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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DTD1-KIF16B (FusionGDB2 ID:24338)

Fusion Gene Summary for DTD1-KIF16B

Fusion gene summary

Fusion gene information	Fusion gene name: DTD1-KIF16B
	Fusion gene ID: 24338
		Hgene	Tgene
	Gene symbol	DTD1	KIF16B
	Gene ID	92675	55614
	Gene name	D-aminoacyl-tRNA deacylase 1	kinesin family member 16B
	Synonyms	C20orf88\|DTD\|DUE-B\|DUEB\|HARS2\|pqn-68	C20orf23\|KISC20ORF\|SNX23
	Cytomap	20p11.23	20p12.1
	Type of gene	protein-coding	protein-coding
	Description	D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2	kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
	Modification date	20200313	20200313
	UniProtAcc	Q8TEA8	Q96L93
	Ensembl transtripts involved in fusion gene	ENST00000494921, ENST00000377452,	ENST00000354981, ENST00000355755, ENST00000378003, ENST00000408042,
Fusion gene scores	* DoF score	10 X 7 X 6=420	7 X 5 X 6=210
	# samples	10	8
	** MAII score	log2(10/420*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DTD1 [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DTD1(18608877)-KIF16B(16496309), # samples:5
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DTD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIF16B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-8469-01A	DTD1	chr20	18608877	-	KIF16B	chr20	16496309	-
ChimerDB4	PRAD	TCGA-EJ-8469-01A	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
ChimerDB4	PRAD	TCGA-EJ-8469	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-

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Fusion Gene ORF analysis for DTD1-KIF16B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000494921	ENST00000354981	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
3UTR-5UTR	ENST00000494921	ENST00000355755	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
3UTR-5UTR	ENST00000494921	ENST00000378003	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
3UTR-5UTR	ENST00000494921	ENST00000408042	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
5CDS-5UTR	ENST00000377452	ENST00000355755	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
5CDS-5UTR	ENST00000377452	ENST00000378003	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
5CDS-5UTR	ENST00000377452	ENST00000408042	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-
In-frame	ENST00000377452	ENST00000354981	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000377452

DTD1

chr20

18608877

ENST00000354981

KIF16B

chr20

16496309

5529

657

180

4379

1399

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377452	ENST00000354981	DTD1	chr20	18608877	+	KIF16B	chr20	16496309	-	0.002050012	0.99795

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Fusion Genomic Features for DTD1-KIF16B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DTD1-KIF16B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:18608877/chr20:16496309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DTD1 Q8TEA8	KIF16B Q96L93
FUNCTION: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269\|PubMed:15653697, ECO:0000269\|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250\|UniProtKB:Q8IIS0}.	FUNCTION: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269\|PubMed:15882625}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DTD1

chr20:18608877

chr20:16496309

ENST00000377452

139_140

159

321.6666666666667

Motif

Gly-cisPro motif%2C important for rejection of L-amino acids

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

370_425

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

595_882

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

936_1087

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

370_425

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

595_882

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

936_1087

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

370_425

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

595_882

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

936_1087

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

597_1070

1318.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

597_1070

1288.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

597_1070

1393.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

1182_1296

1318.0

Domain

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

478_529

1318.0

Domain

Note=FHA

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

1182_1296

1288.0

Domain

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

478_529

1288.0

Domain

Note=FHA

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

1182_1296

1393.0

Domain

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

478_529

1393.0

Domain

Note=FHA

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

102_109

1318.0

Nucleotide binding

ATP

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

102_109

1288.0

Nucleotide binding

ATP

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

102_109

1393.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000354981

3_358

1318.0

Domain

Kinesin motor

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000355755

3_358

1288.0

Domain

Kinesin motor

Tgene

KIF16B

chr20:18608877

chr20:16496309

ENST00000408042

3_358

1393.0

Domain

Kinesin motor

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Fusion Gene Sequence for DTD1-KIF16B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24338_24338_1_DTD1-KIF16B_DTD1_chr20_18608877_ENST00000377452_KIF16B_chr20_16496309_ENST00000354981_length(transcript)=5529nt_BP=657nt
CTATCGCCAGGCCGAGAGTGGGCGTGGCCGACGTGGGGTGGGTAGCAGCCGACCGAGTCGGACCGGCCAGTTGGGCGCGCTTCCGGGTGT
CACCTCCAGAGGGCGCCGGCTGCGGAGCCGCCCTCAGAGTCGCGAGGCCGGACGCAGCGCGGCGCCGCCCCACTCGCCCCAGCCGCCGCC
ATGAAGGCCGTGGTGCAGCGCGTCACCCGGGCCAGCGTCACAGTTGGAGGAGAGCAGATTAGTGCCATTGGAAGGGGCATATGTGTGTTG
CTGGGTATTTCCCTGGAGGATACGCAGAAGGAACTGGAACACATGGTCCGAAAGATTCTAAACCTGCGTGTATTTGAGGATGAGAGTGGG
AAGCACTGGTCGAAGAGTGTGATGGACAAACAGTACGAGATTCTGTGTGTCAGCCAGTTTACCCTCCAGTGTGTCCTGAAGGGAAACAAG
CCTGATTTCCACCTAGCAATGCCCACGGAGCAGGCAGAGGGCTTCTACAACAGCTTCCTGGAGCAGCTGCGTAAAACATACAGGCCGGAG
CTTATCAAAGATGGCAAGTTTGGGGCCTACATGCAGGTGCACATTCAGAATGATGGGCCTGTGACCATAGAGCTGGAATCGCCAGCTCCC
GGCACTGCTACCTCTGACCCAAAGCAGGTTTTCAAAACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTC
TTTGCATATGGGCAAACTGGATCTGGAAAGTCATACACTATGATGGGAAATTCTGGAGATTCTGGCTTAATACCTCGGATCTGTGAAGGA
CTCTTCAGTCGGATAAATGAAACCACCAGATGGGATGAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTG
AGAGATCTACTTCGGCGGAAGTCATCTAAAACCTTCAATTTGAGAGTCCGTGAGCATCCCAAAGAAGGCCCTTATGTTGAGGATTTATCC
AAACATTTAGTACAGAATTATGGTGACGTAGAAGAACTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGAC
GTCAGTAGCAGGTCTCATGCCATCTTCACCATCAAGTTCACTCAGGCTAAATTTGATTCTGAAATGCCATGTGAAACCGTCAGTAAGATC
CACTTGGTTGATCTTGCCGGAAGTGAGCGTGCAGATGCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCC
CTCGTGACTCTGGGGAACGTCATTTCTGCCTTAGCTGATTTATCTCAGGATGCTGCAAATACTCTTGCAAAGAAGAAGCAAGTTTTCGTG
CCTTACAGGGATTCTGTGTTGACTTGGTTGTTAAAAGATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCT
GATGTCAATTATGGAGAAACCCTAAGTACTCTTCGCTATGCAAATAGAGCCAAAAACATCATCAACAAGCCTACCATTAATGAGGATGCC
AACGTCAAACTTATCCGTGAGCTGCGAGCTGAAATAGCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCC
CCCACAGCTTTAAGTATGGAGGAAAAACTTCAGCAGAATGAAGCAAGAGTTCAAGAATTGACCAAGGAATGGACAAATAAGTGGAATGAA
ACCCAAAATATTTTGAAAGAACAAACTCTAGCCCTCAGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGC
ATCGATGATGACCTTTTGAGTACTGGAATCATCTTATATCATTTAAAGGAAGGTCAGACATACGTTGGTAGAGACGATGCTTCCACGGAG
CAAGATATTGTTCTTCATGGCCTTGACTTGGAGAGTGAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGT
GGGTCCCAGTGCTCTGTGAATGGTGTTCAGATCGTGGAGGCCACACATCTAAATCAAGGTGCTGTGATTCTCTTGGGAAGAACCAATATG
TTTCGCTTTAACCATCCAAAGGAAGCCGCCAAGCTCAGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGAC
CTCTCGAAGTCCCGTGAGAACCTGTCTGCAGTCATGTTGTATAACCCCGGACTTGAATTTGAGAGGCAACAGCGTGAAGAACTTGAAAAA
TTAGAAAGTAAAAGGAAACTCATAGAAGAAATGGAGGAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAG
ACCCAGCGCAAGGAGACAGAAATCGTGCAGCTCCAGATTCGCAAGCAGGAGGAGAGCCTCAAACGCCGCAGCTTCCACATCGAGAACAAG
CTAAAGGATTTACTTGCGGAGAAGGAAAAATTTGAAGAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAA
GAAGAGACCTTTCTCCGCGTCCAAGAAGAACTCCAACGACTCAAAGAACTCAACAACAACGAGAAGGCTGAGAAGTTTCAGATATTTCAA
GAACTGGACCAGCTCCAAAAGGAAAAAGATGAACAGTATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAG
GTCATGCTCGTGGCCCATCTGGAAGAGCAGCTCCGAGAGAAGCAGGAGATGATCCAGCTCCTGCGGCGTGGGGAGGTACAGTGGGTGGAA
GAGGAGAAGAGGGACCTGGAAGGCATTCGGGAATCCCTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTA
GAAAAGGCTCAACTGCGTTTCTTCGAATTCAAGAGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAGAAGGACCTGGTTCAGCAGAAAGAC
ATCCTGAAAAAAGAAGTCCAAGAAGAACAGGAGATCCTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACAT
GATGAGAGTGTCACAGATGTCACGGAAGTGCCTCAAGATTTCGAGAAAATAAAGCCAGTGGAGTACAGGCTGCAATATAAAGAACGCCAG
CTACAGTACCTCCTGCAGAATCACTTGCCAACTCTGTTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTA
GACAACACTCTTTATCAAGTAGAAAAGGAAATGGAAGAAAAAGAAGAACAGCTTGCACAGTACCAGGCCAATGCAAACCAGCTGCAAAAG
CTCCAAGCCACCTTTGAATTCACTGCCAACATTGCACGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAG
AAGCAGCAGAGAGAGGCGCTGGAGCGGGCCCTGGCCAGGCTGGAGAGGAGACATTCTGCGCTGCAGAGGCACTCCACCCTGGGCATGGAG
ATTGAAGAGCAGAGGCAGAAACTTGCCAGTCTGAACAGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAA
GCCCTGGAGAAGGACCAGGAGAGGTTAGAATATGAAATCCAGCAGCTGAAACAGAAGATTTATGAGGTCGATGGTGTTCAAAAAGATCAT
CATGGGACCCTGGAAGGGAAGGTGGCTTCTTCCAGCTTGCCAGTCAGTGCTGAAAAATCACACCTGGTTCCCCTCATGGATGCCAGGATC
AATGCTTACATTGAAGAAGAAGTCCAAAGACGCCTTCAGGATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATG
AAGGATAATGAGAAACTTCACAATGGCACCATTCAACGTAAACTAAAATATGAGCGGATGGTTTCTCGCTCTTTGGGCGCAAATCCAGAT
GACCTGAAGGACCCAATTAAAATTAGTATCCCACGCTACGTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATT
ACTGTCCTAGATGAGACATGGACTGTATTCAGGCGTTACAGTCGTTTTCGAGAAATGCATAAAACATTGAAGTTAAAGTATGCAGAGCTT
GCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTC
AGGGACTTTTTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACATACCATTTGT
GAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAACCACCACAGC
AGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAGACAGACATGC
AGCAGCGGGCCCGGGCCACCTCACGTTTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGCCCTGACAGGC
AGCCGTTACCGTTCCATTGCGGTTGAACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCCTGTGGCAAGA
TAGATGTGGTTGGGCCATCGTGGGTTCCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACCCTTAAATGAC
TTTCATCTGGTTTCCTCTTTCACCAAAATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAAAGCATTTTAA
ATTATTTCATTGTATTTTTTTCTTTTTTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACACAGAATTTCA
TATTCTGCAAAAGGGATTTTTTGATCCAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACTTAAAACTTCT
ATAAATCCCTACAATTAGGATATTTATTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCATTCTTGAGCTT
TTTCTGCTAAGCACAAAATGAACGCAAAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATTGGATCTTTGG
CTGGAAAACTAGAATTTATAGCAGTTTATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGTACAGTAAAAC
TGCTTTGTTTTACTAAAGAGAAAAATGTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCTATAGATTTAT
ATATGTATACATTCTGTACAGTAGTTCCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTCAAAATTTAAA

>24338_24338_1_DTD1-KIF16B_DTD1_chr20_18608877_ENST00000377452_KIF16B_chr20_16496309_ENST00000354981_length(amino acids)=1399AA_BP=158
MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNK
PDFHLAMPTEQAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQVFKTLGTDVVKSAFEGYNACV
FAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLS
KHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKS
LVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDA
NVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIG
IDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNM
FRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVE
TQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQ
ELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEEL
EKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQ
LQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESRE
KQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDH
HGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPD
DLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYL

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Fusion Gene PPI Analysis for DTD1-KIF16B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DTD1-KIF16B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DTD1-KIF16B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source