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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTWD2-SLMAP (FusionGDB2 ID:24397)

Fusion Gene Summary for DTWD2-SLMAP

check button Fusion gene summary
Fusion gene informationFusion gene name: DTWD2-SLMAP
Fusion gene ID: 24397
HgeneTgene
Gene symbol

DTWD2

SLMAP

Gene ID

285605

7871

Gene nameDTW domain containing 2sarcolemma associated protein
Synonyms-SLAP
Cytomap

5q23.1

3p14.3

Type of geneprotein-codingprotein-coding
DescriptionDTW domain-containing protein 2sarcolemmal membrane-associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304058, ENST00000510708, 
ENST00000515439, 		ENST00000295952, 
ENST00000383718, ENST00000416870, 
ENST00000428312, ENST00000449503, 
ENST00000442599, ENST00000472546, 
ENST00000494088, ENST00000495364, 
ENST00000295951, 
Fusion gene scores* DoF score6 X 5 X 3=9010 X 16 X 11=1760
# samples 618
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1760*10)=-3.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTWD2 [Title/Abstract] AND SLMAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTWD2(118264232)-SLMAP(57817110), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTWD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLMAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-4884-01ADTWD2chr5

118264232

-SLMAPchr3

57817110

+


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Fusion Gene ORF analysis for DTWD2-SLMAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000304058ENST00000295952DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000304058ENST00000383718DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000304058ENST00000416870DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000304058ENST00000428312DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000304058ENST00000449503DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000510708ENST00000295952DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000510708ENST00000383718DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000510708ENST00000416870DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000510708ENST00000428312DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-5UTRENST00000510708ENST00000449503DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000304058ENST00000442599DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000304058ENST00000472546DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000304058ENST00000494088DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000304058ENST00000495364DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000510708ENST00000442599DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000510708ENST00000472546DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000510708ENST00000494088DTWD2chr5

118264232

-SLMAPchr3

57817110

+
5CDS-intronENST00000510708ENST00000495364DTWD2chr5

118264232

-SLMAPchr3

57817110

+
In-frameENST00000304058ENST00000295951DTWD2chr5

118264232

-SLMAPchr3

57817110

+
In-frameENST00000510708ENST00000295951DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-3CDSENST00000515439ENST00000295951DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-5UTRENST00000515439ENST00000295952DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-5UTRENST00000515439ENST00000383718DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-5UTRENST00000515439ENST00000416870DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-5UTRENST00000515439ENST00000428312DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-5UTRENST00000515439ENST00000449503DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-intronENST00000515439ENST00000442599DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-intronENST00000515439ENST00000472546DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-intronENST00000515439ENST00000494088DTWD2chr5

118264232

-SLMAPchr3

57817110

+
intron-intronENST00000515439ENST00000495364DTWD2chr5

118264232

-SLMAPchr3

57817110

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304058DTWD2chr5118264232-ENST00000295951SLMAPchr357817110+4488470562707883
ENST00000510708DTWD2chr5118264232-ENST00000295951SLMAPchr357817110+4649631162868950

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304058ENST00000295951DTWD2chr5118264232-SLMAPchr357817110+0.000467850.9995322
ENST00000510708ENST00000295951DTWD2chr5118264232-SLMAPchr357817110+0.0004725390.99952745

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Fusion Genomic Features for DTWD2-SLMAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTWD2chr5118264231-SLMAPchr357817109+9.95E-050.9999006
DTWD2chr5118264231-SLMAPchr357817109+9.95E-050.9999006

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTWD2-SLMAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:118264232/chr3:57817110)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTWD2chr5:118264232chr3:57817110ENST00000510708-46178_181199299.0MotifNote=DXTW
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295951122167_20266812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295951122230_38866812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295951122477_79966812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295952021167_20266812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295952021230_38866812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295952021477_79966812.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000383718015167_20266507.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000383718015230_38866507.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000383718015477_79966507.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000416870018167_2020272.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000416870018230_3880272.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000416870018477_7990272.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000428312022167_20266829.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000428312022230_38866829.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000428312022477_79966829.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000449503020167_20266791.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000449503020230_38866791.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST00000449503020477_79966791.0Coiled coilOntology_term=ECO:0000255
TgeneSLMAPchr5:118264232chr3:57817110ENST0000041687001828_850272.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST000004168700181_1630272.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295951122824_82866812.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295952021824_82866812.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST00000383718015824_82866507.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST000004168700181_8020272.0Topological domainCytoplasmic
TgeneSLMAPchr5:118264232chr3:57817110ENST00000416870018824_8280272.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST00000428312022824_82866829.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST00000449503020824_82866791.0Topological domainExtracellular
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295951122803_82366812.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSLMAPchr5:118264232chr3:57817110ENST00000295952021803_82366812.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSLMAPchr5:118264232chr3:57817110ENST00000383718015803_82366507.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSLMAPchr5:118264232chr3:57817110ENST00000416870018803_8230272.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSLMAPchr5:118264232chr3:57817110ENST00000428312022803_82366829.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSLMAPchr5:118264232chr3:57817110ENST00000449503020803_82366791.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLMAPchr5:118264232chr3:57817110ENST0000029595112228_8566812.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST0000029595202128_8566812.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST0000038371801528_8566507.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST0000042831202228_8566829.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST0000044950302028_8566791.0DomainFHA
TgeneSLMAPchr5:118264232chr3:57817110ENST000002959511221_16366812.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST000002959520211_16366812.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST000003837180151_16366507.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST000004283120221_16366829.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST000004495030201_16366791.0RegionNecessary for targeting to centrosomes
TgeneSLMAPchr5:118264232chr3:57817110ENST000002959511221_80266812.0Topological domainCytoplasmic
TgeneSLMAPchr5:118264232chr3:57817110ENST000002959520211_80266812.0Topological domainCytoplasmic
TgeneSLMAPchr5:118264232chr3:57817110ENST000003837180151_80266507.0Topological domainCytoplasmic
TgeneSLMAPchr5:118264232chr3:57817110ENST000004283120221_80266829.0Topological domainCytoplasmic
TgeneSLMAPchr5:118264232chr3:57817110ENST000004495030201_80266791.0Topological domainCytoplasmic


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Fusion Gene Sequence for DTWD2-SLMAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24397_24397_1_DTWD2-SLMAP_DTWD2_chr5_118264232_ENST00000304058_SLMAP_chr3_57817110_ENST00000295951_length(transcript)=4488nt_BP=470nt
GGAGTCGGCGGCTCGGGCAGCTCTGCGATTAGGGCGGCGGAGTTGGCGGGTGCACGTTGGAAATCTCGGAAATGCCAGGCACAGCTACCT
ACCGGCCTCAGAAAGTGTGTTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAG
AGGAAAACAAAGTGTTGCGTACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTG
AAGAAAGAGATCCTGAACTTTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAAT
TTATATTAGATTCTCCTGTTTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCT
TGTTCCGACATCCCAAACAGTTTTATCTTCAAGACACTAAAAGTAGTAATGGTACTTTTATAAATAGCCAGAGATTGAGTCGAGGCTCTG
AAGAAAGTCCACCATGTGAAATTCTTTCCGGTGACATTATCCAGTTTGGAGTAGACGTGACAGAGAATACACGGAAAGTTACCCATGGGT
GTATTGTTTCCACAATAAAACTTTTTCTACCAGATGGTATGGAAGCCCGGCTCCGCTCAGATGTCATCCATGCACCATTACCAAGTCCTG
TTGACAAAGTTGCTGCTAACACTCCAAGTATGTACTCTCAGGAACTATTCCAGCTTTCTCAGTATCTACAGGAGGCCTTACATCGGGAAC
AAATGTTGGAACAGAAGTTAGCCACGCTTCAGCGGCTACTAGCCATCACCCAAGAGGCTTCAGATACCAGTTGGCAGGCTTTAATAGATG
AAGATAGACTCTTATCACGGTTAGAAGTTATGGGAAACCAATTACAGGCATGCTCCAAAAATCAAACAGAAGATAGTTTACGAAAGGAAC
TTATAGCATTACAAGAGGATAAACATAACTATGAGACAACAGCCAAAGAGTCCCTGAGGCGGGTTCTTCAGGAGAAAATTGAAGTGGTTA
GAAAACTTTCAGAAGTTGAGCGAAGTCTGAGTAATACTGAAGATGAATGTACCCATCTGAAAGAAATGAATGAAAGGACTCAGGAAGAAT
TAAGAGAATTAGCCAACAAATATAATGGAGCAGTTAATGAGATTAAAGATTTATCTGATAAATTAAAGGTAGCAGAGGGAAAACAAGAGG
AAATCCAACAGAAGGGACAGGCTGAGAAAAAAGAATTACAACATAAAATAGATGAAATGGAAGAAAAAGAACAGGAGCTCCAGGCAAAAA
TAGAAGCTTTGCAAGCTGATAATGATTTCACCAATGAAAGGCTAACAGCTTTACAAGAGCACTTGCTTTCAAAGAGTGGCGGGGACTGCA
CTTTTATTCATCAATTCATAGAATGCCAGAAGAAGCTGATCGTCGAAGGGCATCTAACCAAAGCGGTAGAAGAAACAAAGCTTTCAAAAG
AAAATCAGACAAGAGCAAAAGAATCTGATTTTTCAGATACTCTGAGTCCAAGCAAGGAAAAAAGCAGTGACGACACTACAGACGCCCAAA
TGGATGAGCAAGACCTAAATGAGCCTCTTGCCAAAGTGTCCCTTTTAAAAGATGACTTGCAGGGTGCACAGTCAGAAATTGAGGCAAAGC
AAGAAATACAGCATCTTCGAAAGGAATTGATCGAAGCCCAGGAGCTAGCTAGAACAAGTAAACAAAAATGCTTTGAACTTCAAGCTCTTT
TGGAAGAAGAAAGAAAAGCCTATCGAAATCAAGTTGAGGAATCCACTAAACAAATACAGGTTCTTCAAGCCCAATTGCAGAGGTTACACA
TCGATACTGAGAATCTCCGGGAGGAGAAGGACAGTGAAATCACAAGTACTAGAGATGAATTGCTTAGTGCCCGAGATGAAATTTTGCTCC
TTCATCAAGCAGCAGCAAAGGTTGCCTCTGAGCGGGACACTGACATTGCTTCTTTACAAGAAGAGCTTAAGAAGGTGAGAGCTGAGCTTG
AGCGGTGGCGGAAAGCAGCGTCTGAATATGAGAAAGAAATCACAAGTCTGCAAAACAGTTTTCAGCTTAGATGTCAACAGTGTGAGGACC
AGCAGAGAGAAGAAGCAACAAGGTTGCAAGGTGAACTAGAGAAGTTGAGAAAGGAATGGAATGCATTGGAAACCGAATGCCATTCTCTAA
AAAGGGAAAATGTTTTGCTATCATCAGAACTGCAACGGCAAGAAAAAGAATTGCACAATTCTCAGAAGCAGAGTTTAGAGCTTACCAGTG
ATCTCAGCATCCTTCAAATGTCTAGGAAAGAACTTGAGAATCAAGTGGGATCCTTGAAAGAACAGCATCTTCGGGATTCAGCTGATTTAA
AAACTCTTCTCAGTAAGGCAGAAAACCAAGCAAAGGATGTGCAGAAAGAGTATGAAAAGACACAGACTGTACTCTCAGAACTGAAGTTGA
AGTTTGAAATGACTGAGCAGGAAAAGCAGTCAATCACAGATGAGCTCAAACAGTGTAAAAACAACCTGAAGCTGCTCCGAGAGAAAGGAA
ATAATAAACCCTGGCCCTGGATGCCCATGTTGGCTGCCCTGGTTGCAGTAACAGCCATCGTGCTGTACGTGCCAGGTCTGGCCAGAGCTT
CTCCATGAGAGCGTTCCTTGAGTCCGTACACCGTCCTCCCTCTAGAAGCTGGCATCACACTCATGCTGGGGACAAACAGAACCATTTTCT
TCCTCTTTACCTCTTAAAACAGCAGAAGTACAAGAATACAGCTGTAGGGTCATTGCTTTAAATTATATAAAATGTATCTGTCTATAAAGA
AGATATAAAATTGTGACTTTATTCTACTGTAAGCAATAATTTGCTTGCAATTTTTCATGTAATTTTTAAATTAGTATGTTAAGATTCTGA
ATATTATGGTGGCCTAAAGTAGGCTTCTTGGTACACCAGATTATTTATAACATTAAATTTATGAGTATTTTACTCTGAATTCTGATCACC
AGATAATTCATTTTTCTGATTTGATAACTACCCAAACCAAACAACCAATACATACATGGGAAGAGAGGCCCTGTGTGCTCAGTGCCTATC
AGTTTGAAATATATACACATATATATATTTTTTACATATTTACGCCATTTTTACTTGTTATGAAACCACTGAGCTATTGGGAACAAGACT
TAGAGACAACTATTTGCGTGGATTTTTTTTTTTTTAAGGAAAAATACGTTTGGAAAATAAACTGTTATGGTGATAATTTGGGGAATATGT
GCACGCTTGTTCAGCCTTAATGTGACTTGAAGATGTGGAGGACATCAACTTTGAAAAACTTTCCATGAGAGTGTATTTTCTTGAGCAAAC
TGAAGTATTTCTGGGAGCAAAAACATAGTAATTACACAATTTCAGTGCAGTCAACCAAAATGTTGAGTCAATTGGAATGTAATTTATTAA
ACCATGTATTTAAAGAGATATTTTTCTTTAAAAGCCAAGTTACTTTCTCATATACAGCATTTTAGGAAGCATGATTTTTTTTTTCTATCA
TCTATTCCTCCAAGCATGTTTAATTGAAGAAAGTATTAATATCTCTTTAGATAAGCTTGTATTGACCTAATTTGGTTTATGATGTGTCAG
AGCTAATTCATGTTCAGGGTGAGCGTTGTACCTACCAACAAATTTCCTGGTTGGGTATGCAAATGGTTATTTTCTTTTTATTGTTGTTAA
TTGGGACTTTCTGTTAATGAAAAGCACTATTCCCAAGATTAATAGTGTTCTATGCACAATGAAGCACCTAAAAACACTGCTTGATATTAT
AAATTTAAAACACAAGTGAAAGTTTAGCCATGGTTTTGTGCGGCATCATAGTTATGTCAATAAAGTTTATTTAGGTCATAGAATATCCTA
AAGTATCACATAGTTAAATTTTTCAGTCAGTGAAGACCGGGAGGGAATGTCAGTGAATTGGCTTGAATGTTCTGTGGCAATCCACAGGTC
TAGCCAAATATTGAAATAGGAGTTTAGGGTATAATTTGCCTTGTGATGTTTGGCAGTCACTGTTTATACTTTAAAGGTTATATTTTAAGC
TATTTGAGATTGCTTTTGGGAAGATCACTAGATTTATGGAGGAATTAGTCACAAATGACTTGTAGAAAATACTGTCATATAGTTCATTTC
ATCATTTTCTGTTGCAGGAAGCCACTCCACCACAGAATGCTAATATGCCAGTGGTACCCAGTACCTCTTGTATATAGGTTATTGCAAATA
TTGTTCTGAAATGCTTAACTTCAGAATTACATTTTTTAAAGTAAATAATTGTTTTAAATCTATTTTGTAAAGATATAAAGTACAATAGAA

>24397_24397_1_DTWD2-SLMAP_DTWD2_chr5_118264232_ENST00000304058_SLMAP_chr3_57817110_ENST00000295951_length(amino acids)=883AA_BP=137
MEISEMPGTATYRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLIL
YPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVD
VTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQE
ASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTH
LKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQ
EHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDD
LQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRD
ELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKE
WNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYE

--------------------------------------------------------------
>24397_24397_2_DTWD2-SLMAP_DTWD2_chr5_118264232_ENST00000510708_SLMAP_chr3_57817110_ENST00000295951_length(transcript)=4649nt_BP=631nt
GCTTCAATGCCACGGCCTGACCGGAGTGTCCGCCATGGAGTCGCAGAAAGAGGCACGAACACTCCAGGAGCCCGTTGCGCGGCCTTCTGG
GGCCTCAAGCTCTCAGACGCCGAACGACAAGGAGCGGCGGGAGGGCGGCGCAGTGCCGGCGGCGGCTGCCCTGGGCGCAGAGGCGGACGA
CGACAGTGCGGACGGGCTGTGGGAGCTGCCGGTGGAGCCGGCCGAGCGGAGGCCTGAGTGCACCCGCTGCAGCCGGCCTCAGAAAGTGTG
TTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAGAGGAAAACAAAGTGTTGCG
TACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTGAAGAAAGAGATCCTGAACT
TTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAATTTATATTAGATTCTCCTGT
TTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCTTGTTCCGACATCCCAAACA
GTTTTATCTTCAAGACACTAAAAGTAGTAATGGTACTTTTATAAATAGCCAGAGATTGAGTCGAGGCTCTGAAGAAAGTCCACCATGTGA
AATTCTTTCCGGTGACATTATCCAGTTTGGAGTAGACGTGACAGAGAATACACGGAAAGTTACCCATGGGTGTATTGTTTCCACAATAAA
ACTTTTTCTACCAGATGGTATGGAAGCCCGGCTCCGCTCAGATGTCATCCATGCACCATTACCAAGTCCTGTTGACAAAGTTGCTGCTAA
CACTCCAAGTATGTACTCTCAGGAACTATTCCAGCTTTCTCAGTATCTACAGGAGGCCTTACATCGGGAACAAATGTTGGAACAGAAGTT
AGCCACGCTTCAGCGGCTACTAGCCATCACCCAAGAGGCTTCAGATACCAGTTGGCAGGCTTTAATAGATGAAGATAGACTCTTATCACG
GTTAGAAGTTATGGGAAACCAATTACAGGCATGCTCCAAAAATCAAACAGAAGATAGTTTACGAAAGGAACTTATAGCATTACAAGAGGA
TAAACATAACTATGAGACAACAGCCAAAGAGTCCCTGAGGCGGGTTCTTCAGGAGAAAATTGAAGTGGTTAGAAAACTTTCAGAAGTTGA
GCGAAGTCTGAGTAATACTGAAGATGAATGTACCCATCTGAAAGAAATGAATGAAAGGACTCAGGAAGAATTAAGAGAATTAGCCAACAA
ATATAATGGAGCAGTTAATGAGATTAAAGATTTATCTGATAAATTAAAGGTAGCAGAGGGAAAACAAGAGGAAATCCAACAGAAGGGACA
GGCTGAGAAAAAAGAATTACAACATAAAATAGATGAAATGGAAGAAAAAGAACAGGAGCTCCAGGCAAAAATAGAAGCTTTGCAAGCTGA
TAATGATTTCACCAATGAAAGGCTAACAGCTTTACAAGAGCACTTGCTTTCAAAGAGTGGCGGGGACTGCACTTTTATTCATCAATTCAT
AGAATGCCAGAAGAAGCTGATCGTCGAAGGGCATCTAACCAAAGCGGTAGAAGAAACAAAGCTTTCAAAAGAAAATCAGACAAGAGCAAA
AGAATCTGATTTTTCAGATACTCTGAGTCCAAGCAAGGAAAAAAGCAGTGACGACACTACAGACGCCCAAATGGATGAGCAAGACCTAAA
TGAGCCTCTTGCCAAAGTGTCCCTTTTAAAAGATGACTTGCAGGGTGCACAGTCAGAAATTGAGGCAAAGCAAGAAATACAGCATCTTCG
AAAGGAATTGATCGAAGCCCAGGAGCTAGCTAGAACAAGTAAACAAAAATGCTTTGAACTTCAAGCTCTTTTGGAAGAAGAAAGAAAAGC
CTATCGAAATCAAGTTGAGGAATCCACTAAACAAATACAGGTTCTTCAAGCCCAATTGCAGAGGTTACACATCGATACTGAGAATCTCCG
GGAGGAGAAGGACAGTGAAATCACAAGTACTAGAGATGAATTGCTTAGTGCCCGAGATGAAATTTTGCTCCTTCATCAAGCAGCAGCAAA
GGTTGCCTCTGAGCGGGACACTGACATTGCTTCTTTACAAGAAGAGCTTAAGAAGGTGAGAGCTGAGCTTGAGCGGTGGCGGAAAGCAGC
GTCTGAATATGAGAAAGAAATCACAAGTCTGCAAAACAGTTTTCAGCTTAGATGTCAACAGTGTGAGGACCAGCAGAGAGAAGAAGCAAC
AAGGTTGCAAGGTGAACTAGAGAAGTTGAGAAAGGAATGGAATGCATTGGAAACCGAATGCCATTCTCTAAAAAGGGAAAATGTTTTGCT
ATCATCAGAACTGCAACGGCAAGAAAAAGAATTGCACAATTCTCAGAAGCAGAGTTTAGAGCTTACCAGTGATCTCAGCATCCTTCAAAT
GTCTAGGAAAGAACTTGAGAATCAAGTGGGATCCTTGAAAGAACAGCATCTTCGGGATTCAGCTGATTTAAAAACTCTTCTCAGTAAGGC
AGAAAACCAAGCAAAGGATGTGCAGAAAGAGTATGAAAAGACACAGACTGTACTCTCAGAACTGAAGTTGAAGTTTGAAATGACTGAGCA
GGAAAAGCAGTCAATCACAGATGAGCTCAAACAGTGTAAAAACAACCTGAAGCTGCTCCGAGAGAAAGGAAATAATAAACCCTGGCCCTG
GATGCCCATGTTGGCTGCCCTGGTTGCAGTAACAGCCATCGTGCTGTACGTGCCAGGTCTGGCCAGAGCTTCTCCATGAGAGCGTTCCTT
GAGTCCGTACACCGTCCTCCCTCTAGAAGCTGGCATCACACTCATGCTGGGGACAAACAGAACCATTTTCTTCCTCTTTACCTCTTAAAA
CAGCAGAAGTACAAGAATACAGCTGTAGGGTCATTGCTTTAAATTATATAAAATGTATCTGTCTATAAAGAAGATATAAAATTGTGACTT
TATTCTACTGTAAGCAATAATTTGCTTGCAATTTTTCATGTAATTTTTAAATTAGTATGTTAAGATTCTGAATATTATGGTGGCCTAAAG
TAGGCTTCTTGGTACACCAGATTATTTATAACATTAAATTTATGAGTATTTTACTCTGAATTCTGATCACCAGATAATTCATTTTTCTGA
TTTGATAACTACCCAAACCAAACAACCAATACATACATGGGAAGAGAGGCCCTGTGTGCTCAGTGCCTATCAGTTTGAAATATATACACA
TATATATATTTTTTACATATTTACGCCATTTTTACTTGTTATGAAACCACTGAGCTATTGGGAACAAGACTTAGAGACAACTATTTGCGT
GGATTTTTTTTTTTTTAAGGAAAAATACGTTTGGAAAATAAACTGTTATGGTGATAATTTGGGGAATATGTGCACGCTTGTTCAGCCTTA
ATGTGACTTGAAGATGTGGAGGACATCAACTTTGAAAAACTTTCCATGAGAGTGTATTTTCTTGAGCAAACTGAAGTATTTCTGGGAGCA
AAAACATAGTAATTACACAATTTCAGTGCAGTCAACCAAAATGTTGAGTCAATTGGAATGTAATTTATTAAACCATGTATTTAAAGAGAT
ATTTTTCTTTAAAAGCCAAGTTACTTTCTCATATACAGCATTTTAGGAAGCATGATTTTTTTTTTCTATCATCTATTCCTCCAAGCATGT
TTAATTGAAGAAAGTATTAATATCTCTTTAGATAAGCTTGTATTGACCTAATTTGGTTTATGATGTGTCAGAGCTAATTCATGTTCAGGG
TGAGCGTTGTACCTACCAACAAATTTCCTGGTTGGGTATGCAAATGGTTATTTTCTTTTTATTGTTGTTAATTGGGACTTTCTGTTAATG
AAAAGCACTATTCCCAAGATTAATAGTGTTCTATGCACAATGAAGCACCTAAAAACACTGCTTGATATTATAAATTTAAAACACAAGTGA
AAGTTTAGCCATGGTTTTGTGCGGCATCATAGTTATGTCAATAAAGTTTATTTAGGTCATAGAATATCCTAAAGTATCACATAGTTAAAT
TTTTCAGTCAGTGAAGACCGGGAGGGAATGTCAGTGAATTGGCTTGAATGTTCTGTGGCAATCCACAGGTCTAGCCAAATATTGAAATAG
GAGTTTAGGGTATAATTTGCCTTGTGATGTTTGGCAGTCACTGTTTATACTTTAAAGGTTATATTTTAAGCTATTTGAGATTGCTTTTGG
GAAGATCACTAGATTTATGGAGGAATTAGTCACAAATGACTTGTAGAAAATACTGTCATATAGTTCATTTCATCATTTTCTGTTGCAGGA
AGCCACTCCACCACAGAATGCTAATATGCCAGTGGTACCCAGTACCTCTTGTATATAGGTTATTGCAAATATTGTTCTGAAATGCTTAAC
TTCAGAATTACATTTTTTAAAGTAAATAATTGTTTTAAATCTATTTTGTAAAGATATAAAGTACAATAGAATTTCTGGAGTACAGATTAA

>24397_24397_2_DTWD2-SLMAP_DTWD2_chr5_118264232_ENST00000510708_SLMAP_chr3_57817110_ENST00000295951_length(amino acids)=950AA_BP=204
MTGVSAMESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFL
PAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTI
IIIDGTWSQAKDIFYKNSLFRHPKQFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPD
GMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMG
NQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAV
NEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQEHLLSKSGGDCTFIHQFIECQKK
LIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIE
AQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASER
DTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQ
RQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSI

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Fusion Gene PPI Analysis for DTWD2-SLMAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTWD2-SLMAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTWD2-SLMAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource