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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DTNA-LDLRAD4 (FusionGDB2 ID:24364)

Fusion Gene Summary for DTNA-LDLRAD4

Fusion gene summary

Fusion gene information	Fusion gene name: DTNA-LDLRAD4
	Fusion gene ID: 24364
		Hgene	Tgene
	Gene symbol	DTNA	LDLRAD4
	Gene ID	1837	753
	Gene name	dystrobrevin alpha	low density lipoprotein receptor class A domain containing 4
	Synonyms	D18S892E\|DRP3\|DTN\|DTN-A\|LVNC1	C18orf1
	Cytomap	18q12.1	18p11.21
	Type of gene	protein-coding	protein-coding
	Description	dystrobrevin alphadystrophin-related protein 3	low-density lipoprotein receptor class A domain-containing protein 4clone 22
	Modification date	20200313	20200320
	UniProtAcc	Q9Y4J8	O15165
	Ensembl transtripts involved in fusion gene	ENST00000283365, ENST00000315456, ENST00000596745, ENST00000269190, ENST00000269191, ENST00000269192, ENST00000348997, ENST00000399097, ENST00000399113, ENST00000399121, ENST00000444659, ENST00000554864, ENST00000556414, ENST00000590831, ENST00000591182, ENST00000592449, ENST00000595022, ENST00000597599, ENST00000597674, ENST00000598142, ENST00000598334, ENST00000598774, ENST00000599844, ENST00000601125,	ENST00000359446, ENST00000361205, ENST00000399848, ENST00000587757, ENST00000585931, ENST00000586765, ENST00000590308, ENST00000592991,
Fusion gene scores	* DoF score	7 X 5 X 5=175	22 X 20 X 7=3080
	# samples	7	24
	** MAII score	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3080*10)=-3.68182403997374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DTNA [Title/Abstract] AND LDLRAD4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DTNA(32073478)-LDLRAD4(13621116), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LDLRAD4	GO:0010991	negative regulation of SMAD protein complex assembly	24627487

Fusion gene breakpoints across DTNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LDLRAD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-D5-6929-01A	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+

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Fusion Gene ORF analysis for DTNA-LDLRAD4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000283365	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000283365	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000283365	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000283365	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000315456	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000315456	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000315456	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000315456	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000596745	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000596745	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000596745	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-3CDS	ENST00000596745	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000283365	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000283365	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000315456	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000315456	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000596745	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-5UTR	ENST00000596745	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000283365	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000283365	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000315456	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000315456	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000596745	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
5UTR-intron	ENST00000596745	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269190	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269190	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269190	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269190	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269191	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269191	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269191	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269191	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269192	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269192	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269192	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000269192	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000348997	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000348997	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000348997	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000348997	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399097	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399097	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399097	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399097	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399113	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399113	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399113	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399113	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399121	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399121	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399121	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000399121	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000444659	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000444659	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000444659	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000444659	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000554864	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000554864	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000554864	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000554864	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000556414	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000556414	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000556414	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000556414	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000590831	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000590831	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000590831	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000590831	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000591182	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000591182	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000591182	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000591182	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000592449	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000592449	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000592449	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000592449	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000595022	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000595022	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000595022	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000595022	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597599	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597599	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597599	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597599	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597674	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597674	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597674	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000597674	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598142	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598142	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598142	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598142	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598334	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598334	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598334	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598334	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598774	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598774	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598774	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000598774	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000599844	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000599844	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000599844	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000599844	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000601125	ENST00000359446	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000601125	ENST00000361205	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000601125	ENST00000399848	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-3CDS	ENST00000601125	ENST00000587757	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269190	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269190	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269191	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269191	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269192	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000269192	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000348997	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000348997	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399097	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399097	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399113	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399113	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399121	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000399121	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000444659	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000444659	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000554864	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000554864	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000556414	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000556414	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000590831	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000590831	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000591182	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000591182	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000592449	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000592449	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000595022	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000595022	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000597599	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000597599	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000597674	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000597674	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598142	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598142	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598334	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598334	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598774	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000598774	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000599844	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000599844	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000601125	ENST00000585931	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-5UTR	ENST00000601125	ENST00000586765	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269190	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269190	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269191	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269191	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269192	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000269192	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000348997	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000348997	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399097	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399097	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399113	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399113	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399121	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000399121	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000444659	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000444659	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000554864	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000554864	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000556414	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000556414	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000590831	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000590831	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000591182	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000591182	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000592449	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000592449	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000595022	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000595022	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000597599	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000597599	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000597674	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000597674	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598142	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598142	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598334	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598334	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598774	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000598774	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000599844	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000599844	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000601125	ENST00000590308	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+
intron-intron	ENST00000601125	ENST00000592991	DTNA	chr18	32073478	+	LDLRAD4	chr18	13621116	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DTNA-LDLRAD4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DTNA	chr18	32073478	+	LDLRAD4	chr18	13621115	+	5.37E-07	0.9999994
DTNA	chr18	32073478	+	LDLRAD4	chr18	13621115	+	5.37E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DTNA-LDLRAD4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32073478/:13621116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DTNA Q9Y4J8	LDLRAD4 O15165
FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.	FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269\|PubMed:24627487}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DTNA-LDLRAD4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DTNA-LDLRAD4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DTNA-LDLRAD4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DTNA-LDLRAD4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source