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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DXO-CLK2 (FusionGDB2 ID:24555)

Fusion Gene Summary for DXO-CLK2

Fusion gene summary

Fusion gene information	Fusion gene name: DXO-CLK2
	Fusion gene ID: 24555
		Hgene	Tgene
	Gene symbol	DXO	CLK2
	Gene ID	1797	9894
	Gene name	decapping exoribonuclease	telomere maintenance 2
	Synonyms	DOM3L\|DOM3Z\|NG6\|RAI1	CLK2\|TEL2\|YHFS
	Cytomap	6p21.33	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	decapping and exoribonuclease proteinprotein Dom3Z	telomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog
	Modification date	20200320	20200313
	UniProtAcc	O77932	P49760
	Ensembl transtripts involved in fusion gene	ENST00000337523, ENST00000375349, ENST00000375356, ENST00000383330, ENST00000399936, ENST00000399937, ENST00000414092, ENST00000419797, ENST00000426498, ENST00000427627, ENST00000427690, ENST00000432110, ENST00000439989, ENST00000443250, ENST00000446967, ENST00000453742, ENST00000454430, ENST00000458308, ENST00000463957, ENST00000468514, ENST00000478221, ENST00000488461, ENST00000496506, ENST00000497174,	ENST00000355560, ENST00000368361, ENST00000361168, ENST00000497188, ENST00000536801,
Fusion gene scores	* DoF score	2 X 2 X 1=4	3 X 3 X 3=27
	# samples	2	3
	** MAII score	log2(2/4*10)=2.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DXO [Title/Abstract] AND CLK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DXO(31939908)-CLK2(155243211), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DXO	GO:0006402	mRNA catabolic process	29601584

Fusion gene breakpoints across DXO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BJ992471	DXO	chr6	31939908	-	CLK2	chr1	155243211	-

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Fusion Gene ORF analysis for DXO-CLK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000337523	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000337523	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000375349	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000375349	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000375356	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000375356	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000383330	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000383330	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000399936	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000399936	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000399937	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000399937	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000414092	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000414092	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000419797	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000419797	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000426498	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000426498	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000427627	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000427627	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000427690	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000427690	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000432110	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000432110	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000439989	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000439989	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000443250	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000443250	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000446967	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000446967	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000453742	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000453742	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000454430	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000454430	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000458308	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000458308	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000463957	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000463957	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000468514	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000468514	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000478221	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000478221	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000488461	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000488461	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000496506	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000496506	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000497174	ENST00000355560	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-5UTR	ENST00000497174	ENST00000368361	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000337523	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000337523	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000337523	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375349	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375349	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375349	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375356	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375356	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000375356	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000383330	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000383330	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000383330	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399936	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399936	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399936	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399937	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399937	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000399937	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000414092	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000414092	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000414092	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000419797	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000419797	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000419797	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000426498	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000426498	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000426498	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427627	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427627	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427627	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427690	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427690	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000427690	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000432110	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000432110	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000432110	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000439989	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000439989	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000439989	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000443250	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000443250	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000443250	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000446967	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000446967	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000446967	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000453742	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000453742	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000453742	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000454430	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000454430	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000454430	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000458308	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000458308	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000458308	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000463957	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000463957	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000463957	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000468514	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000468514	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000468514	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000478221	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000478221	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000478221	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000488461	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000488461	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000488461	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000496506	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000496506	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000496506	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000497174	ENST00000361168	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000497174	ENST00000497188	DXO	chr6	31939908	-	CLK2	chr1	155243211	-
intron-intron	ENST00000497174	ENST00000536801	DXO	chr6	31939908	-	CLK2	chr1	155243211	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for DXO-CLK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DXO-CLK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31939908/:155243211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DXO O77932	CLK2 P49760
FUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058). In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058). Preferentially acts on NAD-capped transcripts in response to environmental stress (PubMed:31101919). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity). Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:29601584). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:29601584). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). {ECO:0000250\|UniProtKB:O70348, ECO:0000269\|PubMed:28283058, ECO:0000269\|PubMed:29601584, ECO:0000269\|PubMed:31101919}.	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269\|PubMed:10480872, ECO:0000269\|PubMed:19168442, ECO:0000269\|PubMed:28289210, ECO:0000269\|PubMed:8910305, ECO:0000269\|PubMed:9637771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

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Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

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Fusion Gene Sequence for DXO-CLK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DXO-CLK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

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Still interaction with

- Lost PPIs in in-frame fusion.

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Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

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Interaction lost with

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Related Drugs for DXO-CLK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

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Related Diseases for DXO-CLK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

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Disease ID

Disease name

# pubmeds

Source