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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DUSP7-PBRM1 (FusionGDB2 ID:24509)

Fusion Gene Summary for DUSP7-PBRM1

Fusion gene summary

Fusion gene information	Fusion gene name: DUSP7-PBRM1
	Fusion gene ID: 24509
		Hgene	Tgene
	Gene symbol	DUSP7	PBRM1
	Gene ID	1849	55193
	Gene name	dual specificity phosphatase 7	polybromo 1
	Synonyms	MKPX\|PYST2	BAF180\|PB1
	Cytomap	3p21.2	3p21.1
	Type of gene	protein-coding	protein-coding
	Description	dual specificity protein phosphatase 7dual specificity protein phosphatase PYST2	protein polybromo-1BRG1-associated factor 180polybromo-1D
	Modification date	20200313	20200313
	UniProtAcc	Q16829	.
	Ensembl transtripts involved in fusion gene	ENST00000296483, ENST00000495880,	ENST00000337303, ENST00000409057, ENST00000409114, ENST00000409767, ENST00000410007, ENST00000296302, ENST00000356770, ENST00000394830,
Fusion gene scores	* DoF score	1 X 1 X 1=1	10 X 10 X 7=700
	# samples	1	10
	** MAII score	log2(1/1*10)=3.32192809488736	log2(10/700*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DUSP7 [Title/Abstract] AND PBRM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DUSP7(52087956)-PBRM1(52588895), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DUSP7	GO:0035335	peptidyl-tyrosine dephosphorylation	9788880
Hgene	DUSP7	GO:0043407	negative regulation of MAP kinase activity	9788880

Fusion gene breakpoints across DUSP7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PBRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A140-01A	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-

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Fusion Gene ORF analysis for DUSP7-PBRM1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000296483	ENST00000337303	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000296483	ENST00000409057	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000296483	ENST00000409114	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000296483	ENST00000409767	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000296483	ENST00000410007	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000495880	ENST00000337303	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000495880	ENST00000409057	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000495880	ENST00000409114	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000495880	ENST00000409767	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
5CDS-intron	ENST00000495880	ENST00000410007	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000296483	ENST00000296302	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000296483	ENST00000356770	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000296483	ENST00000394830	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000495880	ENST00000296302	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000495880	ENST00000356770	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-
In-frame	ENST00000495880	ENST00000394830	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000495880	DUSP7	chr3	52087956	-	ENST00000356770	PBRM1	chr3	52588895	-	4464	1136	109	1752	547
ENST00000495880	DUSP7	chr3	52087956	-	ENST00000394830	PBRM1	chr3	52588895	-	1975	1136	109	1752	547
ENST00000495880	DUSP7	chr3	52087956	-	ENST00000296302	PBRM1	chr3	52588895	-	1826	1136	109	1752	547
ENST00000296483	DUSP7	chr3	52087956	-	ENST00000356770	PBRM1	chr3	52588895	-	4359	1031	4	1647	547
ENST00000296483	DUSP7	chr3	52087956	-	ENST00000394830	PBRM1	chr3	52588895	-	1870	1031	4	1647	547
ENST00000296483	DUSP7	chr3	52087956	-	ENST00000296302	PBRM1	chr3	52588895	-	1721	1031	4	1647	547

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000495880	ENST00000356770	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.002337037	0.997663
ENST00000495880	ENST00000394830	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.051734604	0.94826543
ENST00000495880	ENST00000296302	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.059905134	0.94009495
ENST00000296483	ENST00000356770	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.002392391	0.9976076
ENST00000296483	ENST00000394830	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.05337087	0.9466291
ENST00000296483	ENST00000296302	DUSP7	chr3	52087956	-	PBRM1	chr3	52588895	-	0.060610514	0.93938947

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Fusion Genomic Features for DUSP7-PBRM1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DUSP7-PBRM1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52087956/chr3:52588895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DUSP7 Q16829	.
FUNCTION: Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). {ECO:0000250\|UniProtKB:Q91Z46, ECO:0000269\|PubMed:9788880}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000296483

192_240

266

369.0

Compositional bias

Ser-rich

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000495880

192_240

317

420.0

Compositional bias

Ser-rich

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000296483

68_187

266

369.0

Domain

Rhodanese

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000495880

68_187

317

420.0

Domain

Rhodanese

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

1468_1599

1583.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

630_633

1583.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

1468_1599

1397

1603.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

1468_1599

1377

1583.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

1468_1599

1429

1635.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

1468_1599

1653.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

630_633

1653.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

1468_1599

1598.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

630_633

1598.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

1468_1599

1404

1610.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

1379_1447

1583.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

1379_1447

1377

1583.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

1379_1447

1653.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

1379_1447

1598.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

1156_1272

1583.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

200_270

1583.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

400_470

1583.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

538_608

1583.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

64_134

1583.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

676_746

1583.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

792_862

1583.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000337303

956_1074

1583.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

1156_1272

1653.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

200_270

1653.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

400_470

1653.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

538_608

1653.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

64_134

1653.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

676_746

1653.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

792_862

1653.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409114

956_1074

1653.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

1156_1272

1598.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

200_270

1598.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

400_470

1598.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

538_608

1598.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

64_134

1598.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

676_746

1598.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

792_862

1598.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409767

956_1074

1598.0

Domain

BAH 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000296483

244_387

266

369.0

Domain

Tyrosine-protein phosphatase

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000495880

244_387

317

420.0

Domain

Tyrosine-protein phosphatase

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000296483

331_337

266

369.0

Region

Substrate binding

Hgene

DUSP7

chr3:52087956

chr3:52588895

ENST00000495880

331_337

317

420.0

Region

Substrate binding

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

1468_1599

1484

1690.0

Compositional bias

Note=Pro-rich

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

630_633

1484

1690.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

630_633

1397

1603.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

630_633

1377

1583.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

630_633

1429

1635.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

630_633

1404

1610.0

Compositional bias

Note=Poly-Asp

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

1379_1447

1484

1690.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

1379_1447

1397

1603.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

1379_1447

1429

1635.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

1379_1447

1404

1610.0

DNA binding

HMG box

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

1156_1272

1484

1690.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

200_270

1484

1690.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

400_470

1484

1690.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

538_608

1484

1690.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

64_134

1484

1690.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

676_746

1484

1690.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

792_862

1484

1690.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000296302

956_1074

1484

1690.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

1156_1272

1397

1603.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

200_270

1397

1603.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

400_470

1397

1603.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

538_608

1397

1603.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

64_134

1397

1603.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

676_746

1397

1603.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

792_862

1397

1603.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000356770

956_1074

1397

1603.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

1156_1272

1377

1583.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

200_270

1377

1583.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

400_470

1377

1583.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

538_608

1377

1583.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

64_134

1377

1583.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

676_746

1377

1583.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

792_862

1377

1583.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000394830

956_1074

1377

1583.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

1156_1272

1429

1635.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

200_270

1429

1635.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

400_470

1429

1635.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

538_608

1429

1635.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

64_134

1429

1635.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

676_746

1429

1635.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

792_862

1429

1635.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000409057

956_1074

1429

1635.0

Domain

BAH 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

1156_1272

1404

1610.0

Domain

BAH 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

200_270

1404

1610.0

Domain

Bromo 2

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

400_470

1404

1610.0

Domain

Bromo 3

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

538_608

1404

1610.0

Domain

Bromo 4

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

64_134

1404

1610.0

Domain

Bromo 1

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

676_746

1404

1610.0

Domain

Bromo 5

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

792_862

1404

1610.0

Domain

Bromo 6

Tgene

PBRM1

chr3:52087956

chr3:52588895

ENST00000410007

956_1074

1404

1610.0

Domain

BAH 1

Top

Fusion Gene Sequence for DUSP7-PBRM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24509_24509_1_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000296302_length(transcript)=1721nt_BP=1031nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG

>24509_24509_1_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000296302_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------
>24509_24509_2_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000356770_length(transcript)=4359nt_BP=1031nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG
TTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTT
TAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACC
AGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGG
CTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTA
CAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCT
GAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAAT
AGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCC
TGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAGTGATTTTTGCAGAAC
ACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTCACAATTTATGCCTAT
AAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTATGCATGGAGGTG
ATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAAG
TAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGT
TATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATT
TAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACAT
TTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTG
CCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGT
ACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAAT
ATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATATTGAATTTAAAAAAAT
GTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAATTGAATCATCATGGA
CTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAAATTATTTATTT
ATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGGG
TCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAG
CAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTT
CTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAG
AAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCA
AAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGC
CAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCA
CCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGGTTTATTCTAATTTCT
GTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAAAGCTTTTTAATCCAA

>24509_24509_2_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000356770_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------
>24509_24509_3_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000394830_length(transcript)=1870nt_BP=1031nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG
TTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTT

>24509_24509_3_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000296483_PBRM1_chr3_52588895_ENST00000394830_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------
>24509_24509_4_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000296302_length(transcript)=1826nt_BP=1136nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT

>24509_24509_4_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000296302_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------
>24509_24509_5_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000356770_length(transcript)=4464nt_BP=1136nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT
CAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTT
ATATACGGACACTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTT
CCTTCGTTTAAAACCAGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAG
AGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACAC
ACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGT
TTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGG
TTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGC
AGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAG
TGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTC
ACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAG
GTATGCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGC
ATAATTGTGAACAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTT
AAGTTTCAATGTTGTTATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAG
AAGGGAATCATAATTTAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGA
CCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATA
GTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAAT
CTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTAT
CTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATAT
TGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAA
TTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGG
TTAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCAC
TGGGGGCCACGTGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCA
GGGGCTTCCCTAAAGCAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTT
TAGAATCATGTTTTTCTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAA
AAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATG
GCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAAC
AGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAA
GAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGG
TTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAA

>24509_24509_5_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000356770_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------
>24509_24509_6_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000394830_length(transcript)=1975nt_BP=1136nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT
CAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTT

>24509_24509_6_DUSP7-PBRM1_DUSP7_chr3_52087956_ENST00000495880_PBRM1_chr3_52588895_ENST00000394830_length(amino acids)=547AA_BP=342
MGPARPGRRPRAGLPGPGPGPPALPMKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELE
ARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLG
LLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFP
VQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVD
GLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTP
MFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DUSP7-PBRM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DUSP7-PBRM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DUSP7-PBRM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source