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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTX2-NUB1 (FusionGDB2 ID:24403)

Fusion Gene Summary for DTX2-NUB1

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX2-NUB1
Fusion gene ID: 24403
HgeneTgene
Gene symbol

DTX2

NUB1

Gene ID

113878

51667

Gene namedeltex E3 ubiquitin ligase 2negative regulator of ubiquitin like proteins 1
SynonymsRNF58BS4|NUB1L|NYREN18
Cytomap

7q11.23

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase DTX2RING-type E3 ubiquitin transferase DTX2deltex 2, E3 ubiquitin ligasedeltex homolog 2deltex2hDTX2protein deltex-2ring finger protein 58zinc ion binding proteinNEDD8 ultimate buster 1NEDD8 ultimate buster-1renal carcinoma antigen NY-REN-18
Modification date2020031320200313
UniProtAcc

Q86UW9

.
Ensembl transtripts involved in fusion geneENST00000307569, ENST00000324432, 
ENST00000413936, ENST00000430490, 
ENST00000446600, ENST00000446820, 
ENST00000472426, 		ENST00000355851, 
ENST00000413040, ENST00000566856, 
ENST00000568733, ENST00000477666, 
Fusion gene scores* DoF score9 X 8 X 9=6487 X 7 X 4=196
# samples 158
** MAII scorelog2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTX2 [Title/Abstract] AND NUB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTX2(76091153)-NUB1(151072933), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI909126DTX2chr7

76091153

+NUB1chr7

151072933

+


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Fusion Gene ORF analysis for DTX2-NUB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000307569ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000307569ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000307569ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000307569ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000324432ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000324432ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000324432ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000324432ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000413936ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000413936ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000413936ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000413936ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000430490ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000430490ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000430490ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000430490ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000446600ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000446600ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000446600ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-3CDSENST00000446600ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-intronENST00000307569ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-intronENST00000324432ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-intronENST00000413936ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-intronENST00000430490ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
5UTR-intronENST00000446600ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000446820ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000446820ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000446820ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000446820ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000472426ENST00000355851DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000472426ENST00000413040DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000472426ENST00000566856DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-3CDSENST00000472426ENST00000568733DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-intronENST00000446820ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+
intron-intronENST00000472426ENST00000477666DTX2chr7

76091153

+NUB1chr7

151072933

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DTX2-NUB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTX2chr776091153+NUB1chr7151072933+0.0008204280.99917954
DTX2chr776091153+NUB1chr7151072933+0.0008204280.99917954

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTX2-NUB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76091153/:151072933)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX2

Q86UW9

.
FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DTX2-NUB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DTX2-NUB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTX2-NUB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTX2-NUB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource