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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DSTN-MYO5C (FusionGDB2 ID:24311)

Fusion Gene Summary for DSTN-MYO5C

Fusion gene summary

Fusion gene information	Fusion gene name: DSTN-MYO5C
	Fusion gene ID: 24311
		Hgene	Tgene
	Gene symbol	DSTN	MYO5C
	Gene ID	11034	55930
	Gene name	destrin, actin depolymerizing factor	myosin VC
	Synonyms	ACTDP\|ADF\|HEL32\|bA462D18.2	-
	Cytomap	20p12.1	15q21.2
	Type of gene	protein-coding	protein-coding
	Description	destrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32epididymis secretory sperm binding protein	unconventional myosin-Vcmyosin 5Cmyosin-Vc
	Modification date	20200327	20200313
	UniProtAcc	P60981	Q9NQX4
	Ensembl transtripts involved in fusion gene	ENST00000246069, ENST00000474024,	ENST00000541028, ENST00000261839, ENST00000443683,
Fusion gene scores	* DoF score	18 X 10 X 11=1980	5 X 5 X 5=125
	# samples	24	7
	** MAII score	log2(24/1980*10)=-3.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DSTN [Title/Abstract] AND MYO5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DSTN(17550856)-MYO5C(52553324), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DSTN	GO:0030042	actin filament depolymerization	11812157

Fusion gene breakpoints across DSTN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8IM-01A	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
ChimerDB4	PRAD	TCGA-KK-A8IM	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
ChimerDB4	PRAD	TCGA-KK-A8IM	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-

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Fusion Gene ORF analysis for DSTN-MYO5C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000246069	ENST00000541028	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
5CDS-intron	ENST00000246069	ENST00000541028	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
5UTR-3CDS	ENST00000474024	ENST00000261839	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
5UTR-3CDS	ENST00000474024	ENST00000261839	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
5UTR-3CDS	ENST00000474024	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
5UTR-3CDS	ENST00000474024	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
5UTR-5UTR	ENST00000474024	ENST00000541028	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
5UTR-intron	ENST00000474024	ENST00000541028	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
Frame-shift	ENST00000246069	ENST00000261839	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-
In-frame	ENST00000246069	ENST00000261839	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
In-frame	ENST00000246069	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-
In-frame	ENST00000246069	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000246069	DSTN	chr20	17550856	+	ENST00000261839	MYO5C	chr15	52553324	-	6111	349	298	4530	1410
ENST00000246069	DSTN	chr20	17550856	+	ENST00000443683	MYO5C	chr15	52553324	-	2059	349	636	1685	349
ENST00000246069	DSTN	chr20	17550856	+	ENST00000443683	MYO5C	chr15	52548917	-	1833	349	287	1459	390

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000246069	ENST00000261839	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-	0.00107016	0.9989298
ENST00000246069	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52553324	-	0.007279767	0.99272025
ENST00000246069	ENST00000443683	DSTN	chr20	17550856	+	MYO5C	chr15	52548917	-	0.00679172	0.9932082

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Fusion Genomic Features for DSTN-MYO5C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DSTN-MYO5C

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:17550856/chr15:52553324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSTN P60981	MYO5C Q9NQX4
FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269\|PubMed:11812157}.	FUNCTION: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

884_1351

437

1743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

884_1351

349

1743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

1421_1697

437

1743.0

Domain

Dilute

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

756_779

437

1743.0

Domain

IQ 1

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

780_806

437

1743.0

Domain

IQ 2

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

807_829

437

1743.0

Domain

IQ 3

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

830_854

437

1743.0

Domain

IQ 4

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

855_884

437

1743.0

Domain

IQ 5

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

1421_1697

349

1743.0

Domain

Dilute

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

756_779

349

1743.0

Domain

IQ 1

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

780_806

349

1743.0

Domain

IQ 2

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

807_829

349

1743.0

Domain

IQ 3

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

830_854

349

1743.0

Domain

IQ 4

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

855_884

349

1743.0

Domain

IQ 5

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

632_654

437

1743.0

Region

Actin-binding

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

632_654

349

1743.0

Region

Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSTN

chr20:17550856

chr15:52548917

ENST00000246069

4_153

166.0

Domain

ADF-H

Hgene

DSTN

chr20:17550856

chr15:52553324

ENST00000246069

4_153

166.0

Domain

ADF-H

Hgene

DSTN

chr20:17550856

chr15:52548917

ENST00000246069

30_34

166.0

Motif

Nuclear localization signal

Hgene

DSTN

chr20:17550856

chr15:52553324

ENST00000246069

30_34

166.0

Motif

Nuclear localization signal

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

67_753

437

1743.0

Domain

Myosin motor

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

8_62

437

1743.0

Domain

Myosin N-terminal SH3-like

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

67_753

349

1743.0

Domain

Myosin motor

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

8_62

349

1743.0

Domain

Myosin N-terminal SH3-like

Tgene

MYO5C

chr20:17550856

chr15:52548917

ENST00000261839

161_168

437

1743.0

Nucleotide binding

ATP

Tgene

MYO5C

chr20:17550856

chr15:52553324

ENST00000261839

161_168

349

1743.0

Nucleotide binding

ATP

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Fusion Gene Sequence for DSTN-MYO5C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24311_24311_1_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52548917_ENST00000443683_length(transcript)=1833nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGTTTTGAAACCT
TTGATGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAATGAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAAC
AAGAAGAATACATGAAGGAAGATATACCTTGGACGCTGATAGATTTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGG
GAATTCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGAACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACA
GGAACCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTTGTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTT
TCCTGGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAAATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAG
AAAATCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTTAAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGA
CCACAGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATGGAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGC
CAAATGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATTGTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTA
GTGCACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTACAGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCG
ATAAAAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAGGATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAG
CAGGACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTGAGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCC
AGAGGAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATCCAGCAGTACTTCCGGGGTCAGCAAACTGTGAGAACAAAGAAAACCA
TGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTGGGGATGTGGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGC
AGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACAGGGATGCTGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTC
AGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAGAGAAGACTGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCA
GCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTCTTGAAAAAAGTTTTGAACTGAAAACACAAGACTATGAGAAGCAGAT

>24311_24311_1_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52548917_ENST00000443683_length(amino acids)=390AA_BP=21
MHTRCPPAPSPASLRPPRRRCFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELL
DEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPP
SPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYP
SRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFL

--------------------------------------------------------------
>24311_24311_2_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000261839_length(transcript)=6111nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGAGGATGACAG
TCACCTGAAGGTGTTCTGTGAGCTCCTGGGCCTGGAGAGTGGCAGAGTTGCTCAGTGGCTGTGCAATCGCAAAATCGTCACAAGCTCTGA
GACGGTGGTAAAACCCATGACCAGGCCTCAGGCTGTCAACGCCAGGGATGCACTGGCCAAAAAGATCTATGCTCACCTGTTCGACTTCAT
TGTGGAGAGAATTAACCAAGCGTTGCAGTTTTCAGGCAAGCAGCACACTTTTATTGGTGTTTTGGACATTTATGGTTTTGAAACCTTTGA
TGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAATGAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAACAAGA
AGAATACATGAAGGAAGATATACCTTGGACGCTGATAGATTTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGGGAAT
TCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGAACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACAGGAA
CCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTTGTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTTTCCT
GGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAAATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAGAAAA
TCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTTAAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGACCAC
AGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATGGAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGCCAAA
TGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATTGTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTAGTGC
ACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTACAGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCGATAA
AAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAGGATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAGCAGG
ACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTGAGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCCAGAG
GAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATCCAGCAGTACTTCCGGGGTCAGCAAACTGTGAGGAAAGCTATTACTGCAGT
GGCCTTAAAAGAAGCTTGGGCAGCCATAATCATTCAGAAGCACTGCCGCGGGTATCTTGTTCGCAGCCTGTATCAGTTGATTCGCATGGC
CACCATCACAATGCAGGCCTACAGCCGAGGATTCCTGGCAAGGAGGAGGTATCGAAAGATGCTGGAGGAACATAAGGCTGTGATCCTACA
GAAATACGCACGGGCGTGGCTGGCCAGACGCAGATTCCAGAGTATCCGACGATTCGTGCTTAATATTCAGCTTACTTACAGGGTCCAGCG
TTTGCAGAAAAAGTTGGAAGATCAGAACAAAGAAAACCATGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTGGGGATGT
GGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGCAGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACAGGGATGC
TGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTCAGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAGAGAAGAC
TGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCAGCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTCTTGAAAA
AAGTTTTGAACTGAAAACACAAGACTATGAGAAGCAGATTCAGTCTTTGAAAGAAGAAATTAAAGCTCTCAAGGATGAGAAGATGCAACT
CCAACACCTGGTGGAGGGGGAGCACGTCACTTCTGATGGCTTGAAGGCGGAAGTGGCCCGCCTGAGCAAGCAGGTCAAGACAATCTCTGA
GTTCGAAAAAGAGATAGAACTACTTCAGGCACAGAAGATAGATGTGGAGAAACATGTGCAGTCACAAAAACGGGAAATGAGAGAAAAGAT
GTCAGAGATCACCAAACAACTTCTCGAAAGCTATGACATTGAAGATGTAAGAAGCAGGCTCTCTGTGGAAGATCTGGAACATTTAAATGA
GGATGGAGAACTTTGGTTTGCTTATGAAGGACTAAAGAAAGCAACACGTGTTTTGGAGAGCCATTTCCAGTCTCAGAAGGATTGCTATGA
AAAGGAGATTGAAGCTTTGAACTTCAAAGTGGTGCATCTCAGTCAAGAAATCAACCACCTGCAGAAGTTATTCAGAGAAGAAAATGACAT
CAATGAAAGCATCCGTCATGAAGTTACCAGGCTAACATCAGAGAACATGATGATCCCAGACTTTAAACAGCAAATTTCAGAATTGGAGAA
ACAGAAGCAAGATCTTGAAATCCGCCTGAATGAACAAGCTGAGAAAATGAAAGGAAAACTAGAAGAATTGTCTAATCAGTTACATCGCAG
TCAAGAGGAGGAAGGAACACAAAGAAAGGCCTTGGAAGCCCAAAATGAAATACATACCAAAGAGAAGGAGAAGCTGATTGATAAGATTCA
AGAAATGCAGGAGGCCAGTGACCACTTGAAGAAACAATTTGAAACTGAAAGTGAAGTCAAGTGTAACTTCCGGCAGGAAGCATCCCGGCT
CACTTTGGAAAACAGGGATCTTGAAGAAGAATTAGACATGAAAGACAGAGTGATTAAAAAGCTACAAGATCAAGTCAAGACACTAAGCAA
GACAATTGGAAAAGCCAATGATGTGCACTCGTCCTCAGGACCCAAGGAGTACCTTGGAATGCTGCAATACAAGAGAGAAGACGAGGCCAA
GCTCATTCAGAACCTCATTCTTGACTTGAAGCCCCGTGGCGTGGTGGTGAACATGATCCCCGGGCTGCCGGCTCATATCCTGTTCATGTG
TGTGCGCTACGCAGACTCTCTGAATGATGCCAACATGCTGAAGTCCCTCATGAACAGCACCATTAATGGCATCAAGCAGGTGGTTAAGGA
ACATTTAGAAGACTTTGAAATGCTGTCCTTTTGGCTTTCCAACACTTGTCATTTTCTCAATTGCCTGAAGCAGTACAGCGGAGAAGAGGA
ATTCATGAAGCATAATAGTCCACAGCAGAATAAGAATTGCTTGAACAATTTTGACCTTTCAGAATACAGACAGATTCTCAGTGATGTGGC
TATACGAATATATCATCAATTTATTATCATAATGGAAAAGAATATCCAACCGATAATAGTTCCGGGAATGCTGGAGTATGAGAGCCTGCA
GGGCATTTCCGGCCTGAAGCCCACAGGCTTCCGGAAGCGCTCCTCTAGCATAGACGACACGGACGGCTACACCATGACCTCCGTCCTGCA
ACAGCTGAGCTACTTTTACACCACCATGTGCCAGAACGGCCTGGACCCCGAGCTTGTGAGGCAGGCGGTGAAGCAGCTCTTCTTCTTGAT
CGGGGCGGTCACGCTGAACAGCCTCTTCCTGCGCAAGGACATGTGCTCCTGCAGAAAAGGGATGCAGATCAGGTGCAATATCAGCTACTT
AGAAGAATGGCTTAAAGATAAGAACTTGCAGAACAGCTTAGCAAAGGAAACTTTGGAGCCCCTCTCTCAGGCAGCCTGGTTGCTTCAGGT
CAAGAAGACCACAGACAGTGATGCCAAGGAGATCTACGAACGCTGCACCTCACTGTCTGCTGTGCAGATCATAAAGATCCTTAATTCATA
CACACCTATAGATGACTTTGAGAAGAGAGTGACTCCATCCTTTGTTCGCAAAGTACAGGCTCTCCTAAATAGCCGGGAGGATTCATCACA
GCTGATGTTGGATACCAAATATCTCTTTCAAGTCACATTTCCTTTTACCCCCTCTCCACATGCTCTGGAAATGATTCAGATCCCCAGCAG
TTTCAAGCTAGGCTTTCTGAATAGGTTATAGCAGGAGAAAAAGTCAATGCACTTTTTCTTCAAAAGCTAAGTGAAGGTTCAATATGAGGG
ATGTGTTTTATTAATTGGCAGTGGAAATTGGAATGTGATTTAAGGAAGAAAACAGACTTTTCTCAAATGGACCACATCATCTCTCACTCA
CAGTGACAATGCTGCTCCTGTAATTTTGTAAGAATTCACACACACCAGCTGTATTTGGAAAAGCCATGTCTCACTCTCGAATCTCAGCTG
GTTTTCACTGAAATTCCTGGAGGGCTCATATTTTCTTCCACGTGCCTCTTGATCTGTTCTGTCTTGTGGCAGGGCTCTACCAGGAGGGAG
TGAGATCTGGGGACACAGTGGCTTCCAAGTTTTCTAAGGTTCATGTGAAACCTGAGTACATTTACAAAGCTGCAAGTGGATTCTAGTGCT
GAGTCTTCCAGGAAAAAATCCCGTTTGGCCACCGTGACCTGCCAAAAGTTCTCTTGCCCCATGCCTGCTGGGGACAGAAGGTTTTCATGA
ACTCTTTTTACTGAAAATGCCCTGCATTTAAAAATGTTTATTTTAGACCCTTCTAAATTTTTTTTTTTTTTTTTTTTTGAGACTCCGGAG
TCTCGCTCTATCGCCAGGCTGGAGTGTAGTGGCATGATCTCGGCTTATTGCAACCTCCGCTTCCTGGGTTCAAACAATTCTCCTGCCTCA
GCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTGGAGACAGGTTTCACCATGTTGGCC
AGGATGGCCTCGATCTCTTGACCTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGTGCCACCGCGCCCGGCTG
ACCCTTTTAATTTTTAAGAGTGTTCAATCCGAGATGAATCATTTGAAGTATTTTTATATGTATATCTATTTAAAACTAATATATTATTAA
AGCTTAATTGCCATGCCGTTTATCTTCTCTGAAAGAACTTCAAATCTTACCTGCCAACATATTCACCATAATTTTTTTATTTTTTAATAC
CTTTCATACAATAACTTTTTTAAAACAACCTCAGATTGAAAAAGCAACCTAAATTACTTTCGCTCTCTAATCAGCATTTCAATGTATTTA
TTTTTAAATTTTCTCAAAAAGTAACTAAAAAATTGTGTCGGACCCTACTTTTGAGAAATCTACGTTTCCCAAGTTTTATGGGAACTGGCT
ATTCCTTGTCCCGGCACACCTTCTCATTCCTTCCTTTCAGAGCCTAAAACCTCATTTGATAAGCACTCCTAGTCTCTGGCCTGTGGATCC
AGTGCTATTCTGTCACCAACCTAAGAATCCCAATTGCACCTTCTGTTTCTGACAGTCACAGGTGACAGCTGTGATTCTATAATACAGACT
GGTGTCTTAGAGGTAGGAATAATACATGATTATGAAGCATCACCCTGCTAATACATAATAATGTCTTTTTATATTATAAGTGATTGAGTT

>24311_24311_2_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000261839_length(amino acids)=1410AA_BP=17
MPAGSLPRVPATAAAKMEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQ
FSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECL
LPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGS
MITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTY
IEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFLRERRA
ALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLAR
RRFQSIRRFVLNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKLQ
KHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHV
TSDGLKAEVARLSKQVKTISEFEKEIELLQAQKIDVEKHVQSQKREMREKMSEITKQLLESYDIEDVRSRLSVEDLEHLNEDGELWFAYE
GLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRL
NEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQNEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDLEE
ELDMKDRVIKKLQDQVKTLSKTIGKANDVHSSSGPKEYLGMLQYKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLND
ANMLKSLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFII
IMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLF
LRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKR

--------------------------------------------------------------
>24311_24311_3_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000443683_length(transcript)=2059nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGAGGATGACAG
TCACCTGAAGGTGTTCTGTGAGCTCCTGGGCCTGGAGAGTGGCAGAGTTGCTCAGTGGCTGTGCAATCGCAAAATCGTCACAAGCTCTGA
GACGGTGGTAAAACCCATGACCAGGCCTCAGGCTGTCAACGCCAGGGATGCACTGGCCAAAAAGATCTATGCTCACCTGTTCGACTTCAT
TGTGGAGAGAATTAACCAAGCGTTGCAGTTTTCAGTTTTGAAACCTTTGATGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAAT
GAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAACAAGAAGAATACATGAAGGAAGATATACCTTGGACGCTGATAGAT
TTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGGGAATTCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGA
ACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACAGGAACCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTT
GTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTTTCCTGGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAA
ATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAGAAAATCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTT
AAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGACCACAGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATG
GAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGCCAAATGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATT
GTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTAGTGCACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTAC
AGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCGATAAAAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAG
GATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAGCAGGACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTG
AGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCCAGAGGAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATC
CAGCAGTACTTCCGGGGTCAGCAAACTGTGAGAACAAAGAAAACCATGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTG
GGGATGTGGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGCAGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACA
GGGATGCTGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTCAGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAG
AGAAGACTGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCAGCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTC

>24311_24311_3_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000443683_length(amino acids)=349AA_BP=
MQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVI
QHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMET
LNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DSTN-MYO5C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DSTN-MYO5C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DSTN-MYO5C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source