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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYNC1I2-GREB1L (FusionGDB2 ID:24618)

Fusion Gene Summary for DYNC1I2-GREB1L

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC1I2-GREB1L
Fusion gene ID: 24618
HgeneTgene
Gene symbol

DYNC1I2

GREB1L

Gene ID

1781

80000

Gene namedynein cytoplasmic 1 intermediate chain 2GREB1 like retinoic acid receptor coactivator
SynonymsDIC74|DNCI2|IC2|NEDMIBAC18orf6|KIAA1772|RHDA3
Cytomap

2q31.1

18q11.1-q11.2

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 1 intermediate chain 2DH IC-2dynein intermediate chain 2, cytosolicdynein, cytoplasmic, intermediate polypeptide 2testis tissue sperm-binding protein Li 66nGREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like
Modification date2020031520200313
UniProtAcc

Q13409

Q9C091

Ensembl transtripts involved in fusion geneENST00000263811, ENST00000340296, 
ENST00000358002, ENST00000397119, 
ENST00000409197, ENST00000409317, 
ENST00000409453, ENST00000409773, 
ENST00000410079, ENST00000508530, 
ENST00000534253, 		ENST00000269218, 
ENST00000400483, ENST00000424526, 
ENST00000431264, ENST00000578368, 
ENST00000580732, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 12 X 5=600
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/600*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNC1I2 [Title/Abstract] AND GREB1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNC1I2(172546729)-GREB1L(18927925), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGREB1L

GO:0001822

kidney development

29100091


check buttonFusion gene breakpoints across DYNC1I2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GREB1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF217941DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-


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Fusion Gene ORF analysis for DYNC1I2-GREB1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263811ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000263811ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000263811ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000263811ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000263811ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000263811ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000340296ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000358002ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000397119ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409197ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409317ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409453ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000409773ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000410079ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000508530ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000269218DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000400483DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000424526DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000431264DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000578368DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-
5CDS-intronENST00000534253ENST00000580732DYNC1I2chr2

172546729

+GREB1Lchr18

18927925

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DYNC1I2-GREB1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYNC1I2-GREB1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:172546729/:18927925)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNC1I2

Q13409

GREB1L

Q9C091

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}.FUNCTION: Plays a major role in early metanephros and genital development. {ECO:0000269|PubMed:29100091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DYNC1I2-GREB1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DYNC1I2-GREB1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYNC1I2-GREB1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYNC1I2-GREB1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource