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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYNC2H1-NARS2 (FusionGDB2 ID:24642)

Fusion Gene Summary for DYNC2H1-NARS2

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC2H1-NARS2
Fusion gene ID: 24642
HgeneTgene
Gene symbol

DYNC2H1

NARS2

Gene ID

79659

79731

Gene namedynein cytoplasmic 2 heavy chain 1asparaginyl-tRNA synthetase 2, mitochondrial
SynonymsATD3|DHC1b|DHC2|DNCH2|DYH1B|SRPS2B|SRTD3|hdhc11DFNB94|SLM5|asnRS
Cytomap

11q22.3

11q14.1

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 2 heavy chain 1dynein cytoplasmic heavy chain 2dynein heavy chain 11dynein heavy chain, isotype 1Bdynein, cytoplasmic, heavy polypeptide 2probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial
Modification date2020031320200313
UniProtAcc

Q8NCM8

Q96I59

Ensembl transtripts involved in fusion geneENST00000334267, ENST00000375735, 
ENST00000398093, 		ENST00000528850, 
ENST00000281038, 
Fusion gene scores* DoF score15 X 13 X 9=175529 X 15 X 11=4785
# samples 1537
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/4785*10)=-3.69292174885708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNC2H1 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNC2H1(102988592)-NARS2(78239982), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYNC2H1

GO:0007030

Golgi organization

8666668


check buttonFusion gene breakpoints across DYNC2H1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A57M-01ADYNC2H1chr11

102988592

+NARS2chr11

78239982

-


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Fusion Gene ORF analysis for DYNC2H1-NARS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334267ENST00000528850DYNC2H1chr11

102988592

+NARS2chr11

78239982

-
5CDS-5UTRENST00000375735ENST00000528850DYNC2H1chr11

102988592

+NARS2chr11

78239982

-
5CDS-5UTRENST00000398093ENST00000528850DYNC2H1chr11

102988592

+NARS2chr11

78239982

-
In-frameENST00000334267ENST00000281038DYNC2H1chr11

102988592

+NARS2chr11

78239982

-
In-frameENST00000375735ENST00000281038DYNC2H1chr11

102988592

+NARS2chr11

78239982

-
In-frameENST00000398093ENST00000281038DYNC2H1chr11

102988592

+NARS2chr11

78239982

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375735DYNC2H1chr11102988592+ENST00000281038NARS2chr1178239982-269211431441982612
ENST00000334267DYNC2H1chr11102988592+ENST00000281038NARS2chr1178239982-26011052531891612
ENST00000398093DYNC2H1chr11102988592+ENST00000281038NARS2chr1178239982-254899901838612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375735ENST00000281038DYNC2H1chr11102988592+NARS2chr1178239982-0.0002510740.9997489
ENST00000334267ENST00000281038DYNC2H1chr11102988592+NARS2chr1178239982-0.0002329580.999767
ENST00000398093ENST00000281038DYNC2H1chr11102988592+NARS2chr1178239982-0.00022410.99977595

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Fusion Genomic Features for DYNC2H1-NARS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYNC2H1-NARS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102988592/chr11:78239982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNC2H1

Q8NCM8

NARS2

Q96I59

FUNCTION: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+620145_152333921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+689145_1523334308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+690145_1523334315.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201074_1103333921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202897_2982333921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6203109_3200333921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6203408_3442333921.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891074_11033334308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892897_29823334308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6893109_32003334308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6893408_34423334308.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901074_11033334315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902897_29823334315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6903109_32003334315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6903408_34423334315.0Coiled coilOntology_term=ECO:0000255
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201689_1696333921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201979_1986333921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202291_2298333921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202655_2662333921.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891689_16963334308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891979_19863334308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892291_22983334308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892655_26623334308.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901689_16963334315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901979_19863334315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902291_22983334315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902655_26623334315.0Nucleotide bindingATP
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201651_1875333921.0RegionAAA 1
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201938_2161333921.0RegionAAA 2
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6201_1650333921.0RegionStem
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202251_2505333921.0RegionAAA 3
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202617_2863333921.0RegionAAA 4
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6202881_3169333921.0RegionStalk
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6203244_3473333921.0RegionAAA 5
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000334267+6203690_3905333921.0RegionAAA 6
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891651_18753334308.0RegionAAA 1
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891938_21613334308.0RegionAAA 2
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6891_16503334308.0RegionStem
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892251_25053334308.0RegionAAA 3
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892617_28633334308.0RegionAAA 4
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6892881_31693334308.0RegionStalk
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6893244_34733334308.0RegionAAA 5
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000375735+6893690_39053334308.0RegionAAA 6
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901651_18753334315.0RegionAAA 1
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901938_21613334315.0RegionAAA 2
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6901_16503334315.0RegionStem
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902251_25053334315.0RegionAAA 3
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902617_28633334315.0RegionAAA 4
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6902881_31693334315.0RegionStalk
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6903244_34733334315.0RegionAAA 5
HgeneDYNC2H1chr11:102988592chr11:78239982ENST00000398093+6903690_39053334315.0RegionAAA 6


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Fusion Gene Sequence for DYNC2H1-NARS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24642_24642_1_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000334267_NARS2_chr11_78239982_ENST00000281038_length(transcript)=2601nt_BP=1052nt
CTGGTTTCTTCTTCCTTCCCCCTTCCCCCAACTTCCCTCCACCCCTTCCAATCATGGCGAACGGGACTGCGGACGTTCGGAAGCTCTTCA
TCTTCACTACTACCCAGAATTACTTCGGGTTGATGTCTGAACTCTGGGATCAGCCACTGTTGTGCAACTGTCTTGAAATCAACAACTTCT
TGGATGACGGCAACCAGATGCTCCTCAGGGTGCAGCGATCCGACGCAGGAATCTCCTTTTCCAACACGATTGAGTTTGGTGACACAAAAG
ATAAAGTGCTGGTGTTTTTCAAGCTGCGACCTGAAGTAATTACTGATGAGAATCTACATGATAACATTCTTGTTTCATCTATGTTAGAGT
CACCTATTAGTTCTCTTTACCAAGCAGTACGGCAAGTATTCGCACCAATGTTGTTAAAGGATCAGGAATGGAGCAGAAACTTTGATCCCA
AACTTCAGAATCTTTTGAGTGAACTAGAAGCTGGGTTGGGTATAGTTCTACGAAGATCAGACACTAACTTAACAAAATTGAAATTTAAGG
AAGATGACACACGAGGTATCCTTACACCAAGCGATGAGTTCCAGTTTTGGATAGAACAAGCTCACCGTGGAAATAAACAGATTAGTAAAG
AAAGAGCCAATTATTTTAAAGAATTATTTGAAACAATTGCAAGAGAGTTTTATAACTTGGACAGTCTATCCTTACTAGAAGTTGTTGACT
TGGTGGAGACTACTCAGGATGTTGTAGATGATGTGTGGAGACAAACAGAACATGATCATTATCCTGAGTCACGAATGTTGCATCTCTTAG
ACATCATAGGTGGTTCATTTGGAAGGTTTGTTCAGAAAAAGTTGGGAACTTTGAACCTGTGGGAAGATCCTTATTATCTTGTGAAAGAAA
GTCTGAAAGCTGGTATTTCAATTTGTGAACAGTGGGTGATAGTCTGTAATCATCTAACAGGTCAGGTGTGGCAGCGCTATGTTCCTCATC
CATGGAAAAATGAAAAATATTTTCCAGAAACACTTGACAAACTTGGCAAACGCCTTGAAGAGCCTTCAGGCAAACTTAAGGTACCTGAGG
AGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGCTTTTACTCAAGTGTTTACCT
TTGGTCCGACCTTCCGAGCTGAAAATTCTCAGAGCCGGAGGCACCTGGCAGAGTTTTATATGATAGAAGCAGAGATTTCTTTTGTTGACA
GCCTTCAAGATCTTATGCAGGTTATAGAGGAACTGTTCAAGGCTACAACAATGATGGTTCTCTCAAAATGTCCTGAAGATGTTGAACTCT
GTCACAAATTCATAGCACCTGGCCAAAAGGACAGATTAGAACATATGCTAAAAAACAACTTTTTAATCATTTCTTATACTGAAGCAGTGG
AGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGC
ACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACA
CGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGC
GCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGG
GATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTAT
AGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAG
AAATGCAGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTAT
TTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGA
ATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAAT
TTGTGAGAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTTT
CAGTACTTCATTAAACATTGCAGAAAAAAATATTCCTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTC
ATTGAACTGGATGAAAAAATCATGTTTAATAACTGTTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTTT

>24642_24642_1_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000334267_NARS2_chr11_78239982_ENST00000281038_length(amino acids)=612AA_BP=333
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDEN
LHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL
NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEPSGKLKVPEENFFNVPAFLTVSGQLHL
EVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLK
NNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGG

--------------------------------------------------------------
>24642_24642_2_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000375735_NARS2_chr11_78239982_ENST00000281038_length(transcript)=2692nt_BP=1143nt
GACTACCCCTGGCAACCGCGAAGCTCTGCGGTCCCGCGGTCGGGCTACGGGTTTGAGCAAAGCTCCTCTCTTCCCTTCACTTCCCTCCGG
ACTGGTTTCTTCTTCCTTCCCCCTTCCCCCAACTTCCCTCCACCCCTTCCAATCATGGCGAACGGGACTGCGGACGTTCGGAAGCTCTTC
ATCTTCACTACTACCCAGAATTACTTCGGGTTGATGTCTGAACTCTGGGATCAGCCACTGTTGTGCAACTGTCTTGAAATCAACAACTTC
TTGGATGACGGCAACCAGATGCTCCTCAGGGTGCAGCGATCCGACGCAGGAATCTCCTTTTCCAACACGATTGAGTTTGGTGACACAAAA
GATAAAGTGCTGGTGTTTTTCAAGCTGCGACCTGAAGTAATTACTGATGAGAATCTACATGATAACATTCTTGTTTCATCTATGTTAGAG
TCACCTATTAGTTCTCTTTACCAAGCAGTACGGCAAGTATTCGCACCAATGTTGTTAAAGGATCAGGAATGGAGCAGAAACTTTGATCCC
AAACTTCAGAATCTTTTGAGTGAACTAGAAGCTGGGTTGGGTATAGTTCTACGAAGATCAGACACTAACTTAACAAAATTGAAATTTAAG
GAAGATGACACACGAGGTATCCTTACACCAAGCGATGAGTTCCAGTTTTGGATAGAACAAGCTCACCGTGGAAATAAACAGATTAGTAAA
GAAAGAGCCAATTATTTTAAAGAATTATTTGAAACAATTGCAAGAGAGTTTTATAACTTGGACAGTCTATCCTTACTAGAAGTTGTTGAC
TTGGTGGAGACTACTCAGGATGTTGTAGATGATGTGTGGAGACAAACAGAACATGATCATTATCCTGAGTCACGAATGTTGCATCTCTTA
GACATCATAGGTGGTTCATTTGGAAGGTTTGTTCAGAAAAAGTTGGGAACTTTGAACCTGTGGGAAGATCCTTATTATCTTGTGAAAGAA
AGTCTGAAAGCTGGTATTTCAATTTGTGAACAGTGGGTGATAGTCTGTAATCATCTAACAGGTCAGGTGTGGCAGCGCTATGTTCCTCAT
CCATGGAAAAATGAAAAATATTTTCCAGAAACACTTGACAAACTTGGCAAACGCCTTGAAGAGCCTTCAGGCAAACTTAAGGTACCTGAG
GAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTAGAAGTGATGTCAGGAGCTTTTACTCAAGTGTTTACC
TTTGGTCCGACCTTCCGAGCTGAAAATTCTCAGAGCCGGAGGCACCTGGCAGAGTTTTATATGATAGAAGCAGAGATTTCTTTTGTTGAC
AGCCTTCAAGATCTTATGCAGGTTATAGAGGAACTGTTCAAGGCTACAACAATGATGGTTCTCTCAAAATGTCCTGAAGATGTTGAACTC
TGTCACAAATTCATAGCACCTGGCCAAAAGGACAGATTAGAACATATGCTAAAAAACAACTTTTTAATCATTTCTTATACTGAAGCAGTG
GAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAG
CACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCAC
ACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAG
CGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATG
GGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTA
TAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTA
GAAATGCAGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTA
TTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTG
AATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAA
TTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTT
TCAGTACTTCATTAAACATTGCAGAAAAAAATATTCCTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTT
CATTGAACTGGATGAAAAAATCATGTTTAATAACTGTTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTT

>24642_24642_2_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000375735_NARS2_chr11_78239982_ENST00000281038_length(amino acids)=612AA_BP=333
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDEN
LHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL
NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEPSGKLKVPEENFFNVPAFLTVSGQLHL
EVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLK
NNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGG

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>24642_24642_3_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000398093_NARS2_chr11_78239982_ENST00000281038_length(transcript)=2548nt_BP=999nt
ATGGCGAACGGGACTGCGGACGTTCGGAAGCTCTTCATCTTCACTACTACCCAGAATTACTTCGGGTTGATGTCTGAACTCTGGGATCAG
CCACTGTTGTGCAACTGTCTTGAAATCAACAACTTCTTGGATGACGGCAACCAGATGCTCCTCAGGGTGCAGCGATCCGACGCAGGAATC
TCCTTTTCCAACACGATTGAGTTTGGTGACACAAAAGATAAAGTGCTGGTGTTTTTCAAGCTGCGACCTGAAGTAATTACTGATGAGAAT
CTACATGATAACATTCTTGTTTCATCTATGTTAGAGTCACCTATTAGTTCTCTTTACCAAGCAGTACGGCAAGTATTCGCACCAATGTTG
TTAAAGGATCAGGAATGGAGCAGAAACTTTGATCCCAAACTTCAGAATCTTTTGAGTGAACTAGAAGCTGGGTTGGGTATAGTTCTACGA
AGATCAGACACTAACTTAACAAAATTGAAATTTAAGGAAGATGACACACGAGGTATCCTTACACCAAGCGATGAGTTCCAGTTTTGGATA
GAACAAGCTCACCGTGGAAATAAACAGATTAGTAAAGAAAGAGCCAATTATTTTAAAGAATTATTTGAAACAATTGCAAGAGAGTTTTAT
AACTTGGACAGTCTATCCTTACTAGAAGTTGTTGACTTGGTGGAGACTACTCAGGATGTTGTAGATGATGTGTGGAGACAAACAGAACAT
GATCATTATCCTGAGTCACGAATGTTGCATCTCTTAGACATCATAGGTGGTTCATTTGGAAGGTTTGTTCAGAAAAAGTTGGGAACTTTG
AACCTGTGGGAAGATCCTTATTATCTTGTGAAAGAAAGTCTGAAAGCTGGTATTTCAATTTGTGAACAGTGGGTGATAGTCTGTAATCAT
CTAACAGGTCAGGTGTGGCAGCGCTATGTTCCTCATCCATGGAAAAATGAAAAATATTTTCCAGAAACACTTGACAAACTTGGCAAACGC
CTTGAAGAGCCTTCAGGCAAACTTAAGGTACCTGAGGAGAATTTCTTCAATGTTCCTGCTTTCTTAACTGTCTCAGGACAACTTCATCTA
GAAGTGATGTCAGGAGCTTTTACTCAAGTGTTTACCTTTGGTCCGACCTTCCGAGCTGAAAATTCTCAGAGCCGGAGGCACCTGGCAGAG
TTTTATATGATAGAAGCAGAGATTTCTTTTGTTGACAGCCTTCAAGATCTTATGCAGGTTATAGAGGAACTGTTCAAGGCTACAACAATG
ATGGTTCTCTCAAAATGTCCTGAAGATGTTGAACTCTGTCACAAATTCATAGCACCTGGCCAAAAGGACAGATTAGAACATATGCTAAAA
AACAACTTTTTAATCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCT
GACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCT
TTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGA
GGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGT
CGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTT
ATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACAT
GATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAAT
ATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCT
CAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTT
ACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCC
TTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTACTTCATTAAACATTGCAGAAAAAAATATTCCTTAAGGTCTTAATTGAT
TTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAACTGGATGAAAAAATCATGTTTAATAACTGTTGCTTTTCAATTTTCAA
AGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCACTGTTGTTATAATTTGTTTATATTTGATGTTTATAATTTGTCTAATAA

>24642_24642_3_DYNC2H1-NARS2_DYNC2H1_chr11_102988592_ENST00000398093_NARS2_chr11_78239982_ENST00000281038_length(amino acids)=612AA_BP=333
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDEN
LHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTL
NLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEPSGKLKVPEENFFNVPAFLTVSGQLHL
EVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLK
NNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DYNC2H1-NARS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYNC2H1-NARS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYNC2H1-NARS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource