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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTNB-ASXL2 (FusionGDB2 ID:24368)

Fusion Gene Summary for DTNB-ASXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNB-ASXL2
Fusion gene ID: 24368
HgeneTgene
Gene symbol

DTNB

ASXL2

Gene ID

1838

55252

Gene namedystrobrevin betaASXL transcriptional regulator 2
Synonyms-ASXH2|SHAPNS
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin betaDTN-Bbeta-dystrobrevinputative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2
Modification date2020032720200313
UniProtAcc.

Q76L83

Ensembl transtripts involved in fusion geneENST00000288642, ENST00000404103, 
ENST00000405222, ENST00000406818, 
ENST00000407038, ENST00000407186, 
ENST00000407661, ENST00000496972, 
ENST00000545439, ENST00000472690, 
ENST00000272341, ENST00000404843, 
ENST00000497092, ENST00000336112, 
ENST00000435504, 
Fusion gene scores* DoF score10 X 10 X 7=70011 X 14 X 8=1232
# samples 1216
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTNB [Title/Abstract] AND ASXL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTNB(25818955)-ASXL2(25991737), # samples:3
ASXL2(26022254)-DTNB(25819109), # samples:1
Anticipated loss of major functional domain due to fusion event.DTNB-ASXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DTNB-ASXL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASXL2-DTNB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASXL2

GO:0035360

positive regulation of peroxisome proliferator activated receptor signaling pathway

21047783

TgeneASXL2

GO:0045600

positive regulation of fat cell differentiation

21047783

TgeneASXL2

GO:0045944

positive regulation of transcription by RNA polymerase II

21047783


check buttonFusion gene breakpoints across DTNB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18V-06ADTNBchr2

25818955

-ASXL2chr2

25973282

-
ChimerDB4ESCATCGA-L5-A8NE-01ADTNBchr2

25818955

-ASXL2chr2

25991737

-
ChimerDB4ESCATCGA-L5-A8NEDTNBchr2

25818955

-ASXL2chr2

25991737

-
ChimerDB4STADTCGA-BR-4357-01ADTNBchr2

25754342

-ASXL2chr2

25994409

-


Top

Fusion Gene ORF analysis for DTNB-ASXL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000288642ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000288642ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000288642ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000288642ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000288642ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000288642ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000404103ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000404103ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000404103ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000404103ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000404103ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000404103ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000405222ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000405222ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000405222ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000405222ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000405222ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000405222ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000406818ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000406818ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000406818ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000406818ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000406818ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000406818ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407038ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407038ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407038ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407038ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407038ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407038ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407186ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407186ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407186ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407186ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407186ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407186ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407661ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407661ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407661ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407661ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000407661ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000407661ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000496972ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000496972ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000496972ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000496972ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000496972ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5CDS-5UTRENST00000496972ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000545439ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000545439ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-5UTRENST00000545439ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
5CDS-intronENST00000288642ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000404103ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000405222ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000406818ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000407038ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000407186ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000407661ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5CDS-intronENST00000496972ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
5UTR-3CDSENST00000472690ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
5UTR-3CDSENST00000472690ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
5UTR-3CDSENST00000472690ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
5UTR-3CDSENST00000472690ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
5UTR-3CDSENST00000472690ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
5UTR-3CDSENST00000472690ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
5UTR-5UTRENST00000472690ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
5UTR-5UTRENST00000472690ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
5UTR-5UTRENST00000472690ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
5UTR-intronENST00000472690ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000288642ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000288642ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000288642ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000288642ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000288642ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000288642ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000288642ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000288642ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000404103ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000404103ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000404103ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000404103ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000404103ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000404103ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000404103ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000404103ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000405222ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000405222ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000405222ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000405222ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000405222ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000405222ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000405222ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000405222ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000406818ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000406818ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000406818ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000406818ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000406818ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000406818ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000406818ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000406818ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407038ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407038ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407038ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407038ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407038ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407038ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407038ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407038ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407186ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407186ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407186ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407186ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407186ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407186ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407186ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407186ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407661ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407661ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407661ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407661ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000407661ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407661ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000407661ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
Frame-shiftENST00000407661ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000496972ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000496972ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000496972ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000496972ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000496972ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
Frame-shiftENST00000496972ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000545439ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
Frame-shiftENST00000545439ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
In-frameENST00000496972ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
In-frameENST00000496972ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-3CDSENST00000472690ENST00000336112DTNBchr2

25754342

-ASXL2chr2

25994409

-
intron-3CDSENST00000472690ENST00000435504DTNBchr2

25754342

-ASXL2chr2

25994409

-
intron-3CDSENST00000545439ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25973282

-
intron-3CDSENST00000545439ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25973282

-
intron-3CDSENST00000545439ENST00000336112DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-3CDSENST00000545439ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25973282

-
intron-3CDSENST00000545439ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25973282

-
intron-3CDSENST00000545439ENST00000435504DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-5UTRENST00000472690ENST00000272341DTNBchr2

25754342

-ASXL2chr2

25994409

-
intron-5UTRENST00000472690ENST00000404843DTNBchr2

25754342

-ASXL2chr2

25994409

-
intron-5UTRENST00000472690ENST00000497092DTNBchr2

25754342

-ASXL2chr2

25994409

-
intron-5UTRENST00000545439ENST00000272341DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-5UTRENST00000545439ENST00000404843DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-5UTRENST00000545439ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25991737

-
intron-intronENST00000545439ENST00000497092DTNBchr2

25818955

-ASXL2chr2

25973282

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000496972DTNBchr225818955-ENST00000435504ASXL2chr225991737-1281973930745421411
ENST00000496972DTNBchr225818955-ENST00000336112ASXL2chr225991737-888073930745421411

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000496972ENST00000435504DTNBchr225818955-ASXL2chr225991737-0.0001968250.99980325
ENST00000496972ENST00000336112DTNBchr225818955-ASXL2chr225991737-0.000330440.99966955

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Fusion Genomic Features for DTNB-ASXL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DTNB-ASXL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25818955/chr2:25991737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASXL2

Q76L83

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASXL2chr2:25818955chr2:25991737ENST000002723414131173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr2:25818955chr2:25991737ENST0000027234141395_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr2:25818955chr2:25991737ENST000004048431101173_11760919.0Compositional biasNote=Poly-Ser
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110303_3070919.0Compositional biasNote=Poly-Leu
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110654_6840919.0Compositional biasNote=Ala-rich
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110687_7390919.0Compositional biasNote=Gly-rich
TgeneASXL2chr2:25818955chr2:25991737ENST0000040484311095_2350919.0Compositional biasNote=Ser-rich
TgeneASXL2chr2:25818955chr2:25991737ENST000004355045131173_11761681436.0Compositional biasNote=Poly-Ser
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513303_3071681436.0Compositional biasNote=Poly-Leu
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513654_6841681436.0Compositional biasNote=Ala-rich
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513687_7391681436.0Compositional biasNote=Gly-rich
TgeneASXL2chr2:25818955chr2:25991737ENST0000027234141311_860919.0DomainHTH HARE-type
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413274_3830919.0DomainDEUBAD
TgeneASXL2chr2:25818955chr2:25991737ENST0000040484311011_860919.0DomainHTH HARE-type
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110274_3830919.0DomainDEUBAD
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513274_3831681436.0DomainDEUBAD
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413174_1780919.0MotifNuclear localization signal
TgeneASXL2chr2:25818955chr2:25991737ENST00000272341413887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110174_1780919.0MotifNuclear localization signal
TgeneASXL2chr2:25818955chr2:25991737ENST00000404843110887_8910919.0MotifNote=LXXLL motif 2
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513174_1781681436.0MotifNuclear localization signal
TgeneASXL2chr2:25818955chr2:25991737ENST00000435504513887_8911681436.0MotifNote=LXXLL motif 2
TgeneASXL2chr2:25818955chr2:25991737ENST000002723414131397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr2:25818955chr2:25991737ENST000004048431101397_14340919.0Zinc fingerNote=PHD-type%3B atypical
TgeneASXL2chr2:25818955chr2:25991737ENST000004355045131397_14341681436.0Zinc fingerNote=PHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTNBchr2:25818955chr2:25991737ENST00000404103-620428_529201607.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000405222-618428_529201570.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000406818-621428_529201637.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000407038-619428_529201577.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000407661-620428_529201619.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000496972-518428_529144581.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25818955chr2:25991737ENST00000404103-620399_448201607.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000405222-618399_448201570.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000406818-621399_448201637.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000407038-619399_448201577.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000407661-620399_448201619.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000496972-518399_448144581.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25818955chr2:25991737ENST00000404103-620237_284201607.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25818955chr2:25991737ENST00000405222-618237_284201570.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25818955chr2:25991737ENST00000406818-621237_284201637.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25818955chr2:25991737ENST00000407038-619237_284201577.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25818955chr2:25991737ENST00000407661-620237_284201619.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25818955chr2:25991737ENST00000496972-518237_284144581.3333333333334Zinc fingerZZ-type
TgeneASXL2chr2:25818955chr2:25991737ENST0000043550451395_2351681436.0Compositional biasNote=Ser-rich
TgeneASXL2chr2:25818955chr2:25991737ENST0000043550451311_861681436.0DomainHTH HARE-type


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Fusion Gene Sequence for DTNB-ASXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24368_24368_1_DTNB-ASXL2_DTNB_chr2_25818955_ENST00000496972_ASXL2_chr2_25991737_ENST00000336112_length(transcript)=8880nt_BP=739nt
ACAAACACAGTAATTCCTGATACTAAGAAGAGGCTGGGGTGCCTTAAGTAATACGCATGCAGGCGTTGATGGGGTAGAGATCTGAAGTAG
TCCTGCCAAGAACTGGGTTTACTTCTTTGTGAATGTTACTACTCTTACACAGAAACCTCATATGAATTATCATCCTCTGACTTAAGGATA
ACAGTCAGTCTGGGAGACGTTTGGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACA
AAAACGATGCAACCTTCATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGA
GATCAGTGTGTCCCGCCTCGAAACTGTCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGA
ACAATCTATCAGCCTCCTCCTCAACTTTATGATTGCTGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTAT
GTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATATGTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAG
CAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTTGGTTACACAGAGCACTCAGTCCG
CACCTGTTTTCCACAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCAGCAATGCAGGCCAAGCATATCCATCTCCTCCAACCA
GCATCTCTCACTAAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACCTGCAACATGGGAAGGAAAGCAATCTGATGGACAGAC
AGGCAGCCCTCAAAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAATACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAG
ATCTGAGAGACTCCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGACGTTGAGACACCGGACTCCATTCTGGTTAATACAAA
TCTGCGAGCACTGATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCAGCAACGACTGCTTTTACTACTCCCAGAGGTAGATCG
ACAGGTTGGTCCAGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGAATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAG
ACTCTCAGAAGGTGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGATTGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACA
ATTCTTTGAAAGCTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAAGAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAA
GAAAACCCCAGCTGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTATCAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAA
AGAAGAAGCATTGCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCAAGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGA
GCCCCTGCTTTCCTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCATCAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAA
GCCAGTCACCTCTGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTCTAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGT
TACATCGCCAAGCAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCCCACAGCAGGAGCGGGTCCACAGGAGACTAATATGAA
AGAACCTCTAGCAACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTCTTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGA
GAAGAGGCCACGTGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTCACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCA
GGTGCGAAAAGTACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCCGTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTT
TCCAGTCTCCATCACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACATCAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGC
AGCAGCTGCCGCTGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCATTCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGG
AGAGGGTGGTGAAGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGTCAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGC
AGGAACTGGAAGCAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGACTCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCA
GGCACAGCCTCATAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCCTCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGT
CCCATCACCAGCCCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAGAGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACA
AGGGCCCAGTAGTTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCTAATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGA
TGGCACAGTTGAGCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGCCTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGT
AACTCCCTCCCCTTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCCTGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGG
ATCAGCTCCACCCTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGGAACTTCTTTAAACATGAATGGACCCACTTTAAGACC
AACCTCTAGTATCCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAAAGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCT
CACCAAAGTTGAAATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGATGGGAGCGCTCATAGCTACCAACACAACAGAAAATAG
CACCAGAGAGGAAGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCTGGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGT
TCCAAGGCCCCTTCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGACACACACCAATACCACGAAGGACTAAGTAAAGCAAC
CCAAGATCAGATCCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCTCTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCA
CTCAGGTTTCCAGCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTTTGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGG
GCACTACTTACTGAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAGGACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCT
AAGCAGCCCCACTGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAACAGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGA
TGAGGAAAGTACTGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCAGGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTC
AGGACCTCACAGCAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAATGTGAAGGCTGAGATACCATTGAATGAGCAAACCAC
TTTAAGTAAGGAGAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGACCCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCA
GATGGCTCATGCAGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAGTTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCAC
CCACCAGCCCCTACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCCCACCCAGATAGGGCCAAGCTATAGAGGCATGATCAA
TGTCTCCACCTCATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGTATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGT
GACTGTCACTACCATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCAGACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAG
CATAGAGGGCACGCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTGCAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCAT
CGGCCCCTCCAAACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAAAGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTT
GACCAGTTGGGTTTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTTTCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGG
AATACAAAGTACAGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAGTCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAG
TTTGCACTTACAAAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTCCAAGTGTTTAGGTAATAATGTATTACTTTGAATTCA
GATTAATGTTCTACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAAGGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCT
AGGAAAAGGAAAGTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTTGTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTA
TTCAGCCTTTGCAGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGGTGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAAT
TCATTTCACAGGTAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTTCTACTGTACTAGTTACTAGTTACTGGTACTGTTGCC
AAGCAATCTGCTTGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTGCCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGC
CTCTCTGGGACCCCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAAAAATACCCTATCCCCGCACTTAGTCATTCGTGGTAA
CTAACAATTTTGAAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGGTGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGA
AACCACAGAAACTGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACACTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCC
CAACCTGTTAACCTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTCACCAATGCCACATTTGTTCATTCTGTTCAACCTGTT
TTGACCTCCCAGGCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTACACATACGTGTATGTACACACACACACACAATACAA
GACATTTTTCCTGTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGAGCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAAT
GGCTAAGGGAACATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTTGCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTT
TTTGTTTTTAAATCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTTAGGTCATGGTTAAGGAACATTAAAATAAACCTGCAG
TTTAACAGAATTTTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATATTGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTA
CAAATGTTAATGCAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTGATATTTACAAAATGCAGAACAGTTTAAACTTGTTAA
GTCACATTCCAGATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCATTCTACTACCCACCACTGCCCACCCCACCCCCACAT
CACACACTCTTCGATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAAACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCT
TTTTTGTGGCCCAAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCAGAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCA
GCACACACAGCTAAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATATTTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATG
GTGCTCCCAAATATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCTGTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAA
CTCCACCTTAGTGCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGAGTTTTGGAATTGATTCCATGCTAAATGTCAGTTACC
AGTTTGGATTGATGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGGTTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACA
GACTATAACTAGGAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAGAGCAAACCATATTGTGCCTCTTCATCTTGACCCAGG
CTCTTATAGATAGGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAATACTCAGCTAAATATTTGCATTTAGGAATACTCCTA
AAACAGATATTGCCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAACAGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATAC
CAGTCTATTTATCAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCATCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAA
AACACATTACAATCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTATTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATC
TTTACCTTAGTTTTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTAATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGC
ATTATTTCCAGTGACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCACCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGT
CACCCCAGGAGATAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCTAAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAA
TAATTTTGGAGAATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAATAGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCC
CTATGCTCAAGATACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAATAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGA
GCATACTTATTGGGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCTCAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTT
CCAGGTGAAGGTGCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGTTGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCAT
AAATAACTCTCTGGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGACTTCTCTGGTCATTACACTGCTATTTATTTCTAGAAC
TCACTATCAGTGAGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACATCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTA
CAACTGTGTGCTAAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTATAGAATAGTCCAAAGAGACTTTGAGAAACATGGTGAT
AGGCAGGGGCCTTTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAACAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAG
CTTCGTAGATTCTTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAACTATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAA
TATATTTTAAGTAATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACTTTGAATTTCTCATATATGGTATGTTTGATGTAGGAC
CTCACTGTTAAGGCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGATTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTG
GGGTTTATTTTTTATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTTTTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTT
GGTAAATGCTAAACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTGGAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACA
CCATTTAAAAAGTCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAATTTTAAGTATTTGCAATAAATATATGTATATAGATT

>24368_24368_1_DTNB-ASXL2_DTNB_chr2_25818955_ENST00000496972_ASXL2_chr2_25991737_ENST00000336112_length(amino acids)=1411AA_BP=144
MIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDK
LRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASD
SVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSV
LPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGL
SLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHEL
SSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPE
SLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGA
RTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELL
PCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPS
PTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPSSTLPAAS
SLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHP
ATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQ
RFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVT
VKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRS
SPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMN

--------------------------------------------------------------
>24368_24368_2_DTNB-ASXL2_DTNB_chr2_25818955_ENST00000496972_ASXL2_chr2_25991737_ENST00000435504_length(transcript)=12819nt_BP=739nt
ACAAACACAGTAATTCCTGATACTAAGAAGAGGCTGGGGTGCCTTAAGTAATACGCATGCAGGCGTTGATGGGGTAGAGATCTGAAGTAG
TCCTGCCAAGAACTGGGTTTACTTCTTTGTGAATGTTACTACTCTTACACAGAAACCTCATATGAATTATCATCCTCTGACTTAAGGATA
ACAGTCAGTCTGGGAGACGTTTGGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACA
AAAACGATGCAACCTTCATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGA
GATCAGTGTGTCCCGCCTCGAAACTGTCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGA
ACAATCTATCAGCCTCCTCCTCAACTTTATGATTGCTGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTAT
GTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATATGTTTTCTCCCAGATGTCAGATTCCAATGGCTTAATGATATTTAG
CAAGTTTGACCAGTTTCTGAAGGAAGTTCTGAAGCTCCCAACAGCTGTCTTTGAAGGGCCATCTTTTGGTTACACAGAGCACTCAGTCCG
CACCTGTTTTCCACAGCAGGCGCTAAAGCAGCAACAGCAGAAGAAGCAGCAGCAGCAATGCAGGCCAAGCATATCCATCTCCTCCAACCA
GCATCTCTCACTAAAGACTGTCAAAGCAGCCAGTGACTCTGTACCTGCCAAACCTGCAACATGGGAAGGAAAGCAATCTGATGGACAGAC
AGGCAGCCCTCAAAACTCAAACTCCAGCTTTTCTTCCTCAGTTAAAGTGGAAAATACTTTACTAGGCTTGGGGAAGAAGTCATTCCAGAG
ATCTGAGAGACTCCATACCAGACAAATGAAAAGAACTAAATGTGCTGACATTGACGTTGAGACACCGGACTCCATTCTGGTTAATACAAA
TCTGCGAGCACTGATCAACAAGCACACATTTTCAGTCCTTCCTGGAGATTGCCAGCAACGACTGCTTTTACTACTCCCAGAGGTAGATCG
ACAGGTTGGTCCAGATGGTTTAATGAAGTTAAATGGCTCAGCCCTTAACAATGAATTCTTCACTTCAGCAGCCCAAGGCTGGAAGGAAAG
ACTCTCAGAAGGTGAGTTTACACCTGAGATGCAGGTGAGAATTCGACAAGAGATTGAGAAGGAGAAAAAAGTGGAGCCATGGAAAGAACA
ATTCTTTGAAAGCTACTATGGGCAGAGTTCTGGCCTGAGCCTTGAAGATTCTAAGAAATTGACAGCTTCTCCCAGTGATCCCAAAGTAAA
GAAAACCCCAGCTGAACAACCAAAATCCATGCCTGTGTCAGAGGCCTCTCTTATCAGAATAGTTCCAGTAGTCTCCCAGTCAGAGTGTAA
AGAAGAAGCATTGCAAATGTCATCACCAGGCAGAAAAGAAGAGTGTGAAAGCCAAGGTGAAGTGCAGCCGAACTTCTCCACATCTTCAGA
GCCCCTGCTTTCCTCAGCTCTCAATACACATGAGCTTAGCAGCATTCTTCCCATCAAGTGCCCAAAGGATGAGGATCTCTTGGAGCAGAA
GCCAGTCACCTCTGCTGAACAGGAATCTGAGAAGAACCATCTCACCACAGCTTCTAATTATAACAAAAGTGAAAGCCAAGAATCTTTAGT
TACATCGCCAAGCAAACCCAAGAGTCCTGGGGTTGAAAAACCAATAGTGAAGCCCACAGCAGGAGCGGGTCCACAGGAGACTAATATGAA
AGAACCTCTAGCAACTCTTGTTGATCAGAGCCCAGAAAGCCTCAAGAGGAAGTCTTCCCTCACCCAAGAAGAGGCCCCTGTGAGCTGGGA
GAAGAGGCCACGTGTCACTGAGAATCGCCAGCACCAGCAGCCATTTCAGGTCTCACCACAGCCCTTTCTCAATAGAGGGGACAGAATCCA
GGTGCGAAAAGTACCACCTCTCAAGATCCCGGTCTCCAGAATCTCCCCCATGCCGTTTCATCCATCGCAGGTCTCTCCCAGGGCTCGTTT
TCCAGTCTCCATCACTAGTCCTAACAGAACAGGAGCCAGAACTCTTGCAGACATCAAAGCAAAAGCCCAACTGGTCAAAGCACAGAGGGC
AGCAGCTGCCGCTGCCGCCGCAGCTGCTGCAGCCGCCTCAGTTGGAGGGACCATTCCAGGACCTGGCCCAGGGGGTGGACAAGGTCCAGG
AGAGGGTGGTGAAGGGCAGACTGCTAGAGGAGGCAGTCCAGGCTCAGACAGAGTCAGTGAAACTGGAAAGGGCCCCACACTGGAACTGGC
AGGAACTGGAAGCAGGGGAGGTACGAGAGAGCTTTTACCCTGTGGTCCAGAGACTCAGCCCCAGTCTGAGACCAAGACCACCCCAAGCCA
GGCACAGCCTCATAGTGTCTCTGGAGCACAACTACAGCAAACCCCCCCAGTGCCTCCAACACCTGCCGTCAGTGGAGCATGCACAAGTGT
CCCATCACCAGCCCACATAGAGAAATTGGATAATGAAAAACTGAACCCCACCAGAGCAACAGCCACAGTGGCCTCTGTCAGCCATCCACA
AGGGCCCAGTAGTTGCAGACAGGAGAAAGCACCTTCTCCAACAGGTCCTGCTCTAATCTCAGGTGCCTCACCTGTTCATTGTGCAGCTGA
TGGCACAGTTGAGCTCAAAGCAGGTCCTAGTAAGAATATACCTAACCCTTCAGCCTCATCAAAGACAGATGCTAGTGTGCCAGTGGCTGT
AACTCCCTCCCCTTTAACATCTTTATTGACCACAGCCACTTTAGAAAAGCTTCCTGTACCCCAGGTCAGTGCAACTACAGCACCTGCTGG
ATCAGCTCCACCCTCGAGCACTTTGCCAGCAGCTTCTAGCCTTAAAACCCCAGGAACTTCTTTAAACATGAATGGACCCACTTTAAGACC
AACCTCTAGTATCCCTGCTAATAATCCTTTAGTGACTCAGCTGCTTCAAGGCAAAGATGTTCCCATGGAGCAAATTCTGCCTAAACCTCT
CACCAAAGTTGAAATGAAAACGGTTCCACTGACTGCAAAAGAGGAAAGGGGGATGGGAGCGCTCATAGCTACCAACACAACAGAAAATAG
CACCAGAGAGGAAGTTAATGAGAGACAGTCCCATCCAGCTACGCAGCAGCAGCTGGGCAAAACCTTGCAAAGTAAGCAGCTCCCCCAGGT
TCCAAGGCCCCTTCAGCTCTTTTCAGCTAAGGAGCTGAGGGACTCCAGCATTGACACACACCAATACCACGAAGGACTAAGTAAAGCAAC
CCAAGATCAGATCCTTCAGACTCTCATTCAGAGGGTTCGGAGGCAGAATCTTCTCTCAGTTGTGCCGCCCTCACAGTTCAACTTCGCTCA
CTCAGGTTTCCAGCTGGAAGACATCTCCACAAGCCAGAGGTTCATGCTGGGTTTTGCTGGCAGAAGGACATCCAAACCTGCAATGGCAGG
GCACTACTTACTGAATATTTCTACCTACGGCCGGGGCTCAGAGAGCTTTAGGAGGACCCATTCTGTAAACCCTGAAGATCGTTTTTGTCT
AAGCAGCCCCACTGAAGCCTTGAAAATGGGATATACAGACTGTAAAAATGCAACAGGAGAGAGTAGCAGCAGCAAAGAAGATGACACTGA
TGAGGAAAGTACTGGTGATGAGCAGGAATCTGTCACAGTGAAAGAGGAGCCCCAGGTTTCCCAGAGTGCTGGCAAGGGTGACACAAGTTC
AGGACCTCACAGCAGGGAAACTCTATCTACCAGTGATTGCTTAGCTAGCAAGAATGTGAAGGCTGAGATACCATTGAATGAGCAAACCAC
TTTAAGTAAGGAGAATTACCTGTTCACTAGAGGCCAAACATTTGATGAAAAGACCCTAGCCAGAGATTTAATTCAGGCAGCACAGAAGCA
GATGGCTCATGCAGTGAGAGGTAAGGCAATCCGTAGCAGCCCCGAGCTTTTCAGTTCTACTGTTCTTCCTCTGCCTGCAGACAGCCCCAC
CCACCAGCCCCTACTCCTTCCACCCCTGCAAACCCCGAAGTTGTATGGAAGCCCCACCCAGATAGGGCCAAGCTATAGAGGCATGATCAA
TGTCTCCACCTCATCTGACATGGACCATAACTCTGCTGTACCAGGTAGCCAGGTATCTAGCAATGTAGGTGATGTCATGTCATTTTCAGT
GACTGTCACTACCATCCCTGCTAGCCAAGCTATGAATCCCAGCAGCCATGGCCAGACCATTCCTGTTCAGGCGTTCTCCGAAGAGAACAG
CATAGAGGGCACGCCTTCGAAATGTTACTGCCGCTTGAAAGCCATGATCATGTGCAAAGGCTGTGGCGCTTTCTGCCATGATGATTGCAT
CGGCCCCTCCAAACTGTGCGTCTCCTGCCTTGTCGTTCGGTAATGAGACTAGAAAGAGATACACTGTAAAGGAGGGGGAAGGGAAGGGTT
GACCAGTTGGGTTTTTTGCGTCCTTTTGGAATCACAGAAATAAACAAGTAGGTTTCAGTTGTCTTCAGAGACAAATGTTACTTAATCAGG
AATACAAAGTACAGATTTTTTACATTTTAGAGGAAGAGCACCTTGTATAGTAAGTCTAAGTCAAGCAAGACTTTGTGAATTTGTGACAAG
TTTGCACTTACAAAATCATGTAAATATGTCACATTTTGTTTAACATTATTTTTCCAAGTGTTTAGGTAATAATGTATTACTTTGAATTCA
GATTAATGTTCTACTACTTGTGACTGAGAAAAGTTTAATGCCGGCATGGTAAAAGGAAGCTGTCTCCCTTCTGACATTTCCTAGGAAGCT
AGGAAAAGGAAAGTGAAGGAATGGTCTAAAGAAATGACCATTCACACTGATTTTGTCTGGACAGTCTGGCCGCAGGTTATTCATAGATTA
TTCAGCCTTTGCAGGACTTGGATTCAGGGTTTTACTCAGTCCCTTTACCTTAGGTGGAATCTTCTTAAATTGAAATTTTTGGTAAGGAAT
TCATTTCACAGGTAGTGTTTCAGACTCTGAAAGCCCTGACTTGGTTCTTGGCTTCTACTGTACTAGTTACTAGTTACTGGTACTGTTGCC
AAGCAATCTGCTTGGAATTTGTGGATCCCTGCTGTTCCCTAATCCCACCCCCTGCCCTGAGACAGTGAATGTAGTCCGTGAAGGGAGTGC
CTCTCTGGGACCCCCTGTGTTGTTACAGGCTGTGCAGTGCAACAATTCCAGCAAAAATACCCTATCCCCGCACTTAGTCATTCGTGGTAA
CTAACAATTTTGAAATACTCATATAAAATGAACAGGAAAGTGTTAGTGATTGGGTGATTTGAGCTACATCTTGTTGAGCAAGGGGAGTGA
AACCACAGAAACTGTTAAATTGAACGTAAATAACTTTGGAAAACAGTTTTGACACTAGAACAAGGTCGCTTCTCTTTTCCTCTTCTCTCC
CAACCTGTTAACCTAGTGCTAGATAGTCAGCTGCTGTTGCAGGTAGAAAAGCTCACCAATGCCACATTTGTTCATTCTGTTCAACCTGTT
TTGACCTCCCAGGCATCTGAACAGGATGACATCATCTTATTATATCTTACTTTACACATACGTGTATGTACACACACACACACAATACAA
GACATTTTTCCTGTTTTAGAAAATATAGCCCTTGTTTGGATTACTGCTGTCTGAGCACTAGAAATTTCTAATGGAAAGAGGCCTCTGAAT
GGCTAAGGGAACATCTGGAAAGGAAGGAAAATGAGCCCTAAAGGTTTTTTGGTTGCTTGTTTTTGTTTCTTTTTCTTTCTTGTTTCCTTT
TTTGTTTTTAAATCCTTCTCTAGTGACTGAAGAAATTGTGAGTACATAATATTTAGGTCATGGTTAAGGAACATTAAAATAAACCTGCAG
TTTAACAGAATTTTGTATTAAATGGGGGAGTGTCAATTTGCATCATTTGCATATTGATTTCAAGTCTCCTAATTTGGAATGGGTAAAGTA
CAAATGTTAATGCAACATAGTACAGTTGTATTTGTCCTTCATATTCAGGATGTGATATTTACAAAATGCAGAACAGTTTAAACTTGTTAA
GTCACATTCCAGATTAGGAGAAAATGGGCAATAATCATCTCTGTTTTGCCCCCATTCTACTACCCACCACTGCCCACCCCACCCCCACAT
CACACACTCTTCGATGCTTTCCCACAGCCCCTGCTCCGCTCCTCTCCGTAAGAAACTCACTTCACTGTTTTTCACTTTTCACTTCTGGCT
TTTTTGTGGCCCAAGGCCAATATAGGATTAATATCTGTGTTCCAGCTTCAGCCAGAACGATATGTCTGTCCATCTTTCTCCTTTCTTCCA
GCACACACAGCTAAGAGATAAGAAGGCTGCAAGGATTGGGGATAAGGAGTATATTTTCAAGCCAAGAACCAGTAGAAAACAGAAATAATG
GTGCTCCCAAATATTCAGTACCTTGGGCAATCCAGGAAGGGTTTAAAGAGACCTGTTGCTGCATAGAACTCTCCCTGCCCTACCCCTTAA
CTCCACCTTAGTGCCAGGGCCGAGGGCTGGTCTGCATGCTGGAAGAGGTTGAGAGTTTTGGAATTGATTCCATGCTAAATGTCAGTTACC
AGTTTGGATTGATGAAAGTGATTTTTCTGCTTTACCTTTTTCCTGTCAGAAAGGTTTTCCTCTGTGCTACCCTTAACTTAGGGATGAACA
GACTATAACTAGGAAAGGAGGAAAGGTATCAGGGATTTTTAAGTCCGTTTAGAGAGCAAACCATATTGTGCCTCTTCATCTTGACCCAGG
CTCTTATAGATAGGTCCTAAACATTGCTGTTCACTAGATTATCTTAACAAATAATACTCAGCTAAATATTTGCATTTAGGAATACTCCTA
AAACAGATATTGCCAACTAGATACACTGCCTCAATCTTGACCAGACAAGAGAACAGTTAAGTTCTCTCAGTTGGGTAGTAACTTGAATAC
CAGTCTATTTATCAGTTGGTTTCAACACAGAGGTTTCAAGTGGAAAGCCATTCATCTTAAAAGCTGAACAGAAAAATTAAAAAAAAAAAA
AACACATTACAATCTGGCCTTTTAGAAAATGAAGCAGTAGAAACAAAACCTTTATTAGTATGGTATTCCAGCAGCACCTTTAAAGCAATC
TTTACCTTAGTTTTTTGAGTTGTTTTACCTTTCATCCCAATCTGAAAAGTTTTAATAAATGCTGAGCTTATTCTTAGGGTATGACCTGGC
ATTATTTCCAGTGACTAGTCAGGCATTATGCCTGATGCATACGCCTCCCGTGCACCCCTATCTAGCCTTCAGATGTCCTCCACTGCAGGT
CACCCCAGGAGATAGCATCAATAATATAGTCTCAGTCTTGTTTATAAAGATTCTAAGTTGTCTAGTAAATAAGTCTCCCTGAATCTTAAA
TAATTTTGGAGAATTAGAATTCTCCATCCTATTAAACAGAAAGTAAAGCCAAATAGCCTGGAGTTGTTTGTCCTACTTGTTCCATAACCC
CTATGCTCAAGATACTGAAGCTATCTGTGGTATTTCATGTAACATTTCTAAGAATAAGAGCTGGCAAATGGGAAACTTGGGGTGGAGAGA
GCATACTTATTGGGCTGTGAAGGCATACGGATGTACATGTTTTAGAGCTTATCTCAGATTTAAATAGCCAAAGGAAGACCTCATTGCCTT
CCAGGTGAAGGTGCAAAGTCATACATATTAATGACCTGACAGTTAACATTCTGTTGTTTATTATTGCCTTTCTCCACCTTAGAGAGCCAT
AAATAACTCTCTGGTGAAGTGATTTGCTATAATGGGGGTGAGGAGTGGGGAGACTTCTCTGGTCATTACACTGCTATTTATTTCTAGAAC
TCACTATCAGTGAGCAGTGCCAGAGTGTTTTCTCTTTGACCTAGAGGTTTCACATCATAGCAAGGAGGGAAAAGTCTCCCCATCTCCTTA
CAACTGTGTGCTAAGTAAGTAACTTGGCCAAGGGTAGTTTTCAGCTCAATTTATAGAATAGTCCAAAGAGACTTTGAGAAACATGGTGAT
AGGCAGGGGCCTTTCCTACCATGTTTCAATACCTACAAACCTATTGAAAGAGAACAGTAGGTAAAACATTTCCTAAAGTTGAAGCAATAG
CTTCGTAGATTCTTGGTTACTTTATTTTTTTTAATGCTTTACATTTGATACAACTATTGAAGATCAATTTTAAAAATAGCTTTCCAGTAA
TATATTTTAAGTAATATATATTTTAATATCTGTAAAAAGTGACAGTGGAAGACTTTGAATTTCTCATATATGGTATGTTTGATGTAGGAC
CTCACTGTTAAGGCACAAATTATTTCAAAGGAAGTTACTCTAAAGACACTCAGATTATTTCAGAAAAATGCAATAAGGGGAATAGTTTTG
GGGTTTATTTTTTATTTTAAAAGAAAATTGACTTATTTACCACAAGCTATTTTTTTCCCTTCTGGCTGTAAGGTTTGTACAGACTGGTTT
GGTAAATGCTAAACTTTTGTGTCTTTTGCCTTTTTAAAGGAATTGTTAACATTGGAATTGAGGGTATGTACAGAGAAGTTGGTGTCAACA
CCATTTAAAAAGTCATATTTTTTCACAAATATAGAAAATCATTTTACATAAGAATTTTAAGTATTTGCAATAAATATATGTATATAGATT
GTATGTATTCCTATATTCTTATTTTTCATTTTATTATTAAGTAAAAGATCATTAAAAGTGAAAATAAAAACCTTGGAGTTTTTTGGTGAA
TCTTGAGGTTTAACATACATCTGAGAGTGGCGTGGGTAAGAGTCCTCAGTTACTGCCTTATACTCCTATGGGATGGTTCCCACAGATTGT
ATGGAAGAGAGTAAAATGAGGAACTTGGTGATAAATCAGGGTAGTGTATTTCTTTTGGAATTTAAGTAAAACTGATTAAATTTTCCTTAT
CTGTCTGTCTCCATGTTTTCTCCCTTAATCTGTTTTGTCTCCTAACCCCCTAACATTACTGGAAAAGTGAAGAAATGCGGTGCAGCCTCT
TTATTAATGTGCCCATTGTTTGCTCCTAAATCAAAGAATGGTAAGGAAATATCTCGGGGGAAAAAATAGGTTTTCCTTTCTCCACAGTGG
TTGACATTTACTGCCACCACTTTCCAGGCCTTAGGGGAGTGTGAAGAAATAGTTTCTTGAAGATGATAGAAATTTTTTTTTTTCCGTTTC
CCAGTTCTCTCAGAAGTGAGTTTCATAGCCAGTCATGTCCTTCCTGCCCGTCTAATCTGGAGAGGTCAAAGAGCAAGGAAAATAATGTGA
AGAGAAACACCTGTGCCTTGATTAGGTTCTATTTCAGCATTTGACACTTGAATTTTGAACTCCTCTGGGTCAGGAAGGGTAGCTATGGAA
ATGAGGTCTGAGCCAGTTGGTAGGAGAGGTTGTCTATGTTCCCATACCGAGATTGCTGTCTAATCCACGAGAACTCATTTTGTGGCTGCA
AAGTAAATACTTGATTTTAGGATATGATAGGAGCAAAATGGTGCCTACATCGTCTTTATAAAGAAAAGTATATAGCCCATTTTTTAACAA
ATGAATAATATATCGAATCATTGATGACCTAAAAGAAAAATTGTTAAGGTCAGATTTTCGAGAGTGTATCTTGATGACCCATAAAACTGA
CTTTTTATTGTAGTTCACTAGTTCCCATAATTGCCCAGCTGTGGTTACTTTCACTGAAAAGAAAAAATATATTTTGGAAGTTAATGTAAG
GATACATTGGCTTTTTTTTTTTTTCTTTACATTGGCTTTTTAAAAGACAGTTTTTATTTTTCAGATACTGGAATGTCAAGTATCTGGGTT
GTCCCAAGACGTTGGAGATAATTCAGCCTTCCAAGAGAACAGCAGTCTAGATCTTAGCTGAAAATGTGCTGTTTCTAAAGGAAGCTTCTT
AAGTCTCAGGGGACATTAGCATCTTCATAATTTCCATATATAATAAGAATGAAGGTAAAATATTTAAATGTGTATAAACTAATCCATAAT
GACCATTTACAAAGATTGACTCCCCATTTCTGGTACATATTTATCATTATTTAGATGGGTCTCCTATCTTGTGGGAAGATAAATTTATAT
TCAGGTGATGACATGGGTGCCTGCAAGTAGAGTTGGTCTGCAGCTGAGGGAGAAGGCAACATACCAGAAGACAAGGCAGCTTCAACCTGG
ATCCCCAGCTACCCTTTATTTACTTCACTGAGTCAGAAACCCGTGTTCATTGCTTCTGAGACTACTTGACCTCAGCTGGTCTTTAGAAGT
CTGGTAACTTTTTATGTACAAATCATGTTATTTACTAATTCAAGTATTTATAGAGCACCTACTGTGCACTAAGCACTAAAGTGCTGGTTA
TGCAAAGGTAAGCAAAAATAGTCATGTAAGTTGCAGAAAGGTTTTCCTAAAGTAGTGACTATACAGCATGTTTTTAGTTCTAGGCTCAAG
GAGTAATACTACCTTTTTCCCAAGATAGGTTGAAAATTTAAATGAGTTATGAAATGGAAGTGTTTGAGACACTGGACACAGTAGTGGCAA
ATACATGAAGAAAGAAGGTCCCTAGATGAAAAAAGTGTGGAAATGAGGAGCCATATTAATAAAATGCACCTTTTTTGAGAACTATTGTTG
GAATAGCTAAAGTTGTCTATAGAAATTTCAAGAAATCTCTTAACATCTAAATTAGAAGCAGGCCAACAGCAATCTCTGTCAGTAGTTAAT
TTAGGTCAGTAAGTTAGTGTTTTGTTAAACTAACCCTTTCAAACACAGTTGGGTAAATAATGCAGCTTTCCTGTCACTGTTCAAACCTAA
AAGAAGCTAAAGGGAATTTTTCTTAAAACATGATTTTCATCTTATAGATGATAAGTAACTGTATCTCTTCATTTGGAATTGTTGCATCCC
AGTTTTTCTCCATAATGGATAAAATTACTTTTGTGTCCTTTTCTATTCTAATGTAGAAGTGGCTTTTCCTTTTTTCTCTTGAGTCACAAC
TTGAATTAAAAAGGGCTTCAGCAGGACTCTAGCGCTTTTTAAAGAAGAATTTGGTGTATTCCACTATGTAACGTAGTCTCTGTCCAGGAA
CCAGGAGGATGAGTGTCCTCAGTTTTCCTAATACTTGGTAACATTTAATAATAGATTGAGTTTTGCTTTTGTTTTTCATAGAGACTGTAT
AGACTCTGTACTTCCATGTAACTTTCTGCCTTAACCTAAAAAGGCATTCCCTGGAAGGAGATCTTGTAACAGGAAGAAAAAGCGAAACCA
GGAAAAGAGCCAGAAAGGATCAACTTGGAGATGGGCTGTGGCTAAATAGTGGGTTTTCCTGAAAAGTAACTGCAACCTTGCTTTTCGTGC
TTCTTCAAACCCAAAAGAACCTAAAGGGAATTTTTAAAAATCCTGATTTTCTTCTTAATTGTAAAACCTAGAGGATGCCTTAGGGAGAAG
AAAGATAACCTGGAATTTGGTTTTAAATGGATTTAAGTAAACTTTGAATTAAGTAGCTTATTCCATTTTTGAGAGATTTCTTTTTAAGAT
TTTAGATTCACTTAATGTAATGTTGAATTGCCATGAATGTAACCTGGAGTTTGATTTGAGACATTCTGTGGGATAAGGAATAGTTTTCTA
TTGAACTGTGGTGGCTTTTGCCACTAATCAGGATTTAGGGCTGTGCACCTCCATCTGTTAAGTGAAATGGAACTTGGCTTCCTAAACACT
ATATTAGACCAACTTGAGTCAATACTTTTATTAAGTTTAATCAGGGATTCTCAAAATATTTAGGATTCAAATTAGCCCAATTAGAAAGCA
GTGCATTAAATGTTACCAAAATATCTGAAGATACTTTAGAACTATTTTACACAAAGCTTATGTCTTTCCTATGGAAAGTATCATACATAA
AATTTTACATTCTTTTAAAAAACAGAATCTAATGTCTTCAGATACCTAGAGCTTGGAAATTATAATAGAGTTGGGCTTTGACCCGAAGTC
AGCAGTTCTTTTCATTTTAGATTTTCAGGCAAGTTTCAGTAGTTTGGAGACTTCTTCAGTAGTGACCCCAGCTTAACCTACATATAATCA
CTTTGCACACATTTTAAGTTAATCAGATGCTTCCAGAGTCTTGGATTTGGTTACCCCTTTGTTAGATAAGGAGACAGATTCTAGGTTGGG
ACAAACATCTTAATTTATTCTCTAATAATAAAGTACTGATTAAAGAGCAAGTTCTCAGAGAATTCACAAAATTTCTAGAATCCATGAAAG
ATCTAGAGAACATAACAAATGAAACTCTAGAAATTTGAAAGAAAAAAAAACACTTAGCTGTAAGTGCTTTGACCTATTTTTTTTAAAAAA
AAAAAACCTGTCTTAATTCTGTGACTGCATTGCACCCTTCACCAGCACTAAGAGAAGTCGGAATGGAAGAAATTACCGTATGTAATTCTT
ATTCACTTAAAATCTTTGTGCGCATAGGCCTTAGCACTTTGACAAATAAACTCTGCCTTTTAGCTCCTCACTATTGTCTTCTTTCCTGTC
ACTTTTAGGCTGTTTCATTGGTCGTATAAAAACAACCTTCTTCGAAGTTGAATGTATGTTTCTGCACATAGACAAACCATATTTTACTGA

>24368_24368_2_DTNB-ASXL2_DTNB_chr2_25818955_ENST00000496972_ASXL2_chr2_25991737_ENST00000435504_length(amino acids)=1411AA_BP=144
MIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDK
LRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQALKQQQQKKQQQQCRPSISISSNQHLSLKTVKAASD
SVPAKPATWEGKQSDGQTGSPQNSNSSFSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHTFSV
LPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPEMQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGL
SLEDSKKLTASPSDPKVKKTPAEQPKSMPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNTHEL
SSILPIKCPKDEDLLEQKPVTSAEQESEKNHLTTASNYNKSESQESLVTSPSKPKSPGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPE
SLKRKSSLTQEEAPVSWEKRPRVTENRQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPNRTGA
RTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTARGGSPGSDRVSETGKGPTLELAGTGSRGGTRELL
PCGPETQPQSETKTTPSQAQPHSVSGAQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQEKAPS
PTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSLLTTATLEKLPVPQVSATTAPAGSAPPSSTLPAAS
SLKTPGTSLNMNGPTLRPTSSIPANNPLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEERGMGALIATNTTENSTREEVNERQSHP
ATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQTLIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQ
RFMLGFAGRRTSKPAMAGHYLLNISTYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDEQESVT
VKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYLFTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRS
SPELFSSTVLPLPADSPTHQPLLLPPLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPASQAMN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DTNB-ASXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTNB-ASXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTNB-ASXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource