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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTNA-CD82 (FusionGDB2 ID:24361)

Fusion Gene Summary for DTNA-CD82

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNA-CD82
Fusion gene ID: 24361
HgeneTgene
Gene symbol

DTNA

CD82

Gene ID

1837

3732

Gene namedystrobrevin alphaCD82 molecule
SynonymsD18S892E|DRP3|DTN|DTN-A|LVNC14F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27
Cytomap

18q12.1

11p11.2

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin alphadystrophin-related protein 3CD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27
Modification date2020031320200329
UniProtAcc

Q9Y4J8

P27701

Ensembl transtripts involved in fusion geneENST00000269190, ENST00000269191, 
ENST00000283365, ENST00000315456, 
ENST00000348997, ENST00000399113, 
ENST00000399121, ENST00000444659, 
ENST00000554864, ENST00000595022, 
ENST00000596745, ENST00000597599, 
ENST00000598142, ENST00000598334, 
ENST00000598774, ENST00000399097, 
ENST00000269192, ENST00000556414, 
ENST00000590831, ENST00000591182, 
ENST00000592449, ENST00000597674, 
ENST00000599844, ENST00000601125, 
ENST00000227155, ENST00000342935, 
ENST00000530931, 
Fusion gene scores* DoF score7 X 5 X 5=17510 X 6 X 6=360
# samples 710
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTNA [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTNA(32346005)-CD82(44609025), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CD82 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TQ-A7RK-02BDTNAchr18

32346005

-CD82chr11

44609025

+
ChimerDB4LGGTCGA-TQ-A7RKDTNAchr18

32346005

+CD82chr11

44609025

+


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Fusion Gene ORF analysis for DTNA-CD82

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269190ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269190ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269191ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269191ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000283365ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000283365ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000315456ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000315456ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000348997ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000348997ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399113ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399113ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399121ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399121ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000444659ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000444659ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000554864ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000554864ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000595022ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000595022ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000596745ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000596745ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000597599ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000597599ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598142ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598142ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598334ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598334ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598774ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598774ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000269190ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000269191ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000283365ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000315456ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000348997ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000399113ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000399121ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000444659ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000554864ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000595022ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000596745ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000597599ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598142ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598334ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598774ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-5UTRENST00000399097ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-5UTRENST00000399097ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-intronENST00000399097ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000269192ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000269192ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000556414ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000556414ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000590831ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000590831ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000591182ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000591182ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000592449ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000592449ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000597674ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000597674ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000599844ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000599844ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000601125ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000601125ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000269192ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000556414ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000590831ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000591182ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000592449ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000597674ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000599844ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000601125ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DTNA-CD82


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTNAchr1832346005+CD82chr1144609024+0.0001867720.99981326
DTNAchr1832346005+CD82chr1144609024+0.0001867720.99981326

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTNA-CD82


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32346005/:44609025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNA

Q9Y4J8

CD82

P27701

FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.FUNCTION: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DTNA-CD82


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DTNA-CD82


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTNA-CD82


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTNA-CD82


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource