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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTNA-GABARAPL1 (FusionGDB2 ID:24363)

Fusion Gene Summary for DTNA-GABARAPL1

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNA-GABARAPL1
Fusion gene ID: 24363
HgeneTgene
Gene symbol

DTNA

GABARAPL1

Gene ID

1837

23710

Gene namedystrobrevin alphaGABA type A receptor associated protein like 1
SynonymsD18S892E|DRP3|DTN|DTN-A|LVNC1APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1
Cytomap

18q12.1

12p13.2

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin alphadystrophin-related protein 3gamma-aminobutyric acid receptor-associated protein-like 1GABA(A) receptor-associated protein-like 1early estrogen-regulated proteinglandular epithelial cell protein 1
Modification date2020031320200327
UniProtAcc

Q9Y4J8

Q9H0R8

Ensembl transtripts involved in fusion geneENST00000269190, ENST00000283365, 
ENST00000315456, ENST00000399097, 
ENST00000399121, ENST00000554864, 
ENST00000595022, ENST00000596745, 
ENST00000598142, ENST00000598334, 
ENST00000598774, ENST00000269191, 
ENST00000269192, ENST00000348997, 
ENST00000399113, ENST00000444659, 
ENST00000556414, ENST00000590831, 
ENST00000591182, ENST00000592449, 
ENST00000597599, ENST00000597674, 
ENST00000599844, ENST00000601125, 
ENST00000266458, ENST00000421801, 
ENST00000543602, ENST00000544284, 
ENST00000545047, ENST00000535576, 
ENST00000539170, ENST00000539289, 
ENST00000545887, ENST00000546017, 
Fusion gene scores* DoF score7 X 5 X 5=1755 X 5 X 2=50
# samples 75
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: DTNA [Title/Abstract] AND GABARAPL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTNA(32259553)-GABARAPL1(10365475), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GABARAPL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA275662DTNAchr18

32259553

+GABARAPL1chr12

10365475

+


Top

Fusion Gene ORF analysis for DTNA-GABARAPL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000269190ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000269190ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000269190ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000269190ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000269190ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000283365ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000283365ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000283365ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000283365ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000283365ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000315456ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000315456ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000315456ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000315456ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000315456ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399097ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399097ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399097ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399097ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399097ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399121ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399121ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399121ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399121ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000399121ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000554864ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000554864ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000554864ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000554864ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000554864ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000595022ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000595022ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000595022ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000595022ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000595022ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000596745ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000596745ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000596745ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000596745ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000596745ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598142ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598142ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598142ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598142ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598142ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598334ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598334ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598334ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598334ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598334ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598774ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598774ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598774ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598774ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-5UTRENST00000598774ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000269190ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000269190ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000269190ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000269190ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000269190ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000283365ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000283365ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000283365ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000283365ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000283365ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000315456ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000315456ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000315456ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000315456ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000315456ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399097ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399097ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399097ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399097ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399097ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399121ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399121ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399121ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399121ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000399121ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000554864ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000554864ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000554864ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000554864ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000554864ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000595022ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000595022ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000595022ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000595022ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000595022ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000596745ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000596745ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000596745ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000596745ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000596745ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598142ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598142ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598142ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598142ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598142ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598334ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598334ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598334ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598334ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598334ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598774ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598774ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598774ENST00000539289DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598774ENST00000545887DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
5UTR-intronENST00000598774ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269191ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269191ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269191ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269191ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269191ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269192ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269192ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269192ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269192ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000269192ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000348997ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000348997ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000348997ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000348997ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000348997ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000399113ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000399113ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000399113ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000399113ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000399113ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000444659ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000444659ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000444659ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000444659ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000444659ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000556414ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000556414ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000556414ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000556414ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000556414ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000590831ENST00000266458DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000590831ENST00000421801DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000590831ENST00000543602DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000590831ENST00000544284DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000590831ENST00000545047DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-5UTRENST00000591182ENST00000266458DTNAchr18

32259553

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intron-5UTRENST00000591182ENST00000421801DTNAchr18

32259553

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intron-5UTRENST00000591182ENST00000543602DTNAchr18

32259553

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intron-5UTRENST00000591182ENST00000544284DTNAchr18

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intron-5UTRENST00000591182ENST00000545047DTNAchr18

32259553

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intron-5UTRENST00000592449ENST00000266458DTNAchr18

32259553

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intron-5UTRENST00000592449ENST00000421801DTNAchr18

32259553

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+
intron-5UTRENST00000592449ENST00000543602DTNAchr18

32259553

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intron-5UTRENST00000592449ENST00000544284DTNAchr18

32259553

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intron-5UTRENST00000592449ENST00000545047DTNAchr18

32259553

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intron-5UTRENST00000597599ENST00000266458DTNAchr18

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intron-5UTRENST00000597599ENST00000421801DTNAchr18

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intron-5UTRENST00000597599ENST00000543602DTNAchr18

32259553

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intron-5UTRENST00000597599ENST00000544284DTNAchr18

32259553

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intron-5UTRENST00000597599ENST00000545047DTNAchr18

32259553

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intron-5UTRENST00000597674ENST00000266458DTNAchr18

32259553

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intron-5UTRENST00000597674ENST00000421801DTNAchr18

32259553

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intron-5UTRENST00000597674ENST00000543602DTNAchr18

32259553

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intron-5UTRENST00000597674ENST00000544284DTNAchr18

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intron-5UTRENST00000597674ENST00000545047DTNAchr18

32259553

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intron-5UTRENST00000599844ENST00000266458DTNAchr18

32259553

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intron-5UTRENST00000599844ENST00000421801DTNAchr18

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intron-5UTRENST00000599844ENST00000543602DTNAchr18

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intron-5UTRENST00000599844ENST00000544284DTNAchr18

32259553

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intron-5UTRENST00000599844ENST00000545047DTNAchr18

32259553

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intron-5UTRENST00000601125ENST00000266458DTNAchr18

32259553

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intron-5UTRENST00000601125ENST00000421801DTNAchr18

32259553

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intron-5UTRENST00000601125ENST00000543602DTNAchr18

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intron-5UTRENST00000601125ENST00000544284DTNAchr18

32259553

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intron-5UTRENST00000601125ENST00000545047DTNAchr18

32259553

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intron-intronENST00000269191ENST00000535576DTNAchr18

32259553

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intron-intronENST00000269191ENST00000539170DTNAchr18

32259553

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intron-intronENST00000269191ENST00000539289DTNAchr18

32259553

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intron-intronENST00000269191ENST00000545887DTNAchr18

32259553

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intron-intronENST00000269191ENST00000546017DTNAchr18

32259553

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intron-intronENST00000269192ENST00000535576DTNAchr18

32259553

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intron-intronENST00000269192ENST00000539170DTNAchr18

32259553

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intron-intronENST00000269192ENST00000539289DTNAchr18

32259553

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intron-intronENST00000269192ENST00000545887DTNAchr18

32259553

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intron-intronENST00000269192ENST00000546017DTNAchr18

32259553

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intron-intronENST00000348997ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

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intron-intronENST00000348997ENST00000539170DTNAchr18

32259553

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intron-intronENST00000348997ENST00000539289DTNAchr18

32259553

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intron-intronENST00000348997ENST00000545887DTNAchr18

32259553

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intron-intronENST00000348997ENST00000546017DTNAchr18

32259553

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intron-intronENST00000399113ENST00000535576DTNAchr18

32259553

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intron-intronENST00000399113ENST00000539170DTNAchr18

32259553

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intron-intronENST00000399113ENST00000539289DTNAchr18

32259553

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intron-intronENST00000399113ENST00000545887DTNAchr18

32259553

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10365475

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intron-intronENST00000399113ENST00000546017DTNAchr18

32259553

+GABARAPL1chr12

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intron-intronENST00000444659ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

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intron-intronENST00000444659ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

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intron-intronENST00000444659ENST00000539289DTNAchr18

32259553

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10365475

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intron-intronENST00000444659ENST00000545887DTNAchr18

32259553

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intron-intronENST00000444659ENST00000546017DTNAchr18

32259553

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10365475

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intron-intronENST00000556414ENST00000535576DTNAchr18

32259553

+GABARAPL1chr12

10365475

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intron-intronENST00000556414ENST00000539170DTNAchr18

32259553

+GABARAPL1chr12

10365475

+
intron-intronENST00000556414ENST00000539289DTNAchr18

32259553

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10365475

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intron-intronENST00000556414ENST00000545887DTNAchr18

32259553

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intron-intronENST00000556414ENST00000546017DTNAchr18

32259553

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intron-intronENST00000590831ENST00000535576DTNAchr18

32259553

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intron-intronENST00000590831ENST00000539170DTNAchr18

32259553

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intron-intronENST00000590831ENST00000539289DTNAchr18

32259553

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intron-intronENST00000590831ENST00000545887DTNAchr18

32259553

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+
intron-intronENST00000590831ENST00000546017DTNAchr18

32259553

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intron-intronENST00000591182ENST00000535576DTNAchr18

32259553

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intron-intronENST00000591182ENST00000539170DTNAchr18

32259553

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intron-intronENST00000591182ENST00000539289DTNAchr18

32259553

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intron-intronENST00000591182ENST00000545887DTNAchr18

32259553

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intron-intronENST00000591182ENST00000546017DTNAchr18

32259553

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intron-intronENST00000592449ENST00000535576DTNAchr18

32259553

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intron-intronENST00000592449ENST00000539170DTNAchr18

32259553

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intron-intronENST00000592449ENST00000539289DTNAchr18

32259553

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10365475

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intron-intronENST00000592449ENST00000545887DTNAchr18

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intron-intronENST00000592449ENST00000546017DTNAchr18

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intron-intronENST00000597599ENST00000535576DTNAchr18

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intron-intronENST00000597599ENST00000539170DTNAchr18

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intron-intronENST00000597599ENST00000539289DTNAchr18

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intron-intronENST00000597599ENST00000545887DTNAchr18

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intron-intronENST00000597599ENST00000546017DTNAchr18

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intron-intronENST00000597674ENST00000535576DTNAchr18

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intron-intronENST00000597674ENST00000539170DTNAchr18

32259553

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intron-intronENST00000597674ENST00000539289DTNAchr18

32259553

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intron-intronENST00000597674ENST00000545887DTNAchr18

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intron-intronENST00000597674ENST00000546017DTNAchr18

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intron-intronENST00000599844ENST00000535576DTNAchr18

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intron-intronENST00000599844ENST00000539170DTNAchr18

32259553

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intron-intronENST00000599844ENST00000539289DTNAchr18

32259553

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intron-intronENST00000599844ENST00000545887DTNAchr18

32259553

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intron-intronENST00000599844ENST00000546017DTNAchr18

32259553

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intron-intronENST00000601125ENST00000535576DTNAchr18

32259553

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intron-intronENST00000601125ENST00000539170DTNAchr18

32259553

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intron-intronENST00000601125ENST00000539289DTNAchr18

32259553

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intron-intronENST00000601125ENST00000545887DTNAchr18

32259553

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intron-intronENST00000601125ENST00000546017DTNAchr18

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+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DTNA-GABARAPL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTNAchr1832259556+GABARAPL1chr1210365481+0.997453870.002546127
DTNAchr1832259556+GABARAPL1chr1210365481+0.997453870.002546127

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTNA-GABARAPL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32259553/:10365475)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNA

Q9Y4J8

GABARAPL1

Q9H0R8

FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.FUNCTION: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DTNA-GABARAPL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DTNA-GABARAPL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTNA-GABARAPL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTNA-GABARAPL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource