Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DYRK1A-DENND3 (FusionGDB2 ID:24691)

Fusion Gene Summary for DYRK1A-DENND3

Fusion gene summary

Fusion gene information	Fusion gene name: DYRK1A-DENND3
	Fusion gene ID: 24691
		Hgene	Tgene
	Gene symbol	DYRK1A	DENND3
	Gene ID	1859	22898
	Gene name	dual specificity tyrosine phosphorylation regulated kinase 1A	DENN domain containing 3
	Synonyms	DYRK\|DYRK1\|HP86\|MNB\|MNBH\|MRD7	-
	Cytomap	21q22.13	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs	DENN domain-containing protein 3DENN/MADD domain containing 3
	Modification date	20200315	20200313
	UniProtAcc	Q13627	A2RUS2
	Ensembl transtripts involved in fusion gene	ENST00000462274, ENST00000338785, ENST00000321219, ENST00000339659, ENST00000398956, ENST00000398960, ENST00000451934, ENST00000455387,	ENST00000262585, ENST00000424248, ENST00000518347, ENST00000518806, ENST00000519811, ENST00000523308,
Fusion gene scores	* DoF score	32 X 23 X 11=8096	5 X 6 X 4=120
	# samples	40	6
	** MAII score	log2(40/8096*10)=-4.33913738491959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DYRK1A [Title/Abstract] AND DENND3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DYRK1A(38739930)-DENND3(142185299), # samples:2 DYRK1A(38739930)-DENND3(142185298), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DYRK1A	GO:0018108	peptidyl-tyrosine phosphorylation	9748265
Hgene	DYRK1A	GO:0033120	positive regulation of RNA splicing	28377597
Hgene	DYRK1A	GO:0038083	peptidyl-tyrosine autophosphorylation	24327345

Fusion gene breakpoints across DYRK1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DENND3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OX-01A	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
ChimerDB4	ESCA	TCGA-L5-A4OX	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
ChimerDB4	ESCA	TCGA-L5-A4OX	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+

Top

Fusion Gene ORF analysis for DYRK1A-DENND3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000462274	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
3UTR-intron	ENST00000462274	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
3UTR-intron	ENST00000462274	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
3UTR-intron	ENST00000462274	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
3UTR-intron	ENST00000462274	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
3UTR-intron	ENST00000462274	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
3UTR-intron	ENST00000462274	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
5UTR-intron	ENST00000338785	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
5UTR-intron	ENST00000338785	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000321219	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000321219	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000339659	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000339659	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398956	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398956	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000398960	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000398960	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000451934	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000451934	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000262585	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000424248	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000518347	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000518806	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000519811	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+
intron-intron	ENST00000455387	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185299	+
intron-intron	ENST00000455387	ENST00000523308	DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for DYRK1A-DENND3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+	4.61E-07	0.9999995
DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+	4.61E-07	0.9999995
DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+	4.61E-07	0.9999995
DYRK1A	chr21	38739930	+	DENND3	chr8	142185298	+	4.61E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DYRK1A-DENND3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38739930/:142185299)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DYRK1A Q13627	DENND3 A2RUS2
FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250\|UniProtKB:Q61214, ECO:0000250\|UniProtKB:Q9NR20, ECO:0000269\|PubMed:20981014, ECO:0000269\|PubMed:21127067, ECO:0000269\|PubMed:23665168, ECO:0000269\|PubMed:8769099}.	FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250\|UniProtKB:A2RT67, ECO:0000269\|PubMed:20937701}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for DYRK1A-DENND3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DYRK1A-DENND3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DYRK1A-DENND3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DYRK1A-DENND3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source