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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYNC1H1-EIF5 (FusionGDB2 ID:24591)

Fusion Gene Summary for DYNC1H1-EIF5

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC1H1-EIF5
Fusion gene ID: 24591
HgeneTgene
Gene symbol

DYNC1H1

EIF5

Gene ID

1778

1983

Gene namedynein cytoplasmic 1 heavy chain 1eukaryotic translation initiation factor 5
SynonymsCMT2O|DHC1|DHC1a|DNCH1|DNCL|DNECL|DYHC|Dnchc1|HL-3|SMALED1|p22EIF-5|EIF-5A
Cytomap

14q32.31

14q32.32

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 1 heavy chain 1dynein heavy chain, cytosolicdynein, cytoplasmic, heavy polypeptide 1eukaryotic translation initiation factor 5
Modification date2020032820200313
UniProtAcc

Q14204

O60841

Ensembl transtripts involved in fusion geneENST00000360184, ENST00000556791, 
ENST00000392715, ENST00000560200, 
ENST00000216554, ENST00000558506, 
Fusion gene scores* DoF score21 X 17 X 10=357011 X 10 X 6=660
# samples 2413
** MAII scorelog2(24/3570*10)=-3.89481776330794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNC1H1 [Title/Abstract] AND EIF5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNC1H1(102517128)-EIF5(103805509), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF5

GO:0006446

regulation of translational initiation

22156057


check buttonFusion gene breakpoints across DYNC1H1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8629-01ADYNC1H1chr14

102517128

-EIF5chr14

103805509

+


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Fusion Gene ORF analysis for DYNC1H1-EIF5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360184ENST00000392715DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
5CDS-intronENST00000360184ENST00000560200DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
In-frameENST00000360184ENST00000216554DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
In-frameENST00000360184ENST00000558506DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
intron-3CDSENST00000556791ENST00000216554DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
intron-3CDSENST00000556791ENST00000558506DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
intron-intronENST00000556791ENST00000392715DYNC1H1chr14

102517128

-EIF5chr14

103805509

+
intron-intronENST00000556791ENST00000560200DYNC1H1chr14

102517128

-EIF5chr14

103805509

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360184DYNC1H1chr14102517128-ENST00000216554EIF5chr14103805509+1885814333140141044654
ENST00000360184DYNC1H1chr14102517128-ENST00000558506EIF5chr14103805509+1706114333140141044654

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360184ENST00000216554DYNC1H1chr14102517128-EIF5chr14103805509+0.0006035280.99939644
ENST00000360184ENST00000558506DYNC1H1chr14102517128-EIF5chr14103805509+0.000812650.9991873

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Fusion Genomic Features for DYNC1H1-EIF5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYNC1H1-EIF5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102517128/chr14:103805509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNC1H1

Q14204

EIF5

O60841

FUNCTION: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.FUNCTION: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. {ECO:0000250|UniProtKB:P39730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78781171_125247234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78781357_137347234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-7878181_20247234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78783189_327547234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78783396_350047234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78783737_380047234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-7878455_47847234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-7878543_56647234647.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78781906_191347234647.0Nucleotide bindingATP
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782224_223147234647.0Nucleotide bindingATP
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782595_260247234647.0Nucleotide bindingATP
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782937_294447234647.0Nucleotide bindingATP
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78781868_209947234647.0RegionAAA 1
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782180_245247234647.0RegionAAA 2
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782556_280547234647.0RegionAAA 3
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78782899_316847234647.0RegionAAA 4
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78783189_350047234647.0RegionStalk
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78783553_378247234647.0RegionAAA 5
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-78784005_422147234647.0RegionAAA 6
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-787853_186747234647.0RegionStem
TgeneEIF5chr14:102517128chr14:103805509ENST00000216554712384_402248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000216554712423_429248432.0Compositional biasNote=Asp-rich (acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000392715611384_402248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000392715611423_429248432.0Compositional biasNote=Asp-rich (acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000558506510384_402248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000558506510423_429248432.0Compositional biasNote=Asp-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF5chr14:102517128chr14:103805509ENST00000216554712196_202248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000392715611196_202248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000558506510196_202248432.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF5chr14:102517128chr14:103805509ENST00000216554712233_392248432.0DomainW2
TgeneEIF5chr14:102517128chr14:103805509ENST00000392715611233_392248432.0DomainW2
TgeneEIF5chr14:102517128chr14:103805509ENST00000558506510233_392248432.0DomainW2
TgeneEIF5chr14:102517128chr14:103805509ENST0000021655471227_34248432.0Nucleotide bindingGTP
TgeneEIF5chr14:102517128chr14:103805509ENST0000039271561127_34248432.0Nucleotide bindingGTP
TgeneEIF5chr14:102517128chr14:103805509ENST0000055850651027_34248432.0Nucleotide bindingGTP


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Fusion Gene Sequence for DYNC1H1-EIF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24591_24591_1_DYNC1H1-EIF5_DYNC1H1_chr14_102517128_ENST00000360184_EIF5_chr14_103805509_ENST00000216554_length(transcript)=18858nt_BP=14333nt
CTGGCAGTGGCTGCCTTTAGGGCGGAGCCGGCTCCCGCTCTCCTCAGTCTGCGGTGGGCTAGCGGACGGTCCGGCTTCCGGCGGCCGTTT
CTGTCTCTTGCTGGCTGTCTCGCTGAGTCGCGGCCGCCTTCTCATCGCTCCTGGAAGGTCCCGAGCGCGACACCATGTCGGAGCCCGGGG
GCGGCGGCGGCGAGGACGGCTCGGCCGGATTGGAAGTGTCGGCCGTGCAGAATGTGGCGGACGTGTCGGTGCTGCAGAAGCACCTGCGCA
AGCTGGTGCCGCTGCTGCTGGAGGACGGCGGCGAGGCGCCGGCCGCGCTGGAGGCGGCGCTGGAGGAGAAGAGCGCCCTGGAGCAGATGC
GCAAGTTCCTTTCGGACCCGCAGGTCCACACGGTGCTGGTGGAGCGCTCCACGCTCAAAGAGGACGTCGGTGATGAAGGAGAAGAAGAAA
AAGAATTCATTTCCTATAACATCAACATAGACATTCATTATGGGGTTAAATCCAATAGCTTGGCATTCATTAAACGTACTCCCGTGATTG
ATGCAGATAAACCCGTGTCTTCTCAGCTCCGGGTCCTTACACTCAGTGAAGACTCGCCCTACGAAACTTTGCATTCTTTCATTAGCAATG
CAGTGGCTCCTTTTTTTAAGTCCTACATTAGAGAGTCTGGCAAGGCAGACAGGGATGGTGATAAAATGGCTCCTTCAGTTGAAAAGAAGA
TTGCAGAACTCGAAATGGGACTCCTTCACTTGCAGCAAAATATTGAAATTCCGGAGATCAGCCTGCCGATTCATCCAATGATCACAAATG
TTGCAAAACAGTGTTATGAGCGTGGAGAAAAGCCAAAAGTTACAGACTTTGGTGATAAGGTTGAAGACCCAACATTTCTTAATCAGTTAC
AATCTGGAGTTAACCGCTGGATCCGAGAAATTCAAAAAGTGACCAAACTGGATCGAGATCCTGCATCAGGAACTGCCTTACAGGAAATTA
GTTTTTGGCTAAACTTGGAACGTGCGTTATACCGCATCCAGGAGAAACGGGAGAGCCCGGAAGTTCTCCTGACTCTGGATATCTTGAAAC
ATGGCAAGCGCTTCCATGCCACCGTCAGTTTTGACACTGACACAGGTCTAAAACAGGCTTTGGAAACTGTGAATGACTACAATCCTCTGA
TGAAAGATTTCCCTCTGAATGATTTGCTGTCTGCCACGGAGCTGGACAAAATAAGACAGGCGCTTGTTGCCATTTTCACACATTTGAGAA
AGATCCGAAACACAAAATATCCTATTCAGAGGGCACTGCGTTTGGTGGAGGCAATTTCAAGAGACTTGAGTTCTCAATTACTCAAAGTAT
TGGGCACTAGGAAATTGATGCATGTTGCTTATGAAGAATTTGAAAAAGTTATGGTAGCATGCTTTGAAGTTTTTCAGACTTGGGATGATG
AGTATGAGAAACTTCAGGTATTGTTGAGAGACATCGTCAAAAGAAAAAGGGAAGAAAATCTGAAGATGGTGTGGCGTATCAACCCTGCCC
ACAGGAAGCTGCAGGCCCGCCTTGACCAGATGAGAAAATTTAGACGCCAGCATGAACAGCTAAGAGCTGTTATCGTCAGGGTCCTGAGGC
CACAGGTCACGGCAGTTGCACAACAGAATCAAGGAGAGGTCCCTGAACCCCAAGATATGAAAGTGGCTGAGGTTCTCTTTGATGCTGCAG
ATGCAAATGCCATTGAGGAAGTAAACCTTGCTTATGAGAACGTCAAGGAAGTGGATGGACTGGATGTTTCCAAAGAGGGCACGGAAGCCT
GGGAGGCTGCTATGAAGAGGTACGATGAGAGGATCGACAGAGTGGAGACCCGGATCACCGCTCGCCTTCGGGATCAGCTTGGCACAGCCA
AGAATGCCAACGAGATGTTTAGGATTTTCTCCAGGTTTAATGCACTGTTTGTCAGGCCTCACATCCGTGGGGCCATTCGCGAATACCAGA
CCCAGCTGATCCAGCGCGTGAAAGATGACATTGAGTCTCTTCACGACAAGTTCAAGGTCCAGTACCCACAGAGTCAGGCTTGTAAGATGA
GTCACGTTCGTGACTTGCCCCCTGTGTCAGGGTCTATCATCTGGGCTAAACAGATCGACAGGCAGCTGACGGCCTACATGAAGCGGGTGG
AAGATGTCCTTGGCAAGGGCTGGGAGAATCACGTGGAGGGGCAGAAGCTGAAGCAGGATGGAGACAGCTTCCGCATGAAGCTCAACACGC
AGGAGATCTTTGATGACTGGGCAAGGAAGGTGCAGCAGCGCAACCTCGGTGTCTCGGGGCGCATTTTCACCATCGAAAGTACTCGGGTTC
GGGGCCGAACTGGAAATGTGCTTAAGCTGAAAGTTAACTTTCTTCCTGAGATTATCACACTATCCAAAGAAGTCCGGAACCTCAAATGGC
TTGGTTTCCGCGTCCCACTGGCGATTGTGAACAAAGCCCATCAAGCAAACCAGCTTTACCCGTTTGCCATCTCACTGATCGAGAGCGTTC
GTACCTATGAACGGACCTGCGAGAAGGTGGAGGAGCGGAACACCATTTCCCTTTTGGTGGCTGGCTTGAAAAAGGAAGTGCAGGCCCTGA
TCGCAGAAGGCATTGCGTTGGTGTGGGAGTCCTACAAACTTGACCCATATGTACAGCGCTTAGCAGAGACTGTCTTCAACTTCCAAGAAA
AGGTGGATGATCTGCTGATCATTGAAGAAAAAATAGACCTAGAAGTCCGTTCCTTGGAAACTTGTATGTATGACCATAAGACATTCTCGG
AAATCTTGAACAGAGTCCAGAAAGCAGTGGATGACTTAAATCTGCACTCCTATTCCAATTTGCCCATCTGGGTCAACAAGCTTGACATGG
AGATTGAAAGAATATTGGGCGTCCGTCTGCAAGCTGGCCTGAGAGCTTGGACGCAGGTTCTTCTTGGACAAGCTGAAGATAAAGCAGAAG
TTGACATGGACACAGATGCTCCACAAGTTAGTCACAAGCCTGGTGGAGAGCCAAAGATCAAAAATGTCGTTCATGAGCTAAGAATAACCA
ATCAGGTAATCTACTTGAATCCACCAATTGAAGAGTGCAGATACAAGCTGTATCAGGAAATGTTTGCCTGGAAGATGGTTGTACTGTCTC
TCCCCAGGATCCAGAGTCAGAGGTACCAGGTGGGTGTACATTACGAATTGACTGAGGAAGAGAAATTCTATCGGAATGCTTTAACACGGA
TGCCTGATGGCCCTGTTGCCCTGGAAGAGTCGTATTCTGCTGTCATGGGCATTGTATCTGAAGTTGAACAGTATGTCAAGGTTTGGCTTC
AGTATCAGTGTTTATGGGATATGCAAGCTGAAAACATCTATAACAGACTTGGAGAAGATCTCAACAAATGGCAGGCTCTCCTGGTCCAAA
TAAGGAAGGCCAGAGGAACCTTTGACAATGCAGAAACCAAGAAAGAGTTTGGACCAGTAGTTATAGATTATGGCAAGGTACAATCTAAGG
TGAACTTGAAATATGACTCTTGGCATAAGGAGGTTCTTAGCAAATTTGGGCAGATGCTAGGATCAAACATGACGGAATTCCATTCCCAGA
TCTCAAAGTCCCGCCAAGAGTTGGAGCAGCACTCAGTAGACACGGCCAGCACCTCCGATGCAGTGACCTTCATCACCTATGTGCAGTCTT
TGAAACGGAAGATCAAGCAGTTTGAGAAGCAAGTTGAGCTCTACCGCAATGGCCAGCGCTTACTGGAAAAGCAAAGGTTCCAGTTCCCAC
CTTCCTGGCTTTATATTGACAACATCGAGGGAGAGTGGGGAGCCTTCAATGACATCATGCGGCGAAAGGACTCTGCCATTCAGCAGCAGG
TGGCAAACCTGCAAATGAAGATTGTCCAGGAGGATCGGGCCGTGGAAAGCCGCACCACCGACCTGCTGACTGACTGGGAGAAGACCAAGC
CTGTCACGGGCAACCTTCGCCCAGAAGAGGCACTTCAGGCTCTCACCATATATGAGGGGAAGTTTGGTAGGCTGAAGGACGACAGAGAGA
AGTGTGCAAAGGCCAAGGAGGCGCTGGAATTGACAGATACTGGGCTTCTCAGTGGCAGTGAAGAGCGCGTGCAGGTGGCCTTAGAAGAAT
TACAGGACCTCAAAGGCGTTTGGTCAGAACTTTCTAAGGTTTGGGAGCAAATCGATCAGATGAAGGAGCAACCCTGGGTTTCAGTACAGC
CTCGAAAGCTTCGACAAAATTTGGATGCCCTCCTGAACCAGCTGAAAAGCTTCCCTGCCCGGTTGCGACAGTATGCGTCCTATGAGTTTG
TTCAGAGGCTTCTGAAAGGTTACATGAAGATAAATATGCTGGTGATTGAACTGAAATCCGAAGCACTTAAAGACCGCCATTGGAAACAGC
TCATGAAAAGGCTTCACGTTAATTGGGTTGTTTCTGAGCTAACCCTTGGCCAAATCTGGGATGTTGACTTGCAGAAAAATGAAGCGATTG
TCAAGGATGTACTGCTTGTGGCACAAGGGGAGATGGCTTTGGAAGAATTTTTGAAGCAGATAAGAGAAGTGTGGAATACTTATGAACTAG
ACTTGGTTAATTATCAGAACAAGTGCCGCTTGATCCGTGGCTGGGATGACCTCTTCAACAAGGTCAAAGAACACATCAACAGCGTCTCGG
CCATGAAGCTCTCTCCGTATTACAAGGTTTTTGAAGAGGATGCTCTCAGCTGGGAAGATAAGCTGAACAGGATCATGGCTCTCTTTGATG
TGTGGATTGATGTGCAGAGGCGGTGGGTCTACCTGGAAGGTATCTTCACAGGCAGTGCAGATATCAAGCACCTGCTGCCAGTGGAAACCC
AGCGGTTTCAGAGCATCAGCACTGAGTTTTTGGCTCTAATGAAAAAAGTGTCCAAGTCTCCCCTTGTTATGGATGTTCTGAACATCCAGG
GAGTACAGAGGTCTCTGGAAAGATTGGCAGACCTGCTAGGAAAGATCCAGAAAGCATTGGGAGAATATCTGGAAAGAGAGCGGTCATCTT
TCCCCAGGTTCTATTTTGTGGGTGATGAAGATTTGCTTGAAATCATTGGAAACAGCAAGAATGTCGCTAAATTACAGAAACACTTCAAGA
AGATGTTTGCTGGAGTTTCGAGCATCATCCTGAACGAGGATAACTCTGTTGTTTTGGGTATTTCATCTCGGGAAGGAGAGGAGGTTATGT
TTAAAACTCCTGTGTCAATTACTGAACATCCCAAAATCAATGAGTGGCTCACATTGGTAGAAAAGGAGATGAGAGTCACCCTGGCCAAAC
TGCTTGCTGAGTCTGTTACGGAAGTTGAGATTTTTGGTAAAGCAACTTCAATTGACCCAAATACCTACATCACTTGGATTGATAAATACC
AGGCCCAGCTTGTGGTTTTGTCAGCCCAGATAGCCTGGTCTGAGAACGTGGAGACCGCACTGAGCAGCATGGGCGGAGGTGGAGATGCCG
CGCCCTTGCACTCTGTGCTGAGCAATGTGGAGGTCACCCTCAATGTGTTAGCAGACTCTGTCCTCATGGAGCAGCCCCCACTCCGAAGGC
GGAAGCTAGAACACTTGATTACAGAGTTGGTTCACCAGAGAGATGTTACAAGGTCCTTGATCAAAAGCAAGATTGACAACGCCAAATCTT
TTGAATGGCTCAGCCAGATGCGATTTTACTTTGACCCTAAGCAAACTGATGTGTTACAGCAGTTGTCAATTCAAATGGCAAATGCCAAAT
TTAACTATGGCTTTGAGTACCTGGGTGTTCAGGACAAACTGGTCCAGACCCCCCTCACTGACCGCTGCTATTTGACAATGACACAAGCCT
TGGAGGCCAGGCTGGGGGGTTCCCCATTTGGACCTGCTGGAACTGGGAAAACAGAGTCTGTCAAAGCTCTTGGCCATCAGCTTGGACGGT
TTGTTTTAGTTTTCAACTGTGATGAAACCTTTGATTTCCAGGCAATGGGCCGGATCTTTGTGGGCCTTTGCCAGGTGGGTGCCTGGGGCT
GCTTTGACGAGTTCAACCGCCTGGAGGAGCGGATGCTCTCGGCTGTGTCCCAGCAGGTGCAGTGCATACAGGAAGCACTGCGTGAACATT
CCAACCCCAACTACGACAAGACCTCTGCCCCCATTACTTGTGAGCTGCTGAACAAACAAGTCAAGGTGAGCCCGGACATGGCCATCTTCA
TCACCATGAACCCTGGCTACGCGGGCCGGTCTAACCTTCCTGACAACTTGAAGAAGCTGTTCCGGAGCTTGGCCATGACCAAGCCCGACC
GGCAGTTAATCGCCCAGGTCATGCTGTACTCACAGGGTTTCCGCACTGCTGAAGTGCTTGCCAACAAAATCGTCCCGTTTTTTAAACTAT
GCGATGAGCAGCTCTCTTCCCAAAGCCATTATGACTTCGGTCTTCGGGCTTTGAAGAGTGTGCTGGTGAGTGCAGGCAATGTGAAGAGAG
AGAGAATCCAGAAGATAAAGAGGGAGAAAGAGGAACGAGGGGAAGCAGTTGATGAAGGAGAAATTGCTGAAAATCTCCCTGAACAAGAGA
TTCTGATACAGAGCGTCTGTGAGACGATGGTGCCAAAGCTGGTGGCAGAGGACATCCCGCTGCTCTTCAGCCTCCTGTCGGACGTGTTCC
CTGGAGTCCAGTATCACAGGGGTGAGATGACTGCCCTTCGAGAGGAGCTGAAGAAAGTGTGTCAGGAGATGTATTTGACATATGGAGATG
GAGAAGAAGTTGGTGGAATGTGGGTTGAAAAGGTTCTCCAGCTCTATCAGATCACCCAGATCAATCATGGCCTGATGATGGTGGGGCCCT
CGGGAAGTGGGAAGAGCATGGCCTGGCGTGTCCTGCTGAAGGCATTGGAGAGACTCGAGGGTGTGGAAGGTGTGGCCCATATCATCGACC
CCAAGGCCATCAGCAAAGACCACCTCTACGGAACCCTGGACCCCAACACCAGGGAATGGACAGATGGGCTCTTCACACACGTGCTGAGAA
AGATCATCGACAGCGTGAGAGGCGAGCTGCAGAAGCGCCAGTGGATCGTCTTCGATGGCGATGTGGATCCAGAGTGGGTTGAGAACTTGA
ACTCAGTGCTGGATGACAATAAGCTCCTAACTTTGCCCAATGGAGAGCGCCTCAGTCTTCCACCCAATGTGAGAATAATGTTTGAGGTAC
AGGACTTGAAATACGCGACCTTGGCCACAGTGTCGCGCTGCGGCATGGTCTGGTTCAGTGAGGATGTGCTGAGCACCGACATGATCTTCA
ACAACTTCCTGGCCAGGCTGCGCAGCATCCCGCTGGATGAAGGGGAGGATGAGGCACAGCGGCGGCGTAAGGGCAAAGAGGATGAGGGGG
AGGAGGCCGCTTCCCCCATGCTGCAGATCCAAAGAGATGCAGCTACGATCATGCAACCGTACTTCACGTCCAACGGCCTGGTCACCAAGG
CGCTAGAGCACGCCTTCCAGCTGGAGCACATCATGGACCTAACACGCCTGCGCTGCCTGGGCTCGCTCTTCTCCATGCTGCACCAGGCCT
GCCGCAACGTGGCGCAGTATAACGCCAACCATCCCGACTTCCCCATGCAGATCGAGCAGCTGGAGCGCTACATTCAGCGATATCTGGTTT
ATGCCATACTCTGGTCCCTGTCTGGAGACAGCCGGCTAAAAATGAGAGCAGAGCTGGGTGAATACATCAGAAGAATCACGACCGTGCCTC
TGCCCACTGCGCCCAACATACCCATTATCGATTATGAGGTGTCCATCAGCGGAGAATGGTCTCCGTGGCAGGCCAAGGTGCCTCAGATTG
AAGTGGAGACGCACAAGGTGGCAGCCCCTGATGTCGTCGTGCCAACGCTGGACACAGTCCGCCACGAAGCCCTCTTGTACACTTGGCTGG
CCGAACACAAGCCCCTGGTCTTGTGTGGCCCTCCTGGGTCTGGCAAGACCATGACACTCTTCAGCGCCCTCCGGGCCTTGCCTGACATGG
AGGTGGTGGGTCTCAACTTCTCCAGTGCTACTACTCCAGAGCTGCTTCTGAAGACTTTTGATCACTACTGCGAGTACAGGCGCACACCTA
ATGGGGTGGTTTTGGCTCCTGTTCAACTTGGAAAGTGGCTGGTGTTGTTCTGTGATGAAATCAACTTGCCAGATATGGATAAATATGGGA
CCCAGAGGGTCATATCCTTCATCAGACAGATGGTGGAGCACGGAGGCTTTTACCGTACCTCAGATCAAACATGGGTGAAGCTGGAGAGAA
TCCAGTTTGTTGGGGCTTGTAATCCCCCCACAGACCCTGGAAGAAAGCCCCTCTCACACAGGTTCCTGCGCCACGTGCCTGTCGTGTATG
TGGATTACCCGGGCCCCGCCTCCCTCACACAGATCTACGGCACCTTCAACCGCGCCATGCTGAGGCTCATTCCATCCCTGCGGACGTATG
CAGAGCCGCTCACTGCTGCCATGGTGGAGTTCTACACCATGTCTCAGGAGAGATTCACCCAGGATACACAACCTCACTATATCTATTCAC
CCCGTGAAATGACTAGGTGGGTGAGAGGCATCTTTGAAGCGCTGAGACCTCTGGAGACCCTGCCTGTTGAAGGCCTCATTCGGATTTGGG
CACATGAAGCTCTGCGTCTCTTCCAAGATAGACTCGTAGAGGATGAGGAGAGGCGTTGGACTGATGAGAACATCGACACGGTTGCTCTGA
AGCACTTCCCTAACATCGACAGAGAGAAGGCAATGAGCCGACCCATCTTGTACAGCAACTGGCTGTCAAAGGATTACATCCCAGTAGACC
AAGAAGAGTTAAGAGATTATGTCAAAGCTAGGCTGAAGGTCTTTTATGAAGAAGAACTTGATGTTCCGCTGGTGCTGTTTAATGAAGTCC
TAGACCACGTGCTGAGGATTGACAGAATATTCCGTCAACCTCAAGGCCACTTGCTTCTGATTGGTGTTAGTGGAGCAGGAAAAACTACCC
TGTCTCGTTTCGTCGCCTGGATGAACGGTTTGAGTGTGTACCAGATTAAGGTCCATAGGAAGTACACAGGGGAAGACTTTGATGAAGATC
TACGGACAGTGTTGAGACGTTCTGGCTGTAAAAATGAAAAGATAGCATTTATAATGGATGAATCTAATGTGTTAGATTCTGGATTCCTGG
AGCGAATGAATACCCTTCTGGCCAATGGAGAGGTGCCTGGTCTCTTTGAAGGAGACGAGTATGCCACCTTGATGACGCAGTGCAAAGAGG
GGGCACAGAAGGAAGGCCTGATGCTGGACTCGCACGAGGAGCTCTACAAGTGGTTCACTAGCCAGGTTATCCGCAACCTCCACGTCGTGT
TCACCATGAACCCGTCCTCGGAGGGACTCAAGGACCGGGCAGCTACATCACCAGCACTTTTCAACAGGTGTGTGTTGAATTGGTTTGGAG
ACTGGTCCACCGAAGCACTGTATCAGGTTGGCAAAGAATTCACAAGTAAGATGGATCTGGAGAAGCCAAATTACATCGTGCCTGATTACA
TGCCAGTTGTGTATGATAAGCTGCCGCAGCCACCATCCCATCGGGAAGCCATTGTGAACAGCTGTGTGTTTGTTCATCAGACTCTTCACC
AGGCGAATGCTCGGCTAGCAAAGCGAGGCGGCAGAACGATGGCCATCACCCCTCGCCACTACCTGGACTTCATCAATCACTATGCCAACC
TGTTCCACGAGAAGCGGAGCGAGCTGGAGGAGCAGCAGATGCACTTGAACGTGGGGCTCAGGAAGATCAAAGAGACAGTCGACCAGGTAG
AAGAACTGCGTCGTGACTTGAGGATAAAGAGCCAAGAGCTGGAGGTGAAGAATGCAGCAGCCAATGACAAGCTGAAAAAGATGGTGAAAG
ACCAGCAGGAGGCTGAAAAGAAGAAGGTTATGAGCCAAGAAATCCAGGAACAGCTGCATAAGCAGCAGGAGGTAATTGCAGACAAACAGA
TGAGTGTCAAAGAAGATCTTGATAAGGTGGAACCTGCCGTCATTGAGGCCCAGAATGCTGTGAAGTCGATCAAGAAGCAGCACCTGGTGG
AGGTGAGGTCCATGGCCAACCCTCCTGCTGCTGTGAAGCTGGCGCTGGAGTCCATCTGCCTGCTGCTGGGGGAAAGCACCACAGACTGGA
AGCAGATCCGCTCCATCATCATGCGGGAGAACTTCATCCCCACCATCGTCAACTTCTCTGCAGAGGAGATCAGTGACGCCATAAGGGAGA
AGATGAAGAAAAATTACATGTCCAATCCAAGTTACAATTATGAAATTGTGAATCGGGCTTCCCTGGCTTGCGGCCCTATGGTGAAATGGG
CAATTGCACAGCTTAACTATGCAGACATGTTAAAGAGAGTGGAGCCCCTACGCAATGAGCTGCAGAAGCTGGAAGATGACGCCAAGGACA
ACCAGCAGAAGGCCAACGAGGTGGAGCAGATGATCCGAGACCTGGAAGCCAGCATCGCCCGCTACAAGGAGGAATACGCCGTCCTGATCT
CAGAGGCCCAGGCCATCAAGGCAGACCTGGCAGCTGTCGAGGCAAAAGTAAACCGGAGCACTGCTCTTCTGAAGAGCTTGTCTGCTGAAC
GTGAACGATGGGAAAAAACAAGTGAAACTTTCAAAAACCAGATGTCCACCATTGCTGGGGACTGTCTCTTGTCAGCTGCGTTCATTGCCT
ACGCGGGTTACTTTGACCAGCAGATGCGTCAGAACTTGTTCACTACCTGGTCCCATCACCTACAGCAAGCCAACATCCAGTTCCGTACAG
ATATTGCCAGGACGGAATACCTTTCCAATGCTGATGAGCGTCTTCGCTGGCAGGCCAGCTCCTTGCCTGCTGATGACCTTTGCACAGAAA
ATGCCATCATGCTGAAACGATTCAATAGGTATCCGCTGATCATTGACCCCTCTGGACAGGCCACAGAATTCATTATGAATGAATATAAGG
ATCGTAAGATCACACGGACCAGCTTCCTGGATGACGCCTTCAGAAAGAACTTAGAGAGTGCACTGAGATTCGGTAACCCCCTTCTGGTCC
AGGATGTGGAAAGCTACGATCCAGTTTTGAACCCGGTGCTGAACCGTGAAGTGCGGCGAACAGGGGGGAGAGTGCTGATCACTCTCGGGG
ACCAGGACATAGACCTGTCGCCATCGTTTGTCATCTTCCTGTCCACCCGGGATCCAACTGTCGAGTTCCCACCAGATCTCTGTTCCCGGG
TTACTTTTGTAAACTTCACAGTTACCCGTAGCAGTTTACAAAGCCAGTGTCTAAATGAAGTACTTAAAGCAGAAAGACCTGATGTGGACG
AGAAACGATCTGATCTTCTTAAACTTCAAGGGGAATTTCAGCTCCGTTTGCGTCAGCTGGAAAAATCTCTACTACAAGCTCTGAACGAGG
TGAAAGGGCGCATTTTGGATGACGACACGATCATAACCACTCTGGAGAACCTGAAGAGAGAGGCTGCAGAGGTCACCAGGAAAGTTGAGG
AGACGGACATTGTCATGCAGGAGGTGGAGACCGTGTCCCAGCAGTACCTCCCGCTCTCCACCGCCTGCAGCAGCATCTACTTCACCATGG
AGTCCCTCAAGCAGATACACTTCTTGTACCAGTACTCCCTCCAGTTTTTCCTGGACATTTATCACAACGTCCTATACGAGAACCCGAACC
TGAAGGGTGTCACCGACCACACACAGCGCCTGTCCATTATAACAAAGGACCTCTTCCAGGTGGCGTTTAACCGAGTGGCTCGAGGCATGC
TGCATCAGGACCACATTACCTTTGCCATGCTGCTGGCAAGAATCAAACTGAAGGGCACCGTGGGGGAGCCCACCTACGATGCAGAATTCC
AGCACTTCTTGAGAGGAAATGAGATTGTCCTGAGTGCTGGCTCCACCCCCAGGATCCAGGGCCTGACTGTGGAGCAGGCGGAGGCGGTGG
TGAGGCTGAGCTGCCTTCCCGCGTTTAAGGACTTGATTGCAAAGGTTCAGGCAGACGAGCAATTTGGCATCTGGCTGGACAGCAGCTCCC
CGGAGCAGACTGTGCCCTACCTCTGGAGTGAAGAAACACCTGCAACACCCATTGGCCAGGCCATCCACCGCCTGCTCCTGATCCAGGCTT
TCCGGCCCGATCGCCTGTTGGCCATGGCCCACATGTTTGTTTCAACAAACCTTGGGGAGTCTTTCATGTCCATCATGGAGCAGCCGCTCG
ACCTGACCCACATTGTGGGCACAGAGGTGAAGCCCAACACTCCTGTCTTAATGTGCTCTGTGCCTGGTTATGATGCCAGTGGACATGTCG
AGGACCTTGCAGCCGAGCAGAACACGCAGATCACTTCAATTGCAATCGGCTCTGCAGAAGGCTTTAACCAAGCAGATAAGGCAATAAACA
CCGCTGTAAAGTCGGGCAGGTGGGTGATGCTGAAGAATGTGCATCTGGCCCCAGGGTGGCTGATGCAGCTGGAGAAGAAGTTGCATTCCC
TGCAGCCGCATGCCTGCTTCCGACTCTTCCTCACCATGGAGATCAACCCCAAGGTGCCTGTGAATCTGCTCCGTGCGGGCCGCATCTTTG
TGTTCGAGCCACCGCCAGGGGTGAAGGCCAACATGCTGAGGACGTTCAGCAGCATTCCCGTCTCACGGATATGCAAGTCTCCCAACGAGC
GTGCCCGCTTGTACTTCCTGCTGGCCTGGTTTCATGCGATCATCCAAGAACGCTTACGATACGCACCACTGGGGTGGTCAAAGAAGTATG
AATTTGGAGAGTCTGACCTGCGGTCAGCTTGCGATACGGTGGACACGTGGCTGGATGACACGGCCAAGGGCAGGCAGAACATCTCACCGG
ATAAGATCCCGTGGTCTGCACTAAAGACCTTAATGGCCCAGTCCATTTATGGCGGGCGCGTGGACAACGAGTTTGACCAGCGTCTGCTCA
ACACCTTCCTGGAGCGCCTGTTCACAACCAGGAGTTTCGACAGTGAGTTTAAGCTGGCATGCAAGGTCGACGGACATAAAGACATTCAAA
TGCCAGATGGCATCAGGCGAGAGGAGTTTGTGCAGTGGGTGGAGTTGCTCCCCGACACCCAGACGCCCTCCTGGCTGGGCCTGCCCAACA
ACGCCGAGAGAGTCCTCCTTACCACACAGGGTGTGGACATGATCAGTAAAATGCTGAAGATGCAGATGTTGGAGGATGAGGACGACCTGG
CCTACGCAGAGACTGAGAAGAAGACGAGGACAGACTCCACGTCCGACGGGCGCCCTGCCTGGATGCGGACACTGCACACCACCGCGTCCA
ACTGGCTGCACCTCATCCCCCAGACGCTGAGCCACCTCAAGCGCACCGTGGAGAATATCAAGGATCCTTTGTTCAGGTTCTTTGAGAGAG
AAGTGAAGATGGGCGCAAAGCTGCTTCAGGACGTTCGCCAGGACCTTGCAGATGTCGTCCAGGTGTGCGAAGGAAAGAAGAAGCAGACCA
ACTACTTGCGCACGCTGATCAACGAGCTAGTGAAAGGGATCTTGCCTCGGAGCTGGTCCCACTACACGGTGCCTGCCGGCATGACCGTCA
TCCAGTGGGTGTCCGACTTCAGCGAGAGGATCAAACAGCTGCAGAACATCTCACTGGCAGCTGCATCTGGTGGCGCCAAGGAGCTAAAGA
ACATCCACGTGTGCCTGGGTGGCCTGTTCGTGCCTGAGGCGTACATCACTGCCACCAGGCAGTATGTGGCCCAGGCCAACAGCTGGTCCC
TGGAGGAGCTCTGCCTGGAAGTCAACGTCACCACCTCACAGGGCGCCACCCTTGACGCTTGCAGCTTCGGAGTCACGGGTTTGAAACTTC
AAGGGGCCACGTGCAACAACAACAAGCTGTCACTGTCCAATGCCATCTCAACCGCCCTTCCCCTGACGCAGCTGCGCTGGGTCAAGCAGA
CAAACACCGAGAAGAAGGCCAGTGTGGTAACCTTACCTGTCTACCTGAACTTCACCCGTGCAGACCTCATCTTCACCGTGGACTTCGAAA
TTGCTACAAAGGAGGATCCTCGCAGCTTCTACGAGCGGGGTGTCGCAGTCTTGTGCACAGAGTAAACTTTTCTAGCTGCCCCTTTCTGTA
ATAGTGAAAGTTGGTATTTAACATTTATTCATTTTTAAAATATTTGGAAGGTCTGAGCTTGTGAAAAGAAAGTGGTTGGTCTGAGGTTGG
AGGAAGCTGAATGGAATCTGACGGTTGGGAGTGGTGGAAATTGGAAGGATACCAGGAGGTATTTGGGAAGGCCAATGGCGTGGCTCCTTT
GAGGAAATAAAACACTAAGCATGAAAAAGAAAGAAGAGGGTGTTATTGATTCATCTGACAAAGAAATCGTTGCTGAAGCAGAAAGACTGG
ATGTAAAAGCCATGGGCCCTCTTGTTCTAACTGAAGTTCTTTTTAATGAGAAGATTAGAGAACAGATTAAGAAATACAGGCGCCATTTCC
TACGATTTTGTCACAACAACAAAAAAGCCCAACGGTACCTTCTTCATGGTTTGGAGTGTGTGGTAGCAATGCATCAAGCTCAGCTTATCT
CCAAGATTCCACATATCTTGAAGGAGATGTACGATGCAGACCTTTTAGAAGAAGAGGTCATCATCAGCTGGTCGGAAAAGGCCTCTAAGA
AATATGTCTCCAAAGAACTTGCCAAAGAGATTCGTGTCAAAGCAGAACCATTTATAAAATGGTTGAAGGAGGCAGAGGAAGAATCTTCTG
GTGGCGAAGAAGAAGATGAAGATGAGAACATTGAGGTGGTGTATTCGAAGGCTGCCAGTGTACCGAAAGTTGAGACTGTAAAGTCAGACA
ACAAGGATGACGACATCGATATTGATGCCATTTAAAGGGATGGATGCAACCTAGCTTAACAGTATAATGCTGCAAATTTTCCTCCATTAT
CAGCCAGAAGTGCAACATGTATGTGCAAAAGCTAAAATGGCTTAACATCATGCTACACTTTACACTAAAAATCTATTACTGTGAGTGGTC
TGTTATTAAGCCCAATGAGACATCTAGGGAGTCCATACACATCAGTGAGCAGATGTAGTTTGCTTATTTATAGCATGTTTCTTTTTGAAA
AACTAGTGGTGGACACATTTGGATCACATTTATACAGTTATAAAAATAAAGGTTTGATTTTGGTCGTTCTTCAGATGTTTGGCTCTGAAT
GACTTAAGCTGAAGTAACTGGCTCCTTACTTTAAATGTTCTGCCATCATTTCACCTGATGAGCATTCTTGGAGCCTGCCAGATATTGTTA
GGTCCTGGGGCTGCAAAGAGGTCCTCAACAGGATGTAAAGCAAACTTAATTGTAATTAATTTATTCAGCCCATTAAGAAAGTACTAAAGT
TTTATCTCTGTAGTTCCTCAAATTGGCATCTGGTAATGTACATTGTGAGGTAGACTGATAATGAAATGACAGTGTAACATCTTAACCAAG
AAGTAAATATGACCTCAGTGTCCTATAAATAATGTAAGAGCAGGATTTGAAACTTGGAGAGCTGTTTTCTCATTTCATGTACACTTGCCC
CAAATTGTCTTTGAAGTCGTGTGCATTGCACGTTGGATGAGCCAGGGAAATTATTACATTAACAAGCATTTTGTGTGTACGTAGTAGTTA
CTTTGTACTGAGAGAACTTGCTTTGGGGTGCAATTAATAAACTGATTTTATTTGGGAGAAACAAGGAAGGGTGCACTTAACTAGCAACCT
AAGCATGATTTTTCAGCTTTTGCCCTTAGGGTTTAAATTACAATTCCAAAATGTTAGACATACTGTATTTTTTCGTTCAGTGTGGCTTTA
ATTTTCCCCTCTTGCAGTTTGTTCTGTAATGCCTTTTACATTTGGACACATAGTTTATGCTTTTTAGATTTTGGTTGCTTTCTTGCCAAA
ATAAGTGTTAACTGTGTTTCAAACTTGATTTTCTTTCCTTTTTCTTTTTTTTTTCTTCCAGAATGTCTTATTTAAAAAGAAAGCTAAAAG
CATACTTCTAAGTCAGAGCCTCTATTTTGGTGTAAGACTTGGGATATTTTTTACTTCACATTGAATATAGCCAGGCACCCAAGAAGTCTG
ATGGCCACCTGAGTGCAGGTGACAAGGACCTGACAGAGCCCATGCAGGGCTTTAGATTTGGACACACAAGAGTTGATAACTTCCTCATGA
ACTCCTTGCCTGATCTAAACTCATATTATGGGTTCTGACTGTTTGAGTAATCATCTTCAAGGTTAAACCTCTTGGCAGTTACCCTTTTCA
CAAAGTGCACAGTGGGAATCGAGAATCGATAGGGTTAATTTTGGAGCAGTGGCTTATACCATTCACCTCTGTTTTTTTGTGATTATTTCA
CAGATAATGAGACCTTAATAACAAATAGGCGTAAAAAAATTTTCACATTGAAATGATAGAAACATTTGATGTAATAAAACTTGGTTGGCT
TGATATTTTAAGGAATTGAAACCTAGCAATCTTATTGGAGAGACAAGAATTGGTCTCCAGCTGCCTTTGATCAAGATTCGGGTGCAAGTG
GAGCAGGAGCCATATACCTGGAGGGAATGTGCTTTGTCACACCAAAGAGGATTTTTTTTTCTTCAAACTTGTATGTTGCCTAGGTTTCAA
ATTCTTTGCCGCAAGGCTGATCTGCTTTCATTAACTGGAATTCTGTAGGAGATACTGGTGACCTAAGCTAAGTTGCACTCAGCATACTCA
GTGTCAAGCTAATGAGGTTCTATTATAAAGGTTCTACTTTTAATCTGAGGGAAAACATGTTCAGGGCTTCTAGAACACTAAAAAATTTGG
CTTAAACCAGTGTTCAGTCTGGTGCCAAACTTCGAATGGAATACAAATTCACATAATCTGAACTTTGTTCACAGGTTATCCTAATAGAGT
AATTCTTCACTTTGCTCTATTGAACTGTCTTAAGGATTTGTTTAAACAGCTAAGTTACTTGATTAAAATAATGATAAAATTGTATTTTGT
CTTTGCTTTAATATTAAAGTTAACAAGTTTTCATTTTATAATGAGATCAAAGCATTGGAATCTGCCCTGTTTTGTAGCCGTTGCTTTGGA
TTTGTGTTGGATGTATCCTGCAGTTACACTTGCCAGCCCCACTCACAAAAGTTGTTCATTTCATTGGGTCACTGGCTTTATTTGCTAGTC
TTGTCTGTGAACTGAGCATCTGCCTCAGTTTTATTACTTGAAATCTTGGCAGGTGCTTAATAGGGAACATACATACAGCTATGTAACTGT
GAATAATTGTATATATCTCTAGTTAAGAATGAGGGAATGGGGAGGTTTGCTTTCTAAACAAGTGCATTCTGAAATTGACTTAAAAATTTT
TAGTGTGGGTCCTAAAGTTTAGAGATGGGCAAGGAGGTCTCTAATCCACCGCTTCCCGCTTGAGAAGGGAGGGGTATCAAAATTGAGCCC
CAAGCTGTTTGTTCCAGTGTACCAAGCACTGACTTTATGCCTTTGGCCTGGAGATGGCAGAAGTGAAAGCTGGCCATCTGCAAAAAGCAG
ATAAGTGAGTTTGAACCTTTTGCATTTTGTTAGCTCAGTCAGTCCTCATCGTGGTCCTGAGGCATAGGTACTGTTGTACCAAGGTCACTT
ATCTAACAAAATAACCCTTCATGTATTTTAAATTTATTTGACAAGTCTGCAGACAATCCTTATCTAACCAGCTATTTTCTTAATTGCTAC
AGCTTGACCTACCAGTATTCCGGAGTAACCAGCAAATGCAAAGTTGACCTTGTTCCTGCATCATCTTTTTGATGGTTCAAATTTCAGCCT
CCCTGACTACTACAAAGCCAGAGCAGTCTTAGTACCAGAAACAGTGTTGCACTTTCGTTGCATGTGCTGTGTGACCCCAAGGGGACAGGG
AGTCACTTTGGTCATCTCTGTCCCCAGTACAGATCTTGATTCATAGTGACATTCCATAAGTGGGGTGACAGCAAATGACTTGCAGGTAGT
CTCATTGTAGGTTTGTGCACCAGAGTGACCCTGTGAGCCTTTGTTAATAGGTTGGGAGCTCAGGGTGTTTATGTCCACCTGTCTGGTCTA
GCCAAACAGTTTTTTTCTGGGAATCAAATTTCTGTGGTTTTTATGGCCAGAAATTTTAAGGACTTGTGTGTGCTGGGATATGAGAATAGA
AGCTACAGAGTTCTTTTCTTGGGACCTAGACTGGGAGGTGCAATGTCAGGACCTCCAGGTGAATGGTAGGATCTGAGTTGACCCTGCAGT
TCGGTTATGCAGTCAATTATTTCTTTTTAAGAGGAGGAGGATTCACTTGGGTGTTGGGATCAAATTTGGATTCTGTCCCAGGCCTTACTG
TAAAACTAGGGGATTGCCTTTCCATATCTGCTGGGGGTGGAGACCCTTATGTGCAGCACTCAATCCCACTGGAAGCCTAATGCTGCAGTC
AGAAGCAATGCCTGGCTGGGGCAGTAGGGGAAATTCCACCCAATTTTGCTATGAGCCTAAAACCTCTTTAAAAACGGTCAGTTAACTAAA
AAATAAAAATCAAGTCTTTAGGAGAGTAGAAAACACAATTAACTAAAAAGCAGGGACATCTGAAAGAGACGTATTAAGTTAACATTTTTA
AAAATCCAAATGAAAGTAAATGGAATAAATGTATCAGGTAAAGGACAAGTTGTAAGCTTGGATTTTTAGGTCTAGCAATACACTGTTTAC
AAGAGCATCACCTAAAATGTGACAAAAGATGTTGAAAGGATGAAAAAAGGTATAGTAGACATACACTAACCAAAAATGTAGCTCTTTGAA

>24591_24591_1_DYNC1H1-EIF5_DYNC1H1_chr14_102517128_ENST00000360184_EIF5_chr14_103805509_ENST00000216554_length(amino acids)=4654AA_BP=
MEGPERDTMSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERS
TLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKAD
RDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKL
DRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDK
IRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKR
EENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKE
VDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDK
FKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLG
VSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTIS
LLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHS
YSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYKL
YQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRL
GEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTAS
TSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVES
RTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQ
IDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLG
QIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALS
WEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQ
KALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINEWL
TLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVL
ADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQT
PLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVS
QQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTA
EVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAE
DIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALE
RLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGER
LSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATI
MQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRA
ELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKT
MTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGF
YRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQE
RFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPIL
YSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIK
VHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYK
WFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREA
IVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVK
NAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALE
SICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPL
RNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMST
IAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDP
SGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTR
DPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLEN
LKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKD
LFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQ
ADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVL
MCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINP
KVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTW
LDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELL
PDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTV
ENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNI
SLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGVTGLKLQGATCNNNKLSLSNAIS

--------------------------------------------------------------
>24591_24591_2_DYNC1H1-EIF5_DYNC1H1_chr14_102517128_ENST00000360184_EIF5_chr14_103805509_ENST00000558506_length(transcript)=17061nt_BP=14333nt
CTGGCAGTGGCTGCCTTTAGGGCGGAGCCGGCTCCCGCTCTCCTCAGTCTGCGGTGGGCTAGCGGACGGTCCGGCTTCCGGCGGCCGTTT
CTGTCTCTTGCTGGCTGTCTCGCTGAGTCGCGGCCGCCTTCTCATCGCTCCTGGAAGGTCCCGAGCGCGACACCATGTCGGAGCCCGGGG
GCGGCGGCGGCGAGGACGGCTCGGCCGGATTGGAAGTGTCGGCCGTGCAGAATGTGGCGGACGTGTCGGTGCTGCAGAAGCACCTGCGCA
AGCTGGTGCCGCTGCTGCTGGAGGACGGCGGCGAGGCGCCGGCCGCGCTGGAGGCGGCGCTGGAGGAGAAGAGCGCCCTGGAGCAGATGC
GCAAGTTCCTTTCGGACCCGCAGGTCCACACGGTGCTGGTGGAGCGCTCCACGCTCAAAGAGGACGTCGGTGATGAAGGAGAAGAAGAAA
AAGAATTCATTTCCTATAACATCAACATAGACATTCATTATGGGGTTAAATCCAATAGCTTGGCATTCATTAAACGTACTCCCGTGATTG
ATGCAGATAAACCCGTGTCTTCTCAGCTCCGGGTCCTTACACTCAGTGAAGACTCGCCCTACGAAACTTTGCATTCTTTCATTAGCAATG
CAGTGGCTCCTTTTTTTAAGTCCTACATTAGAGAGTCTGGCAAGGCAGACAGGGATGGTGATAAAATGGCTCCTTCAGTTGAAAAGAAGA
TTGCAGAACTCGAAATGGGACTCCTTCACTTGCAGCAAAATATTGAAATTCCGGAGATCAGCCTGCCGATTCATCCAATGATCACAAATG
TTGCAAAACAGTGTTATGAGCGTGGAGAAAAGCCAAAAGTTACAGACTTTGGTGATAAGGTTGAAGACCCAACATTTCTTAATCAGTTAC
AATCTGGAGTTAACCGCTGGATCCGAGAAATTCAAAAAGTGACCAAACTGGATCGAGATCCTGCATCAGGAACTGCCTTACAGGAAATTA
GTTTTTGGCTAAACTTGGAACGTGCGTTATACCGCATCCAGGAGAAACGGGAGAGCCCGGAAGTTCTCCTGACTCTGGATATCTTGAAAC
ATGGCAAGCGCTTCCATGCCACCGTCAGTTTTGACACTGACACAGGTCTAAAACAGGCTTTGGAAACTGTGAATGACTACAATCCTCTGA
TGAAAGATTTCCCTCTGAATGATTTGCTGTCTGCCACGGAGCTGGACAAAATAAGACAGGCGCTTGTTGCCATTTTCACACATTTGAGAA
AGATCCGAAACACAAAATATCCTATTCAGAGGGCACTGCGTTTGGTGGAGGCAATTTCAAGAGACTTGAGTTCTCAATTACTCAAAGTAT
TGGGCACTAGGAAATTGATGCATGTTGCTTATGAAGAATTTGAAAAAGTTATGGTAGCATGCTTTGAAGTTTTTCAGACTTGGGATGATG
AGTATGAGAAACTTCAGGTATTGTTGAGAGACATCGTCAAAAGAAAAAGGGAAGAAAATCTGAAGATGGTGTGGCGTATCAACCCTGCCC
ACAGGAAGCTGCAGGCCCGCCTTGACCAGATGAGAAAATTTAGACGCCAGCATGAACAGCTAAGAGCTGTTATCGTCAGGGTCCTGAGGC
CACAGGTCACGGCAGTTGCACAACAGAATCAAGGAGAGGTCCCTGAACCCCAAGATATGAAAGTGGCTGAGGTTCTCTTTGATGCTGCAG
ATGCAAATGCCATTGAGGAAGTAAACCTTGCTTATGAGAACGTCAAGGAAGTGGATGGACTGGATGTTTCCAAAGAGGGCACGGAAGCCT
GGGAGGCTGCTATGAAGAGGTACGATGAGAGGATCGACAGAGTGGAGACCCGGATCACCGCTCGCCTTCGGGATCAGCTTGGCACAGCCA
AGAATGCCAACGAGATGTTTAGGATTTTCTCCAGGTTTAATGCACTGTTTGTCAGGCCTCACATCCGTGGGGCCATTCGCGAATACCAGA
CCCAGCTGATCCAGCGCGTGAAAGATGACATTGAGTCTCTTCACGACAAGTTCAAGGTCCAGTACCCACAGAGTCAGGCTTGTAAGATGA
GTCACGTTCGTGACTTGCCCCCTGTGTCAGGGTCTATCATCTGGGCTAAACAGATCGACAGGCAGCTGACGGCCTACATGAAGCGGGTGG
AAGATGTCCTTGGCAAGGGCTGGGAGAATCACGTGGAGGGGCAGAAGCTGAAGCAGGATGGAGACAGCTTCCGCATGAAGCTCAACACGC
AGGAGATCTTTGATGACTGGGCAAGGAAGGTGCAGCAGCGCAACCTCGGTGTCTCGGGGCGCATTTTCACCATCGAAAGTACTCGGGTTC
GGGGCCGAACTGGAAATGTGCTTAAGCTGAAAGTTAACTTTCTTCCTGAGATTATCACACTATCCAAAGAAGTCCGGAACCTCAAATGGC
TTGGTTTCCGCGTCCCACTGGCGATTGTGAACAAAGCCCATCAAGCAAACCAGCTTTACCCGTTTGCCATCTCACTGATCGAGAGCGTTC
GTACCTATGAACGGACCTGCGAGAAGGTGGAGGAGCGGAACACCATTTCCCTTTTGGTGGCTGGCTTGAAAAAGGAAGTGCAGGCCCTGA
TCGCAGAAGGCATTGCGTTGGTGTGGGAGTCCTACAAACTTGACCCATATGTACAGCGCTTAGCAGAGACTGTCTTCAACTTCCAAGAAA
AGGTGGATGATCTGCTGATCATTGAAGAAAAAATAGACCTAGAAGTCCGTTCCTTGGAAACTTGTATGTATGACCATAAGACATTCTCGG
AAATCTTGAACAGAGTCCAGAAAGCAGTGGATGACTTAAATCTGCACTCCTATTCCAATTTGCCCATCTGGGTCAACAAGCTTGACATGG
AGATTGAAAGAATATTGGGCGTCCGTCTGCAAGCTGGCCTGAGAGCTTGGACGCAGGTTCTTCTTGGACAAGCTGAAGATAAAGCAGAAG
TTGACATGGACACAGATGCTCCACAAGTTAGTCACAAGCCTGGTGGAGAGCCAAAGATCAAAAATGTCGTTCATGAGCTAAGAATAACCA
ATCAGGTAATCTACTTGAATCCACCAATTGAAGAGTGCAGATACAAGCTGTATCAGGAAATGTTTGCCTGGAAGATGGTTGTACTGTCTC
TCCCCAGGATCCAGAGTCAGAGGTACCAGGTGGGTGTACATTACGAATTGACTGAGGAAGAGAAATTCTATCGGAATGCTTTAACACGGA
TGCCTGATGGCCCTGTTGCCCTGGAAGAGTCGTATTCTGCTGTCATGGGCATTGTATCTGAAGTTGAACAGTATGTCAAGGTTTGGCTTC
AGTATCAGTGTTTATGGGATATGCAAGCTGAAAACATCTATAACAGACTTGGAGAAGATCTCAACAAATGGCAGGCTCTCCTGGTCCAAA
TAAGGAAGGCCAGAGGAACCTTTGACAATGCAGAAACCAAGAAAGAGTTTGGACCAGTAGTTATAGATTATGGCAAGGTACAATCTAAGG
TGAACTTGAAATATGACTCTTGGCATAAGGAGGTTCTTAGCAAATTTGGGCAGATGCTAGGATCAAACATGACGGAATTCCATTCCCAGA
TCTCAAAGTCCCGCCAAGAGTTGGAGCAGCACTCAGTAGACACGGCCAGCACCTCCGATGCAGTGACCTTCATCACCTATGTGCAGTCTT
TGAAACGGAAGATCAAGCAGTTTGAGAAGCAAGTTGAGCTCTACCGCAATGGCCAGCGCTTACTGGAAAAGCAAAGGTTCCAGTTCCCAC
CTTCCTGGCTTTATATTGACAACATCGAGGGAGAGTGGGGAGCCTTCAATGACATCATGCGGCGAAAGGACTCTGCCATTCAGCAGCAGG
TGGCAAACCTGCAAATGAAGATTGTCCAGGAGGATCGGGCCGTGGAAAGCCGCACCACCGACCTGCTGACTGACTGGGAGAAGACCAAGC
CTGTCACGGGCAACCTTCGCCCAGAAGAGGCACTTCAGGCTCTCACCATATATGAGGGGAAGTTTGGTAGGCTGAAGGACGACAGAGAGA
AGTGTGCAAAGGCCAAGGAGGCGCTGGAATTGACAGATACTGGGCTTCTCAGTGGCAGTGAAGAGCGCGTGCAGGTGGCCTTAGAAGAAT
TACAGGACCTCAAAGGCGTTTGGTCAGAACTTTCTAAGGTTTGGGAGCAAATCGATCAGATGAAGGAGCAACCCTGGGTTTCAGTACAGC
CTCGAAAGCTTCGACAAAATTTGGATGCCCTCCTGAACCAGCTGAAAAGCTTCCCTGCCCGGTTGCGACAGTATGCGTCCTATGAGTTTG
TTCAGAGGCTTCTGAAAGGTTACATGAAGATAAATATGCTGGTGATTGAACTGAAATCCGAAGCACTTAAAGACCGCCATTGGAAACAGC
TCATGAAAAGGCTTCACGTTAATTGGGTTGTTTCTGAGCTAACCCTTGGCCAAATCTGGGATGTTGACTTGCAGAAAAATGAAGCGATTG
TCAAGGATGTACTGCTTGTGGCACAAGGGGAGATGGCTTTGGAAGAATTTTTGAAGCAGATAAGAGAAGTGTGGAATACTTATGAACTAG
ACTTGGTTAATTATCAGAACAAGTGCCGCTTGATCCGTGGCTGGGATGACCTCTTCAACAAGGTCAAAGAACACATCAACAGCGTCTCGG
CCATGAAGCTCTCTCCGTATTACAAGGTTTTTGAAGAGGATGCTCTCAGCTGGGAAGATAAGCTGAACAGGATCATGGCTCTCTTTGATG
TGTGGATTGATGTGCAGAGGCGGTGGGTCTACCTGGAAGGTATCTTCACAGGCAGTGCAGATATCAAGCACCTGCTGCCAGTGGAAACCC
AGCGGTTTCAGAGCATCAGCACTGAGTTTTTGGCTCTAATGAAAAAAGTGTCCAAGTCTCCCCTTGTTATGGATGTTCTGAACATCCAGG
GAGTACAGAGGTCTCTGGAAAGATTGGCAGACCTGCTAGGAAAGATCCAGAAAGCATTGGGAGAATATCTGGAAAGAGAGCGGTCATCTT
TCCCCAGGTTCTATTTTGTGGGTGATGAAGATTTGCTTGAAATCATTGGAAACAGCAAGAATGTCGCTAAATTACAGAAACACTTCAAGA
AGATGTTTGCTGGAGTTTCGAGCATCATCCTGAACGAGGATAACTCTGTTGTTTTGGGTATTTCATCTCGGGAAGGAGAGGAGGTTATGT
TTAAAACTCCTGTGTCAATTACTGAACATCCCAAAATCAATGAGTGGCTCACATTGGTAGAAAAGGAGATGAGAGTCACCCTGGCCAAAC
TGCTTGCTGAGTCTGTTACGGAAGTTGAGATTTTTGGTAAAGCAACTTCAATTGACCCAAATACCTACATCACTTGGATTGATAAATACC
AGGCCCAGCTTGTGGTTTTGTCAGCCCAGATAGCCTGGTCTGAGAACGTGGAGACCGCACTGAGCAGCATGGGCGGAGGTGGAGATGCCG
CGCCCTTGCACTCTGTGCTGAGCAATGTGGAGGTCACCCTCAATGTGTTAGCAGACTCTGTCCTCATGGAGCAGCCCCCACTCCGAAGGC
GGAAGCTAGAACACTTGATTACAGAGTTGGTTCACCAGAGAGATGTTACAAGGTCCTTGATCAAAAGCAAGATTGACAACGCCAAATCTT
TTGAATGGCTCAGCCAGATGCGATTTTACTTTGACCCTAAGCAAACTGATGTGTTACAGCAGTTGTCAATTCAAATGGCAAATGCCAAAT
TTAACTATGGCTTTGAGTACCTGGGTGTTCAGGACAAACTGGTCCAGACCCCCCTCACTGACCGCTGCTATTTGACAATGACACAAGCCT
TGGAGGCCAGGCTGGGGGGTTCCCCATTTGGACCTGCTGGAACTGGGAAAACAGAGTCTGTCAAAGCTCTTGGCCATCAGCTTGGACGGT
TTGTTTTAGTTTTCAACTGTGATGAAACCTTTGATTTCCAGGCAATGGGCCGGATCTTTGTGGGCCTTTGCCAGGTGGGTGCCTGGGGCT
GCTTTGACGAGTTCAACCGCCTGGAGGAGCGGATGCTCTCGGCTGTGTCCCAGCAGGTGCAGTGCATACAGGAAGCACTGCGTGAACATT
CCAACCCCAACTACGACAAGACCTCTGCCCCCATTACTTGTGAGCTGCTGAACAAACAAGTCAAGGTGAGCCCGGACATGGCCATCTTCA
TCACCATGAACCCTGGCTACGCGGGCCGGTCTAACCTTCCTGACAACTTGAAGAAGCTGTTCCGGAGCTTGGCCATGACCAAGCCCGACC
GGCAGTTAATCGCCCAGGTCATGCTGTACTCACAGGGTTTCCGCACTGCTGAAGTGCTTGCCAACAAAATCGTCCCGTTTTTTAAACTAT
GCGATGAGCAGCTCTCTTCCCAAAGCCATTATGACTTCGGTCTTCGGGCTTTGAAGAGTGTGCTGGTGAGTGCAGGCAATGTGAAGAGAG
AGAGAATCCAGAAGATAAAGAGGGAGAAAGAGGAACGAGGGGAAGCAGTTGATGAAGGAGAAATTGCTGAAAATCTCCCTGAACAAGAGA
TTCTGATACAGAGCGTCTGTGAGACGATGGTGCCAAAGCTGGTGGCAGAGGACATCCCGCTGCTCTTCAGCCTCCTGTCGGACGTGTTCC
CTGGAGTCCAGTATCACAGGGGTGAGATGACTGCCCTTCGAGAGGAGCTGAAGAAAGTGTGTCAGGAGATGTATTTGACATATGGAGATG
GAGAAGAAGTTGGTGGAATGTGGGTTGAAAAGGTTCTCCAGCTCTATCAGATCACCCAGATCAATCATGGCCTGATGATGGTGGGGCCCT
CGGGAAGTGGGAAGAGCATGGCCTGGCGTGTCCTGCTGAAGGCATTGGAGAGACTCGAGGGTGTGGAAGGTGTGGCCCATATCATCGACC
CCAAGGCCATCAGCAAAGACCACCTCTACGGAACCCTGGACCCCAACACCAGGGAATGGACAGATGGGCTCTTCACACACGTGCTGAGAA
AGATCATCGACAGCGTGAGAGGCGAGCTGCAGAAGCGCCAGTGGATCGTCTTCGATGGCGATGTGGATCCAGAGTGGGTTGAGAACTTGA
ACTCAGTGCTGGATGACAATAAGCTCCTAACTTTGCCCAATGGAGAGCGCCTCAGTCTTCCACCCAATGTGAGAATAATGTTTGAGGTAC
AGGACTTGAAATACGCGACCTTGGCCACAGTGTCGCGCTGCGGCATGGTCTGGTTCAGTGAGGATGTGCTGAGCACCGACATGATCTTCA
ACAACTTCCTGGCCAGGCTGCGCAGCATCCCGCTGGATGAAGGGGAGGATGAGGCACAGCGGCGGCGTAAGGGCAAAGAGGATGAGGGGG
AGGAGGCCGCTTCCCCCATGCTGCAGATCCAAAGAGATGCAGCTACGATCATGCAACCGTACTTCACGTCCAACGGCCTGGTCACCAAGG
CGCTAGAGCACGCCTTCCAGCTGGAGCACATCATGGACCTAACACGCCTGCGCTGCCTGGGCTCGCTCTTCTCCATGCTGCACCAGGCCT
GCCGCAACGTGGCGCAGTATAACGCCAACCATCCCGACTTCCCCATGCAGATCGAGCAGCTGGAGCGCTACATTCAGCGATATCTGGTTT
ATGCCATACTCTGGTCCCTGTCTGGAGACAGCCGGCTAAAAATGAGAGCAGAGCTGGGTGAATACATCAGAAGAATCACGACCGTGCCTC
TGCCCACTGCGCCCAACATACCCATTATCGATTATGAGGTGTCCATCAGCGGAGAATGGTCTCCGTGGCAGGCCAAGGTGCCTCAGATTG
AAGTGGAGACGCACAAGGTGGCAGCCCCTGATGTCGTCGTGCCAACGCTGGACACAGTCCGCCACGAAGCCCTCTTGTACACTTGGCTGG
CCGAACACAAGCCCCTGGTCTTGTGTGGCCCTCCTGGGTCTGGCAAGACCATGACACTCTTCAGCGCCCTCCGGGCCTTGCCTGACATGG
AGGTGGTGGGTCTCAACTTCTCCAGTGCTACTACTCCAGAGCTGCTTCTGAAGACTTTTGATCACTACTGCGAGTACAGGCGCACACCTA
ATGGGGTGGTTTTGGCTCCTGTTCAACTTGGAAAGTGGCTGGTGTTGTTCTGTGATGAAATCAACTTGCCAGATATGGATAAATATGGGA
CCCAGAGGGTCATATCCTTCATCAGACAGATGGTGGAGCACGGAGGCTTTTACCGTACCTCAGATCAAACATGGGTGAAGCTGGAGAGAA
TCCAGTTTGTTGGGGCTTGTAATCCCCCCACAGACCCTGGAAGAAAGCCCCTCTCACACAGGTTCCTGCGCCACGTGCCTGTCGTGTATG
TGGATTACCCGGGCCCCGCCTCCCTCACACAGATCTACGGCACCTTCAACCGCGCCATGCTGAGGCTCATTCCATCCCTGCGGACGTATG
CAGAGCCGCTCACTGCTGCCATGGTGGAGTTCTACACCATGTCTCAGGAGAGATTCACCCAGGATACACAACCTCACTATATCTATTCAC
CCCGTGAAATGACTAGGTGGGTGAGAGGCATCTTTGAAGCGCTGAGACCTCTGGAGACCCTGCCTGTTGAAGGCCTCATTCGGATTTGGG
CACATGAAGCTCTGCGTCTCTTCCAAGATAGACTCGTAGAGGATGAGGAGAGGCGTTGGACTGATGAGAACATCGACACGGTTGCTCTGA
AGCACTTCCCTAACATCGACAGAGAGAAGGCAATGAGCCGACCCATCTTGTACAGCAACTGGCTGTCAAAGGATTACATCCCAGTAGACC
AAGAAGAGTTAAGAGATTATGTCAAAGCTAGGCTGAAGGTCTTTTATGAAGAAGAACTTGATGTTCCGCTGGTGCTGTTTAATGAAGTCC
TAGACCACGTGCTGAGGATTGACAGAATATTCCGTCAACCTCAAGGCCACTTGCTTCTGATTGGTGTTAGTGGAGCAGGAAAAACTACCC
TGTCTCGTTTCGTCGCCTGGATGAACGGTTTGAGTGTGTACCAGATTAAGGTCCATAGGAAGTACACAGGGGAAGACTTTGATGAAGATC
TACGGACAGTGTTGAGACGTTCTGGCTGTAAAAATGAAAAGATAGCATTTATAATGGATGAATCTAATGTGTTAGATTCTGGATTCCTGG
AGCGAATGAATACCCTTCTGGCCAATGGAGAGGTGCCTGGTCTCTTTGAAGGAGACGAGTATGCCACCTTGATGACGCAGTGCAAAGAGG
GGGCACAGAAGGAAGGCCTGATGCTGGACTCGCACGAGGAGCTCTACAAGTGGTTCACTAGCCAGGTTATCCGCAACCTCCACGTCGTGT
TCACCATGAACCCGTCCTCGGAGGGACTCAAGGACCGGGCAGCTACATCACCAGCACTTTTCAACAGGTGTGTGTTGAATTGGTTTGGAG
ACTGGTCCACCGAAGCACTGTATCAGGTTGGCAAAGAATTCACAAGTAAGATGGATCTGGAGAAGCCAAATTACATCGTGCCTGATTACA
TGCCAGTTGTGTATGATAAGCTGCCGCAGCCACCATCCCATCGGGAAGCCATTGTGAACAGCTGTGTGTTTGTTCATCAGACTCTTCACC
AGGCGAATGCTCGGCTAGCAAAGCGAGGCGGCAGAACGATGGCCATCACCCCTCGCCACTACCTGGACTTCATCAATCACTATGCCAACC
TGTTCCACGAGAAGCGGAGCGAGCTGGAGGAGCAGCAGATGCACTTGAACGTGGGGCTCAGGAAGATCAAAGAGACAGTCGACCAGGTAG
AAGAACTGCGTCGTGACTTGAGGATAAAGAGCCAAGAGCTGGAGGTGAAGAATGCAGCAGCCAATGACAAGCTGAAAAAGATGGTGAAAG
ACCAGCAGGAGGCTGAAAAGAAGAAGGTTATGAGCCAAGAAATCCAGGAACAGCTGCATAAGCAGCAGGAGGTAATTGCAGACAAACAGA
TGAGTGTCAAAGAAGATCTTGATAAGGTGGAACCTGCCGTCATTGAGGCCCAGAATGCTGTGAAGTCGATCAAGAAGCAGCACCTGGTGG
AGGTGAGGTCCATGGCCAACCCTCCTGCTGCTGTGAAGCTGGCGCTGGAGTCCATCTGCCTGCTGCTGGGGGAAAGCACCACAGACTGGA
AGCAGATCCGCTCCATCATCATGCGGGAGAACTTCATCCCCACCATCGTCAACTTCTCTGCAGAGGAGATCAGTGACGCCATAAGGGAGA
AGATGAAGAAAAATTACATGTCCAATCCAAGTTACAATTATGAAATTGTGAATCGGGCTTCCCTGGCTTGCGGCCCTATGGTGAAATGGG
CAATTGCACAGCTTAACTATGCAGACATGTTAAAGAGAGTGGAGCCCCTACGCAATGAGCTGCAGAAGCTGGAAGATGACGCCAAGGACA
ACCAGCAGAAGGCCAACGAGGTGGAGCAGATGATCCGAGACCTGGAAGCCAGCATCGCCCGCTACAAGGAGGAATACGCCGTCCTGATCT
CAGAGGCCCAGGCCATCAAGGCAGACCTGGCAGCTGTCGAGGCAAAAGTAAACCGGAGCACTGCTCTTCTGAAGAGCTTGTCTGCTGAAC
GTGAACGATGGGAAAAAACAAGTGAAACTTTCAAAAACCAGATGTCCACCATTGCTGGGGACTGTCTCTTGTCAGCTGCGTTCATTGCCT
ACGCGGGTTACTTTGACCAGCAGATGCGTCAGAACTTGTTCACTACCTGGTCCCATCACCTACAGCAAGCCAACATCCAGTTCCGTACAG
ATATTGCCAGGACGGAATACCTTTCCAATGCTGATGAGCGTCTTCGCTGGCAGGCCAGCTCCTTGCCTGCTGATGACCTTTGCACAGAAA
ATGCCATCATGCTGAAACGATTCAATAGGTATCCGCTGATCATTGACCCCTCTGGACAGGCCACAGAATTCATTATGAATGAATATAAGG
ATCGTAAGATCACACGGACCAGCTTCCTGGATGACGCCTTCAGAAAGAACTTAGAGAGTGCACTGAGATTCGGTAACCCCCTTCTGGTCC
AGGATGTGGAAAGCTACGATCCAGTTTTGAACCCGGTGCTGAACCGTGAAGTGCGGCGAACAGGGGGGAGAGTGCTGATCACTCTCGGGG
ACCAGGACATAGACCTGTCGCCATCGTTTGTCATCTTCCTGTCCACCCGGGATCCAACTGTCGAGTTCCCACCAGATCTCTGTTCCCGGG
TTACTTTTGTAAACTTCACAGTTACCCGTAGCAGTTTACAAAGCCAGTGTCTAAATGAAGTACTTAAAGCAGAAAGACCTGATGTGGACG
AGAAACGATCTGATCTTCTTAAACTTCAAGGGGAATTTCAGCTCCGTTTGCGTCAGCTGGAAAAATCTCTACTACAAGCTCTGAACGAGG
TGAAAGGGCGCATTTTGGATGACGACACGATCATAACCACTCTGGAGAACCTGAAGAGAGAGGCTGCAGAGGTCACCAGGAAAGTTGAGG
AGACGGACATTGTCATGCAGGAGGTGGAGACCGTGTCCCAGCAGTACCTCCCGCTCTCCACCGCCTGCAGCAGCATCTACTTCACCATGG
AGTCCCTCAAGCAGATACACTTCTTGTACCAGTACTCCCTCCAGTTTTTCCTGGACATTTATCACAACGTCCTATACGAGAACCCGAACC
TGAAGGGTGTCACCGACCACACACAGCGCCTGTCCATTATAACAAAGGACCTCTTCCAGGTGGCGTTTAACCGAGTGGCTCGAGGCATGC
TGCATCAGGACCACATTACCTTTGCCATGCTGCTGGCAAGAATCAAACTGAAGGGCACCGTGGGGGAGCCCACCTACGATGCAGAATTCC
AGCACTTCTTGAGAGGAAATGAGATTGTCCTGAGTGCTGGCTCCACCCCCAGGATCCAGGGCCTGACTGTGGAGCAGGCGGAGGCGGTGG
TGAGGCTGAGCTGCCTTCCCGCGTTTAAGGACTTGATTGCAAAGGTTCAGGCAGACGAGCAATTTGGCATCTGGCTGGACAGCAGCTCCC
CGGAGCAGACTGTGCCCTACCTCTGGAGTGAAGAAACACCTGCAACACCCATTGGCCAGGCCATCCACCGCCTGCTCCTGATCCAGGCTT
TCCGGCCCGATCGCCTGTTGGCCATGGCCCACATGTTTGTTTCAACAAACCTTGGGGAGTCTTTCATGTCCATCATGGAGCAGCCGCTCG
ACCTGACCCACATTGTGGGCACAGAGGTGAAGCCCAACACTCCTGTCTTAATGTGCTCTGTGCCTGGTTATGATGCCAGTGGACATGTCG
AGGACCTTGCAGCCGAGCAGAACACGCAGATCACTTCAATTGCAATCGGCTCTGCAGAAGGCTTTAACCAAGCAGATAAGGCAATAAACA
CCGCTGTAAAGTCGGGCAGGTGGGTGATGCTGAAGAATGTGCATCTGGCCCCAGGGTGGCTGATGCAGCTGGAGAAGAAGTTGCATTCCC
TGCAGCCGCATGCCTGCTTCCGACTCTTCCTCACCATGGAGATCAACCCCAAGGTGCCTGTGAATCTGCTCCGTGCGGGCCGCATCTTTG
TGTTCGAGCCACCGCCAGGGGTGAAGGCCAACATGCTGAGGACGTTCAGCAGCATTCCCGTCTCACGGATATGCAAGTCTCCCAACGAGC
GTGCCCGCTTGTACTTCCTGCTGGCCTGGTTTCATGCGATCATCCAAGAACGCTTACGATACGCACCACTGGGGTGGTCAAAGAAGTATG
AATTTGGAGAGTCTGACCTGCGGTCAGCTTGCGATACGGTGGACACGTGGCTGGATGACACGGCCAAGGGCAGGCAGAACATCTCACCGG
ATAAGATCCCGTGGTCTGCACTAAAGACCTTAATGGCCCAGTCCATTTATGGCGGGCGCGTGGACAACGAGTTTGACCAGCGTCTGCTCA
ACACCTTCCTGGAGCGCCTGTTCACAACCAGGAGTTTCGACAGTGAGTTTAAGCTGGCATGCAAGGTCGACGGACATAAAGACATTCAAA
TGCCAGATGGCATCAGGCGAGAGGAGTTTGTGCAGTGGGTGGAGTTGCTCCCCGACACCCAGACGCCCTCCTGGCTGGGCCTGCCCAACA
ACGCCGAGAGAGTCCTCCTTACCACACAGGGTGTGGACATGATCAGTAAAATGCTGAAGATGCAGATGTTGGAGGATGAGGACGACCTGG
CCTACGCAGAGACTGAGAAGAAGACGAGGACAGACTCCACGTCCGACGGGCGCCCTGCCTGGATGCGGACACTGCACACCACCGCGTCCA
ACTGGCTGCACCTCATCCCCCAGACGCTGAGCCACCTCAAGCGCACCGTGGAGAATATCAAGGATCCTTTGTTCAGGTTCTTTGAGAGAG
AAGTGAAGATGGGCGCAAAGCTGCTTCAGGACGTTCGCCAGGACCTTGCAGATGTCGTCCAGGTGTGCGAAGGAAAGAAGAAGCAGACCA
ACTACTTGCGCACGCTGATCAACGAGCTAGTGAAAGGGATCTTGCCTCGGAGCTGGTCCCACTACACGGTGCCTGCCGGCATGACCGTCA
TCCAGTGGGTGTCCGACTTCAGCGAGAGGATCAAACAGCTGCAGAACATCTCACTGGCAGCTGCATCTGGTGGCGCCAAGGAGCTAAAGA
ACATCCACGTGTGCCTGGGTGGCCTGTTCGTGCCTGAGGCGTACATCACTGCCACCAGGCAGTATGTGGCCCAGGCCAACAGCTGGTCCC
TGGAGGAGCTCTGCCTGGAAGTCAACGTCACCACCTCACAGGGCGCCACCCTTGACGCTTGCAGCTTCGGAGTCACGGGTTTGAAACTTC
AAGGGGCCACGTGCAACAACAACAAGCTGTCACTGTCCAATGCCATCTCAACCGCCCTTCCCCTGACGCAGCTGCGCTGGGTCAAGCAGA
CAAACACCGAGAAGAAGGCCAGTGTGGTAACCTTACCTGTCTACCTGAACTTCACCCGTGCAGACCTCATCTTCACCGTGGACTTCGAAA
TTGCTACAAAGGAGGATCCTCGCAGCTTCTACGAGCGGGGTGTCGCAGTCTTGTGCACAGAGTAAACTTTTCTAGCTGCCCCTTTCTGTA
ATAGTGAAAGTTGGTATTTAACATTTATTCATTTTTAAAATATTTGGAAGGTCTGAGCTTGTGAAAAGAAAGTGGTTGGTCTGAGGTTGG
AGGAAGCTGAATGGAATCTGACGGTTGGGAGTGGTGGAAATTGGAAGGATACCAGGAGGTATTTGGGAAGGCCAATGGCGTGGCTCCTTT
GAGGAAATAAAACACTAAGCATGAAAAAGAAAGAAGAGGGTGTTATTGATTCATCTGACAAAGAAATCGTTGCTGAAGCAGAAAGACTGG
ATGTAAAAGCCATGGGCCCTCTTGTTCTAACTGAAGTTCTTTTTAATGAGAAGATTAGAGAACAGATTAAGAAATACAGGCGCCATTTCC
TACGATTTTGTCACAACAACAAAAAAGCCCAACGGTACCTTCTTCATGGTTTGGAGTGTGTGGTAGCAATGCATCAAGCTCAGCTTATCT
CCAAGATTCCACATATCTTGAAGGAGATGTACGATGCAGACCTTTTAGAAGAAGAGGTCATCATCAGCTGGTCGGAAAAGGCCTCTAAGA
AATATGTCTCCAAAGAACTTGCCAAAGAGATTCGTGTCAAAGCAGAACCATTTATAAAATGGTTGAAGGAGGCAGAGGAAGAATCTTCTG
GTGGCGAAGAAGAAGATGAAGATGAGAACATTGAGGTGGTGTATTCGAAGGCTGCCAGTGTACCGAAAGTTGAGACTGTAAAGTCAGACA
ACAAGGATGACGACATCGATATTGATGCCATTTAAAGGGATGGATGCAACCTAGCTTAACAGTATAATGCTGCAAATTTTCCTCCATTAT
CAGCCAGAAGTGCAACATGTATGTGCAAAAGCTAAAATGGCTTAACATCATGCTACACTTTACACTAAAAATCTATTACTGTGAGTGGTC
TGTTATTAAGCCCAATGAGACATCTAGGGAGTCCATACACATCAGTGAGCAGATGTAGTTTGCTTATTTATAGCATGTTTCTTTTTGAAA
AACTAGTGGTGGACACATTTGGATCACATTTATACAGTTATAAAAATAAAGGTTTGATTTTGGTCGTTCTTCAGATGTTTGGCTCTGAAT
GACTTAAGCTGAAGTAACTGGCTCCTTACTTTAAATGTTCTGCCATCATTTCACCTGATGAGCATTCTTGGAGCCTGCCAGATATTGTTA
GGTCCTGGGGCTGCAAAGAGGTCCTCAACAGGATGTAAAGCAAACTTAATTGTAATTAATTTATTCAGCCCATTAAGAAAGTACTAAAGT
TTTATCTCTGTAGTTCCTCAAATTGGCATCTGGTAATGTACATTGTGAGGTAGACTGATAATGAAATGACAGTGTAACATCTTAACCAAG
AAGTAAATATGACCTCAGTGTCCTATAAATAATGTAAGAGCAGGATTTGAAACTTGGAGAGCTGTTTTCTCATTTCATGTACACTTGCCC
CAAATTGTCTTTGAAGTCGTGTGCATTGCACGTTGGATGAGCCAGGGAAATTATTACATTAACAAGCATTTTGTGTGTACGTAGTAGTTA
CTTTGTACTGAGAGAACTTGCTTTGGGGTGCAATTAATAAACTGATTTTATTTGGGAGAAACAAGGAAGGGTGCACTTAACTAGCAACCT
AAGCATGATTTTTCAGCTTTTGCCCTTAGGGTTTAAATTACAATTCCAAAATGTTAGACATACTGTATTTTTTCGTTCAGTGTGGCTTTA
ATTTTCCCCTCTTGCAGTTTGTTCTGTAATGCCTTTTACATTTGGACACATAGTTTATGCTTTTTAGATTTTGGTTGCTTTCTTGCCAAA
ATAAGTGTTAACTGTGTTTCAAACTTGATTTTCTTTCCTTTTTCTTTTTTTTTTCTTCCAGAATGTCTTATTTAAAAAGAAAGCTAAAAG
CATACTTCTAAGTCAGAGCCTCTATTTTGGTGTAAGACTTGGGATATTTTTTACTTCACATTGAATATAGCCAGGCACCCAAGAAGTCTG
ATGGCCACCTGAGTGCAGGTGACAAGGACCTGACAGAGCCCATGCAGGGCTTTAGATTTGGACACACAAGAGTTGATAACTTCCTCATGA
ACTCCTTGCCTGATCTAAACTCATATTATGGGTTCTGACTGTTTGAGTAATCATCTTCAAGGTTAAACCTCTTGGCAGTTACCCTTTTCA
CAAAGTGCACAGTGGGAATCGAGAATCGATAGGGTTAATTTTGGAGCAGTGGCTTATACCATTCACCTCTGTTTTTTTGTGATTATTTCA
CAGATAATGAGACCTTAATAACAAATAGGCGTAAAAAAATTTTCACATTGAAATGATAGAAACATTTGATGTAATAAAACTTGGTTGGCT
TGATATTTTAAGGAATTGAAACCTAGCAATCTTATTGGAGAGACAAGAATTGGTCTCCAGCTGCCTTTGATCAAGATTCGGGTGCAAGTG
GAGCAGGAGCCATATACCTGGAGGGAATGTGCTTTGTCACACCAAAGAGGATTTTTTTTTCTTCAAACTTGTATGTTGCCTAGGTTTCAA
ATTCTTTGCCGCAAGGCTGATCTGCTTTCATTAACTGGAATTCTGTAGGAGATACTGGTGACCTAAGCTAAGTTGCACTCAGCATACTCA
GTGTCAAGCTAATGAGGTTCTATTATAAAGGTTCTACTTTTAATCTGAGGGAAAACATGTTCAGGGCTTCTAGAACACTAAAAAATTTGG
CTTAAACCAGTGTTCAGTCTGGTGCCAAACTTCGAATGGAATACAAATTCACATAATCTGAACTTTGTTCACAGGTTATCCTAATAGAGT
AATTCTTCACTTTGCTCTATTGAACTGTCTTAAGGATTTGTTTAAACAGCTAAGTTACTTGATTAAAATAATGATAAAATTGTATTTTGT

>24591_24591_2_DYNC1H1-EIF5_DYNC1H1_chr14_102517128_ENST00000360184_EIF5_chr14_103805509_ENST00000558506_length(amino acids)=4654AA_BP=
MEGPERDTMSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKSALEQMRKFLSDPQVHTVLVERS
TLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKAD
RDGDKMAPSVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVNRWIREIQKVTKL
DRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDK
IRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKR
EENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKE
VDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIESLHDK
FKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLG
VSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTIS
LLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHS
YSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYKL
YQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRL
GEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTAS
TSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVES
RTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQ
IDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLG
QIWDVDLQKNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALS
WEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQ
KALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINEWL
TLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVL
ADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQT
PLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVS
QQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTA
EVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAE
DIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALE
RLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGER
LSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATI
MQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRA
ELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKT
MTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGF
YRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQE
RFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPIL
YSNWLSKDYIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIK
VHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYK
WFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREA
IVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVK
NAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALE
SICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPL
RNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMST
IAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDP
SGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTR
DPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLEN
LKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKD
LFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPTYDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQ
ADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVL
MCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINP
KVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLGWSKKYEFGESDLRSACDTVDTW
LDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELL
PDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTV
ENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNI
SLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGVTGLKLQGATCNNNKLSLSNAIS

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Fusion Gene PPI Analysis for DYNC1H1-EIF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-7878448_7034723.04647.0DYNC1I2
HgeneDYNC1H1chr14:102517128chr14:103805509ENST00000360184-7878651_8024723.04647.0DYNC1LI2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYNC1H1-EIF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYNC1H1-EIF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource