FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DUSP10-SUSD4 (FusionGDB2 ID:24451)

Fusion Gene Summary for DUSP10-SUSD4

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP10-SUSD4
Fusion gene ID: 24451
HgeneTgene
Gene symbol

DUSP10

SUSD4

Gene ID

11221

55061

Gene namedual specificity phosphatase 10sushi domain containing 4
SynonymsMKP-5|MKP5PRO222
Cytomap

1q41

1q41

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 10dual specificity phosphatase MKP-5map kinase phosphatase 5mitogen-activated protein kinase phosphatase 5serine/threonine specific protein phosphatasesushi domain-containing protein 4YHGM196testicular secretory protein Li 55
Modification date2020031320200313
UniProtAcc

Q9Y6W6

.
Ensembl transtripts involved in fusion geneENST00000366899, ENST00000323825, 
ENST00000468085, ENST00000544095, 
ENST00000344029, ENST00000454695, 
ENST00000478605, ENST00000366877, 
ENST00000343846, ENST00000366878, 
ENST00000484758, ENST00000494793, 
Fusion gene scores* DoF score1 X 2 X 1=29 X 5 X 7=315
# samples 19
** MAII scorelog2(1/2*10)=2.32192809488736log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUSP10 [Title/Abstract] AND SUSD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDUSP10(221912276)-SUSD4(223442017), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUSP10

GO:0000188

inactivation of MAPK activity

22375048

HgeneDUSP10

GO:0006470

protein dephosphorylation

22375048

HgeneDUSP10

GO:0016311

dephosphorylation

24531476

HgeneDUSP10

GO:0035970

peptidyl-threonine dephosphorylation

10391943

HgeneDUSP10

GO:0043508

negative regulation of JUN kinase activity

10391943

HgeneDUSP10

GO:0046329

negative regulation of JNK cascade

10391943

HgeneDUSP10

GO:1903753

negative regulation of p38MAPK cascade

10391943

HgeneDUSP10

GO:1990264

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

10391943

TgeneSUSD4

GO:0030449

regulation of complement activation

23482636


check buttonFusion gene breakpoints across DUSP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUSD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-KR-A7K8-01ADUSP10chr1

221912276

-SUSD4chr1

223442017

-
ChimerDB4LIHCTCGA-KR-A7K8-01ADUSP10chr1

221915323

-SUSD4chr1

223442017

-


Top

Fusion Gene ORF analysis for DUSP10-SUSD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000366899ENST00000344029DUSP10chr1

221912276

-SUSD4chr1

223442017

-
5CDS-5UTRENST00000366899ENST00000454695DUSP10chr1

221912276

-SUSD4chr1

223442017

-
5CDS-5UTRENST00000366899ENST00000478605DUSP10chr1

221912276

-SUSD4chr1

223442017

-
5CDS-intronENST00000366899ENST00000366877DUSP10chr1

221912276

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000323825ENST00000343846DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000323825ENST00000366878DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000323825ENST00000484758DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000323825ENST00000494793DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000366899ENST00000343846DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000366899ENST00000366878DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000366899ENST00000484758DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-3CDSENST00000366899ENST00000494793DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000323825ENST00000344029DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000323825ENST00000454695DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000323825ENST00000478605DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000366899ENST00000344029DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000366899ENST00000454695DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-5UTRENST00000366899ENST00000478605DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-intronENST00000323825ENST00000366877DUSP10chr1

221915323

-SUSD4chr1

223442017

-
5UTR-intronENST00000366899ENST00000366877DUSP10chr1

221915323

-SUSD4chr1

223442017

-
In-frameENST00000366899ENST00000343846DUSP10chr1

221912276

-SUSD4chr1

223442017

-
In-frameENST00000366899ENST00000366878DUSP10chr1

221912276

-SUSD4chr1

223442017

-
In-frameENST00000366899ENST00000484758DUSP10chr1

221912276

-SUSD4chr1

223442017

-
In-frameENST00000366899ENST00000494793DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000323825ENST00000343846DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000323825ENST00000366878DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000323825ENST00000484758DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000323825ENST00000494793DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000343846DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000343846DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000366878DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000366878DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000484758DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000484758DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000494793DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000468085ENST00000494793DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000343846DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000343846DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000366878DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000366878DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000484758DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000484758DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000494793DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-3CDSENST00000544095ENST00000494793DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000323825ENST00000344029DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000323825ENST00000454695DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000323825ENST00000478605DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000344029DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000344029DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000454695DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000454695DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000478605DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000468085ENST00000478605DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000344029DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000344029DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000454695DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000454695DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000478605DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-5UTRENST00000544095ENST00000478605DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-intronENST00000323825ENST00000366877DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-intronENST00000468085ENST00000366877DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-intronENST00000468085ENST00000366877DUSP10chr1

221915323

-SUSD4chr1

223442017

-
intron-intronENST00000544095ENST00000366877DUSP10chr1

221912276

-SUSD4chr1

223442017

-
intron-intronENST00000544095ENST00000366877DUSP10chr1

221915323

-SUSD4chr1

223442017

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366899DUSP10chr1221912276-ENST00000343846SUSD4chr1223442017-353510502182161647
ENST00000366899DUSP10chr1221912276-ENST00000366878SUSD4chr1223442017-353310502182161647
ENST00000366899DUSP10chr1221912276-ENST00000484758SUSD4chr1223442017-352910502182167649
ENST00000366899DUSP10chr1221912276-ENST00000494793SUSD4chr1223442017-236510502182155645

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366899ENST00000343846DUSP10chr1221912276-SUSD4chr1223442017-0.0020313510.9979686
ENST00000366899ENST00000366878DUSP10chr1221912276-SUSD4chr1223442017-0.0020279630.9979721
ENST00000366899ENST00000484758DUSP10chr1221912276-SUSD4chr1223442017-0.001983920.9980161
ENST00000366899ENST00000494793DUSP10chr1221912276-SUSD4chr1223442017-0.0032412890.99675876

Top

Fusion Genomic Features for DUSP10-SUSD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DUSP10-SUSD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:221912276/chr1:223442017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP10

Q9Y6W6

.
FUNCTION: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:22375048}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034384618120_179120491.0DomainSushi 2
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034384618178_239120491.0DomainSushi 3
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034384618241_304120491.0DomainSushi 4
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034402926120_179120291.0DomainSushi 2
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034402926178_239120291.0DomainSushi 3
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034402926241_304120291.0DomainSushi 4
TgeneSUSD4chr1:221912276chr1:223442017ENST0000036687829120_179120491.0DomainSushi 2
TgeneSUSD4chr1:221912276chr1:223442017ENST0000036687829178_239120491.0DomainSushi 3
TgeneSUSD4chr1:221912276chr1:223442017ENST0000036687829241_304120491.0DomainSushi 4
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034384618341_490120491.0Topological domainCytoplasmic
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034402926341_490120291.0Topological domainCytoplasmic
TgeneSUSD4chr1:221912276chr1:223442017ENST0000036687829341_490120491.0Topological domainCytoplasmic
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034384618320_340120491.0TransmembraneHelical
TgeneSUSD4chr1:221912276chr1:223442017ENST0000034402926320_340120291.0TransmembraneHelical
TgeneSUSD4chr1:221912276chr1:223442017ENST0000036687829320_340120491.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP10chr1:221912276chr1:223442017ENST00000323825-13168_2850141.0DomainRhodanese
HgeneDUSP10chr1:221912276chr1:223442017ENST00000323825-13321_4640141.0DomainTyrosine-protein phosphatase
HgeneDUSP10chr1:221912276chr1:223442017ENST00000366899-24168_285270483.0DomainRhodanese
HgeneDUSP10chr1:221912276chr1:223442017ENST00000366899-24321_464270483.0DomainTyrosine-protein phosphatase
HgeneDUSP10chr1:221912276chr1:223442017ENST00000544095-13168_2850141.0DomainRhodanese
HgeneDUSP10chr1:221912276chr1:223442017ENST00000544095-13321_4640141.0DomainTyrosine-protein phosphatase
TgeneSUSD4chr1:221912276chr1:223442017ENST000003438461855_119120491.0DomainSushi 1
TgeneSUSD4chr1:221912276chr1:223442017ENST000003440292655_119120291.0DomainSushi 1
TgeneSUSD4chr1:221912276chr1:223442017ENST000003668782955_119120491.0DomainSushi 1
TgeneSUSD4chr1:221912276chr1:223442017ENST000003438461842_319120491.0Topological domainExtracellular
TgeneSUSD4chr1:221912276chr1:223442017ENST000003440292642_319120291.0Topological domainExtracellular
TgeneSUSD4chr1:221912276chr1:223442017ENST000003668782942_319120491.0Topological domainExtracellular


Top

Fusion Gene Sequence for DUSP10-SUSD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24451_24451_1_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000343846_length(transcript)=3535nt_BP=1050nt
GGATTCTTATTGGCCCAACCCGCCGTCGGTCGGCGGCGAGTCCGCCCCCTCAGAACCTTACATTTACAGTGTAGCAAAAGAGAAAGTAAC
TATGTTGCTGCTGGAGATCAATGAAGCCGAGTGAATGGGGGCTGAATGTGCGAGTCCATAGCTGAAGAGGAGCGCCAGATGGTGGAGGAA
TACACTTATTTATGAAACTGTCTTGAGTTCTTCTTGAATTGCCAGTTTTCAGCCTCCTCATGCCTCCGTCTCCTTTAGACGACAGGGTAG
TAGTGGCACTATCTAGGCCCGTCCGACCTCAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAACA
GCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTATATGCCCTCATCCAGCGGCTCTGCCCGCTCGC
TGAATTGTGGATGCAGCAGTGCCAGCTGCTGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGCA
CCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAATAATGAGAATACAGGCTCTCTAAGTCCATCAA
GTGGGGTGGGCAGCCCTGTGTCAGGGACCCCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACCA
AATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTCATGGAGTACAACAAGAGTCACATCCAAGGAG
CTGTCCACATTAACTGTGCCGATAAGATCAGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAAG
GCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACCAATGAACCAAGCCGAGTGATGCCCTCCCAGC
CACTTCACATAGTCCTCGAGTCCCTGAAGAGAGAAGGCAAAGAACCTCTGGTGTTGAAAGATTGCCGTATCCCTCAAATCGAAGATGCTG
AGATTCATAACAAGACATATAGACATGGAGAGAAGCTAATCATCACTTGTCATGAAGGATTCAAGATCCGGTACCCCGACCTACACAATA
TGGTTTCATTATGTCGCGATGATGGAACGTGGAATAATCTGCCCATCTGTCAAGGCTGCCTGAGACCTCTAGCCTCTTCTAATGGCTATG
TAAACATCTCTGAGCTCCAGACCTCCTTCCCGGTGGGGACTGTGATCTCCTATCGCTGCTTTCCCGGATTTAAACTTGATGGGTCTGCGT
ATCTTGAGTGCTTACAAAACCTTATCTGGTCGTCCAGCCCACCCCGGTGCCTTGCTCTGGAAGTCTGTCCACTACCTCCAATGGTGAGTC
ACGGAGATTTCGTCTGCCACCCGCGGCCTTGTGAGCGCTACAACCACGGAACTGTGGTGGAGTTTTACTGCGATCCTGGCTACAGCCTCA
CCAGCGACTACAAGTACATCACCTGCCAGTATGGAGAGTGGTTTCCTTCTTATCAAGTCTACTGCATCAAATCAGAGCAAACGTGGCCCA
GCACCCATGAGACCCTCCTGACCACGTGGAAGATTGTGGCGTTCACGGCAACCAGTGTGCTGCTGGTGCTGCTGCTCGTCATCCTGGCCA
GGATGTTCCAGACCAAGTTCAAGGCCCACTTTCCCCCCAGGGGGCCTCCCCGGAGTTCCAGCAGTGACCCTGACTTTGTGGTGGTAGACG
GCGTGCCCGTCATGCTCCCGTCCTATGACGAAGCTGTGAGTGGCGGCTTGAGTGCCTTAGGCCCCGGGTACATGGCCTCTGTGGGCCAGG
GCTGCCCCTTACCCGTGGACGACCAGAGCCCCCCAGCATACCCCGGCTCAGGGGACACGGACACAGGCCCAGGGGAGTCAGAAACCTGTG
ACAGCGTCTCAGGCTCTTCTGAGCTGCTCCAAAGTCTGTATTCACCTCCCAGGTGCCAAGAGAGCACCCACCCTGCTTCGGACAACCCTG
ACATAATTGCCAGCACGGCAGAGGAGGTGGCATCCACCAGCCCAGGCATCGACATTGCAGATGAGATTCCTCTAATGGAAGAAGATCCCT
AATATGGGTCAAGATCCAGATGACTCTCCTGCTCCTTCGGGGAAAGGACCTTGTATCTTGGAGTGAGGTCACAGAAGGATAGAGCCTGGG
GGCAAAATGTCTAACTTGTCTACATGGGGACCACAGTTCACATTATGCATCTCAGGCTCCACAGTGAGGCTGACAAACTGCAATGGCAGT
GCTTTTAAATGAGATTTGAGGATTCACCAAGACCCATGGGGAACCGGGGCAGCAGGGAAGCCCTCGCGTGGTCTTGGATGAGGGGTGTTA
AATGTGTATCGTGCTGTGGAACATGGGACAATTCCACGCACATCCCACCGAATCATCACGCATCCCATTGACTGGCAAGTACTCCCCGCC
CCCTCTGAAAGCATGTCACATCATGTAAATTTGCTTCTAACATCTGCTTCAAACTGTCTCTGGACTCCAAATTTGGATGGGTCAGCCTCT
GCAGAAAGTTTGTGTTGAGATGCTGGAAGAACAGCAGAGCCTCCTGCACCCTCAGCAAGGGACCAGCTCCCAAAGGAAAGGTCCTTGTGT
GACATTTGGAGAATCTTCCTTCATCCAGACAACTCTACTCGAAGCAAGACGAAAGCAGGATGTGGCAGTTGCAGTGAGAAAGGAAAGGAA
AGATGGGCAGACTCTGCTTTCTGGAAATTTCTTCACAAAGTAGAGCTCATGAACTCTGTGCTGTCTTCTGGTAACATATCATCAGTGTTT
GTATTCATGGTGTGGCACATGGATCCATGGCATTGGGTAAATCTGGTGGTTTTTACACATGGTCAGAATGTGTTCAAATACATCTCATGA
TGGAGACAGTAACCAAGGTAATGTTTTGTTTCAGCATTTTAAAAAGACTCCACTTAACATTTATCTCAGAATCATGAGCCTCTCTCTAGT
TGACAATTGTCATTGTTCCCCCAGCCCCAAATTGAACCATACATTTATTTTCCAAAACAGAAATTGTTTCTGTAAACATATCCGACCTTC
AAAAGAAGTGTGAGGTTGGATTTTTCCCCCTTTTATTTGTCCTAAGATTCCAGGAGGCTGGCCTCCCAGCCCAGATAGCTCAGCCACCTC
ACCTGCCTATCATTCCTGCATTCCTACTTTGAGGGTCTCATCATGCCCACTGGGTGTTGTTCCTAAGAAACTGATTGATTAAAAAATTTC
CCAAAGTGTCCTGAAGTGTCTCTTCAAATACATGTTGATCTGTGGAGTTGATTCCTTTCCTTCTCTTGGTTTTAGACAAATGTAAACAAA
GCTCTGATCCTTAAAATTGCTATGCTGATAGAGTGGTGAGGGCTGGAAGCTTGATCAAGTCCTGTTTCTTCTTGACACAGACTGATTAAA

>24451_24451_1_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000343846_length(amino acids)=647AA_BP=277
MPVFSLLMPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTV
ATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPV
IIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREG
KEPLVLKDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVG
TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGE
WFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAV
SGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVAST

--------------------------------------------------------------
>24451_24451_2_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000366878_length(transcript)=3533nt_BP=1050nt
GGATTCTTATTGGCCCAACCCGCCGTCGGTCGGCGGCGAGTCCGCCCCCTCAGAACCTTACATTTACAGTGTAGCAAAAGAGAAAGTAAC
TATGTTGCTGCTGGAGATCAATGAAGCCGAGTGAATGGGGGCTGAATGTGCGAGTCCATAGCTGAAGAGGAGCGCCAGATGGTGGAGGAA
TACACTTATTTATGAAACTGTCTTGAGTTCTTCTTGAATTGCCAGTTTTCAGCCTCCTCATGCCTCCGTCTCCTTTAGACGACAGGGTAG
TAGTGGCACTATCTAGGCCCGTCCGACCTCAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAACA
GCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTATATGCCCTCATCCAGCGGCTCTGCCCGCTCGC
TGAATTGTGGATGCAGCAGTGCCAGCTGCTGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGCA
CCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAATAATGAGAATACAGGCTCTCTAAGTCCATCAA
GTGGGGTGGGCAGCCCTGTGTCAGGGACCCCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACCA
AATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTCATGGAGTACAACAAGAGTCACATCCAAGGAG
CTGTCCACATTAACTGTGCCGATAAGATCAGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAAG
GCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACCAATGAACCAAGCCGAGTGATGCCCTCCCAGC
CACTTCACATAGTCCTCGAGTCCCTGAAGAGAGAAGGCAAAGAACCTCTGGTGTTGAAAGATTGCCGTATCCCTCAAATCGAAGATGCTG
AGATTCATAACAAGACATATAGACATGGAGAGAAGCTAATCATCACTTGTCATGAAGGATTCAAGATCCGGTACCCCGACCTACACAATA
TGGTTTCATTATGTCGCGATGATGGAACGTGGAATAATCTGCCCATCTGTCAAGGCTGCCTGAGACCTCTAGCCTCTTCTAATGGCTATG
TAAACATCTCTGAGCTCCAGACCTCCTTCCCGGTGGGGACTGTGATCTCCTATCGCTGCTTTCCCGGATTTAAACTTGATGGGTCTGCGT
ATCTTGAGTGCTTACAAAACCTTATCTGGTCGTCCAGCCCACCCCGGTGCCTTGCTCTGGAAGTCTGTCCACTACCTCCAATGGTGAGTC
ACGGAGATTTCGTCTGCCACCCGCGGCCTTGTGAGCGCTACAACCACGGAACTGTGGTGGAGTTTTACTGCGATCCTGGCTACAGCCTCA
CCAGCGACTACAAGTACATCACCTGCCAGTATGGAGAGTGGTTTCCTTCTTATCAAGTCTACTGCATCAAATCAGAGCAAACGTGGCCCA
GCACCCATGAGACCCTCCTGACCACGTGGAAGATTGTGGCGTTCACGGCAACCAGTGTGCTGCTGGTGCTGCTGCTCGTCATCCTGGCCA
GGATGTTCCAGACCAAGTTCAAGGCCCACTTTCCCCCCAGGGGGCCTCCCCGGAGTTCCAGCAGTGACCCTGACTTTGTGGTGGTAGACG
GCGTGCCCGTCATGCTCCCGTCCTATGACGAAGCTGTGAGTGGCGGCTTGAGTGCCTTAGGCCCCGGGTACATGGCCTCTGTGGGCCAGG
GCTGCCCCTTACCCGTGGACGACCAGAGCCCCCCAGCATACCCCGGCTCAGGGGACACGGACACAGGCCCAGGGGAGTCAGAAACCTGTG
ACAGCGTCTCAGGCTCTTCTGAGCTGCTCCAAAGTCTGTATTCACCTCCCAGGTGCCAAGAGAGCACCCACCCTGCTTCGGACAACCCTG
ACATAATTGCCAGCACGGCAGAGGAGGTGGCATCCACCAGCCCAGGCATCGACATTGCAGATGAGATTCCTCTAATGGAAGAAGATCCCT
AATATGGGTCAAGATCCAGATGACTCTCCTGCTCCTTCGGGGAAAGGACCTTGTATCTTGGAGTGAGGTCACAGAAGGATAGAGCCTGGG
GGCAAAATGTCTAACTTGTCTACATGGGGACCACAGTTCACATTATGCATCTCAGGCTCCACAGTGAGGCTGACAAACTGCAATGGCAGT
GCTTTTAAATGAGATTTGAGGATTCACCAAGACCCATGGGGAACCGGGGCAGCAGGGAAGCCCTCGCGTGGTCTTGGATGAGGGGTGTTA
AATGTGTATCGTGCTGTGGAACATGGGACAATTCCACGCACATCCCACCGAATCATCACGCATCCCATTGACTGGCAAGTACTCCCCGCC
CCCTCTGAAAGCATGTCACATCATGTAAATTTGCTTCTAACATCTGCTTCAAACTGTCTCTGGACTCCAAATTTGGATGGGTCAGCCTCT
GCAGAAAGTTTGTGTTGAGATGCTGGAAGAACAGCAGAGCCTCCTGCACCCTCAGCAAGGGACCAGCTCCCAAAGGAAAGGTCCTTGTGT
GACATTTGGAGAATCTTCCTTCATCCAGACAACTCTACTCGAAGCAAGACGAAAGCAGGATGTGGCAGTTGCAGTGAGAAAGGAAAGGAA
AGATGGGCAGACTCTGCTTTCTGGAAATTTCTTCACAAAGTAGAGCTCATGAACTCTGTGCTGTCTTCTGGTAACATATCATCAGTGTTT
GTATTCATGGTGTGGCACATGGATCCATGGCATTGGGTAAATCTGGTGGTTTTTACACATGGTCAGAATGTGTTCAAATACATCTCATGA
TGGAGACAGTAACCAAGGTAATGTTTTGTTTCAGCATTTTAAAAAGACTCCACTTAACATTTATCTCAGAATCATGAGCCTCTCTCTAGT
TGACAATTGTCATTGTTCCCCCAGCCCCAAATTGAACCATACATTTATTTTCCAAAACAGAAATTGTTTCTGTAAACATATCCGACCTTC
AAAAGAAGTGTGAGGTTGGATTTTTCCCCCTTTTATTTGTCCTAAGATTCCAGGAGGCTGGCCTCCCAGCCCAGATAGCTCAGCCACCTC
ACCTGCCTATCATTCCTGCATTCCTACTTTGAGGGTCTCATCATGCCCACTGGGTGTTGTTCCTAAGAAACTGATTGATTAAAAAATTTC
CCAAAGTGTCCTGAAGTGTCTCTTCAAATACATGTTGATCTGTGGAGTTGATTCCTTTCCTTCTCTTGGTTTTAGACAAATGTAAACAAA
GCTCTGATCCTTAAAATTGCTATGCTGATAGAGTGGTGAGGGCTGGAAGCTTGATCAAGTCCTGTTTCTTCTTGACACAGACTGATTAAA

>24451_24451_2_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000366878_length(amino acids)=647AA_BP=277
MPVFSLLMPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTV
ATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPV
IIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREG
KEPLVLKDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVG
TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGE
WFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAV
SGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVAST

--------------------------------------------------------------
>24451_24451_3_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000484758_length(transcript)=3529nt_BP=1050nt
GGATTCTTATTGGCCCAACCCGCCGTCGGTCGGCGGCGAGTCCGCCCCCTCAGAACCTTACATTTACAGTGTAGCAAAAGAGAAAGTAAC
TATGTTGCTGCTGGAGATCAATGAAGCCGAGTGAATGGGGGCTGAATGTGCGAGTCCATAGCTGAAGAGGAGCGCCAGATGGTGGAGGAA
TACACTTATTTATGAAACTGTCTTGAGTTCTTCTTGAATTGCCAGTTTTCAGCCTCCTCATGCCTCCGTCTCCTTTAGACGACAGGGTAG
TAGTGGCACTATCTAGGCCCGTCCGACCTCAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAACA
GCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTATATGCCCTCATCCAGCGGCTCTGCCCGCTCGC
TGAATTGTGGATGCAGCAGTGCCAGCTGCTGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGCA
CCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAATAATGAGAATACAGGCTCTCTAAGTCCATCAA
GTGGGGTGGGCAGCCCTGTGTCAGGGACCCCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACCA
AATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTCATGGAGTACAACAAGAGTCACATCCAAGGAG
CTGTCCACATTAACTGTGCCGATAAGATCAGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAAG
GCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACCAATGAACCAAGCCGAGTGATGCCCTCCCAGC
CACTTCACATAGTCCTCGAGTCCCTGAAGAGAGAAGGCAAAGAACCTCTGGTGTTGAAAGATTGCCGTATCCCTCAAATCGAAGATGCTG
AGATTCATAACAAGACATATAGACATGGAGAGAAGCTAATCATCACTTGTCATGAAGGATTCAAGATCCGGTACCCCGACCTACACAATA
TGGTTTCATTATGTCGCGATGATGGAACGTGGAATAATCTGCCCATCTGTCAAGGCTGCCTGAGACCTCTAGCCTCTTCTAATGGCTATG
TAAACATCTCTGAGCTCCAGACCTCCTTCCCGGTGGGGACTGTGATCTCCTATCGCTGCTTTCCCGGATTTAAACTTGATGGGTCTGCGT
ATCTTGAGTGCTTACAAAACCTTATCTGGTCGTCCAGCCCACCCCGGTGCCTTGCTCTGGAAGCCCAAGTCTGTCCACTACCTCCAATGG
TGAGTCACGGAGATTTCGTCTGCCACCCGCGGCCTTGTGAGCGCTACAACCACGGAACTGTGGTGGAGTTTTACTGCGATCCTGGCTACA
GCCTCACCAGCGACTACAAGTACATCACCTGCCAGTATGGAGAGTGGTTTCCTTCTTATCAAGTCTACTGCATCAAATCAGAGCAAACGT
GGCCCAGCACCCATGAGACCCTCCTGACCACGTGGAAGATTGTGGCGTTCACGGCAACCAGTGTGCTGCTGGTGCTGCTGCTCGTCATCC
TGGCCAGGATGTTCCAGACCAAGTTCAAGGCCCACTTTCCCCCCAGGGGGCCTCCCCGGAGTTCCAGCAGTGACCCTGACTTTGTGGTGG
TAGACGGCGTGCCCGTCATGCTCCCGTCCTATGACGAAGCTGTGAGTGGCGGCTTGAGTGCCTTAGGCCCCGGGTACATGGCCTCTGTGG
GCCAGGGCTGCCCCTTACCCGTGGACGACCAGAGCCCCCCAGCATACCCCGGCTCAGGGGACACGGACACAGGCCCAGGGGAGTCAGAAA
CCTGTGACAGCGTCTCAGGCTCTTCTGAGCTGCTCCAAAGTCTGTATTCACCTCCCAGGTGCCAAGAGAGCACCCACCCTGCTTCGGACA
ACCCTGACATAATTGCCAGCACGGCAGAGGAGGTGGCATCCACCAGCCCAGGCATCGACATTGCAGATGAGATTCCTCTAATGGAAGAAG
ATCCCTAATATGGGTCAAGATCCAGATGACTCTCCTGCTCCTTCGGGGAAAGGACCTTGTATCTTGGAGTGAGGTCACAGAAGGATAGAG
CCTGGGGGCAAAATGTCTAACTTGTCTACATGGGGACCACAGTTCACATTATGCATCTCAGGCTCCACAGTGAGGCTGACAAACTGCAAT
GGCAGTGCTTTTAAATGAGATTTGAGGATTCACCAAGACCCATGGGGAACCGGGGCAGCAGGGAAGCCCTCGCGTGGTCTTGGATGAGGG
GTGTTAAATGTGTATCGTGCTGTGGAACATGGGACAATTCCACGCACATCCCACCGAATCATCACGCATCCCATTGACTGGCAAGTACTC
CCCGCCCCCTCTGAAAGCATGTCACATCATGTAAATTTGCTTCTAACATCTGCTTCAAACTGTCTCTGGACTCCAAATTTGGATGGGTCA
GCCTCTGCAGAAAGTTTGTGTTGAGATGCTGGAAGAACAGCAGAGCCTCCTGCACCCTCAGCAAGGGACCAGCTCCCAAAGGAAAGGTCC
TTGTGTGACATTTGGAGAATCTTCCTTCATCCAGACAACTCTACTCGAAGCAAGACGAAAGCAGGATGTGGCAGTTGCAGTGAGAAAGGA
AAGGAAAGATGGGCAGACTCTGCTTTCTGGAAATTTCTTCACAAAGTAGAGCTCATGAACTCTGTGCTGTCTTCTGGTAACATATCATCA
GTGTTTGTATTCATGGTGTGGCACATGGATCCATGGCATTGGGTAAATCTGGTGGTTTTTACACATGGTCAGAATGTGTTCAAATACATC
TCATGATGGAGACAGTAACCAAGGTAATGTTTTGTTTCAGCATTTTAAAAAGACTCCACTTAACATTTATCTCAGAATCATGAGCCTCTC
TCTAGTTGACAATTGTCATTGTTCCCCCAGCCCCAAATTGAACCATACATTTATTTTCCAAAACAGAAATTGTTTCTGTAAACATATCCG
ACCTTCAAAAGAAGTGTGAGGTTGGATTTTTCCCCCTTTTATTTGTCCTAAGATTCCAGGAGGCTGGCCTCCCAGCCCAGATAGCTCAGC
CACCTCACCTGCCTATCATTCCTGCATTCCTACTTTGAGGGTCTCATCATGCCCACTGGGTGTTGTTCCTAAGAAACTGATTGATTAAAA
AATTTCCCAAAGTGTCCTGAAGTGTCTCTTCAAATACATGTTGATCTGTGGAGTTGATTCCTTTCCTTCTCTTGGTTTTAGACAAATGTA
AACAAAGCTCTGATCCTTAAAATTGCTATGCTGATAGAGTGGTGAGGGCTGGAAGCTTGATCAAGTCCTGTTTCTTCTTGACACAGACTG

>24451_24451_3_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000484758_length(amino acids)=649AA_BP=277
MPVFSLLMPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTV
ATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPV
IIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREG
KEPLVLKDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVG
TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEAQVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQY
GEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDE
AVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVA

--------------------------------------------------------------
>24451_24451_4_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000494793_length(transcript)=2365nt_BP=1050nt
GGATTCTTATTGGCCCAACCCGCCGTCGGTCGGCGGCGAGTCCGCCCCCTCAGAACCTTACATTTACAGTGTAGCAAAAGAGAAAGTAAC
TATGTTGCTGCTGGAGATCAATGAAGCCGAGTGAATGGGGGCTGAATGTGCGAGTCCATAGCTGAAGAGGAGCGCCAGATGGTGGAGGAA
TACACTTATTTATGAAACTGTCTTGAGTTCTTCTTGAATTGCCAGTTTTCAGCCTCCTCATGCCTCCGTCTCCTTTAGACGACAGGGTAG
TAGTGGCACTATCTAGGCCCGTCCGACCTCAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAACA
GCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTATATGCCCTCATCCAGCGGCTCTGCCCGCTCGC
TGAATTGTGGATGCAGCAGTGCCAGCTGCTGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGCA
CCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAATAATGAGAATACAGGCTCTCTAAGTCCATCAA
GTGGGGTGGGCAGCCCTGTGTCAGGGACCCCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACCA
AATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTCATGGAGTACAACAAGAGTCACATCCAAGGAG
CTGTCCACATTAACTGTGCCGATAAGATCAGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAAG
GCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACCAATGAACCAAGCCGAGTGATGCCCTCCCAGC
CACTTCACATAGTCCTCGAGTCCCTGAAGAGAGAAGGCAAAGAACCTCTGGTGTTGAAAGATTGCCGTATCCCTCAAATCGAAGATGCTG
AGATTCATAACAAGACATATAGACATGGAGAGAAGCTAATCATCACTTGTCATGAAGGATTCAAGATCCGGTACCCCGACCTACACAATA
TGGTTTCATTATGTCGCGATGATGGAACGTGGAATAATCTGCCCATCTGTCAAGGCTGCCTGAGACCTCTAGCCTCTTCTAATGGCTATG
TAAACATCTCTGAGCTCCAGACCTCCTTCCCGGTGGGGACTGTGATCTCCTATCGCTGCTTTCCCGGATTTAAACTTGATGGGTCTGCGT
ATCTTGAGTGCTTACAAAACCTTATCTGGTCGTCCAGCCCACCCCGGTGCCTTGCTCTGGAAGTCTGTCCACTACCTCCAATGGTGAGTC
ACGGAGATTTCGTCTGCCACCCGCGGCCTTGTGAGCGCTACAACCACGGAACTGTGGTGGAGTTTTACTGCGATCCTGGCTACAGCCTCA
CCAGCGACTACAAGTACATCACCTGCCAGTATGGAGAGTGGTTTCCTTCTTATCAAGTCTACTGCATCAAATCAGAGCAAACGTGGCCCA
GCACCCATGAGACCCTCCTGACCACGTGGAAGATTGTGGCGTTCACGGCAACCAGTGTGCTGCTGGTGCTGCTGCTCGTCATCCTGGCCA
GGATGTTCCAGACCAAGTTCAAGGCCCACTTTCCCCCCAGGGGGCCTCCCCGGAGTTCCAGCAGTGACCCTGACTTTGTGGTGGTAGACG
GCGTGCCCGTCATGCTCCCGTCCTATGACGAAGCTGTGAGTGGCGGCTTGAGTGCCTTAGGCCCCGGGTACATGGCCTCTGTGGGCCAGG
GCTGCCCCTTACCCGTGGACGACCAGAGCCCCCCAGCATACCCCGGCTCAGGGGACACGGACACAGGCCCAGGGGAGTCAGAAACCTGTG
ACAGCGTCTCAGGCTCTTCTGAGCTGCTCCAAAGTCTGTATTCACCTCCCAGGTGCCAAGAGAGCACCCACCCTGCTTCGGACAACCCTG
ACATAATTGCCAGCACGGCAGAGGAGGTGGCATCCACCAGCCCAGGGTCTCATCATGCCCACTGGGTGTTGTTCCTAAGAAACTGATTGA
TTAAAAAATTTCCCAAAGTGTCCTGAAGTGTCTCTTCAAATACATGTTGATCTGTGGAGTTGATTCCTTTCCTTCTCTTGGTTTTAGACA
AATGTAAACAAAGCTCTGATCCTTAAAATTGCTATGCTGATAGAGTGGTGAGGGCTGGAAGCTTGATCAAGTCCTGTTTCTTCTTGACAC

>24451_24451_4_DUSP10-SUSD4_DUSP10_chr1_221912276_ENST00000366899_SUSD4_chr1_223442017_ENST00000494793_length(amino acids)=645AA_BP=277
MPVFSLLMPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTV
ATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPV
IIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREG
KEPLVLKDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVG
TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGE
WFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAV
SGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVAST

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DUSP10-SUSD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDUSP10chr1:221912276chr1:223442017ENST00000366899-24199_215270.3333333333333483.0MAP kinases


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDUSP10chr1:221912276chr1:223442017ENST00000323825-13199_2150141.0MAP kinases
HgeneDUSP10chr1:221912276chr1:223442017ENST00000544095-13199_2150141.0MAP kinases


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DUSP10-SUSD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DUSP10-SUSD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource