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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTX3L-FAM162A (FusionGDB2 ID:24413)

Fusion Gene Summary for DTX3L-FAM162A

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX3L-FAM162A
Fusion gene ID: 24413
HgeneTgene
Gene symbol

DTX3L

FAM162A

Gene ID

151636

26355

Gene namedeltex E3 ubiquitin ligase 3Lfamily with sequence similarity 162 member A
SynonymsBBAP|RNF143C3orf28|E2IG5|HGTD-P
Cytomap

3q21.1

3q21.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase DTX3LB-lymphoma- and BAL-associated proteinRING-type E3 ubiquitin transferase DTX3Ldeltex 3 like, E3 ubiquitin ligasedeltex 3-likerhysin-2rhysin2protein FAM162AE2-induced gene 5 proteinHIF-1 alpha-responsive proapoptotic moleculegrowth and transformation-dependent protein
Modification date2020031320200313
UniProtAcc

Q8TDB6

Q96A26

Ensembl transtripts involved in fusion geneENST00000296161, ENST00000383661, 
ENST00000469967, ENST00000232125, 
ENST00000477892, 
Fusion gene scores* DoF score4 X 5 X 2=405 X 5 X 2=50
# samples 55
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/50*10)=0
Context

PubMed: DTX3L [Title/Abstract] AND FAM162A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTX3L(122289519)-FAM162A(122126128), # samples:2
Anticipated loss of major functional domain due to fusion event.DTX3L-FAM162A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDTX3L

GO:0010390

histone monoubiquitination

19818714|28525742

HgeneDTX3L

GO:0070936

protein K48-linked ubiquitination

26479788

HgeneDTX3L

GO:1901666

positive regulation of NAD+ ADP-ribosyltransferase activity

28525742

TgeneFAM162A

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

15082785

TgeneFAM162A

GO:0043065

positive regulation of apoptotic process

15082785

TgeneFAM162A

GO:0071456

cellular response to hypoxia

15082785

TgeneFAM162A

GO:0090200

positive regulation of release of cytochrome c from mitochondria

15082785


check buttonFusion gene breakpoints across DTX3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM162A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A9UV-01ADTX3Lchr3

122289519

+FAM162Achr3

122126128

+
ChimerDB4CESCTCGA-VS-A9UVDTX3Lchr3

122289519

+FAM162Achr3

122126128

+


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Fusion Gene ORF analysis for DTX3L-FAM162A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296161ENST00000469967DTX3Lchr3

122289519

+FAM162Achr3

122126128

+
Frame-shiftENST00000383661ENST00000469967DTX3Lchr3

122289519

+FAM162Achr3

122126128

+
In-frameENST00000296161ENST00000232125DTX3Lchr3

122289519

+FAM162Achr3

122126128

+
In-frameENST00000296161ENST00000477892DTX3Lchr3

122289519

+FAM162Achr3

122126128

+
In-frameENST00000383661ENST00000232125DTX3Lchr3

122289519

+FAM162Achr3

122126128

+
In-frameENST00000383661ENST00000477892DTX3Lchr3

122289519

+FAM162Achr3

122126128

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296161DTX3Lchr3122289519+ENST00000232125FAM162Achr3122126128+263023421892543784
ENST00000296161DTX3Lchr3122289519+ENST00000477892FAM162Achr3122126128+504723421892543784
ENST00000383661DTX3Lchr3122289519+ENST00000232125FAM162Achr3122126128+9056170818272
ENST00000383661DTX3Lchr3122289519+ENST00000477892FAM162Achr3122126128+33226170818272

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296161ENST00000232125DTX3Lchr3122289519+FAM162Achr3122126128+0.0025293340.99747074
ENST00000296161ENST00000477892DTX3Lchr3122289519+FAM162Achr3122126128+0.0006284040.9993716
ENST00000383661ENST00000232125DTX3Lchr3122289519+FAM162Achr3122126128+0.0010301630.9989698
ENST00000383661ENST00000477892DTX3Lchr3122289519+FAM162Achr3122126128+0.0001746330.9998254

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Fusion Genomic Features for DTX3L-FAM162A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTX3Lchr3122289519+FAM162Achr3122126127+0.020288260.9797117
DTX3Lchr3122289519+FAM162Achr3122126127+0.020288260.9797117
DTX3Lchr3122289519+FAM162Achr3122126127+0.020288260.9797117
DTX3Lchr3122289519+FAM162Achr3122126127+0.020288260.9797117

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTX3L-FAM162A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:122289519/chr3:122126128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX3L

Q8TDB6

FAM162A

Q96A26

FUNCTION: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.FUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTX3Lchr3:122289519chr3:122126128ENST00000296161+45561_600717741.0Zinc fingerRING-type
TgeneFAM162Achr3:122289519chr3:122126128ENST0000047789225103_12087155.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTX3Lchr3:122289519chr3:122126128ENST00000383661+34561_600205229.0Zinc fingerRING-type
TgeneFAM162Achr3:122289519chr3:122126128ENST000004778922576_10287155.0RegionRequired for proapoptotic activity


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Fusion Gene Sequence for DTX3L-FAM162A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24413_24413_1_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000296161_FAM162A_chr3_122126128_ENST00000232125_length(transcript)=2630nt_BP=2342nt
TACTCACCCGGCAGGCCGCTCTCCTCGGTGCAGACAGCACAGGGAGGAGGGGGAAGCGGCTCTGCCGGGAACAGGGAGGGACCTCCAGGG
AAGCGAAACTGAAACTTTGCGCCCAGTCCGCAGGGCGGGCCGCGCCTTTACCGCCCAGCTGCCTCCCGGAGCCCCCGCGCCCTCCCGACG
CGCAGAGCCATGGCCTCCCACCTGCGCCCGCCGTCCCCGCTCCTCGTGCGGGTGTACAAGTCCGGCCCCCGAGTACGAAGGAAGCTGGAG
AGCTACTTCCAGAGCTCTAAGTCCTCGGGCGGCGGGGAGTGCACGGTCAGCACCCAGGAACACGAAGCCCCGGGCACCTTCCGGGTGGAG
TTCAGTGAAAGGGCAGCTAAGGAGAGAGTGTTGAAAAAAGGAGAGCACCAAATACTTGTTGACGAAAAACCTGTGCCCATTTTCCTGGTA
CCCACTGAAAATTCAATAAAGAAGAACACGAGACCTCAAATTTCTTCACTGACACAATCACAAGCAGAAACACCGTCTGGTGATATGCAT
CAACATGAAGGACATATTCCTAATGCTGTGGATTCCTGTCTCCAAAAGATCTTTCTTACTGTAACAGCTGACCTGAACTGTAACCTGTTC
TCCAAAGAGCAGAGGGCATACATAACCACACTGTGCCCTAGTATCAGAAAAATGGAAGGTCACGATGGAATTGAGAAGGTGTGTGGTGAC
TTCCAAGACATTGAAAGAATACATCAATTTTTGAGTGAGCAGTTCCTGGAAAGTGAGCAGAAACAACAATTTTCCCCTTCAATGACAGAG
AGGAAGCCACTCAGTCAGCAGGAGAGGGACAGCTGCATTTCTCCTTCTGAACCAGAAACCAAGGCAGAACAAAAAAGCAACTATTTTGAA
GTTCCCTTGCCTTACTTTGAATACTTTAAATATATCTGTCCTGATAAAATCAACTCAATAGAGAAAAGATTTGGTGTAAACATTGAAATC
CAGGAGAGTTCTCCAAATATGGTCTGTTTAGATTTCACCTCAAGTCGATCAGGTGACCTGGAAGCAGCTCGTGAGTCTTTTGCTAGTGAA
TTTCAGAAGAACACAGAACCTCTGAAGCAAGAATGTGTCTCTTTAGCAGACAGTAAGCAGGCAAATAAATTCAAACAGGAATTGAATCAC
CAGTTTACAAAGCTCCTTATAAAGGAGAAAGGAGGCGAATTAACTCTCCTTGGGACCCAAGATGACATTTCAGCTGCCAAACAAAAAATC
TCTGAAGCTTTTGTCAAGATACCTGTGAAACTATTTGCTGCCAATTACATGATGAATGTAATTGAGGTTGATAGTGCCCACTATAAACTT
TTAGAAACTGAATTACTACAGGAGATATCAGAGATCGAAAAAAGGTATGACATTTGCAGCAAGGTTTCTGAGAAAGGTCAGAAAACCTGC
ATTCTGTTTGAATCCAAGGACAGGCAGGTAGATCTATCTGTGCATGCTTATGCAAGTTTCATCGATGCCTTTCAACATGCCTCATGTCAG
TTGATGAGAGAAGTTCTTTTACTGAAGTCTTTGGGCAAGGAGAGAAAGCACTTACATCAGACCAAGTTTGCTGATGACTTTAGAAAAAGA
CATCCAAATGTACACTTTGTGCTAAATCAAGAGTCAATGACTTTGACTGGTTTGCCAAATCACCTTGCAAAGGCGAAGCAGTATGTTCTA
AAAGGAGGAGGAATGTCTTCATTGGCTGGAAAGAAATTGAAAGAGGGTCATGAAACACCGATGGACATTGATAGCGATGATTCCAAAGCA
GCTTCTCCGCCACTCAAGGGCTCTGTGAGTTCTGAGGCCTCAGAACTGGACAAGAAGGAAAAGGGCATCTGTGTCATCTGTATGGACACC
ATTAGTAACAAAAAAGTGCTACCAAAGTGCAAGCATGAATTCTGCGCCCCTTGTATCAACAAAGCCATGTCATATAAGCCAATCTGTCCC
ACATGCCAGACTTCCTATGGTATTCAGAAAGGAAATCAGCCAGAGGGAAGCATGGTTTTCACTGTTTCAAGAGACTCACTTCCAGGTTAT
GAGTCCTTTGGCACCATTGTGATTACTTATTCTATGAAAGCAGGCATACAAACAGAAGAACACCCAAACCCAGGAAAGAGATACCCTGGA
ATACAGCGAACTGCATACTTGCCTGATAATAAGGAAGGAAGGAAGGTTTTGAAACTGCTTTATAGGGCCTTTGACCAAAAGCTGATTTTT
ACAGTGGGGTACTCTCGCGTATTAGGAGTCTCAGATGTCATCACTTGGAATGATATTCACCACAAAACATCCCGGTTTGGAGGACCAGAA
ATGTTGGAGATGCTTGATGCTGCAAAGAACAAGATGCGAGTGAAGATCAGCTATCTAATGATTGCCCTGACGGTGGTAGGATGCATCTTC
ATGGTTATTGAGGGCAAGAAGGCTGCCCAAAGACACGAGACTTTAACAAGCTTGAACTTAGAAAAGAAAGCTCGTCTGAAAGAGGAAGCA
GCTATGAAGGCCAAAACAGAGTAGCAGAGGTATCCGTGTTGGCTGGATTTTGAAAATCCAGGAATTATGTTATAACGTGCCTGTATTAAA

>24413_24413_1_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000296161_FAM162A_chr3_122126128_ENST00000232125_length(amino acids)=784AA_BP=718
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTE
NSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQD
IERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPLPYFEYFKYICPDKINSIEKRFGVNIEIQES
SPNMVCLDFTSSRSGDLEAARESFASEFQKNTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEA
FVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMR
EVLLLKSLGKERKHLHQTKFADDFRKRHPNVHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASP
PLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPEGSMVFTVSRDSLPGYESF
GTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMLE

--------------------------------------------------------------
>24413_24413_2_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000296161_FAM162A_chr3_122126128_ENST00000477892_length(transcript)=5047nt_BP=2342nt
TACTCACCCGGCAGGCCGCTCTCCTCGGTGCAGACAGCACAGGGAGGAGGGGGAAGCGGCTCTGCCGGGAACAGGGAGGGACCTCCAGGG
AAGCGAAACTGAAACTTTGCGCCCAGTCCGCAGGGCGGGCCGCGCCTTTACCGCCCAGCTGCCTCCCGGAGCCCCCGCGCCCTCCCGACG
CGCAGAGCCATGGCCTCCCACCTGCGCCCGCCGTCCCCGCTCCTCGTGCGGGTGTACAAGTCCGGCCCCCGAGTACGAAGGAAGCTGGAG
AGCTACTTCCAGAGCTCTAAGTCCTCGGGCGGCGGGGAGTGCACGGTCAGCACCCAGGAACACGAAGCCCCGGGCACCTTCCGGGTGGAG
TTCAGTGAAAGGGCAGCTAAGGAGAGAGTGTTGAAAAAAGGAGAGCACCAAATACTTGTTGACGAAAAACCTGTGCCCATTTTCCTGGTA
CCCACTGAAAATTCAATAAAGAAGAACACGAGACCTCAAATTTCTTCACTGACACAATCACAAGCAGAAACACCGTCTGGTGATATGCAT
CAACATGAAGGACATATTCCTAATGCTGTGGATTCCTGTCTCCAAAAGATCTTTCTTACTGTAACAGCTGACCTGAACTGTAACCTGTTC
TCCAAAGAGCAGAGGGCATACATAACCACACTGTGCCCTAGTATCAGAAAAATGGAAGGTCACGATGGAATTGAGAAGGTGTGTGGTGAC
TTCCAAGACATTGAAAGAATACATCAATTTTTGAGTGAGCAGTTCCTGGAAAGTGAGCAGAAACAACAATTTTCCCCTTCAATGACAGAG
AGGAAGCCACTCAGTCAGCAGGAGAGGGACAGCTGCATTTCTCCTTCTGAACCAGAAACCAAGGCAGAACAAAAAAGCAACTATTTTGAA
GTTCCCTTGCCTTACTTTGAATACTTTAAATATATCTGTCCTGATAAAATCAACTCAATAGAGAAAAGATTTGGTGTAAACATTGAAATC
CAGGAGAGTTCTCCAAATATGGTCTGTTTAGATTTCACCTCAAGTCGATCAGGTGACCTGGAAGCAGCTCGTGAGTCTTTTGCTAGTGAA
TTTCAGAAGAACACAGAACCTCTGAAGCAAGAATGTGTCTCTTTAGCAGACAGTAAGCAGGCAAATAAATTCAAACAGGAATTGAATCAC
CAGTTTACAAAGCTCCTTATAAAGGAGAAAGGAGGCGAATTAACTCTCCTTGGGACCCAAGATGACATTTCAGCTGCCAAACAAAAAATC
TCTGAAGCTTTTGTCAAGATACCTGTGAAACTATTTGCTGCCAATTACATGATGAATGTAATTGAGGTTGATAGTGCCCACTATAAACTT
TTAGAAACTGAATTACTACAGGAGATATCAGAGATCGAAAAAAGGTATGACATTTGCAGCAAGGTTTCTGAGAAAGGTCAGAAAACCTGC
ATTCTGTTTGAATCCAAGGACAGGCAGGTAGATCTATCTGTGCATGCTTATGCAAGTTTCATCGATGCCTTTCAACATGCCTCATGTCAG
TTGATGAGAGAAGTTCTTTTACTGAAGTCTTTGGGCAAGGAGAGAAAGCACTTACATCAGACCAAGTTTGCTGATGACTTTAGAAAAAGA
CATCCAAATGTACACTTTGTGCTAAATCAAGAGTCAATGACTTTGACTGGTTTGCCAAATCACCTTGCAAAGGCGAAGCAGTATGTTCTA
AAAGGAGGAGGAATGTCTTCATTGGCTGGAAAGAAATTGAAAGAGGGTCATGAAACACCGATGGACATTGATAGCGATGATTCCAAAGCA
GCTTCTCCGCCACTCAAGGGCTCTGTGAGTTCTGAGGCCTCAGAACTGGACAAGAAGGAAAAGGGCATCTGTGTCATCTGTATGGACACC
ATTAGTAACAAAAAAGTGCTACCAAAGTGCAAGCATGAATTCTGCGCCCCTTGTATCAACAAAGCCATGTCATATAAGCCAATCTGTCCC
ACATGCCAGACTTCCTATGGTATTCAGAAAGGAAATCAGCCAGAGGGAAGCATGGTTTTCACTGTTTCAAGAGACTCACTTCCAGGTTAT
GAGTCCTTTGGCACCATTGTGATTACTTATTCTATGAAAGCAGGCATACAAACAGAAGAACACCCAAACCCAGGAAAGAGATACCCTGGA
ATACAGCGAACTGCATACTTGCCTGATAATAAGGAAGGAAGGAAGGTTTTGAAACTGCTTTATAGGGCCTTTGACCAAAAGCTGATTTTT
ACAGTGGGGTACTCTCGCGTATTAGGAGTCTCAGATGTCATCACTTGGAATGATATTCACCACAAAACATCCCGGTTTGGAGGACCAGAA
ATGTTGGAGATGCTTGATGCTGCAAAGAACAAGATGCGAGTGAAGATCAGCTATCTAATGATTGCCCTGACGGTGGTAGGATGCATCTTC
ATGGTTATTGAGGGCAAGAAGGCTGCCCAAAGACACGAGACTTTAACAAGCTTGAACTTAGAAAAGAAAGCTCGTCTGAAAGAGGAAGCA
GCTATGAAGGCCAAAACAGAGTAGCAGAGGTATCCGTGTTGGCTGGATTTTGAAAATCCAGGAATTATGTTATAACGTGCCTGTATTAAA
AAGGATGTGGTATGAGGATCCATTTCATAAAGTATGATTTGCCCAAACCTGTACCATTTCCGTATTTCTGCTGTAGAAGTAGAAATAAAT
TTTCTTAAATAATGACTGTGTTTTATTGTTTTGATCCAAGTCAAGTGTAGCCTCTCAGCCTTTTGGAGAAAAATGAAACAATTTATTTCA
ACTTGAATACCAACTCTTCAGAGAAGCAGGTACCATATCTTACTTCTCTTCCCATTATCAAAGTAACCTCTCCACAGGCGAACTCATTTT
GAGGAGATAAGGAAGGCCAGTTGAGTATATGGCCCAGGTGCAGCTTGGAGGGCCAGCCTTCTCAAATGTCCTGGTGTACTGGTGGGGAGG
CTGCCCCCTAATAGAGCGAGCGCTGAGAAGCAGCCAGACCACATTCTATAATCTTTGAACATGCTGGCAGATGGAGGCTTTTAGGAGAAT
AGTTTTTTAAACATTCTGACAAGGTCCAGCCAGGAATTTCTAAGGACTTAGAAATCCCAGCGTCATGGAGTTGCTTGGGGTCAACACAAG
TCACCTCTTAGCTTCATGCCTTAGAATTCTCAACTGGCTGTTTTCTTACCACCTGAGAAACTAAATTTCTCAATTATAAAAATCTCATGT
ATTATTACTGTTAGAAGTATTTGCACCTCATATATATCTCATTTACAGTTTGACCTTGGGATATCGAGTTGTCTCATATTTAGGTATGAA
TACAGGTTTCTATTTTAAACATTGATTCTCACATGCTTCTTAATTATTCATGGATGACAAGCCATTATAGTAGTCCCTTCTTATCCACGG
CTTTGTTTTCTGTGGTTTCAGTTACCTGAGGTCTGAAAATATTAAATGGAAAATTCCTATAACAATGCATAAGTTATAGATTACATACCA
TTCAGTGTAGCATGATGAAATCTCTTGCCAATCTGTTCCATCCACCTGGGATGTGAATCATCCCTCTCTCTGGTGTATTCACACTGTATG
TGCTAGCCGTCTCTGTTACGAGATCAGCTGTCGTGGAATCAGTGCTAGTGTTCAGGTAACTCTTATTTAATAATTGCCTCAAAGTGCATT
GTGCTGTGCCTAATTTATAAAATAAACGGTATCATAGGTATGTATGTATACGAAAAACATAGTATATGCAGGGTTGGGTACTATCCACAG
TTTCAGGCATCTACTGGGGGGTCTTGGAATATATCCCCAGAGGGTAAGGGGTGACTACTGTATACAGCCATGCCAACATGCTGGTTCTCA
GAGAGTTATAAGAGAGATTAAAAATACATGCAGCTGTTTGGGCACTTTCTTCCCAAATAAAATACCCAGTAAAATGTAACATACTACCTA
TAGCTTGATAATCTATCTGAGGATGTTTATGATGTCTGTCTATATACTTTAATTTGGCCTTAGCTTCTTTGTAGGTATCAAGTTATCACT
TGCAAATTTATTTTCAAAAAGCATAGTTTCTTGTACATTTTAGAAGATTAGTTTTTCTTATTTTGGGACACCTACACCAATGTTTTAAAT
GTGGATAAATTTTAATGTGGAATTTCTTTTAAAAATAATCCTCTTCATAGAGCAATACAACAAAAATGTGTTGTATCTTGGAGATTTACA
TTATAAATGTAGTAACATTTATGAGCTTAAATTTAATGAAACCTTTTTTTTTTTTTTGAGACAGTCTTGCACTGTCGCCCAGGCTAGAGT
GCAGGGCATGATCTCAGCTCACTGCAACCTCCGTCTCCCGGGTTCAAGCAATTCTCGTGCCTCAGCCTCCTCAGTAACTGGCATTATAGG
TGTGCACCACCACACCTGGCTAATTTTTGTATTTTTCATAAAGACGGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCT
CAGGTGATCAGCCTCCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATGGTGCCTGGCCAAACGTTTTTATTACAAATATTA
CATTAAACTAAAGCTCACAACTGTTATTATGCATCAGGAATTAACAGTCATTTCTCATTTGTGTTATTCTCCTATTTGATAACATATAGT
GACTATCTCTTTATGGGTTAAATATCAGTTTCTTGGCCAGAATTCAAGATCTGCCCCTAACTAATCCTACTTCTCCCAGTACCCTTACAG
CACTCCTACCCTACTAGTAACTCTGATATCTCATAGTCCTCAGATTTATCAAGCAAACGAAACTGAATGAGCACTACTATAAGGTACCAC
AAACTACAAAAGGAGACAGTTTTGCCCTTGTTGCTTTCAGTTAAATTATTGTGCTATTTTTTGCTTAATTTCTAGGTTTTTTTTGCGTGT
TTATCATGTCTCCGTAGGTAAAGTGGGCAGAAATCTTTTTCTACTTTACATTTCCTGTAAGTGCTGTTTGTTTGAATAAAGTTAATGTGT

>24413_24413_2_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000296161_FAM162A_chr3_122126128_ENST00000477892_length(amino acids)=784AA_BP=718
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTE
NSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKIFLTVTADLNCNLFSKEQRAYITTLCPSIRKMEGHDGIEKVCGDFQD
IERIHQFLSEQFLESEQKQQFSPSMTERKPLSQQERDSCISPSEPETKAEQKSNYFEVPLPYFEYFKYICPDKINSIEKRFGVNIEIQES
SPNMVCLDFTSSRSGDLEAARESFASEFQKNTEPLKQECVSLADSKQANKFKQELNHQFTKLLIKEKGGELTLLGTQDDISAAKQKISEA
FVKIPVKLFAANYMMNVIEVDSAHYKLLETELLQEISEIEKRYDICSKVSEKGQKTCILFESKDRQVDLSVHAYASFIDAFQHASCQLMR
EVLLLKSLGKERKHLHQTKFADDFRKRHPNVHFVLNQESMTLTGLPNHLAKAKQYVLKGGGMSSLAGKKLKEGHETPMDIDSDDSKAASP
PLKGSVSSEASELDKKEKGICVICMDTISNKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPEGSMVFTVSRDSLPGYESF
GTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMLE

--------------------------------------------------------------
>24413_24413_3_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000383661_FAM162A_chr3_122126128_ENST00000232125_length(transcript)=905nt_BP=617nt
ATGGCCTCCCACCTGCGCCCGCCGTCCCCGCTCCTCGTGCGGGTGTACAAGTCCGGCCCCCGAGTACGAAGGAAGCTGGAGAGCTACTTC
CAGAGCTCTAAGTCCTCGGGCGGCGGGGAGTGCACGGTCAGCACCCAGGAACACGAAGCCCCGGGCACCTTCCGGGTGGAGTTCAGTGAA
AGGGCAGCTAAGGAGAGAGTGTTGAAAAAAGGAGAGCACCAAATACTTGTTGACGAAAAACCTGTGCCCATTTTCCTGGTACCCACTGAA
AATTCAATAAAGAAGAACACGAGACCTCAAATTTCTTCACTGACACAATCACAAGCAGAAACACCGTCTGGTGATATGCATCAACATGAA
GGACATATTCCTAATGCTGTGGATTCCTGTCTCCAAAAGGAAGAACACCCAAACCCAGGAAAGAGATACCCTGGAATACAGCGAACTGCA
TACTTGCCTGATAATAAGGAAGGAAGGAAGGTTTTGAAACTGCTTTATAGGGCCTTTGACCAAAAGCTGATTTTTACAGTGGGGTACTCT
CGCGTATTAGGAGTCTCAGATGTCATCACTTGGAATGATATTCACCACAAAACATCCCGGTTTGGAGGACCAGAAATGTTGGAGATGCTT
GATGCTGCAAAGAACAAGATGCGAGTGAAGATCAGCTATCTAATGATTGCCCTGACGGTGGTAGGATGCATCTTCATGGTTATTGAGGGC
AAGAAGGCTGCCCAAAGACACGAGACTTTAACAAGCTTGAACTTAGAAAAGAAAGCTCGTCTGAAAGAGGAAGCAGCTATGAAGGCCAAA
ACAGAGTAGCAGAGGTATCCGTGTTGGCTGGATTTTGAAAATCCAGGAATTATGTTATAACGTGCCTGTATTAAAAAGGATGTGGTATGA

>24413_24413_3_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000383661_FAM162A_chr3_122126128_ENST00000232125_length(amino acids)=272AA_BP=206
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTE
NSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYS
RVLGVSDVITWNDIHHKTSRFGGPEMLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAK

--------------------------------------------------------------
>24413_24413_4_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000383661_FAM162A_chr3_122126128_ENST00000477892_length(transcript)=3322nt_BP=617nt
ATGGCCTCCCACCTGCGCCCGCCGTCCCCGCTCCTCGTGCGGGTGTACAAGTCCGGCCCCCGAGTACGAAGGAAGCTGGAGAGCTACTTC
CAGAGCTCTAAGTCCTCGGGCGGCGGGGAGTGCACGGTCAGCACCCAGGAACACGAAGCCCCGGGCACCTTCCGGGTGGAGTTCAGTGAA
AGGGCAGCTAAGGAGAGAGTGTTGAAAAAAGGAGAGCACCAAATACTTGTTGACGAAAAACCTGTGCCCATTTTCCTGGTACCCACTGAA
AATTCAATAAAGAAGAACACGAGACCTCAAATTTCTTCACTGACACAATCACAAGCAGAAACACCGTCTGGTGATATGCATCAACATGAA
GGACATATTCCTAATGCTGTGGATTCCTGTCTCCAAAAGGAAGAACACCCAAACCCAGGAAAGAGATACCCTGGAATACAGCGAACTGCA
TACTTGCCTGATAATAAGGAAGGAAGGAAGGTTTTGAAACTGCTTTATAGGGCCTTTGACCAAAAGCTGATTTTTACAGTGGGGTACTCT
CGCGTATTAGGAGTCTCAGATGTCATCACTTGGAATGATATTCACCACAAAACATCCCGGTTTGGAGGACCAGAAATGTTGGAGATGCTT
GATGCTGCAAAGAACAAGATGCGAGTGAAGATCAGCTATCTAATGATTGCCCTGACGGTGGTAGGATGCATCTTCATGGTTATTGAGGGC
AAGAAGGCTGCCCAAAGACACGAGACTTTAACAAGCTTGAACTTAGAAAAGAAAGCTCGTCTGAAAGAGGAAGCAGCTATGAAGGCCAAA
ACAGAGTAGCAGAGGTATCCGTGTTGGCTGGATTTTGAAAATCCAGGAATTATGTTATAACGTGCCTGTATTAAAAAGGATGTGGTATGA
GGATCCATTTCATAAAGTATGATTTGCCCAAACCTGTACCATTTCCGTATTTCTGCTGTAGAAGTAGAAATAAATTTTCTTAAATAATGA
CTGTGTTTTATTGTTTTGATCCAAGTCAAGTGTAGCCTCTCAGCCTTTTGGAGAAAAATGAAACAATTTATTTCAACTTGAATACCAACT
CTTCAGAGAAGCAGGTACCATATCTTACTTCTCTTCCCATTATCAAAGTAACCTCTCCACAGGCGAACTCATTTTGAGGAGATAAGGAAG
GCCAGTTGAGTATATGGCCCAGGTGCAGCTTGGAGGGCCAGCCTTCTCAAATGTCCTGGTGTACTGGTGGGGAGGCTGCCCCCTAATAGA
GCGAGCGCTGAGAAGCAGCCAGACCACATTCTATAATCTTTGAACATGCTGGCAGATGGAGGCTTTTAGGAGAATAGTTTTTTAAACATT
CTGACAAGGTCCAGCCAGGAATTTCTAAGGACTTAGAAATCCCAGCGTCATGGAGTTGCTTGGGGTCAACACAAGTCACCTCTTAGCTTC
ATGCCTTAGAATTCTCAACTGGCTGTTTTCTTACCACCTGAGAAACTAAATTTCTCAATTATAAAAATCTCATGTATTATTACTGTTAGA
AGTATTTGCACCTCATATATATCTCATTTACAGTTTGACCTTGGGATATCGAGTTGTCTCATATTTAGGTATGAATACAGGTTTCTATTT
TAAACATTGATTCTCACATGCTTCTTAATTATTCATGGATGACAAGCCATTATAGTAGTCCCTTCTTATCCACGGCTTTGTTTTCTGTGG
TTTCAGTTACCTGAGGTCTGAAAATATTAAATGGAAAATTCCTATAACAATGCATAAGTTATAGATTACATACCATTCAGTGTAGCATGA
TGAAATCTCTTGCCAATCTGTTCCATCCACCTGGGATGTGAATCATCCCTCTCTCTGGTGTATTCACACTGTATGTGCTAGCCGTCTCTG
TTACGAGATCAGCTGTCGTGGAATCAGTGCTAGTGTTCAGGTAACTCTTATTTAATAATTGCCTCAAAGTGCATTGTGCTGTGCCTAATT
TATAAAATAAACGGTATCATAGGTATGTATGTATACGAAAAACATAGTATATGCAGGGTTGGGTACTATCCACAGTTTCAGGCATCTACT
GGGGGGTCTTGGAATATATCCCCAGAGGGTAAGGGGTGACTACTGTATACAGCCATGCCAACATGCTGGTTCTCAGAGAGTTATAAGAGA
GATTAAAAATACATGCAGCTGTTTGGGCACTTTCTTCCCAAATAAAATACCCAGTAAAATGTAACATACTACCTATAGCTTGATAATCTA
TCTGAGGATGTTTATGATGTCTGTCTATATACTTTAATTTGGCCTTAGCTTCTTTGTAGGTATCAAGTTATCACTTGCAAATTTATTTTC
AAAAAGCATAGTTTCTTGTACATTTTAGAAGATTAGTTTTTCTTATTTTGGGACACCTACACCAATGTTTTAAATGTGGATAAATTTTAA
TGTGGAATTTCTTTTAAAAATAATCCTCTTCATAGAGCAATACAACAAAAATGTGTTGTATCTTGGAGATTTACATTATAAATGTAGTAA
CATTTATGAGCTTAAATTTAATGAAACCTTTTTTTTTTTTTTGAGACAGTCTTGCACTGTCGCCCAGGCTAGAGTGCAGGGCATGATCTC
AGCTCACTGCAACCTCCGTCTCCCGGGTTCAAGCAATTCTCGTGCCTCAGCCTCCTCAGTAACTGGCATTATAGGTGTGCACCACCACAC
CTGGCTAATTTTTGTATTTTTCATAAAGACGGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCAGCCTC
CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATGGTGCCTGGCCAAACGTTTTTATTACAAATATTACATTAAACTAAAGCT
CACAACTGTTATTATGCATCAGGAATTAACAGTCATTTCTCATTTGTGTTATTCTCCTATTTGATAACATATAGTGACTATCTCTTTATG
GGTTAAATATCAGTTTCTTGGCCAGAATTCAAGATCTGCCCCTAACTAATCCTACTTCTCCCAGTACCCTTACAGCACTCCTACCCTACT
AGTAACTCTGATATCTCATAGTCCTCAGATTTATCAAGCAAACGAAACTGAATGAGCACTACTATAAGGTACCACAAACTACAAAAGGAG
ACAGTTTTGCCCTTGTTGCTTTCAGTTAAATTATTGTGCTATTTTTTGCTTAATTTCTAGGTTTTTTTTGCGTGTTTATCATGTCTCCGT

>24413_24413_4_DTX3L-FAM162A_DTX3L_chr3_122289519_ENST00000383661_FAM162A_chr3_122126128_ENST00000477892_length(amino acids)=272AA_BP=206
MASHLRPPSPLLVRVYKSGPRVRRKLESYFQSSKSSGGGECTVSTQEHEAPGTFRVEFSERAAKERVLKKGEHQILVDEKPVPIFLVPTE
NSIKKNTRPQISSLTQSQAETPSGDMHQHEGHIPNAVDSCLQKEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKLIFTVGYS
RVLGVSDVITWNDIHHKTSRFGGPEMLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DTX3L-FAM162A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTX3L-FAM162A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTX3L-FAM162A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource