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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTX4-MS4A1 (FusionGDB2 ID:24426)

Fusion Gene Summary for DTX4-MS4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX4-MS4A1
Fusion gene ID: 24426
HgeneTgene
Gene symbol

DTX4

MS4A1

Gene ID

23220

2206

Gene namedeltex E3 ubiquitin ligase 4membrane spanning 4-domains A2
SynonymsRNF155APY|ATOPY|FCER1B|FCERI|IGEL|IGER|IGHER|MS4A1
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase DTX4RING finger protein 155RING-type E3 ubiquitin transferase DTX4deltex 4 homologdeltex 4, E3 ubiquitin ligasedeltex homolog 4deltex4protein deltex-4high affinity immunoglobulin epsilon receptor subunit betaFc fragment of IgE, high affinity I, receptor for; beta polypeptideHigh affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-c
Modification date2020031320200313
UniProtAcc

Q9Y2E6

Q96JA4

Ensembl transtripts involved in fusion geneENST00000227451, ENST00000532982, 
ENST00000531902, 		ENST00000534503, 
ENST00000345732, ENST00000389939, 
ENST00000528313, ENST00000532073, 
ENST00000534668, 
Fusion gene scores* DoF score7 X 5 X 5=1754 X 4 X 2=32
# samples 85
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DTX4 [Title/Abstract] AND MS4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTX4(58949935)-MS4A1(60229832), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTX4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MS4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2051-01ADTX4chr11

58949935

+MS4A1chr11

60229832

+
ChimerDB4OVTCGA-09-2051DTX4chr11

58949935

+MS4A1chr11

60229831

+


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Fusion Gene ORF analysis for DTX4-MS4A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000227451ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-3UTRENST00000227451ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-3UTRENST00000532982ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-3UTRENST00000532982ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000227451ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000227451ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000227451ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000227451ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000227451ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000532982ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000532982ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000532982ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000532982ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229831

+
5CDS-5UTRENST00000532982ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-3UTRENST00000531902ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-3UTRENST00000531902ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-5UTRENST00000531902ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-5UTRENST00000531902ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-5UTRENST00000531902ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-5UTRENST00000531902ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229831

+
intron-5UTRENST00000531902ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DTX4-MS4A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTX4chr1158949935+MS4A1chr1160229831+0.0043519340.9956481
DTX4chr1158949935+MS4A1chr1160229831+0.0043519340.9956481
DTX4chr1158949935+MS4A1chr1160229831+0.0043519340.9956481
DTX4chr1158949935+MS4A1chr1160229831+0.0043519340.9956481

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DTX4-MS4A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58949935/:60229832)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX4

Q9Y2E6

MS4A1

Q96JA4

FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}.FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DTX4-MS4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DTX4-MS4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTX4-MS4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTX4-MS4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource