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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTNB-DNMT3A (FusionGDB2 ID:24371)

Fusion Gene Summary for DTNB-DNMT3A

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNB-DNMT3A
Fusion gene ID: 24371
HgeneTgene
Gene symbol

DTNB

DNMT3A

Gene ID

1838

1788

Gene namedystrobrevin betaDNA methyltransferase 3 alpha
Synonyms-DNMT3A2|HESJAS|M.HsaIIIA|TBRS
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin betaDTN-Bbeta-dystrobrevinDNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2
Modification date2020032720200322
UniProtAcc.

Q9Y6K1

Ensembl transtripts involved in fusion geneENST00000288642, ENST00000404103, 
ENST00000405222, ENST00000406818, 
ENST00000407038, ENST00000407186, 
ENST00000407661, ENST00000496972, 
ENST00000472690, ENST00000545439, 
ENST00000380746, ENST00000402667, 
ENST00000474887, ENST00000264709, 
ENST00000321117, ENST00000406659, 
Fusion gene scores* DoF score10 X 10 X 7=7004 X 4 X 3=48
# samples 124
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTNB [Title/Abstract] AND DNMT3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNMT3A(25564695)-DTNB(25602192), # samples:3
DTNB(25830105)-DNMT3A(25505580), # samples:1
Anticipated loss of major functional domain due to fusion event.DTNB-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DTNB-DNMT3A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DTNB-DNMT3A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DTNB-DNMT3A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DTNB-DNMT3A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DTNB-DNMT3A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNMT3A

GO:0006306

DNA methylation

12138111|19786833|23042785


check buttonFusion gene breakpoints across DTNB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNMT3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A4SD-01ADTNBchr2

25830105

-DNMT3Achr2

25505580

-


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Fusion Gene ORF analysis for DTNB-DNMT3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288642ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000288642ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000288642ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000404103ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000404103ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000404103ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000405222ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000405222ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000405222ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000406818ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000406818ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000406818ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407038ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407038ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407038ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407186ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407186ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407186ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407661ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407661ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000407661ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000496972ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000496972ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
5CDS-intronENST00000496972ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000288642ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000288642ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000288642ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000404103ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000404103ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000404103ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000405222ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000405222ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000405222ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000406818ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000406818ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000406818ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407038ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407038ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407038ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407186ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407186ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407186ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407661ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407661ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000407661ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000496972ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
Frame-shiftENST00000496972ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
In-frameENST00000496972ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000472690ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000472690ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000472690ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000545439ENST00000264709DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000545439ENST00000321117DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-3CDSENST00000545439ENST00000406659DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000472690ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000472690ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000472690ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000545439ENST00000380746DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000545439ENST00000402667DTNBchr2

25830105

-DNMT3Achr2

25505580

-
intron-intronENST00000545439ENST00000474887DTNBchr2

25830105

-DNMT3Achr2

25505580

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000496972DTNBchr225830105-ENST00000406659DNMT3Achr225505580-18445841040432202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000496972ENST00000406659DTNBchr225830105-DNMT3Achr225505580-0.7655760.234424

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Fusion Genomic Features for DTNB-DNMT3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DTNB-DNMT3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25564695/chr2:25602192)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNMT3A

Q9Y6K1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223292_35059913.0DomainPWWP
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223482_61459913.0DomainADD
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223634_91259913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223292_35059913.0DomainPWWP
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223482_61459913.0DomainADD
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223634_91259913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019292_3500724.0DomainPWWP
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019482_6140724.0DomainADD
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019634_9120724.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018292_3500690.0DomainPWWP
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018482_6140690.0DomainADD
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018634_9120690.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924292_35059167.0DomainPWWP
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924482_61459167.0DomainADD
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924634_91259167.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223641_64559913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223686_68859913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223891_89359913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223641_64559913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223686_68859913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223891_89359913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019641_6450724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019686_6880724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019891_8930724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018641_6450690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018686_6880690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018891_8930690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924641_64559167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924686_68859167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924891_89359167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223493_52359913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223534_59059913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223493_52359913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223534_59059913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019493_5230724.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019534_5900724.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018493_5230690.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018534_5900690.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924493_52359167.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924534_59059167.0Zinc fingerPHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTNBchr2:25830105chr2:25505580ENST00000404103-520428_529149607.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000405222-518428_529149570.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000406818-521428_529149637.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000407038-519428_529149577.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000407661-520428_529149619.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000496972-418428_52992581.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNBchr2:25830105chr2:25505580ENST00000404103-520399_448149607.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000405222-518399_448149570.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000406818-521399_448149637.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000407038-519399_448149577.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000407661-520399_448149619.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000496972-418399_44892581.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNBchr2:25830105chr2:25505580ENST00000404103-520237_284149607.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25830105chr2:25505580ENST00000405222-518237_284149570.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25830105chr2:25505580ENST00000406818-521237_284149637.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25830105chr2:25505580ENST00000407038-519237_284149577.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25830105chr2:25505580ENST00000407661-520237_284149619.3333333333334Zinc fingerZZ-type
HgeneDTNBchr2:25830105chr2:25505580ENST00000496972-418237_28492581.3333333333334Zinc fingerZZ-type


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Fusion Gene Sequence for DTNB-DNMT3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24371_24371_1_DTNB-DNMT3A_DTNB_chr2_25830105_ENST00000496972_DNMT3A_chr2_25505580_ENST00000406659_length(transcript)=1844nt_BP=584nt
ACAAACACAGTAATTCCTGATACTAAGAAGAGGCTGGGGTGCCTTAAGTAATACGCATGCAGGCGTTGATGGGGTAGAGATCTGAAGTAG
TCCTGCCAAGAACTGGGTTTACTTCTTTGTGAATGTTACTACTCTTACACAGAAACCTCATATGAATTATCATCCTCTGACTTAAGGATA
ACAGTCAGTCTGGGAGACGTTTGGTGCTCAGAATTTTGATGTCATACGACTATCAACTTACAGAACAGCCTGCAAATTACGATTTGTACA
AAAACGATGCAACCTTCATCTTGTTGATATCTGGAACATGATTGAAGCCTTCCGAGACAATGGCCTTAATACACTGGACCATACCACCGA
GATCAGTGTGTCCCGCCTCGAAACTGTCATCTCCTCCATCTACTATCAGTTGAACAAGCGCCTTCCTTCTACTCACCAAATTAGTGTGGA
ACAATCTATCAGCCTCCTCCTCAACTTTATGATTGCTGCATATGACAGTGAGGGCCGAGGCAAGTTGACGGTATTTTCAGTTAAAGCTAT
GTTAGCAACCATGTGTGGTGGAAAAATGCTGGACAAATTGAGATGTGGAAAGCGGTGACACGCCAAAGGACCCTGCGGTGATCTCCAAGT
CCCCATCCATGGCCCAGGACTCAGGCGCCTCAGAGCTATTACCCAATGGGGACTTGGAGAAGCGGAGTGAGCCCCAGCCAGAGGAGGGGA
GCCCTGCTGGGGGGCAGAAGGGCGGGGCCCCAGCAGAGGGAGAGGGTGCAGCTGAGACCCTGCCTGAAGCCTCAAGAGCAGTGGAAAATG
GCTGCTGCACCCCCAAGGAGGGCCGAGGAGCCCCTGCAGAAGCGGGTGAGTCCTCAGCACCAGGGGCAGCCTCTTCTGGGCCCACCAGCA
TACCCTGAGAGTCAGGGACTTGGCTCTCCAGCAGGTCCCAGGAAGGATGGTCTGGGTCGTGGCTAAAGGTCTGCTTGCCAAGGCTATGGC
CTGGAGGCTACTGGCTGGATGCAGCCTGCGCATATGTTTTATTTGGCCCATAGAGTGTTTTAAACATTTAAAAAATTAGTTGCCAGTATT
TAAAAATCAAAAAATTTCACATAAAAATCTGGAGTTTTGGCTTCTCATGAAAAAAAAAAAAGCTAGATCTGGCAACAGCGGGCTTTCATA
ACGCCAACGATTGCTAGACTGGGATAATGGCGGTCCCTCCATCGCCTTCTGTGGCTGGTTGTGGGCCTTAGTTTTCTGCAGCTCTACCTG
GCCTGCTTACTCTCCCACGTGCCATGCAGTTCCTGGGGGTTGCTGTATTTGTAGCCCCTGGCCTGGGCACTCAAGGGCAGCAGATACCCT
GTTTGCCTCCCTGAGTGCAGAGGTCCTGAGCCCACCCTAGTTGGGCTGACTCAACTGGAAATTTGGTTGTGACAGTGGCGTGGGGAGAGG
GCTGGGTGATTGTATTCTGTGTACTGCCCAGCCCAGGCCTCTTCATCTGGGGACTTTTTGGCCTAACCCTGGAAGCCTGGAAAGTTGCCC
ACTTTTCTCTTTCAGGTTAAGCCAGCAATTTCAGGGCCAACCGAGCTGTAAACATGTTAGTAATGAGGACAACTAGCATTTGTACAGGGC
TTCACAGTTTACAAAGCGCTTTCTCATACATTATCACATTTGATCCTCCCAGGGCCCTGCCAGGTTGTTTTGCATATGTGCATTTTAATT
TCAAAAAGTCTTCCTTCCAAGCGTGTATGATGAAATGAGTAAATTGATTAATTGGCGTAACTTATTTTGCATGGATCCAACCTAATGTTC

>24371_24371_1_DTNB-DNMT3A_DTNB_chr2_25830105_ENST00000496972_DNMT3A_chr2_25505580_ENST00000406659_length(amino acids)=202AA_BP=0
MGQIKHMRRLHPASSLQAIALASRPLATTQTILPGTCWRAKSLTLRVCWWAQKRLPLVLRTHPLLQGLLGPPWGCSSHFPLLLRLQAGSQ
LHPLPLLGPRPSAPQQGSPPLAGAHSASPSPHWVIALRRLSPGPWMGTWRSPQGPLACHRFPHLNLSSIFPPHMVANIALTENTVNLPRP

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Fusion Gene PPI Analysis for DTNB-DNMT3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223199_40359.0913.0DNMT1 and DNMT3B
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223199_40359.0913.0DNMT1 and DNMT3B
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019199_4030724.0DNMT1 and DNMT3B
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018199_4030690.0DNMT1 and DNMT3B
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924199_40359.0167.0DNMT1 and DNMT3B
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000264709223494_58659.0913.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000321117223494_58659.0913.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000380746019494_5860724.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr2:25830105chr2:25505580ENST00000402667018494_5860690.0the PRC2/EED-EZH2 complex
TgeneDNMT3Achr2:25830105chr2:25505580ENST0000040665924494_58659.0167.0the PRC2/EED-EZH2 complex


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTNB-DNMT3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTNB-DNMT3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource