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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DYNC1LI1-GADL1 (FusionGDB2 ID:24622)

Fusion Gene Summary for DYNC1LI1-GADL1

Fusion gene summary

Fusion gene information	Fusion gene name: DYNC1LI1-GADL1
	Fusion gene ID: 24622
		Hgene	Tgene
	Gene symbol	DYNC1LI1	GADL1
	Gene ID	51143	339896
	Gene name	dynein cytoplasmic 1 light intermediate chain 1	glutamate decarboxylase like 1
	Synonyms	DLC-A\|DNCLI1\|LIC1	ADC\|CSADC\|HuADC\|HuCSADC
	Cytomap	3p22.3	3p24.1-p23
	Type of gene	protein-coding	protein-coding
	Description	cytoplasmic dynein 1 light intermediate chain 1dynein light chain Adynein light intermediate chain 1, cytosolicdynein, cytoplasmic, light intermediate polypeptide 1	acidic amino acid decarboxylase GADL1aspartate 1-decarboxylasecysteine sulfinic acid decarboxylaseglutamate decarboxylase-like protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q9Y6G9	Q6ZQY3
	Ensembl transtripts involved in fusion gene	ENST00000273130, ENST00000432458,	ENST00000454381, ENST00000498387, ENST00000282538,
Fusion gene scores	* DoF score	5 X 6 X 4=120	7 X 7 X 6=294
	# samples	6	7
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DYNC1LI1 [Title/Abstract] AND GADL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DYNC1LI1(32611838)-GADL1(30903257), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DYNC1LI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GADL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-0790-01B	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-

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Fusion Gene ORF analysis for DYNC1LI1-GADL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000273130	ENST00000454381	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-
5CDS-intron	ENST00000273130	ENST00000498387	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-
5CDS-intron	ENST00000432458	ENST00000454381	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-
5CDS-intron	ENST00000432458	ENST00000498387	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-
In-frame	ENST00000273130	ENST00000282538	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-
In-frame	ENST00000432458	ENST00000282538	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000273130	DYNC1LI1	chr3	32611838	-	ENST00000282538	GADL1	chr3	30903257	-	3895	324	104	1852	582
ENST00000432458	DYNC1LI1	chr3	32611838	-	ENST00000282538	GADL1	chr3	30903257	-	3879	308	88	1836	582

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000273130	ENST00000282538	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-	0.000357809	0.99964213
ENST00000432458	ENST00000282538	DYNC1LI1	chr3	32611838	-	GADL1	chr3	30903257	-	0.000362424	0.9996376

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Fusion Genomic Features for DYNC1LI1-GADL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYNC1LI1-GADL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:32611838/chr3:30903257)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DYNC1LI1 Q9Y6G9	GADL1 Q6ZQY3
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. {ECO:0000269\|PubMed:19229290}.	FUNCTION: May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000269\|PubMed:23038267}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DYNC1LI1

chr3:32611838

chr3:30903257

ENST00000273130

74_81

524.0

Nucleotide binding

ATP

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Fusion Gene Sequence for DYNC1LI1-GADL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24622_24622_1_DYNC1LI1-GADL1_DYNC1LI1_chr3_32611838_ENST00000273130_GADL1_chr3_30903257_ENST00000282538_length(transcript)=3895nt_BP=324nt
GTGCGCTGAACGCCCCATATCCGGGTTCCCGCCGCCTCCACCGCCACCGCCTCAGCCGCCTCGCACATTTAGTCTTGCCGGGAGTGGTGT
GATTCCCGACCAAGATGGCGGCCGTGGGGCGAGTCGGCTCCTTCGGTTCTTCTCCGCCGGGATTATCCTCGACTTACACTGGCGGCCCCT
TGGGCAACGAGATAGCGTCGGGCAACGGTGGCGCCGCGGCAGGCGACGACGAGGACGGGCAGAACCTTTGGTCCTGCATCCTCAGCGAGG
TCTCCACCCGCTCGCGCTCCAAGCTCCCTGCGGGGAAGAACGTGCTACTGCTGGGAGATATTGATCAACAAGAGATGATTCCAAGTAAGA
AGAATGCTGTTCTTGTGGATGGGGTTGTGCTGAATGGTCCTACAACAGATGCAAAAGCTGGAGAAAAATTTGTTGAAGAGGCCTGTAGGC
TAATAATGGAAGAGGTGGTTTTGAAAGCTACAGATGTCAATGAGAAGGTGTGTGAATGGAGGCCTCCTGAACAACTGAAACAGCTTCTTG
ATTTGGAGATGAGAGACTCAGGCGAGCCACCCCATAAACTATTGGAACTCTGTCGGGATGTCATACACTACAGTGTCAAAACTAACCACC
CAAGATTTTTCAACCAATTGTATGCTGGACTTGATTATTACTCCTTGGTGGCCCGATTTATGACCGAAGCATTGAATCCAAGTGTTTATA
CGTATGAGGTGTCCCCAGTGTTTCTGTTAGTGGAAGAAGCGGTTCTGAAGAAAATGATTGAATTTATTGGCTGGAAAGAAGGGGATGGAA
TATTTAACCCAGGTGGCTCAGTGTCCAATATGTATGCAATGAATTTAGCTAGATACAAATATTGTCCTGATATTAAGGAAAAGGGGCTGT
CTGGTTCGCCAAGATTAATCCTTTTCACATCTGCAGAGTGTCATTACTCTATGAAGAAGGCAGCCTCTTTTCTTGGGATTGGCACTGAGA
ATGTTTGCTTTGTGGAAACAGATGGAAGAGGTAAAATGATACCTGAGGAACTGGAGAAGCAAGTCTGGCAAGCCAGAAAAGAGGGGGCAG
CACCGTTTCTTGTCTGTGCCACTTCTGGTACAACTGTGTTGGGAGCTTTTGACCCTCTGGATGAAATAGCAGACATCTGCGAGAGGCACA
GCCTCTGGCTTCATGTAGATGCTTCTTGGGGTGGCTCAGCTTTGATGTCGAGGAAGCACCGCAAGCTTCTGCATGGCATCCACAGGGCTG
ACTCTGTGGCCTGGAACCCACACAAGATGCTGATGGCTGGGATCCAGTGCTGTGCTCTCCTTGTGAAAGACAAATCTGATCTTCTTAAAA
AATGCTACTCTGCCAAGGCATCTTACCTCTTCCAGCAGGATAAATTCTATGATGTGAGCTATGACACAGGAGACAAGTCTATCCAGTGTA
GCAGAAGACCAGATGCATTCAAGTTCTGGATGACCTGGAAGGCCCTGGGTACATTAGGCCTTGAAGAAAGAGTTAATCGTGCTCTTGCTT
TATCTAGGTACCTAGTAGATGAAATCAAGAAAAGAGAAGGATTCAAGTTACTGATGGAACCTGAATATGCCAATATTTGCTTTTGGTACA
TTCCACCGAGCCTCAGAGAGATGGAAGAAGGACCCGAGTTCTGGGCAAAACTTAATTTGGTGGCCCCAGCCATTAAGGAGAGGATGATGA
AGAAGGGAAGCTTGATGCTGGGCTACCAGCCGCACCGGGGAAAGGTCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGG
AGGACATGGACTTCCTCCTGGATGAGATAGACTTACTGGGTAAAGACATGTAGCTGTGGCTTTGGTCCCCCAGAGGCATAGATCCTATCC
TGGGAGAGTTTAGATCCAGAACATCTTGGAGATACACAGTAGATTGCAGCCCTTCTGATGAGAAATAGGGAATACTCCCAGTCCAGGCCC
AGCAAAACCAAAATGCTAAGCAATGAATATTAAGGACTCTCTAGCTGCCTGGGCATTACTGTTGCTAAAAGAAGAAAGTTTAAAAAAAAA
AATGATTTTCTCAAGGAATGCCCCTGGAACACAGCTCTGAAGAGAGTTTAGTAAGTACCATGTAGGTTCTGGATTCTAAGCTTACATTGC
TCTTTAAAGAACTTATAAACTAACGGTTTAAAGCAGTGGTTCTCAAAGTGTGGTCCCTGGACTATCAGCATCAAAGCATCACCTGGGAAC
TTGCTAAAAATGCAGATTCTCAGGCTTTCTCTAGACCAACTGGATCAGAAGCTCTGGGGGTGAGGCCCAGTATTCTGTGTTTTAACAAGC
CCGTCAGGGAATTCTGATGCACAGTAAAATCCGAGAAACACTGGTTTAAGAAAAACCTTGTAATGATCGAATACCCACTCTGATGTTTTG
CCAGCAAAGGGATATCTAATATTTCAGAAGCCTCTGAGCCAGTCTTTGAAAAAATACAACTATGGCATCTGCAGCACAAATATTTAAGGA
CATCAGAAGCATGTCAAAGCTATTTTTAAAGAGAGAAACTGTATAAGATGTTTACTTCATAGAGATTTATGTTTTATGCAGGCTGAATGT
TTATCTCAAAAGTTAAAATTATCCATTCTCAAAAGTTAAAATTATATATATATATATATATACACACACACACATATATATATATATATA
ATTCAAAGCACAATAATTGAAAGCACAATAATTGACAGAAAAATACAGGTTCTATTAATAAATTAATAAACTGTTGGTCTTCAAAATAGA
AATGCATGTAATATCCATATTAGTTTTTTCTTGGTAGACAACTGGAAGGTTTTCTTTTTTTTCGTCTATGACTAATTTTCTTTATTCAAG
ATACCTGAACTGGGGTGCTTTTTAAGAAAAATTTGGGAAATATATATGTTTCTGTGATATACATATATACATATATATGTATATATATAC
ACACACATACATATGTGTGTGTATAGTATATATATATATACACACATATATGTTTCTGTGTTCCTCTTTTAGCTTGAGGGGCTTGTTTAT
TATCTTGCTCTGTGCCTCATAGGGAATAAACACAATGAAGTCCAGGGTTGTACAACATTCCCTTTCCTAAGCTTTGAAATGTCAGTATAG
ATTATTAAGTGGTTTATATTACAGAATCTGGGATTCAGCAGACTTTCAGTGTAAATGCTTCCTCCATTTCTCCTGAGAGTGGGTGATTTT
AATTCTATCTCTGACCCTGGTCCTAGGTTTCTAGGAGAGTTTTGTTTAACTAAGAAATTGACAGAATTCATAGGTGTGGGTGTAGAGTTC
ACCAAGATAAGATTATGAATATAATTAAAGGTCTGCATTAAAAGGTGAATGATTGAAGAGTGTTAAAGCATTAGACTTAGCACATTCAAT
AACCTTTTCGTACTCCATTGTTAACCAATGTCATTTAAATTTTGAGTACTATTTGCTTTTATTGCTTATTTTCATTTTAGTGTGCACAGT
TTCTCGGTATCTCTATTGGTCAAAGAATATTAAATCTGTCTCTGAATTACTTCAAATTCTCAGGTGAAACCTATTGGTGTGTGTGTGTGT
GTGTGTGTGTTTATTTTGCATTTCTTGTTGCCTTTTTGTTTTAATGTCTACATAAAATATTTCTAAAATTGATGTTTGTAACAATTTGGG
TTTCATGAAACAAAAAGGAACATTACTATACTTAGTGTTGTTGACTTTTCTTTTCCTGTCATCTCCTCTTTACTGGATTGTACCAATACA
TTTTAGAAGTGAACTGGACTTGGTTGGCATTTTAGTTTAATGACTGAAAAAGTAGGTTGAAAGCTCTCTGTATTTTAGTTAACACCTTGA

>24622_24622_1_DYNC1LI1-GADL1_DYNC1LI1_chr3_32611838_ENST00000273130_GADL1_chr3_30903257_ENST00000282538_length(amino acids)=582AA_BP=70
MAAVGRVGSFGSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGDIDQQEMIPSKKNAVL
VDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFN
QLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPR
LILFTSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLH
VDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPD
AFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSL

--------------------------------------------------------------
>24622_24622_2_DYNC1LI1-GADL1_DYNC1LI1_chr3_32611838_ENST00000432458_GADL1_chr3_30903257_ENST00000282538_length(transcript)=3879nt_BP=308nt
ATATCCGGGTTCCCGCCGCCTCCACCGCCACCGCCTCAGCCGCCTCGCACATTTAGTCTTGCCGGGAGTGGTGTGATTCCCGACCAAGAT
GGCGGCCGTGGGGCGAGTCGGCTCCTTCGGTTCTTCTCCGCCGGGATTATCCTCGACTTACACTGGCGGCCCCTTGGGCAACGAGATAGC
GTCGGGCAACGGTGGCGCCGCGGCAGGCGACGACGAGGACGGGCAGAACCTTTGGTCCTGCATCCTCAGCGAGGTCTCCACCCGCTCGCG
CTCCAAGCTCCCTGCGGGGAAGAACGTGCTACTGCTGGGAGATATTGATCAACAAGAGATGATTCCAAGTAAGAAGAATGCTGTTCTTGT
GGATGGGGTTGTGCTGAATGGTCCTACAACAGATGCAAAAGCTGGAGAAAAATTTGTTGAAGAGGCCTGTAGGCTAATAATGGAAGAGGT
GGTTTTGAAAGCTACAGATGTCAATGAGAAGGTGTGTGAATGGAGGCCTCCTGAACAACTGAAACAGCTTCTTGATTTGGAGATGAGAGA
CTCAGGCGAGCCACCCCATAAACTATTGGAACTCTGTCGGGATGTCATACACTACAGTGTCAAAACTAACCACCCAAGATTTTTCAACCA
ATTGTATGCTGGACTTGATTATTACTCCTTGGTGGCCCGATTTATGACCGAAGCATTGAATCCAAGTGTTTATACGTATGAGGTGTCCCC
AGTGTTTCTGTTAGTGGAAGAAGCGGTTCTGAAGAAAATGATTGAATTTATTGGCTGGAAAGAAGGGGATGGAATATTTAACCCAGGTGG
CTCAGTGTCCAATATGTATGCAATGAATTTAGCTAGATACAAATATTGTCCTGATATTAAGGAAAAGGGGCTGTCTGGTTCGCCAAGATT
AATCCTTTTCACATCTGCAGAGTGTCATTACTCTATGAAGAAGGCAGCCTCTTTTCTTGGGATTGGCACTGAGAATGTTTGCTTTGTGGA
AACAGATGGAAGAGGTAAAATGATACCTGAGGAACTGGAGAAGCAAGTCTGGCAAGCCAGAAAAGAGGGGGCAGCACCGTTTCTTGTCTG
TGCCACTTCTGGTACAACTGTGTTGGGAGCTTTTGACCCTCTGGATGAAATAGCAGACATCTGCGAGAGGCACAGCCTCTGGCTTCATGT
AGATGCTTCTTGGGGTGGCTCAGCTTTGATGTCGAGGAAGCACCGCAAGCTTCTGCATGGCATCCACAGGGCTGACTCTGTGGCCTGGAA
CCCACACAAGATGCTGATGGCTGGGATCCAGTGCTGTGCTCTCCTTGTGAAAGACAAATCTGATCTTCTTAAAAAATGCTACTCTGCCAA
GGCATCTTACCTCTTCCAGCAGGATAAATTCTATGATGTGAGCTATGACACAGGAGACAAGTCTATCCAGTGTAGCAGAAGACCAGATGC
ATTCAAGTTCTGGATGACCTGGAAGGCCCTGGGTACATTAGGCCTTGAAGAAAGAGTTAATCGTGCTCTTGCTTTATCTAGGTACCTAGT
AGATGAAATCAAGAAAAGAGAAGGATTCAAGTTACTGATGGAACCTGAATATGCCAATATTTGCTTTTGGTACATTCCACCGAGCCTCAG
AGAGATGGAAGAAGGACCCGAGTTCTGGGCAAAACTTAATTTGGTGGCCCCAGCCATTAAGGAGAGGATGATGAAGAAGGGAAGCTTGAT
GCTGGGCTACCAGCCGCACCGGGGAAAGGTCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGGAGGACATGGACTTCCT
CCTGGATGAGATAGACTTACTGGGTAAAGACATGTAGCTGTGGCTTTGGTCCCCCAGAGGCATAGATCCTATCCTGGGAGAGTTTAGATC
CAGAACATCTTGGAGATACACAGTAGATTGCAGCCCTTCTGATGAGAAATAGGGAATACTCCCAGTCCAGGCCCAGCAAAACCAAAATGC
TAAGCAATGAATATTAAGGACTCTCTAGCTGCCTGGGCATTACTGTTGCTAAAAGAAGAAAGTTTAAAAAAAAAAATGATTTTCTCAAGG
AATGCCCCTGGAACACAGCTCTGAAGAGAGTTTAGTAAGTACCATGTAGGTTCTGGATTCTAAGCTTACATTGCTCTTTAAAGAACTTAT
AAACTAACGGTTTAAAGCAGTGGTTCTCAAAGTGTGGTCCCTGGACTATCAGCATCAAAGCATCACCTGGGAACTTGCTAAAAATGCAGA
TTCTCAGGCTTTCTCTAGACCAACTGGATCAGAAGCTCTGGGGGTGAGGCCCAGTATTCTGTGTTTTAACAAGCCCGTCAGGGAATTCTG
ATGCACAGTAAAATCCGAGAAACACTGGTTTAAGAAAAACCTTGTAATGATCGAATACCCACTCTGATGTTTTGCCAGCAAAGGGATATC
TAATATTTCAGAAGCCTCTGAGCCAGTCTTTGAAAAAATACAACTATGGCATCTGCAGCACAAATATTTAAGGACATCAGAAGCATGTCA
AAGCTATTTTTAAAGAGAGAAACTGTATAAGATGTTTACTTCATAGAGATTTATGTTTTATGCAGGCTGAATGTTTATCTCAAAAGTTAA
AATTATCCATTCTCAAAAGTTAAAATTATATATATATATATATATACACACACACACATATATATATATATATAATTCAAAGCACAATAA
TTGAAAGCACAATAATTGACAGAAAAATACAGGTTCTATTAATAAATTAATAAACTGTTGGTCTTCAAAATAGAAATGCATGTAATATCC
ATATTAGTTTTTTCTTGGTAGACAACTGGAAGGTTTTCTTTTTTTTCGTCTATGACTAATTTTCTTTATTCAAGATACCTGAACTGGGGT
GCTTTTTAAGAAAAATTTGGGAAATATATATGTTTCTGTGATATACATATATACATATATATGTATATATATACACACACATACATATGT
GTGTGTATAGTATATATATATATACACACATATATGTTTCTGTGTTCCTCTTTTAGCTTGAGGGGCTTGTTTATTATCTTGCTCTGTGCC
TCATAGGGAATAAACACAATGAAGTCCAGGGTTGTACAACATTCCCTTTCCTAAGCTTTGAAATGTCAGTATAGATTATTAAGTGGTTTA
TATTACAGAATCTGGGATTCAGCAGACTTTCAGTGTAAATGCTTCCTCCATTTCTCCTGAGAGTGGGTGATTTTAATTCTATCTCTGACC
CTGGTCCTAGGTTTCTAGGAGAGTTTTGTTTAACTAAGAAATTGACAGAATTCATAGGTGTGGGTGTAGAGTTCACCAAGATAAGATTAT
GAATATAATTAAAGGTCTGCATTAAAAGGTGAATGATTGAAGAGTGTTAAAGCATTAGACTTAGCACATTCAATAACCTTTTCGTACTCC
ATTGTTAACCAATGTCATTTAAATTTTGAGTACTATTTGCTTTTATTGCTTATTTTCATTTTAGTGTGCACAGTTTCTCGGTATCTCTAT
TGGTCAAAGAATATTAAATCTGTCTCTGAATTACTTCAAATTCTCAGGTGAAACCTATTGGTGTGTGTGTGTGTGTGTGTGTGTTTATTT
TGCATTTCTTGTTGCCTTTTTGTTTTAATGTCTACATAAAATATTTCTAAAATTGATGTTTGTAACAATTTGGGTTTCATGAAACAAAAA
GGAACATTACTATACTTAGTGTTGTTGACTTTTCTTTTCCTGTCATCTCCTCTTTACTGGATTGTACCAATACATTTTAGAAGTGAACTG
GACTTGGTTGGCATTTTAGTTTAATGACTGAAAAAGTAGGTTGAAAGCTCTCTGTATTTTAGTTAACACCTTGAATAAAATGGAAAAAGC

>24622_24622_2_DYNC1LI1-GADL1_DYNC1LI1_chr3_32611838_ENST00000432458_GADL1_chr3_30903257_ENST00000282538_length(amino acids)=582AA_BP=70
MAAVGRVGSFGSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGDIDQQEMIPSKKNAVL
VDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFN
QLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPR
LILFTSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLH
VDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPD
AFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DYNC1LI1-GADL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DYNC1LI1-GADL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DYNC1LI1-GADL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source