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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DVL3-PKP4 (FusionGDB2 ID:24548)

Fusion Gene Summary for DVL3-PKP4

check button Fusion gene summary
Fusion gene informationFusion gene name: DVL3-PKP4
Fusion gene ID: 24548
HgeneTgene
Gene symbol

DVL3

PKP4

Gene ID

1857

8502

Gene namedishevelled segment polarity protein 3plakophilin 4
SynonymsDRS3p0071
Cytomap

3q27.1

2q24.1

Type of geneprotein-codingprotein-coding
Descriptionsegment polarity protein dishevelled homolog DVL-3dishevelled 3 (homologous to Drosophila dsh)dishevelled, dsh homolog 3plakophilin-4catenin 4
Modification date2020031320200313
UniProtAcc

Q92997

.
Ensembl transtripts involved in fusion geneENST00000313143, ENST00000431765, 
ENST00000462665, 		ENST00000495123, 
ENST00000389757, ENST00000389759, 
Fusion gene scores* DoF score8 X 8 X 4=25615 X 19 X 6=1710
# samples 1022
** MAII scorelog2(10/256*10)=-1.35614381022528
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1710*10)=-2.9584208962486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DVL3 [Title/Abstract] AND PKP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDVL3(183885479)-PKP4(159389774), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDVL3

GO:0043547

positive regulation of GTPase activity

23109420

HgeneDVL3

GO:0045893

positive regulation of transcription, DNA-templated

10644691|12805222|17593335

HgeneDVL3

GO:0060070

canonical Wnt signaling pathway

10644691|17593335

HgeneDVL3

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

12805222

HgeneDVL3

GO:1903827

regulation of cellular protein localization

19625296

TgenePKP4

GO:0043547

positive regulation of GTPase activity

17115030


check buttonFusion gene breakpoints across DVL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PKP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW842036DVL3chr3

183885479

-PKP4chr2

159389774

+


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Fusion Gene ORF analysis for DVL3-PKP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313143ENST00000495123DVL3chr3

183885479

-PKP4chr2

159389774

+
5CDS-intronENST00000431765ENST00000495123DVL3chr3

183885479

-PKP4chr2

159389774

+
In-frameENST00000313143ENST00000389757DVL3chr3

183885479

-PKP4chr2

159389774

+
In-frameENST00000313143ENST00000389759DVL3chr3

183885479

-PKP4chr2

159389774

+
In-frameENST00000431765ENST00000389757DVL3chr3

183885479

-PKP4chr2

159389774

+
In-frameENST00000431765ENST00000389759DVL3chr3

183885479

-PKP4chr2

159389774

+
intron-3CDSENST00000462665ENST00000389757DVL3chr3

183885479

-PKP4chr2

159389774

+
intron-3CDSENST00000462665ENST00000389759DVL3chr3

183885479

-PKP4chr2

159389774

+
intron-intronENST00000462665ENST00000495123DVL3chr3

183885479

-PKP4chr2

159389774

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313143DVL3chr3183885479-ENST00000389757PKP4chr2159389774+7040146624848371529
ENST00000313143DVL3chr3183885479-ENST00000389759PKP4chr2159389774+5719146624849661572
ENST00000431765DVL3chr3183885479-ENST00000389757PKP4chr2159389774+681712437646141512
ENST00000431765DVL3chr3183885479-ENST00000389759PKP4chr2159389774+549612437647431555

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313143ENST00000389757DVL3chr3183885479-PKP4chr2159389774+0.0010642510.99893576
ENST00000313143ENST00000389759DVL3chr3183885479-PKP4chr2159389774+0.0019665230.99803346
ENST00000431765ENST00000389757DVL3chr3183885479-PKP4chr2159389774+0.0008402450.9991598
ENST00000431765ENST00000389759DVL3chr3183885479-PKP4chr2159389774+0.0015826590.9984174

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Fusion Genomic Features for DVL3-PKP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DVL3-PKP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183885479/chr2:159389774)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DVL3

Q92997

.
FUNCTION: Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePKP4chr3:183885479chr2:159389774ENST0000038975702136_7001150.0Coiled coilOntology_term=ECO:0000255
TgenePKP4chr3:183885479chr2:159389774ENST0000038975902236_7001193.0Coiled coilOntology_term=ECO:0000255
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021788_79401150.0Compositional biasNote=Poly-Lys
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022788_79401193.0Compositional biasNote=Poly-Lys
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021415_45501150.0RepeatNote=ARM 1
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021518_55701150.0RepeatNote=ARM 2
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021560_59901150.0RepeatNote=ARM 3
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021604_64401150.0RepeatNote=ARM 4
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021660_70201150.0RepeatNote=ARM 5
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021706_75101150.0RepeatNote=ARM 6
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021815_85501150.0RepeatNote=ARM 7
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021862_90101150.0RepeatNote=ARM 8
TgenePKP4chr3:183885479chr2:159389774ENST00000389757021950_99301150.0RepeatNote=ARM 9
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022415_45501193.0RepeatNote=ARM 1
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022518_55701193.0RepeatNote=ARM 2
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022560_59901193.0RepeatNote=ARM 3
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022604_64401193.0RepeatNote=ARM 4
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022660_70201193.0RepeatNote=ARM 5
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022706_75101193.0RepeatNote=ARM 6
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022815_85501193.0RepeatNote=ARM 7
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022862_90101193.0RepeatNote=ARM 8
TgenePKP4chr3:183885479chr2:159389774ENST00000389759022950_99301193.0RepeatNote=ARM 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDVL3chr3:183885479chr2:159389774ENST00000313143-1151_820717.0DomainDIX
HgeneDVL3chr3:183885479chr2:159389774ENST00000313143-115249_3210717.0DomainPDZ
HgeneDVL3chr3:183885479chr2:159389774ENST00000313143-115422_4960717.0DomainDEP
HgeneDVL3chr3:183885479chr2:159389774ENST00000431765-1151_820700.0DomainDIX
HgeneDVL3chr3:183885479chr2:159389774ENST00000431765-115249_3210700.0DomainPDZ
HgeneDVL3chr3:183885479chr2:159389774ENST00000431765-115422_4960700.0DomainDEP


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Fusion Gene Sequence for DVL3-PKP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24548_24548_1_DVL3-PKP4_DVL3_chr3_183885479_ENST00000313143_PKP4_chr2_159389774_ENST00000389757_length(transcript)=7040nt_BP=1466nt
GCCGCGGCCACCGGAAGAGTCGCGGTCGCCAGTCCAGTCGGGAGAGTGGGGAGCGGAAGCGGCGGCCGCGGCGGCGGCGGGCGGCGCTGG
GACCCGGTAGCGGCCGGAGAACAAGGGAGCTGGCGCCGCCAGCAGCCGCCGAGCTGGGTTGAGCCGCTGGGCCGCGCCGCGCGCCGCCGC
CGTCTGGGAGGCTCGGCCCGGCCGCCCGAGCAGGCCGCGCGCGGGCCGCCGGGCCCGAGGCCAGAGCCATGGGCGAGACCAAGATCATCT
ACCACTTGGATGGGCAGGAGACGCCGTACCTTGTGAAGCTGCCCCTGCCCGCCGAGCGCGTCACCTTGGCGGACTTTAAGGGCGTTTTGC
AGCGACCCAGCTATAAGTTCTTCTTCAAGTCTATGGACGACGATTTCGGAGTGGTGAAGGAGGAGATCTCGGATGACAATGCCAAGCTAC
CATGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTGTCAGCTGAGGGCTCACACCCAGACCCAGCCCCCTTCTGTGCTGATAACCCATCGG
AGCTGCCACCACCTATGGAGCGCACGGGAGGCATCGGGGACTCCCGACCCCCATCCTTCCACCCTCATGCTGGTGGGGGCAGCCAGGAGA
ACCTGGACAATGACACAGAGACGGACTCTTTGGTGTCTGCCCAGCGAGAGCGGCCACGCCGGAGGGATGGCCCAGAGCATGCAACCCGGC
TAAATGGAACTGCGAAGGGGGAACGGCGGCGAGAACCAGGGGGTTATGATAGCTCATCCACCCTTATGAGCAGTGAGCTGGAGACCACCA
GCTTCTTTGACTCAGATGAGGATGACTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTGATGAGAAGACACA
AGCGGCGGCGGCGGAAGCAGAAGGTTTCTCGGATTGAGCGGTCCTCGTCCTTCAGCAGCATCACGGACTCCACCATGTCACTCAACATCA
TCACGGTCACTCTCAACATGGAAAAATATAACTTCTTGGGCATCTCCATTGTGGGCCAAAGCAACGAGCGTGGTGACGGCGGCATCTACA
TTGGCTCTATCATGAAGGGTGGGGCCGTGGCTGCTGATGGACGCATCGAGCCAGGAGATATGTTGTTACAGGTAAACGAGATCAACTTTG
AGAACATGAGTAATGACGATGCAGTCCGGGTACTGCGGGAGATTGTGCACAAACCGGGGCCCATCACCCTGACTGTAGCCAAGTGCTGGG
ACCCAAGTCCACGTGGTTGCTTCACATTGCCCAGGAGCGAGCCCATCCGGCCCATTGACCCTGCGGCCTGGGTCTCCCACACTGCAGCCA
TGACCGGCACCTTCCCTGCATACGGCATGAGCCCCTCCCTGAGCACCATCACCTCCACCAGCTCCTCCATCACCAGTTCCATCCCTGACA
CAGAGCCATCCCTAATGCTTTCATCGGGCATGGAACCCGAGACCACAGCCACCACTATTCTAGCATCCGTGAAGGAGCAGGAGCTTCAGT
TTCAGCGACTCACCCGAGAACTGGAAGTGGAAAGGCAGATTGTTGCCAGTCAGCTAGAAAGATGTAGGCTTGGAGCAGAATCACCAAGCA
TCGCCAGCACCAGCTCAACTGAGAAGTCATTTCCTTGGAGATCAACAGACGTGCCAAATACTGGTGTAAGCAAACCTAGAGTTTCTGACG
CTGTCCAGCCCAACAACTATCTCATCAGGACAGAGCCAGAACAAGGAACCCTCTATTCACCAGAACAGACATCTCTCCATGAAAGTGAGG
GATCATTGGGTAACTCAAGAAGTTCAACACAAATGAATTCTTATTCCGACAGTGGATACCAGGAAGCAGGGAGTTTCCACAACAGCCAGA
ACGTGAGCAAGGCAGACAACAGACAGCAGCATTCATTCATAGGATCAACTAACAACCATGTGGTGAGGAATTCAAGAGCTGAAGGACAAA
CACTGGTTCAGCCATCAGTAGCCAATCGGGCCATGAGAAGAGTTAGTTCAGTTCCATCTAGAGCACAGTCTCCTTCTTATGTTATCAGCA
CAGGCGTGTCTCCTTCAAGGGGGTCTCTGAGAACTTCTCTGGGTAGTGGATTTGGCTCTCCGTCAGTGACCGACCCCCGACCTCTGAACC
CCAGTGCATATTCCTCCACCACATTACCTGCTGCACGGGCAGCCTCTCCGTACTCACAGAGACCCGCCTCCCCAACAGCTATACGGCGGA
TTGGGTCAGTCACCTCCCGGCAGACCTCCAATCCCAACGGACCAACCCCTCAATACCAAACCACCGCCAGAGTGGGGTCCCCACTGACCC
TGACGGATGCACAGACTCGAGTAGCTTCCCCATCCCAAGGCCAGGTGGGGTCGTCGTCCCCCAAACGCTCAGGGATGACCGCCGTACCAC
AGCATCTGGGACCTTCACTGCAAAGGACTGTTCATGACATGGAGCAATTCGGACAGCAGCAGTATGACATTTATGAGAGGATGGTTCCAC
CCAGGCCAGACAGCCTGACAGGCTTACGGAGTTCCTATGCTAGTCAGCATAGTCAGCTTGGGCAAGACCTTCGTTCTGCCGTGTCTCCCG
ACTTGCACATTACTCCTATATATGAGGGGAGGACCTATTACAGCCCAGTGTACCGCAGCCCAAACCATGGAACTGTGGAGCTCCAAGGAT
CGCAGACGGCGTTGTATCGCACAGGTTCAGTAGGTATTGGAAATCTACAAAGGACATCCAGCCAACGAAGTACCCTTACATACCAAAGAA
ATAATTATGCTCTGAACACAACAGCTACCTACGCGGAGCCCTACAGGCCTATACAATACCGAGTGCAAGAGTGCAATTATAACAGGCTTC
AGCATGCAGTGCCGGCTGATGATGGCACCACAAGATCCCCATCAATAGACAGCATTCAGAAGGACCCCAGGGAGTTTGCCTGGCGTGATC
CTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTG
GTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGA
AGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTG
CCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTG
TAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATG
ATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTC
GGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGA
CGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAAT
TGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGC
AAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAA
AACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACT
GGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAG
TTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGG
TCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCA
AAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTC
TGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATC
AGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCAC
CCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGC
ATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAG
ATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACT
TTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGA
ACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATG
AATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTG
TTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGG
ATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGC
CCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACA
TTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAA
GGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACC
GCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCA
TCCTTGGAAATGTGTTCTCTATTCTTTTTAAATTTTCTGTATGTATATGGAAAAGCAGATTTAATAAACACAAATCTAACTGCATGTTGG
AAACAGCTTAAATATATCCAACTATTTTGGACTTTTCCTAGTTTTATATATACTTTGTGAGATGGACCACACCAAAGAATTAAGCTATGA
ACTTTCCTTCTCTGACAATCTAGGTATTTTTATTTCTTGGAATCTATTTCAAATCTAGTACCCTTCACAGTTTTATCATGTTTTTCTATA
TGGCAGCCCGGCCATAACTAAATTGATATAACTAAATTGATACCTTTTTTAGGCATCATTTTTAAGAACTCAGTAACTTCATAAGAACAG
TGGTTGGGCATTTATTTGGTTGGCACCAATATAATAAAACAAATTCTAAATTATGATCTTGTTGAGTAATTCCTGGATTAGGAATGGGGT
AGGGGAAAGAAGCCCCACAGTAGGGTAGGCAGAGGTCCCCATAGCACCACACAGCATTACTTGGGAGCTTTTCTCCATCTGTGGAGGCAA
TGAGGGACACCAGGCCCAAAGTCTGAGGCCTTCTCAGGTCTTGCAGTTTCCACCCTTCAGTCCTAGCTCCTGGATCTTTGTTGGTGTAAA
TATGGAAATGCCACATTGGTTAAGTGCCATCATGGAAAACTAGGAACTAGTTTACCTGTAGCTGTACTAGGAAAACTAGGAACTAACGCC
CATGGCAAGTCAAACCCAGAAGTGTTGTCTTAGCTCAATATACCCTGCAAGTGTAATACAAATCGCAGATTAAAACATTTGTACTTATAT
TTGTGAGTATATGGAAAGACACCCAAGAGAAAACTGCGTTTTCTTGCCGAATGGACAGCAGCCCAAGATGAGCATCCAAAGTGAAATGGA
AATACCAGTGCGAGCATGAAAGTTCCTAAGATCTGCAAGCCGGGAGCCCTTCTGGGGTGCCTTCTGAAGAACACTCGAGCCAGCTTGCGG
AGTCGACTGCCCAGCTACTGAGCCCTGGCTGCCTCATACCTGGCGGAGCTCAGCAGACAGCCCTTGTTAGATGGCAGAGGTCGCCAGATG
TTCCTGAGGAACTGGCATCAGGACTTCTGGGACGTAACCACTTCAGTTTCCAATCACTGACTTCCCTGAACCTGGTATCTTCAGATCTGG
GTTGAAGCTGAAGGCTCAGTTGGGGAATCAGGAAAACAAGGGAATCGGAGCCAGCCCAAGCCAACTGACAATAACTTTCTTTTAGTGACT
GCATTAGTTTGGGGTAATGCTGTAACAGGCAGCATTTCAAAAACGGATCCAAATTTGGGTTGAAAATAACTCACCTGGGTCTCCAATCAG
ACCTAACAGAGCCAGAAAGAGGCCTGTACACGGGGACTGGGCAGAAGATCTAATGCCGTTTAAGACTCCTCCCTTGAGACCAGAGAAAAG

>24548_24548_1_DVL3-PKP4_DVL3_chr3_183885479_ENST00000313143_PKP4_chr2_159389774_ENST00000389757_length(amino acids)=1529AA_BP=406
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAP
FCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLM
SSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNE
RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAA
WVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTEPSLMLSSGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCR
LGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEA
GSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSV
TDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKR
SGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNH
GTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDP
REFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAM
KNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNL
SSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKK
KKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVEL
LRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITK
GRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSGSSKPSPIYISSYSSPAR

--------------------------------------------------------------
>24548_24548_2_DVL3-PKP4_DVL3_chr3_183885479_ENST00000313143_PKP4_chr2_159389774_ENST00000389759_length(transcript)=5719nt_BP=1466nt
GCCGCGGCCACCGGAAGAGTCGCGGTCGCCAGTCCAGTCGGGAGAGTGGGGAGCGGAAGCGGCGGCCGCGGCGGCGGCGGGCGGCGCTGG
GACCCGGTAGCGGCCGGAGAACAAGGGAGCTGGCGCCGCCAGCAGCCGCCGAGCTGGGTTGAGCCGCTGGGCCGCGCCGCGCGCCGCCGC
CGTCTGGGAGGCTCGGCCCGGCCGCCCGAGCAGGCCGCGCGCGGGCCGCCGGGCCCGAGGCCAGAGCCATGGGCGAGACCAAGATCATCT
ACCACTTGGATGGGCAGGAGACGCCGTACCTTGTGAAGCTGCCCCTGCCCGCCGAGCGCGTCACCTTGGCGGACTTTAAGGGCGTTTTGC
AGCGACCCAGCTATAAGTTCTTCTTCAAGTCTATGGACGACGATTTCGGAGTGGTGAAGGAGGAGATCTCGGATGACAATGCCAAGCTAC
CATGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTGTCAGCTGAGGGCTCACACCCAGACCCAGCCCCCTTCTGTGCTGATAACCCATCGG
AGCTGCCACCACCTATGGAGCGCACGGGAGGCATCGGGGACTCCCGACCCCCATCCTTCCACCCTCATGCTGGTGGGGGCAGCCAGGAGA
ACCTGGACAATGACACAGAGACGGACTCTTTGGTGTCTGCCCAGCGAGAGCGGCCACGCCGGAGGGATGGCCCAGAGCATGCAACCCGGC
TAAATGGAACTGCGAAGGGGGAACGGCGGCGAGAACCAGGGGGTTATGATAGCTCATCCACCCTTATGAGCAGTGAGCTGGAGACCACCA
GCTTCTTTGACTCAGATGAGGATGACTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTGATGAGAAGACACA
AGCGGCGGCGGCGGAAGCAGAAGGTTTCTCGGATTGAGCGGTCCTCGTCCTTCAGCAGCATCACGGACTCCACCATGTCACTCAACATCA
TCACGGTCACTCTCAACATGGAAAAATATAACTTCTTGGGCATCTCCATTGTGGGCCAAAGCAACGAGCGTGGTGACGGCGGCATCTACA
TTGGCTCTATCATGAAGGGTGGGGCCGTGGCTGCTGATGGACGCATCGAGCCAGGAGATATGTTGTTACAGGTAAACGAGATCAACTTTG
AGAACATGAGTAATGACGATGCAGTCCGGGTACTGCGGGAGATTGTGCACAAACCGGGGCCCATCACCCTGACTGTAGCCAAGTGCTGGG
ACCCAAGTCCACGTGGTTGCTTCACATTGCCCAGGAGCGAGCCCATCCGGCCCATTGACCCTGCGGCCTGGGTCTCCCACACTGCAGCCA
TGACCGGCACCTTCCCTGCATACGGCATGAGCCCCTCCCTGAGCACCATCACCTCCACCAGCTCCTCCATCACCAGTTCCATCCCTGACA
CAGAGCCATCCCTAATGCTTTCATCGGGCATGGAACCCGAGACCACAGCCACCACTATTCTAGCATCCGTGAAGGAGCAGGAGCTTCAGT
TTCAGCGACTCACCCGAGAACTGGAAGTGGAAAGGCAGATTGTTGCCAGTCAGCTAGAAAGATGTAGGCTTGGAGCAGAATCACCAAGCA
TCGCCAGCACCAGCTCAACTGAGAAGTCATTTCCTTGGAGATCAACAGACGTGCCAAATACTGGTGTAAGCAAACCTAGAGTTTCTGACG
CTGTCCAGCCCAACAACTATCTCATCAGGACAGAGCCAGAACAAGGAACCCTCTATTCACCAGAACAGACATCTCTCCATGAAAGTGAGG
GATCATTGGGTAACTCAAGAAGTTCAACACAAATGAATTCTTATTCCGACAGTGGATACCAGGAAGCAGGGAGTTTCCACAACAGCCAGA
ACGTGAGCAAGGCAGACAACAGACAGCAGCATTCATTCATAGGATCAACTAACAACCATGTGGTGAGGAATTCAAGAGCTGAAGGACAAA
CACTGGTTCAGCCATCAGTAGCCAATCGGGCCATGAGAAGAGTTAGTTCAGTTCCATCTAGAGCACAGTCTCCTTCTTATGTTATCAGCA
CAGGCGTGTCTCCTTCAAGGGGGTCTCTGAGAACTTCTCTGGGTAGTGGATTTGGCTCTCCGTCAGTGACCGACCCCCGACCTCTGAACC
CCAGTGCATATTCCTCCACCACATTACCTGCTGCACGGGCAGCCTCTCCGTACTCACAGAGACCCGCCTCCCCAACAGCTATACGGCGGA
TTGGGTCAGTCACCTCCCGGCAGACCTCCAATCCCAACGGACCAACCCCTCAATACCAAACCACCGCCAGAGTGGGGTCCCCACTGACCC
TGACGGATGCACAGACTCGAGTAGCTTCCCCATCCCAAGGCCAGGTGGGGTCGTCGTCCCCCAAACGCTCAGGGATGACCGCCGTACCAC
AGCATCTGGGACCTTCACTGCAAAGGACTGTTCATGACATGGAGCAATTCGGACAGCAGCAGTATGACATTTATGAGAGGATGGTTCCAC
CCAGGCCAGACAGCCTGACAGGCTTACGGAGTTCCTATGCTAGTCAGCATAGTCAGCTTGGGCAAGACCTTCGTTCTGCCGTGTCTCCCG
ACTTGCACATTACTCCTATATATGAGGGGAGGACCTATTACAGCCCAGTGTACCGCAGCCCAAACCATGGAACTGTGGAGCTCCAAGGAT
CGCAGACGGCGTTGTATCGCACAGGTTCAGTAGGTATTGGAAATCTACAAAGGACATCCAGCCAACGAAGTACCCTTACATACCAAAGAA
ATAATTATGCTCTGAACACAACAGCTACCTACGCGGAGCCCTACAGGCCTATACAATACCGAGTGCAAGAGTGCAATTATAACAGGCTTC
AGCATGCAGTGCCGGCTGATGATGGCACCACAAGATCCCCATCAATAGACAGCATTCAGAAGGACCCCAGGGAGTTTGCCTGGCGTGATC
CTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTG
GTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGA
AGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTG
CCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTG
TAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATG
ATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTC
GGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGA
CGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAAT
TGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGC
AAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAA
AACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACT
GGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAG
TTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGG
TCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCA
AAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTC
TGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATC
AGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCAC
CCATCATTCAGTCAGTCGGCAGCACCTCTTCCTCACCAGCACTGTTAGGAATCAGAGACCCTCGCTCTGAATACGATAGGACCCAGCCAC
CTATGCAGTATTACAATAGCCAAGGGGATGCCACACATAAAGGCCTGTACCCTGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCT
ATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATG
CATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAA
CACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCC
CAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTG
ATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGG
AAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACG
TGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTT
ATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTT
GTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTT
GAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACA
CATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATT

>24548_24548_2_DVL3-PKP4_DVL3_chr3_183885479_ENST00000313143_PKP4_chr2_159389774_ENST00000389759_length(amino acids)=1572AA_BP=406
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAP
FCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLM
SSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNE
RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAA
WVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTEPSLMLSSGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCR
LGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEA
GSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSV
TDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKR
SGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNH
GTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDP
REFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAM
KNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNL
SSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKK
KKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVEL
LRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITK
GRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRS
EYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHF

--------------------------------------------------------------
>24548_24548_3_DVL3-PKP4_DVL3_chr3_183885479_ENST00000431765_PKP4_chr2_159389774_ENST00000389757_length(transcript)=6817nt_BP=1243nt
GCCGCCGCCGTCTGGGAGGCTCGGCCCGGCCGCCCGAGCAGGCCGCGCGCGGGCCGCCGGGCCCGAGGCCAGAGCCATGGGCGAGACCAA
GATCATCTACCACTTGGATGGGCAGGAGACGCCGTACCTTGTGAAGCTGCCCCTGCCCGCCGAGCGCGTCACCTTGGCGGACTTTAAGGG
CGTTTTGCAGCGACCCAGCTATAAGTTCTTCTTCAAGTCTATGGACGACGATTTCGGAGTGGTGAAGGAGGAGATCTCGGATGACAATGC
CAAGCTACCATGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTGTCAGCTGAGGGCTCACACCCAGACCCAGCCCCCTTCTGTGCTGATAA
CCCATCGGAGCTGCCACCACCTATGGAGCGCACGGGAGGCATCGGGGACTCCCGACCCCCATCCTTCCACCCTCATGCTGGTGGGGGCAG
CCAGGAGAACCTGGACAATGACACAGAGACGGACTCTTTGGTGTCTGCCCAGCGAGAGCGGCCACGCCGGAGGGATGGCCCAGAGCATGC
AACCCGGCTAAATGGAACTGCGAAGGGGGAACGGCGGCGAGAACCAGGGGGTTATGATAGCTCATCCACCCTTATGAGCAGTGAGCTGGA
GACCACCAGCTTCTTTGACTCAGATGAGGATGACTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTGATGAG
AAGACACAAGCGGCGGCGGCGGAAGCAGAAGGTTTCTCGGATTGAGCGGTCCTCGTCCTTCAGCAGCATCACGGACTCCACCATGTCACT
CAACATCATCACGGTCACTCTCAACATGGAAAAATATAACTTCTTGGGCATCTCCATTGTGGGCCAAAGCAACGAGCGTGGTGACGGCGG
CATCTACATTGGCTCTATCATGAAGGGTGGGGCCGTGGCTGCTGATGGACGCATCGAGCCAGGAGATATGTTGTTACAGGTAAACGAGAT
CAACTTTGAGAACATGAGTAATGACGATGCAGTCCGGGTACTGCGGGAGATTGTGCACAAACCGGGGCCCATCACCCTGACTGTAGCCAA
GTGCTGGGACCCAAGTCCACGTGGTTGCTTCACATTGCCCAGGACCATGACCGGCACCTTCCCTGCATACGGCATGAGCCCCTCCCTGAG
CACCATCACCTCCACCAGCTCCTCCATCACCAGTTCCATCCCTGACACAGAGCCATCCCTAATGCTTTCATCGGGCATGGAACCCGAGAC
CACAGCCACCACTATTCTAGCATCCGTGAAGGAGCAGGAGCTTCAGTTTCAGCGACTCACCCGAGAACTGGAAGTGGAAAGGCAGATTGT
TGCCAGTCAGCTAGAAAGATGTAGGCTTGGAGCAGAATCACCAAGCATCGCCAGCACCAGCTCAACTGAGAAGTCATTTCCTTGGAGATC
AACAGACGTGCCAAATACTGGTGTAAGCAAACCTAGAGTTTCTGACGCTGTCCAGCCCAACAACTATCTCATCAGGACAGAGCCAGAACA
AGGAACCCTCTATTCACCAGAACAGACATCTCTCCATGAAAGTGAGGGATCATTGGGTAACTCAAGAAGTTCAACACAAATGAATTCTTA
TTCCGACAGTGGATACCAGGAAGCAGGGAGTTTCCACAACAGCCAGAACGTGAGCAAGGCAGACAACAGACAGCAGCATTCATTCATAGG
ATCAACTAACAACCATGTGGTGAGGAATTCAAGAGCTGAAGGACAAACACTGGTTCAGCCATCAGTAGCCAATCGGGCCATGAGAAGAGT
TAGTTCAGTTCCATCTAGAGCACAGTCTCCTTCTTATGTTATCAGCACAGGCGTGTCTCCTTCAAGGGGGTCTCTGAGAACTTCTCTGGG
TAGTGGATTTGGCTCTCCGTCAGTGACCGACCCCCGACCTCTGAACCCCAGTGCATATTCCTCCACCACATTACCTGCTGCACGGGCAGC
CTCTCCGTACTCACAGAGACCCGCCTCCCCAACAGCTATACGGCGGATTGGGTCAGTCACCTCCCGGCAGACCTCCAATCCCAACGGACC
AACCCCTCAATACCAAACCACCGCCAGAGTGGGGTCCCCACTGACCCTGACGGATGCACAGACTCGAGTAGCTTCCCCATCCCAAGGCCA
GGTGGGGTCGTCGTCCCCCAAACGCTCAGGGATGACCGCCGTACCACAGCATCTGGGACCTTCACTGCAAAGGACTGTTCATGACATGGA
GCAATTCGGACAGCAGCAGTATGACATTTATGAGAGGATGGTTCCACCCAGGCCAGACAGCCTGACAGGCTTACGGAGTTCCTATGCTAG
TCAGCATAGTCAGCTTGGGCAAGACCTTCGTTCTGCCGTGTCTCCCGACTTGCACATTACTCCTATATATGAGGGGAGGACCTATTACAG
CCCAGTGTACCGCAGCCCAAACCATGGAACTGTGGAGCTCCAAGGATCGCAGACGGCGTTGTATCGCACAGGTTCAGTAGGTATTGGAAA
TCTACAAAGGACATCCAGCCAACGAAGTACCCTTACATACCAAAGAAATAATTATGCTCTGAACACAACAGCTACCTACGCGGAGCCCTA
CAGGCCTATACAATACCGAGTGCAAGAGTGCAATTATAACAGGCTTCAGCATGCAGTGCCGGCTGATGATGGCACCACAAGATCCCCATC
AATAGACAGCATTCAGAAGGACCCCAGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCC
ATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAAT
CAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTC
TACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAG
GGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAA
CACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAA
CACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTT
GTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCG
GCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGA
GCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTC
GAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCAC
CTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAA
GGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGA
TGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGA
TGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCAT
AGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATG
GCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCG
ATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACAT
CAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAA
CTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGA
TTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCC
AGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCA
TCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGG
AAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGT
GGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGA
ATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTAT
TATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAA
AGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCT
CCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCA
CTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCATCCTTGGAAATGTGTTCTCTATTCTTTTTAAATTTTCTGTATG
TATATGGAAAAGCAGATTTAATAAACACAAATCTAACTGCATGTTGGAAACAGCTTAAATATATCCAACTATTTTGGACTTTTCCTAGTT
TTATATATACTTTGTGAGATGGACCACACCAAAGAATTAAGCTATGAACTTTCCTTCTCTGACAATCTAGGTATTTTTATTTCTTGGAAT
CTATTTCAAATCTAGTACCCTTCACAGTTTTATCATGTTTTTCTATATGGCAGCCCGGCCATAACTAAATTGATATAACTAAATTGATAC
CTTTTTTAGGCATCATTTTTAAGAACTCAGTAACTTCATAAGAACAGTGGTTGGGCATTTATTTGGTTGGCACCAATATAATAAAACAAA
TTCTAAATTATGATCTTGTTGAGTAATTCCTGGATTAGGAATGGGGTAGGGGAAAGAAGCCCCACAGTAGGGTAGGCAGAGGTCCCCATA
GCACCACACAGCATTACTTGGGAGCTTTTCTCCATCTGTGGAGGCAATGAGGGACACCAGGCCCAAAGTCTGAGGCCTTCTCAGGTCTTG
CAGTTTCCACCCTTCAGTCCTAGCTCCTGGATCTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATGGAAAACTAG
GAACTAGTTTACCTGTAGCTGTACTAGGAAAACTAGGAACTAACGCCCATGGCAAGTCAAACCCAGAAGTGTTGTCTTAGCTCAATATAC
CCTGCAAGTGTAATACAAATCGCAGATTAAAACATTTGTACTTATATTTGTGAGTATATGGAAAGACACCCAAGAGAAAACTGCGTTTTC
TTGCCGAATGGACAGCAGCCCAAGATGAGCATCCAAAGTGAAATGGAAATACCAGTGCGAGCATGAAAGTTCCTAAGATCTGCAAGCCGG
GAGCCCTTCTGGGGTGCCTTCTGAAGAACACTCGAGCCAGCTTGCGGAGTCGACTGCCCAGCTACTGAGCCCTGGCTGCCTCATACCTGG
CGGAGCTCAGCAGACAGCCCTTGTTAGATGGCAGAGGTCGCCAGATGTTCCTGAGGAACTGGCATCAGGACTTCTGGGACGTAACCACTT
CAGTTTCCAATCACTGACTTCCCTGAACCTGGTATCTTCAGATCTGGGTTGAAGCTGAAGGCTCAGTTGGGGAATCAGGAAAACAAGGGA
ATCGGAGCCAGCCCAAGCCAACTGACAATAACTTTCTTTTAGTGACTGCATTAGTTTGGGGTAATGCTGTAACAGGCAGCATTTCAAAAA
CGGATCCAAATTTGGGTTGAAAATAACTCACCTGGGTCTCCAATCAGACCTAACAGAGCCAGAAAGAGGCCTGTACACGGGGACTGGGCA

>24548_24548_3_DVL3-PKP4_DVL3_chr3_183885479_ENST00000431765_PKP4_chr2_159389774_ENST00000389757_length(amino acids)=1512AA_BP=389
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAP
FCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLM
SSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNE
RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRTMTGTFPAYGM
SPSLSTITSTSSSITSSIPDTEPSLMLSSGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKS
FPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQ
HSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLP
AARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRT
VHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGS
VGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHML
QHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSI
DAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGL
VDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGP
IPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALR
NMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQV
LNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDD

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>24548_24548_4_DVL3-PKP4_DVL3_chr3_183885479_ENST00000431765_PKP4_chr2_159389774_ENST00000389759_length(transcript)=5496nt_BP=1243nt
GCCGCCGCCGTCTGGGAGGCTCGGCCCGGCCGCCCGAGCAGGCCGCGCGCGGGCCGCCGGGCCCGAGGCCAGAGCCATGGGCGAGACCAA
GATCATCTACCACTTGGATGGGCAGGAGACGCCGTACCTTGTGAAGCTGCCCCTGCCCGCCGAGCGCGTCACCTTGGCGGACTTTAAGGG
CGTTTTGCAGCGACCCAGCTATAAGTTCTTCTTCAAGTCTATGGACGACGATTTCGGAGTGGTGAAGGAGGAGATCTCGGATGACAATGC
CAAGCTACCATGCTTCAATGGCCGGGTGGTGTCCTGGCTGGTGTCAGCTGAGGGCTCACACCCAGACCCAGCCCCCTTCTGTGCTGATAA
CCCATCGGAGCTGCCACCACCTATGGAGCGCACGGGAGGCATCGGGGACTCCCGACCCCCATCCTTCCACCCTCATGCTGGTGGGGGCAG
CCAGGAGAACCTGGACAATGACACAGAGACGGACTCTTTGGTGTCTGCCCAGCGAGAGCGGCCACGCCGGAGGGATGGCCCAGAGCATGC
AACCCGGCTAAATGGAACTGCGAAGGGGGAACGGCGGCGAGAACCAGGGGGTTATGATAGCTCATCCACCCTTATGAGCAGTGAGCTGGA
GACCACCAGCTTCTTTGACTCAGATGAGGATGACTCCACCAGCAGGTTCAGCAGCTCCACAGAACAGAGCAGTGCCTCACGCCTGATGAG
AAGACACAAGCGGCGGCGGCGGAAGCAGAAGGTTTCTCGGATTGAGCGGTCCTCGTCCTTCAGCAGCATCACGGACTCCACCATGTCACT
CAACATCATCACGGTCACTCTCAACATGGAAAAATATAACTTCTTGGGCATCTCCATTGTGGGCCAAAGCAACGAGCGTGGTGACGGCGG
CATCTACATTGGCTCTATCATGAAGGGTGGGGCCGTGGCTGCTGATGGACGCATCGAGCCAGGAGATATGTTGTTACAGGTAAACGAGAT
CAACTTTGAGAACATGAGTAATGACGATGCAGTCCGGGTACTGCGGGAGATTGTGCACAAACCGGGGCCCATCACCCTGACTGTAGCCAA
GTGCTGGGACCCAAGTCCACGTGGTTGCTTCACATTGCCCAGGACCATGACCGGCACCTTCCCTGCATACGGCATGAGCCCCTCCCTGAG
CACCATCACCTCCACCAGCTCCTCCATCACCAGTTCCATCCCTGACACAGAGCCATCCCTAATGCTTTCATCGGGCATGGAACCCGAGAC
CACAGCCACCACTATTCTAGCATCCGTGAAGGAGCAGGAGCTTCAGTTTCAGCGACTCACCCGAGAACTGGAAGTGGAAAGGCAGATTGT
TGCCAGTCAGCTAGAAAGATGTAGGCTTGGAGCAGAATCACCAAGCATCGCCAGCACCAGCTCAACTGAGAAGTCATTTCCTTGGAGATC
AACAGACGTGCCAAATACTGGTGTAAGCAAACCTAGAGTTTCTGACGCTGTCCAGCCCAACAACTATCTCATCAGGACAGAGCCAGAACA
AGGAACCCTCTATTCACCAGAACAGACATCTCTCCATGAAAGTGAGGGATCATTGGGTAACTCAAGAAGTTCAACACAAATGAATTCTTA
TTCCGACAGTGGATACCAGGAAGCAGGGAGTTTCCACAACAGCCAGAACGTGAGCAAGGCAGACAACAGACAGCAGCATTCATTCATAGG
ATCAACTAACAACCATGTGGTGAGGAATTCAAGAGCTGAAGGACAAACACTGGTTCAGCCATCAGTAGCCAATCGGGCCATGAGAAGAGT
TAGTTCAGTTCCATCTAGAGCACAGTCTCCTTCTTATGTTATCAGCACAGGCGTGTCTCCTTCAAGGGGGTCTCTGAGAACTTCTCTGGG
TAGTGGATTTGGCTCTCCGTCAGTGACCGACCCCCGACCTCTGAACCCCAGTGCATATTCCTCCACCACATTACCTGCTGCACGGGCAGC
CTCTCCGTACTCACAGAGACCCGCCTCCCCAACAGCTATACGGCGGATTGGGTCAGTCACCTCCCGGCAGACCTCCAATCCCAACGGACC
AACCCCTCAATACCAAACCACCGCCAGAGTGGGGTCCCCACTGACCCTGACGGATGCACAGACTCGAGTAGCTTCCCCATCCCAAGGCCA
GGTGGGGTCGTCGTCCCCCAAACGCTCAGGGATGACCGCCGTACCACAGCATCTGGGACCTTCACTGCAAAGGACTGTTCATGACATGGA
GCAATTCGGACAGCAGCAGTATGACATTTATGAGAGGATGGTTCCACCCAGGCCAGACAGCCTGACAGGCTTACGGAGTTCCTATGCTAG
TCAGCATAGTCAGCTTGGGCAAGACCTTCGTTCTGCCGTGTCTCCCGACTTGCACATTACTCCTATATATGAGGGGAGGACCTATTACAG
CCCAGTGTACCGCAGCCCAAACCATGGAACTGTGGAGCTCCAAGGATCGCAGACGGCGTTGTATCGCACAGGTTCAGTAGGTATTGGAAA
TCTACAAAGGACATCCAGCCAACGAAGTACCCTTACATACCAAAGAAATAATTATGCTCTGAACACAACAGCTACCTACGCGGAGCCCTA
CAGGCCTATACAATACCGAGTGCAAGAGTGCAATTATAACAGGCTTCAGCATGCAGTGCCGGCTGATGATGGCACCACAAGATCCCCATC
AATAGACAGCATTCAGAAGGACCCCAGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCC
ATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAAT
CAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTC
TACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAG
GGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAA
CACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAA
CACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTT
GTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCG
GCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGA
GCCAAGTTGCTGGGGGAAGAAGAAGAAAAAGAAAAAGAGGACTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTC
GAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCAC
CTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAA
GGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGA
TGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGA
TGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCAT
AGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATG
GCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCG
ATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGTCGGCAGCACCTCTTCCTCACCAGCACT
GTTAGGAATCAGAGACCCTCGCTCTGAATACGATAGGACCCAGCCACCTATGCAGTATTACAATAGCCAAGGGGATGCCACACATAAAGG
CCTGTACCCTGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCA
ACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCC
TTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTA
TTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTC
TTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATG
AAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAG
ATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATAT
GTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCAT
GTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGG
TTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAA
CTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAG
CGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCATCCT

>24548_24548_4_DVL3-PKP4_DVL3_chr3_183885479_ENST00000431765_PKP4_chr2_159389774_ENST00000389759_length(amino acids)=1555AA_BP=389
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAP
FCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLM
SSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNE
RGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRTMTGTFPAYGM
SPSLSTITSTSSSITSSIPDTEPSLMLSSGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKS
FPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQ
HSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLP
AARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRT
VHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGS
VGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHML
QHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSI
DAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGL
VDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGP
IPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALR
NMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQV
LNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGD
ATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTN

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Fusion Gene PPI Analysis for DVL3-PKP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DVL3-PKP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DVL3-PKP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource