTTCTCCGTGACTCTCTTTGGAGCCGCCATAAAGTCTG
TAAAAAACCCAGATAAGAAGAGTATAGAGAACCAAGTCCTGGACAGCTTGGTCCCACTACTTCTGTATTCTCAGGATGAAAATGATGCAG
TAGCTGAGGAGAGCAGGCAAGTCCTAACTATATGTGCCCAGTTCCTGAAGTGGAAGCTGCCCCAAGAAGTGTACTCCAAAGATCCCTGGC
ACATCAAACCTACTGAAGCAGGAACAATCTGCAGATTCTTTGGAAAAAAAGTGCAAGGGGAAAATTAACATCCTAGAACAAACACTGATG
TACTCCAAGAACCCAAAACTTCCCATCAGAAGATCAGCAGTCTTGTTTGTAGGCCTTTTATCGAAGTACATGGATCACAATGAGCTCAGG
AGGATGGGTACTGACTGGATAGAGGACGATCTGAGAGACCTGCTGTGTGACCCTGAGCCCTCGCTGTGCATCATCGCTTCCCAGACTCTG
TTACTAGTCCAGATGGCGAGGGCCGAACCAAAACCTAAGCAGAGAGTGAACTGGTTGCAGAAGCTCATGGGCAGGTCCTCTGCCTAGAAA
CACAAGGCAAGCAACATCAGAGACAGAATCTTGCTATGTTGTGCGGCAAGCTAGTCTTGAACTCATGGCCTCAAGTCATCCTCCTGTGTC
AGCCTCCCAAAGTGCTGGGATTACAAGCATGCACCACGGCACCCAGCAGAATTCCAGTCTTGAGAAACAGGTCAAGGACAGCTTCAAAAG

>24258_24258_1_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373734_MROH8_chr20_35769717_ENST00000441008_length(amino acids)=515AA_BP=14
MKVPSASRRCQYSSVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSIISQPRVRQQII
NTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRA
ATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLF
LLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMR
EDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSL

--------------------------------------------------------------
>24258_24258_2_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373740_MROH8_chr20_35769717_ENST00000441008_length(transcript)=2829nt_BP=819nt
GCAAGGCGTCCAGGAGTGACCTGGGGCTGTGGAGAGCGACCCGTGGCCTTGTGTTTCAGAGTTTACCACCTAGGATGACTTCAGTGACTA
GATCAGAGATCATAGATGAACAATCTGCCAGTTATCAAGACAGGAGGCAATCCTGGCGGCGAGCAAGTATGAAAGAAACGAACCGGCGGA
AGTCGCTGCATCCCATTCACCAGGGCATCACAGAGCTCAGCCGGTCTATCAGTGTCGATTTAGCAGAAAGCAAACGGCTTGGCTGTCTCC
TGCTTTCCAGTTTCCAGTTCTCTATTCAGAAACTTGAACCTTTCCTAAGGGACACTAAGGGCTTCAGTCTTGAAAGTTTTAGAGCCAAAG
CATCTTCTCTTTCTGAAGAATTGAAACATTTTGCAGACGGACTGGAAACTGATGGAACTCTACAAAAATGTTTTGAAGATTCAAATGGAA
AAGCATCAGATTTTTCTTTGGAAGCATCTGTGGCTGAGATGAAGGAATACATAACAAAGTTTTCTTTAGAACGTCAGACTTGGGATCAGC
TCTTGCTTCACTACCAGCAGGAGGCTAAAGAGATATTGTCCAGAGGATCAACTGAGGCCAAAATTACTGAGGTCAAAGTGGAACCTATGA
CATATCTTGGGTCTTCTCAGAATGAAGTTCTTAATACAAAACCTGACTACCAGAAAATATTACAGAACCAGAGCAAAGTCTTTGACTGTA
TGGAGTTGGTGATGGATGAACTGCAAGGATCAGTGAAACAGCTGCAGGCCTTTATGGATGAAAGTACCCAGTGCTTCCAGAAGGTGTCAG
TACAGCTCGGTCTTTGAAGGTTTTCTTGATTCAAATGAGCTCTGCCAGTTTATAATGACTACATTTGATACCCTGAAAACCCTGAAACAT
CCCTGCATCCAGCGATCAGCAGGAGAATTACTGCTAACTTTGGCAAAAAATACAGAGTCCCAATTTGAGAAGGTGCCAGAAATTATGGGA
GTTATCTGTGCCCAGTTATCCATAATCAGCCAGCCTAGAGTCCGCCAACAAATCATAAATACCGTGAGTTTATTTATATCCAGACCCAAG
TACACAGATATAGTGCTCAGCTTCCTTCTGTGTCATCCAGTGCCGTATAACAGGCACCTGGCTGAGGTGTGGAGAATGCTGTCGGTGGAG
CTTCCCAGCACGACCTGGATTCTGTGGAGGCTCCTGAGGAAGCTGCAGAAATGCCATAATGAGCCTGCACAGGAGAAGATGGCATATGTG
GCTGTGGCTGCAACAGATGCCCTTTATGAGGTGTTTTTGGGAAACAGGCTTCGAGCAGCTACGTTCCGACTCTTTCCTCAGCTTCTCATG
ACACTGCTTATCCAGATTCATCACAGCATCGGCCTCACCATGTCTGATGTCGACATCCCAAGTGGCCTGTACACAGAACAGGAAGTGCCT
TCAGAGGTCACCCCTTTGTGCTTTGCCATGCAGGCTACAAAGACTCTCCTCCTCAGAACATGCTGCTTGCAGGAATTCAACATCATGGAA
AAGAATAAAGGATGGGCTCTCCTGGGAGGAAAAGATGGCCATCTTCAGGGACTATTTCTCCTTGCCAACGCATTGCTGGAAAGAAATCAG
CTCCTTGCACAGAAGGTCATGTACTTATTAGTCCCTCTTCTTAACCGAGGGAATGATAAACATAAACTCACATCTGCAGGCTTTTTTGTG
GAGCTTCTCCGGAGTCCAGTGGCCAAGAGACTGCCCAGCATATACTCTGTTGCCCGCTTTAAAGACTGGCTACAAGATGGAAATCATCTC
TTTAGAATTCTCGGCCTGAGGGGACTGTACAATCTTGTTGGACACCAGGAGATGAGAGAAGACATCAAGAGCCTGTTGCCATACATTGTA
GACAGCTTGCGTGAAACCGATGAGAAGATCGTTCTGTCAGCCATCCAGATACTCCTGCAACTTGTTAGAACAATGGATTTCACTACCCTG
GCTGCCATGATGAGGACCCTGTTCTCCTTATTTGGTGATGTGAGATCTGATGTTCATCGTTTCTCCGTGACTCTCTTTGGAGCCGCCATA
AAGTCTGTAAAAAACCCAGATAAGAAGAGTATAGAGAACCAAGTCCTGGACAGCTTGGTCCCACTACTTCTGTATTCTCAGGATGAAAAT
GATGCAGTAGCTGAGGAGAGCAGGCAAGTCCTAACTATATGTGCCCAGTTCCTGAAGTGGAAGCTGCCCCAAGAAGTGTACTCCAAAGAT
CCCTGGCACATCAAACCTACTGAAGCAGGAACAATCTGCAGATTCTTTGGAAAAAAAGTGCAAGGGGAAAATTAACATCCTAGAACAAAC
ACTGATGTACTCCAAGAACCCAAAACTTCCCATCAGAAGATCAGCAGTCTTGTTTGTAGGCCTTTTATCGAAGTACATGGATCACAATGA
GCTCAGGAGGATGGGTACTGACTGGATAGAGGACGATCTGAGAGACCTGCTGTGTGACCCTGAGCCCTCGCTGTGCATCATCGCTTCCCA
GACTCTGTTACTAGTCCAGATGGCGAGGGCCGAACCAAAACCTAAGCAGAGAGTGAACTGGTTGCAGAAGCTCATGGGCAGGTCCTCTGC
CTAGAAACACAAGGCAAGCAACATCAGAGACAGAATCTTGCTATGTTGTGCGGCAAGCTAGTCTTGAACTCATGGCCTCAAGTCATCCTC
CTGTGTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGCACCACGGCACCCAGCAGAATTCCAGTCTTGAGAAACAGGTCAAGGACAGCT

>24258_24258_2_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373740_MROH8_chr20_35769717_ENST00000441008_length(amino acids)=515AA_BP=14
MKVPSASRRCQYSSVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSIISQPRVRQQII
NTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRA
ATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLF
LLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMR
EDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSL

--------------------------------------------------------------
>24258_24258_3_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373750_MROH8_chr20_35769717_ENST00000441008_length(transcript)=3140nt_BP=1130nt
TGCGCCCTTGGTTGGCGGGAGTTTCGGAGGCGGTGACCGTGACGTAGAAGGTGGAGACCGCTTCACCCTGATCAGGGAGTATCGGCTGCG
GGTGCGCAAGGCGTCCAGGAGTGACCTGGGGCTGTGGAGAGCGACCCGTGGCCTTGTGTTTCAGAGTTTACCACCTAGGATGACTTCAGT
GACTAGATCAGAGATCATAGATGAAAAAGGACCAGTGATGTCTAAGACTCATGATCATCAATTGGAATCAAGTCTCAGTCCTGTGGAAGT
GTTTGCTAAAACATCTGCCTCCCTGGAGATGAATCAAGGCGTTTCAGAGGAAAGAATTCACCTTGGCTCTAGCCCTAAAAAAGGGGGAAA
TTGTGATCTCAGCCACCAGGAAAGACTTCAGTCGAAGTCCCTTCATTTGTCTCCTCAAGAACAATCTGCCAGTTATCAAGACAGGAGGCA
ATCCTGGCGGCGAGCAAGTATGAAAGAAACGAACCGGCGGAAGTCGCTGCATCCCATTCACCAGGGCATCACAGAGCTCAGCCGGTCTAT
CAGTGTCGATTTAGCAGAAAGCAAACGGCTTGGCTGTCTCCTGCTTTCCAGTTTCCAGTTCTCTATTCAGAAACTTGAACCTTTCCTAAG
GGACACTAAGGGCTTCAGTCTTGAAAGTTTTAGAGCCAAAGCATCTTCTCTTTCTGAAGAATTGAAACATTTTGCAGACGGACTGGAAAC
TGATGGAACTCTACAAAAATGTTTTGAAGATTCAAATGGAAAAGCATCAGATTTTTCTTTGGAAGCATCTGTGGCTGAGATGAAGGAATA
CATAACAAAGTTTTCTTTAGAACGTCAGACTTGGGATCAGCTCTTGCTTCACTACCAGCAGGAGGCTAAAGAGATATTGTCCAGAGGATC
AACTGAGGCCAAAATTACTGAGGTCAAAGTGGAACCTATGACATATCTTGGGTCTTCTCAGAATGAAGTTCTTAATACAAAACCTGACTA
CCAGAAAATATTACAGAACCAGAGCAAAGTCTTTGACTGTATGGAGTTGGTGATGGATGAACTGCAAGGATCAGTGAAACAGCTGCAGGC
CTTTATGGATGAAAGTACCCAGTGCTTCCAGAAGGTGTCAGTACAGCTCGGTCTTTGAAGGTTTTCTTGATTCAAATGAGCTCTGCCAGT
TTATAATGACTACATTTGATACCCTGAAAACCCTGAAACATCCCTGCATCCAGCGATCAGCAGGAGAATTACTGCTAACTTTGGCAAAAA
ATACAGAGTCCCAATTTGAGAAGGTGCCAGAAATTATGGGAGTTATCTGTGCCCAGTTATCCATAATCAGCCAGCCTAGAGTCCGCCAAC
AAATCATAAATACCGTGAGTTTATTTATATCCAGACCCAAGTACACAGATATAGTGCTCAGCTTCCTTCTGTGTCATCCAGTGCCGTATA
ACAGGCACCTGGCTGAGGTGTGGAGAATGCTGTCGGTGGAGCTTCCCAGCACGACCTGGATTCTGTGGAGGCTCCTGAGGAAGCTGCAGA
AATGCCATAATGAGCCTGCACAGGAGAAGATGGCATATGTGGCTGTGGCTGCAACAGATGCCCTTTATGAGGTGTTTTTGGGAAACAGGC
TTCGAGCAGCTACGTTCCGACTCTTTCCTCAGCTTCTCATGACACTGCTTATCCAGATTCATCACAGCATCGGCCTCACCATGTCTGATG
TCGACATCCCAAGTGGCCTGTACACAGAACAGGAAGTGCCTTCAGAGGTCACCCCTTTGTGCTTTGCCATGCAGGCTACAAAGACTCTCC
TCCTCAGAACATGCTGCTTGCAGGAATTCAACATCATGGAAAAGAATAAAGGATGGGCTCTCCTGGGAGGAAAAGATGGCCATCTTCAGG
GACTATTTCTCCTTGCCAACGCATTGCTGGAAAGAAATCAGCTCCTTGCACAGAAGGTCATGTACTTATTAGTCCCTCTTCTTAACCGAG
GGAATGATAAACATAAACTCACATCTGCAGGCTTTTTTGTGGAGCTTCTCCGGAGTCCAGTGGCCAAGAGACTGCCCAGCATATACTCTG
TTGCCCGCTTTAAAGACTGGCTACAAGATGGAAATCATCTCTTTAGAATTCTCGGCCTGAGGGGACTGTACAATCTTGTTGGACACCAGG
AGATGAGAGAAGACATCAAGAGCCTGTTGCCATACATTGTAGACAGCTTGCGTGAAACCGATGAGAAGATCGTTCTGTCAGCCATCCAGA
TACTCCTGCAACTTGTTAGAACAATGGATTTCACTACCCTGGCTGCCATGATGAGGACCCTGTTCTCCTTATTTGGTGATGTGAGATCTG
ATGTTCATCGTTTCTCCGTGACTCTCTTTGGAGCCGCCATAAAGTCTGTAAAAAACCCAGATAAGAAGAGTATAGAGAACCAAGTCCTGG
ACAGCTTGGTCCCACTACTTCTGTATTCTCAGGATGAAAATGATGCAGTAGCTGAGGAGAGCAGGCAAGTCCTAACTATATGTGCCCAGT
TCCTGAAGTGGAAGCTGCCCCAAGAAGTGTACTCCAAAGATCCCTGGCACATCAAACCTACTGAAGCAGGAACAATCTGCAGATTCTTTG
GAAAAAAAGTGCAAGGGGAAAATTAACATCCTAGAACAAACACTGATGTACTCCAAGAACCCAAAACTTCCCATCAGAAGATCAGCAGTC
TTGTTTGTAGGCCTTTTATCGAAGTACATGGATCACAATGAGCTCAGGAGGATGGGTACTGACTGGATAGAGGACGATCTGAGAGACCTG
CTGTGTGACCCTGAGCCCTCGCTGTGCATCATCGCTTCCCAGACTCTGTTACTAGTCCAGATGGCGAGGGCCGAACCAAAACCTAAGCAG
AGAGTGAACTGGTTGCAGAAGCTCATGGGCAGGTCCTCTGCCTAGAAACACAAGGCAAGCAACATCAGAGACAGAATCTTGCTATGTTGT
GCGGCAAGCTAGTCTTGAACTCATGGCCTCAAGTCATCCTCCTGTGTCAGCCTCCCAAAGTGCTGGGATTACAAGCATGCACCACGGCAC

>24258_24258_3_DSN1-MROH8_DSN1_chr20_35383166_ENST00000373750_MROH8_chr20_35769717_ENST00000441008_length(amino acids)=515AA_BP=14
MKVPSASRRCQYSSVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVPEIMGVICAQLSIISQPRVRQQII
NTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVWRMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRA
ATFRLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRTCCLQEFNIMEKNKGWALLGGKDGHLQGLF
LLANALLERNQLLAQKVMYLLVPLLNRGNDKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQEMR
EDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDVRSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSL

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Fusion Gene PPI Analysis for DSN1-MROH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSN1-MROH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSN1-MROH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource