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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DST-EYS (FusionGDB2 ID:24283)

Fusion Gene Summary for DST-EYS

Fusion gene summary

Fusion gene information	Fusion gene name: DST-EYS
	Fusion gene ID: 24283
		Hgene	Tgene
	Gene symbol	DST	EYS
	Gene ID	667	346007
	Gene name	dystonin	eyes shut homolog
	Synonyms	BP240\|BPA\|BPAG1\|CATX-15\|CATX15\|D6S1101\|DMH\|DT\|EBSB2\|HSAN6\|MACF2	C6orf178\|C6orf179\|C6orf180\|EGFL10\|EGFL11\|RP25\|SPAM\|bA166P24.2\|bA307F22.3\|bA74E24.1\|dJ1018A4.2\|dJ22I17.2\|dJ303F19.1
	Cytomap	6p12.1	6q12
	Type of gene	protein-coding	protein-coding
	Description	dystoninbullous pemphigoid antigen 1dystonia musculorum proteinhemidesmosomal plaque proteintrabeculin-beta	protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
	Modification date	20200313	20200313
	UniProtAcc	Q03001	Q5T1H1
	Ensembl transtripts involved in fusion gene	ENST00000312431, ENST00000244364, ENST00000361203, ENST00000370754, ENST00000370769, ENST00000370788, ENST00000421834, ENST00000446842, ENST00000340834, ENST00000370765, ENST00000518935,	ENST00000342421, ENST00000370618, ENST00000370621, ENST00000393380, ENST00000503581, ENST00000370616, ENST00000486069,
Fusion gene scores	* DoF score	28 X 24 X 12=8064	36 X 24 X 15=12960
	# samples	27	38
	** MAII score	log2(27/8064*10)=-4.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(38/12960*10)=-5.09192248944104 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DST [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DST(56391159)-EYS(66205886), # samples:2
Anticipated loss of major functional domain due to fusion event.	DST-EYS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DST	GO:0009611	response to wounding	19403692

Fusion gene breakpoints across DST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EYS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0216-01B	DST	chr6	56716195	-	EYS	chr6	64574251	-
ChimerDB4	LIHC	TCGA-UB-A7MA-01A	DST	chr6	56391159	-	EYS	chr6	66205886	-

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Fusion Gene ORF analysis for DST-EYS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000312431	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-5UTR	ENST00000312431	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-5UTR	ENST00000312431	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-5UTR	ENST00000312431	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-5UTR	ENST00000312431	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-intron	ENST00000312431	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
3UTR-intron	ENST00000312431	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000244364	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000244364	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000244364	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000244364	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000244364	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000361203	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000361203	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000361203	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000361203	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000361203	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370754	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370754	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370754	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370754	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370754	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370769	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370769	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370769	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370769	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370769	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370788	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370788	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370788	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370788	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000370788	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000421834	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000421834	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000421834	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000421834	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000421834	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000446842	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000446842	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000446842	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000446842	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-5UTR	ENST00000446842	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000244364	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000244364	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000361203	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000361203	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370754	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
5CDS-intron	ENST00000370754	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370754	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
5CDS-intron	ENST00000370754	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
5CDS-intron	ENST00000370754	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
5CDS-intron	ENST00000370754	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370769	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370769	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370788	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000370788	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000421834	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000421834	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000446842	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5CDS-intron	ENST00000446842	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-5UTR	ENST00000340834	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-5UTR	ENST00000340834	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-5UTR	ENST00000340834	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-5UTR	ENST00000340834	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-5UTR	ENST00000340834	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-intron	ENST00000340834	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
5UTR-intron	ENST00000340834	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
Frame-shift	ENST00000370754	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
Frame-shift	ENST00000370754	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
Frame-shift	ENST00000370754	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000244364	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000244364	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000244364	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000312431	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000312431	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000312431	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000340834	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000340834	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000340834	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000361203	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000361203	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000361203	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370765	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370765	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370765	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370769	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370769	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370769	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370788	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370788	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000370788	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000421834	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000421834	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000421834	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000446842	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000446842	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000446842	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000518935	ENST00000370616	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000518935	ENST00000370621	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-3CDS	ENST00000518935	ENST00000503581	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-5UTR	ENST00000370765	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000370765	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000370765	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000370765	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000370765	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000518935	ENST00000342421	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000518935	ENST00000370618	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000518935	ENST00000370621	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000518935	ENST00000393380	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-5UTR	ENST00000518935	ENST00000503581	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-intron	ENST00000244364	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000244364	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000244364	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000244364	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000312431	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000312431	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000312431	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000312431	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000340834	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000340834	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000340834	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000340834	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000361203	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000361203	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000361203	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000361203	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370765	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370765	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-intron	ENST00000370765	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370765	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370765	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370765	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-intron	ENST00000370769	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370769	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370769	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370769	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370788	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370788	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370788	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000370788	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000421834	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000421834	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000421834	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000421834	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000446842	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000446842	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000446842	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000446842	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000518935	ENST00000342421	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000518935	ENST00000370616	DST	chr6	56391159	-	EYS	chr6	66205886	-
intron-intron	ENST00000518935	ENST00000370618	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000518935	ENST00000393380	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000518935	ENST00000486069	DST	chr6	56716195	-	EYS	chr6	64574251	-
intron-intron	ENST00000518935	ENST00000486069	DST	chr6	56391159	-	EYS	chr6	66205886	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DST-EYS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DST-EYS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:56391159/:66205886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DST Q03001	EYS Q5T1H1
FUNCTION: Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250\|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269\|PubMed:10428034, ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692}.; FUNCTION: [Isoform 7]: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.	FUNCTION: Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity). {ECO:0000250\|UniProtKB:B8JI71, ECO:0000269\|PubMed:18836446}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DST-EYS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DST-EYS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DST-EYS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DST-EYS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source