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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYNLL1-RNF10 (FusionGDB2 ID:24659)

Fusion Gene Summary for DYNLL1-RNF10

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNLL1-RNF10
Fusion gene ID: 24659
HgeneTgene
Gene symbol

DYNLL1

RNF10

Gene ID

8655

9921

Gene namedynein light chain LC8-type 1ring finger protein 10
SynonymsDLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1RIE2
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptiondynein light chain 1, cytoplasmic8 kDa dynein light chaincytoplasmic dynein light polypeptidedynein, cytoplasmic, light polypeptide 1protein inhibitor of neuronal nitric oxide synthaseRING finger protein 10epididymis secretory sperm binding protein
Modification date2020032220200313
UniProtAcc

P63167

.
Ensembl transtripts involved in fusion geneENST00000242577, ENST00000392508, 
ENST00000392509, ENST00000548214, 
ENST00000548342, ENST00000549989, 
ENST00000550178, ENST00000550845, 
ENST00000552870, ENST00000552316, 
ENST00000542701, ENST00000325954, 
ENST00000413266, 
Fusion gene scores* DoF score9 X 7 X 5=3157 X 10 X 5=350
# samples 1010
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/350*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNLL1 [Title/Abstract] AND RNF10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYNLL1(120934356)-RNF10(120992520), # samples:2
Anticipated loss of major functional domain due to fusion event.DYNLL1-RNF10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYNLL1

GO:0042326

negative regulation of phosphorylation

18579519

TgeneRNF10

GO:0045893

positive regulation of transcription, DNA-templated

16335786

TgeneRNF10

GO:0051865

protein autoubiquitination

24105792


check buttonFusion gene breakpoints across DYNLL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4A9DYNLL1chr12

120934356

+RNF10chr12

120992520

+
ChimerDB4ESCATCGA-LN-A4A9DYNLL1chr12

120934356

+RNF10chr12

120995084

+
ChimerDB4PRADTCGA-2A-A8W3-01ADYNLL1chr12

120907907

+RNF10chr12

121013434

+


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Fusion Gene ORF analysis for DYNLL1-RNF10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000242577ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000242577ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000392508ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000392508ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000392509ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000392509ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000548214ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000548214ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000548342ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000548342ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000549989ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000549989ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000550178ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000550178ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000550845ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000550845ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5CDS-intronENST00000552870ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
5CDS-intronENST00000552870ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+
5UTR-3CDSENST00000392509ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
5UTR-3CDSENST00000392509ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
5UTR-3CDSENST00000548342ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
5UTR-3CDSENST00000548342ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
5UTR-3UTRENST00000392509ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
5UTR-3UTRENST00000548342ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
Frame-shiftENST00000242577ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000242577ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000392508ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000392508ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000392509ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000392509ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000548214ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000548214ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000548214ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000548214ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000548342ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000548342ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000549989ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000549989ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000550178ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000550178ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000550845ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000550845ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000550845ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000550845ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
Frame-shiftENST00000552870ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
Frame-shiftENST00000552870ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
In-frameENST00000242577ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000242577ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000392508ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000392508ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000392509ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000392509ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000548342ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000548342ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000549989ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000549989ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000550178ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
In-frameENST00000550178ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
In-frameENST00000552870ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
In-frameENST00000552870ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
intron-3CDSENST00000242577ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000242577ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000392508ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000392508ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000548214ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000548214ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000549989ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000549989ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000550178ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000550178ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000550845ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000550845ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000552316ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120992520

+
intron-3CDSENST00000552316ENST00000325954DYNLL1chr12

120934356

+RNF10chr12

120995084

+
intron-3CDSENST00000552316ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000552316ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120992520

+
intron-3CDSENST00000552316ENST00000413266DYNLL1chr12

120934356

+RNF10chr12

120995084

+
intron-3CDSENST00000552316ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000552870ENST00000325954DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3CDSENST00000552870ENST00000413266DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000242577ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000392508ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000548214ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000549989ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000550178ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000550845ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000552316ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-3UTRENST00000552870ENST00000542701DYNLL1chr12

120907907

+RNF10chr12

121013434

+
intron-intronENST00000552316ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120992520

+
intron-intronENST00000552316ENST00000542701DYNLL1chr12

120934356

+RNF10chr12

120995084

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DYNLL1-RNF10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DYNLL1chr12120907907+RNF10chr12121013433+4.67E-050.99995327
DYNLL1chr12120934356+RNF10chr12120992520+3.76E-141
DYNLL1chr12120934356+RNF10chr12120995084+6.48E-091
DYNLL1chr12120907907+RNF10chr12121013433+4.67E-050.99995327
DYNLL1chr12120934356+RNF10chr12120992520+3.76E-141
DYNLL1chr12120934356+RNF10chr12120995084+6.48E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DYNLL1-RNF10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:120934356/chr12:120992520)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNLL1

P63167

.
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.; FUNCTION: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.; FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF10chr12:120934356chr12:120992520ENST00000325954217225_267184812.0Zinc fingerRING-type
TgeneRNF10chr12:120934356chr12:120992520ENST00000413266217225_267184817.0Zinc fingerRING-type
TgeneRNF10chr12:120934356chr12:120995084ENST00000325954317225_267215812.0Zinc fingerRING-type
TgeneRNF10chr12:120934356chr12:120995084ENST00000413266317225_267215817.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRNF10chr12:120934356chr12:120992520ENST0000032595421719_110184812.0Compositional biasNote=Ser-rich
TgeneRNF10chr12:120934356chr12:120992520ENST0000041326621719_110184817.0Compositional biasNote=Ser-rich
TgeneRNF10chr12:120934356chr12:120995084ENST0000032595431719_110215812.0Compositional biasNote=Ser-rich
TgeneRNF10chr12:120934356chr12:120995084ENST0000041326631719_110215817.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for DYNLL1-RNF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DYNLL1-RNF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDYNLL1chr12:120934356chr12:120992520ENST00000242577+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120992520ENST00000392508+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120992520ENST00000392509+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120992520ENST00000548342+4567_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120992520ENST00000549989+1267_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120995084ENST00000242577+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120995084ENST00000392508+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120995084ENST00000392509+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120995084ENST00000548342+4567_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr12:120995084ENST00000549989+1267_8944.090.0ESR1
TgeneRNF10chr12:120934356chr12:120992520ENST00000325954217101_185184.66666666666666812.0MEOX2
TgeneRNF10chr12:120934356chr12:120992520ENST00000413266217101_185184.66666666666666817.0MEOX2
TgeneRNF10chr12:120934356chr12:120995084ENST00000325954317101_185215.0812.0MEOX2
TgeneRNF10chr12:120934356chr12:120995084ENST00000413266317101_185215.0817.0MEOX2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYNLL1-RNF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYNLL1-RNF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource