FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DTX2-PEX5 (FusionGDB2 ID:24406)

Fusion Gene Summary for DTX2-PEX5

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX2-PEX5
Fusion gene ID: 24406
HgeneTgene
Gene symbol

DTX2

PEX5

Gene ID

113878

5830

Gene namedeltex E3 ubiquitin ligase 2peroxisomal biogenesis factor 5
SynonymsRNF58PBD2A|PBD2B|PTS1-BP|PTS1R|PXR1|RCDP5
Cytomap

7q11.23

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase DTX2RING-type E3 ubiquitin transferase DTX2deltex 2, E3 ubiquitin ligasedeltex homolog 2deltex2hDTX2protein deltex-2ring finger protein 58zinc ion binding proteinperoxisomal biogenesis factor 5PTS1 receptorperoxin-5peroxisomal C-terminal targeting signal import receptorperoxisomal import receptor 5peroxisomal targeting signal 1 (SKL type) receptorperoxisomal targeting signal 1 receptorperoxisomal targeting
Modification date2020031320200313
UniProtAcc

Q86UW9

PEX5L

Ensembl transtripts involved in fusion geneENST00000307569, ENST00000324432, 
ENST00000430490, ENST00000446600, 
ENST00000413936, ENST00000446820, 
ENST00000472426, 		ENST00000266563, 
ENST00000266564, ENST00000412720, 
ENST00000420616, ENST00000434354, 
ENST00000455147, ENST00000545220, 
Fusion gene scores* DoF score9 X 8 X 9=6487 X 7 X 6=294
# samples 157
** MAII scorelog2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTX2 [Title/Abstract] AND PEX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTX2(76093026)-PEX5(7342957), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePEX5

GO:0016560

protein import into peroxisome matrix, docking

21976670

TgenePEX5

GO:0031333

negative regulation of protein complex assembly

21976670


check buttonFusion gene breakpoints across DTX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PEX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-5474DTX2chr7

76093026

+PEX5chr12

7342957

+


Top

Fusion Gene ORF analysis for DTX2-PEX5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000307569ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000307569ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000307569ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000307569ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000307569ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000307569ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000324432ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000430490ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-5UTRENST00000446600ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-intronENST00000307569ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-intronENST00000324432ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-intronENST00000430490ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
5UTR-intronENST00000446600ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000413936ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000446820ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000266563DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000266564DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000412720DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000420616DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000434354DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-5UTRENST00000472426ENST00000455147DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-intronENST00000413936ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-intronENST00000446820ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+
intron-intronENST00000472426ENST00000545220DTX2chr7

76093026

+PEX5chr12

7342957

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DTX2-PEX5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTX2chr776093026+PEX5chr127342956+0.0004423230.9995577
DTX2chr776093026+PEX5chr127342956+0.0004423230.9995577

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DTX2-PEX5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76093026/:7342957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX2

Q86UW9

PEX5

PEX5L

FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.626

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DTX2-PEX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DTX2-PEX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DTX2-PEX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DTX2-PEX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource