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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSN1-SOGA1 (FusionGDB2 ID:24259)

Fusion Gene Summary for DSN1-SOGA1

check button Fusion gene summary
Fusion gene informationFusion gene name: DSN1-SOGA1
Fusion gene ID: 24259
HgeneTgene
Gene symbol

DSN1

SOGA1

Gene ID

79980

140710

Gene nameDSN1 component of MIS12 kinetochore complexsuppressor of glucose, autophagy associated 1
SynonymsC20orf172|KNL3|MIS13|dJ469A13.2|hKNL-3C20orf117|KIAA0889|SOGA
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionkinetochore-associated protein DSN1 homologDSN1 homolog, MIS12 kinetochore complex componentDSN1, MIND kinetochore complex component, homologDSN1, MIS12 kinetochore complex componentkinetochore null 3 homologprotein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1
Modification date2020032020200313
UniProtAcc

Q9H410

O94964

Ensembl transtripts involved in fusion geneENST00000373734, ENST00000373740, 
ENST00000373745, ENST00000373750, 
ENST00000426836, ENST00000448110, 
ENST00000473615, 		ENST00000279034, 
ENST00000357779, ENST00000456801, 
ENST00000237536, 
Fusion gene scores* DoF score5 X 5 X 4=10010 X 10 X 4=400
# samples 612
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSN1 [Title/Abstract] AND SOGA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSN1(35383166)-SOGA1(35415040), # samples:2
Anticipated loss of major functional domain due to fusion event.DSN1-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DSN1-SOGA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DSN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SOGA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TS-01ADSN1chr20

35383166

-SOGA1chr20

35415040

-
ChimerDB4BRCATCGA-AR-A0TSDSN1chr20

35383165

-SOGA1chr20

35415040

-


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Fusion Gene ORF analysis for DSN1-SOGA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373734ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373734ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373734ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373734ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373734ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373734ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373740ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373745ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000373750ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000426836ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5CDS-intronENST00000448110ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
5UTR-3CDSENST00000473615ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
5UTR-3CDSENST00000473615ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000279034DSN1chr20

35383166

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000279034DSN1chr20

35383165

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000357779DSN1chr20

35383166

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000357779DSN1chr20

35383165

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000456801DSN1chr20

35383166

-SOGA1chr20

35415040

-
5UTR-intronENST00000473615ENST00000456801DSN1chr20

35383165

-SOGA1chr20

35415040

-
Frame-shiftENST00000373745ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
Frame-shiftENST00000373745ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
Frame-shiftENST00000426836ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
Frame-shiftENST00000426836ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
Frame-shiftENST00000448110ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
Frame-shiftENST00000448110ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
In-frameENST00000373734ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
In-frameENST00000373734ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
In-frameENST00000373740ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
In-frameENST00000373740ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-
In-frameENST00000373750ENST00000237536DSN1chr20

35383166

-SOGA1chr20

35415040

-
In-frameENST00000373750ENST00000237536DSN1chr20

35383165

-SOGA1chr20

35415040

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DSN1-SOGA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSN1-SOGA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35383166/chr20:35415040)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSN1

Q9H410

SOGA1

O94964

FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270}.FUNCTION: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DSN1-SOGA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DSN1-SOGA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSN1-SOGA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSN1-SOGA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource