FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DYNC1I2-HNRNPA2B1 (FusionGDB2 ID:24619)

Fusion Gene Summary for DYNC1I2-HNRNPA2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC1I2-HNRNPA2B1
Fusion gene ID: 24619
HgeneTgene
Gene symbol

DYNC1I2

HNRNPA2B1

Gene ID

1781

3181

Gene namedynein cytoplasmic 1 intermediate chain 2heterogeneous nuclear ribonucleoprotein A2/B1
SynonymsDIC74|DNCI2|IC2|NEDMIBAHNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1
Cytomap

2q31.1

7p15.2

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 1 intermediate chain 2DH IC-2dynein intermediate chain 2, cytosolicdynein, cytoplasmic, intermediate polypeptide 2testis tissue sperm-binding protein Li 66nheterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1/MYC fusionepididymis secretory sperm binding proteinhnRNP A2 / hnRNP B1nuclear ribonucleoprotein particle A2 protein
Modification date2020031520200314
UniProtAcc

Q13409

P22626

Ensembl transtripts involved in fusion geneENST00000358002, ENST00000409197, 
ENST00000409317, ENST00000409453, 
ENST00000409773, ENST00000263811, 
ENST00000340296, ENST00000397119, 
ENST00000410079, ENST00000508530, 
ENST00000534253, 		ENST00000354667, 
ENST00000356674, ENST00000476233, 
Fusion gene scores* DoF score3 X 3 X 2=1824 X 27 X 5=3240
# samples 330
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(30/3240*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNC1I2 [Title/Abstract] AND HNRNPA2B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNC1I2(172544311)-HNRNPA2B1(26233215), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHNRNPA2B1

GO:0006397

mRNA processing

2557628

TgeneHNRNPA2B1

GO:0006406

mRNA export from nucleus

10567417

TgeneHNRNPA2B1

GO:0031053

primary miRNA processing

26321680

TgeneHNRNPA2B1

GO:0050658

RNA transport

17004321

TgeneHNRNPA2B1

GO:1990428

miRNA transport

24356509


check buttonFusion gene breakpoints across DYNC1I2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HNRNPA2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE841726DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+


Top

Fusion Gene ORF analysis for DYNC1I2-HNRNPA2B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000358002ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000358002ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000358002ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409197ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409197ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409197ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409317ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409317ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409317ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409453ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409453ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409453ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409773ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409773ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
5UTR-intronENST00000409773ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000263811ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000263811ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000263811ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000340296ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000340296ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000340296ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000397119ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000397119ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000397119ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000410079ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000410079ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000410079ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000508530ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000508530ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000508530ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000534253ENST00000354667DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000534253ENST00000356674DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+
intron-intronENST00000534253ENST00000476233DYNC1I2chr2

172544311

-HNRNPA2B1chr7

26233215

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DYNC1I2-HNRNPA2B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DYNC1I2-HNRNPA2B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:172544311/:26233215)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNC1I2

Q13409

HNRNPA2B1

P22626

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}.FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for DYNC1I2-HNRNPA2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DYNC1I2-HNRNPA2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DYNC1I2-HNRNPA2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DYNC1I2-HNRNPA2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource