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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DUSP14-ATP6V0A1 (FusionGDB2 ID:24461)

Fusion Gene Summary for DUSP14-ATP6V0A1

Fusion gene summary

Fusion gene information	Fusion gene name: DUSP14-ATP6V0A1
	Fusion gene ID: 24461
		Hgene	Tgene
	Gene symbol	DUSP14	ATP6V0A1
	Gene ID	11072	535
	Gene name	dual specificity phosphatase 14	ATPase H+ transporting V0 subunit a1
	Synonyms	MKP-L\|MKP6	ATP6N1\|ATP6N1A\|Stv1\|VPP1\|Vph1\|a1
	Cytomap	17q12	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	dual specificity protein phosphatase 14MAP kinase phosphatase 6MKP-1-like protein tyrosine phosphataseMKP-6mitogen-activated protein kinase phosphatase 6	V-type proton ATPase 116 kDa subunit a isoform 1V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal V0 subunit a1ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)H(+)-transporting two-sector ATPase,
	Modification date	20200313	20200324
	UniProtAcc	O95147	Q93050
	Ensembl transtripts involved in fusion gene	ENST00000394389, ENST00000394386, ENST00000487847,	ENST00000264649, ENST00000343619, ENST00000393829, ENST00000537728, ENST00000546249, ENST00000585525, ENST00000544137, ENST00000587797,
Fusion gene scores	* DoF score	14 X 8 X 4=448	8 X 10 X 4=320
	# samples	15	9
	** MAII score	log2(15/448*10)=-1.57853623156172 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DUSP14 [Title/Abstract] AND ATP6V0A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DUSP14(35850058)-ATP6V0A1(40629656), # samples:1 DUSP14(35850059)-ATP6V0A1(40629657), # samples:1 DUSP14(35850059)-ATP6V0A1(40629678), # samples:1 DUSP14(35850064)-ATP6V0A1(40629657), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DUSP14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP6V0A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-O2-A52S-01A	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
ChimerDB4	LUSC	TCGA-O2-A52S-01A	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
ChimerDB4	LUSC	TCGA-O2-A52S	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
ChimerDB4	LUSC	TCGA-O2-A52S	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+

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Fusion Gene ORF analysis for DUSP14-ATP6V0A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000394389	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-3CDS	ENST00000394389	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-3CDS	ENST00000394389	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-3CDS	ENST00000394389	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-3CDS	ENST00000394389	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-3CDS	ENST00000394389	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-intron	ENST00000394389	ENST00000264649	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000264649	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000343619	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000343619	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000393829	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000393829	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000537728	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000537728	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000544137	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000544137	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
5UTR-intron	ENST00000394389	ENST00000546249	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000546249	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000585525	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000585525	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000587797	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
5UTR-intron	ENST00000394389	ENST00000587797	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
5UTR-intron	ENST00000394389	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000394386	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-3CDS	ENST00000487847	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-intron	ENST00000394386	ENST00000264649	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000264649	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000343619	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000343619	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000393829	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000393829	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000537728	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000537728	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000544137	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000544137	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-intron	ENST00000394386	ENST00000546249	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000546249	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000585525	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000585525	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000587797	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000394386	ENST00000587797	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000394386	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-intron	ENST00000487847	ENST00000264649	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000264649	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000264649	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000343619	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000343619	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000343619	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000393829	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000393829	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000393829	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000537728	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000537728	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000537728	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000544137	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000544137	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000544137	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+
intron-intron	ENST00000487847	ENST00000546249	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000546249	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000546249	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000585525	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000585525	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000585525	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000587797	DUSP14	chr17	35850058	+	ATP6V0A1	chr17	40629656	+
intron-intron	ENST00000487847	ENST00000587797	DUSP14	chr17	35850064	-	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629657	+
intron-intron	ENST00000487847	ENST00000587797	DUSP14	chr17	35850059	+	ATP6V0A1	chr17	40629678	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DUSP14-ATP6V0A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629677	+	4.47E-06	0.9999956
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629656	+	2.28E-07	0.99999976
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629656	+	2.28E-07	0.99999976
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629677	+	4.47E-06	0.9999956
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629656	+	2.28E-07	0.99999976
DUSP14	chr17	35850064	+	ATP6V0A1	chr17	40629656	+	2.28E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DUSP14-ATP6V0A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35850058/:40629656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DUSP14 O95147	ATP6V0A1 Q93050
FUNCTION: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.	FUNCTION: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DUSP14-ATP6V0A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DUSP14-ATP6V0A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DUSP14-ATP6V0A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DUSP14-ATP6V0A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source