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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYRK1A-IFNGR2 (FusionGDB2 ID:24697)

Fusion Gene Summary for DYRK1A-IFNGR2

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK1A-IFNGR2
Fusion gene ID: 24697
HgeneTgene
Gene symbol

DYRK1A

IFNGR2

Gene ID

1859

3460

Gene namedual specificity tyrosine phosphorylation regulated kinase 1Ainterferon gamma receptor 2
SynonymsDYRK|DYRK1|HP86|MNB|MNBH|MRD7AF-1|IFGR2|IFNGT1|IMD28
Cytomap

21q22.13

21q22.11

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologsinterferon gamma receptor 2IFN-gamma receptor 2IFN-gamma-R-betaIFN-gamma-R2interferon gamma receptor accessory factor-1interferon gamma receptor beta chaininterferon gamma transducer 1
Modification date2020031520200313
UniProtAcc

Q13627

P38484

Ensembl transtripts involved in fusion geneENST00000462274, ENST00000338785, 
ENST00000321219, ENST00000339659, 
ENST00000398956, ENST00000398960, 
ENST00000451934, ENST00000455387, 
ENST00000290219, ENST00000381995, 
ENST00000405436, 
Fusion gene scores* DoF score32 X 23 X 11=809610 X 9 X 8=720
# samples 4011
** MAII scorelog2(40/8096*10)=-4.33913738491959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/720*10)=-2.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK1A [Title/Abstract] AND IFNGR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYRK1A(38739930)-IFNGR2(34793787), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

HgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

HgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345


check buttonFusion gene breakpoints across DYRK1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IFNGR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-D6-A4Z9-01ADYRK1Achr21

38739930

-IFNGR2chr21

34793787

+
ChimerDB4HNSCTCGA-D6-A4Z9-01ADYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
ChimerDB4HNSCTCGA-D6-A4Z9DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
ChimerDB4HNSCTCGA-D6-A4Z9DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+


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Fusion Gene ORF analysis for DYRK1A-IFNGR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462274ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
3UTR-3CDSENST00000462274ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
3UTR-3CDSENST00000462274ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
3UTR-3CDSENST00000462274ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
3UTR-5UTRENST00000462274ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
3UTR-5UTRENST00000462274ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
5UTR-3CDSENST00000338785ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
5UTR-3CDSENST00000338785ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
5UTR-3CDSENST00000338785ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
5UTR-3CDSENST00000338785ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
5UTR-5UTRENST00000338785ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
5UTR-5UTRENST00000338785ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000321219ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000321219ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000321219ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000321219ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000339659ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000339659ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000339659ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000339659ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000398956ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000398956ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000398956ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000398956ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000398960ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000398960ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000398960ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000398960ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000451934ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000451934ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000451934ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000451934ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000455387ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000455387ENST00000290219DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-3CDSENST00000455387ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-3CDSENST00000455387ENST00000381995DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000321219ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000321219ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000339659ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000339659ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000398956ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000398956ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000398960ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000398960ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000451934ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000451934ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+
intron-5UTRENST00000455387ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793787

+
intron-5UTRENST00000455387ENST00000405436DYRK1Achr21

38739930

+IFNGR2chr21

34793786

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DYRK1A-IFNGR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DYRK1Achr2138739930+IFNGR2chr2134793786+3.10E-101
DYRK1Achr2138739930+IFNGR2chr2134793786+3.10E-101
DYRK1Achr2138739930+IFNGR2chr2134793786+3.10E-101
DYRK1Achr2138739930+IFNGR2chr2134793786+3.10E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DYRK1A-IFNGR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38739930/:34793787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK1A

Q13627

IFNGR2

P38484

FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.FUNCTION: Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7673114, ECO:0000269|PubMed:8124716}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DYRK1A-IFNGR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DYRK1A-IFNGR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYRK1A-IFNGR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYRK1A-IFNGR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource