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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYRK1A-KCNJ6 (FusionGDB2 ID:24698)

Fusion Gene Summary for DYRK1A-KCNJ6

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK1A-KCNJ6
Fusion gene ID: 24698
HgeneTgene
Gene symbol

DYRK1A

KCNJ6

Gene ID

1859

3763

Gene namedual specificity tyrosine phosphorylation regulated kinase 1Apotassium inwardly rectifying channel subfamily J member 6
SynonymsDYRK|DYRK1|HP86|MNB|MNBH|MRD7BIR1|GIRK-2|GIRK2|KATP-2|KATP2|KCNJ7|KIR3.2|KPLBS|hiGIRK2
Cytomap

21q22.13

21q22.13

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologsG protein-activated inward rectifier potassium channel 2inward rectifier K(+) channel Kir3.2inward rectifier potassium channel KIR3.2potassium channel, inwardly rectifying subfamily J, member 6potassium voltage-gated channel subfamily J member 6
Modification date2020031520200313
UniProtAcc

Q13627

P48051

Ensembl transtripts involved in fusion geneENST00000321219, ENST00000338785, 
ENST00000339659, ENST00000398956, 
ENST00000398960, ENST00000451934, 
ENST00000455387, ENST00000462274, 
ENST00000288309, ENST00000609713, 
Fusion gene scores* DoF score32 X 23 X 11=809613 X 9 X 6=702
# samples 4014
** MAII scorelog2(40/8096*10)=-4.33913738491959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/702*10)=-2.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK1A [Title/Abstract] AND KCNJ6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYRK1A(38792686)-KCNJ6(39087434), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

HgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

HgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345


check buttonFusion gene breakpoints across DYRK1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNJ6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XK-AAJA-01ADYRK1Achr21

38792686

-KCNJ6chr21

39087434

-
ChimerDB4PRADTCGA-XK-AAJA-01ADYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
ChimerDB4PRADTCGA-XK-AAJADYRK1Achr21

38792686

+KCNJ6chr21

39087434

-


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Fusion Gene ORF analysis for DYRK1A-KCNJ6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000321219ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000321219ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000338785ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000338785ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000339659ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000339659ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000398956ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000398956ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000398960ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000398960ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000451934ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
In-frameENST00000451934ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
intron-3CDSENST00000455387ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
intron-3CDSENST00000455387ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
intron-3CDSENST00000462274ENST00000288309DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-
intron-3CDSENST00000462274ENST00000609713DYRK1Achr21

38792686

+KCNJ6chr21

39087434

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338785DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-192692392291485418
ENST00000338785DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-14862392291485419
ENST00000451934DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-20510148014702726418
ENST00000451934DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-2727148014702726418
ENST00000321219DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-20510148014702726418
ENST00000321219DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-2727148014702726418
ENST00000339659DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-20510148014702726418
ENST00000339659DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-2727148014702726418
ENST00000398960DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-1911585751331418
ENST00000398960DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-133285751331418
ENST00000398956DYRK1Achr2138792686+ENST00000609713KCNJ6chr2139087434-190401001256418
ENST00000398956DYRK1Achr2138792686+ENST00000288309KCNJ6chr2139087434-12571001256418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338785ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002239720.99977607
ENST00000338785ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.0017613850.99823856
ENST00000451934ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002037690.9997962
ENST00000451934ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002374940.9997625
ENST00000321219ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002037690.9997962
ENST00000321219ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002374940.9997625
ENST00000339659ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002037690.9997962
ENST00000339659ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002374940.9997625
ENST00000398960ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002202980.99977976
ENST00000398960ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.001401910.99859804
ENST00000398956ENST00000609713DYRK1Achr2138792686+KCNJ6chr2139087434-0.0002194280.9997806
ENST00000398956ENST00000288309DYRK1Achr2138792686+KCNJ6chr2139087434-0.0014430660.9985569

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Fusion Genomic Features for DYRK1A-KCNJ6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYRK1A-KCNJ6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:38792686/chr21:39087434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK1A

Q13627

KCNJ6

P48051

FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914139_1508424.0IntramembraneHelical%3B Pore-forming%3B Name%3DH5
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914151_1578424.0IntramembranePore-forming
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914152_1578424.0MotifSelectivity filter
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914420_4238424.0MotifNote=PDZ-binding
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914115_1388424.0Topological domainExtracellular
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914158_1668424.0Topological domainExtracellular
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914189_4238424.0Topological domainCytoplasmic
TgeneKCNJ6chr21:38792686chr21:39087434ENST0000028830914167_1888424.0TransmembraneHelical%3B Name%3DM2
TgeneKCNJ6chr21:38792686chr21:39087434ENST000002883091490_1148424.0TransmembraneHelical%3B Name%3DM1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313509_51531723.3333333333333Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313599_60231723.3333333333333Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313607_61931723.3333333333333Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313656_67231723.3333333333333Compositional biasNote=Ser/Thr-rich
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313664_67131723.3333333333333Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111509_5153755.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111599_6023755.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111607_6193755.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111656_6723755.0Compositional biasNote=Ser/Thr-rich
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111664_6713755.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110509_5153530.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110599_6023530.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110607_6193530.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110656_6723530.0Compositional biasNote=Ser/Thr-rich
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110664_6713530.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111509_5153764.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111599_6023764.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111607_6193764.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111656_6723764.0Compositional biasNote=Ser/Thr-rich
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111664_6713764.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110509_5153585.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110599_6023585.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110607_6193585.0Compositional biasNote=Poly-His
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110656_6723585.0Compositional biasNote=Ser/Thr-rich
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110664_6713585.0Compositional biasNote=Poly-Ser
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313159_47931723.3333333333333DomainProtein kinase
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111159_4793755.0DomainProtein kinase
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110159_4793530.0DomainProtein kinase
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111159_4793764.0DomainProtein kinase
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110159_4793585.0DomainProtein kinase
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313117_13431723.3333333333333MotifBipartite nuclear localization signal
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111117_1343755.0MotifBipartite nuclear localization signal
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110117_1343530.0MotifBipartite nuclear localization signal
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111117_1343764.0MotifBipartite nuclear localization signal
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110117_1343585.0MotifBipartite nuclear localization signal
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313165_17331723.3333333333333Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000338785+313238_24131723.3333333333333Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111165_1733755.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000339659+111238_2413755.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110165_1733530.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398956+110238_2413530.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111165_1733764.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000398960+111238_2413764.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110165_1733585.0Nucleotide bindingATP
HgeneDYRK1Achr21:38792686chr21:39087434ENST00000451934+110238_2413585.0Nucleotide bindingATP
TgeneKCNJ6chr21:38792686chr21:39087434ENST00000288309141_898424.0Topological domainCytoplasmic


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Fusion Gene Sequence for DYRK1A-KCNJ6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24698_24698_1_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=2727nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA

>24698_24698_1_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_2_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=20510nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA
AACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCT
CTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATA
TCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTG
GTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGT
GTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTT
ATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACA
AACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGA
ACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGA
AAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCA
TGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGT
CTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTT
TAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTT
TTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCT
ACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGC
ATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCT
TGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCT
CTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAAT
CTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAA
AAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATA
AGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTT
GAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTG
GTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCA
TCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAG
CATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTC
GATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCT
GCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGA
AGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGC
CTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTG
ACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTT
TGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACA
GTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGT
AGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCAT
TCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATC
ACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAAT
TTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGC
ATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCAT
TTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAAT
GTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTT
CCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATG
TTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATG
TCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGC
TTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATA
TTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGA
ATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTC
TTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATT
GTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATT
GATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTT
AAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATT
CTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGA
GAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAA
AACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGG
GCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGC
TAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAA
TTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAG
AGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTG
TACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATA
TTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTC
AAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAG
GAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGAT
ACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTT
GGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTC
CTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTA
GCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACT
AAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAA
GTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAG
TCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTT
CTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTG
GAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCC
TGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAA
ACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATT
GCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAA
ATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACAC
TATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGA
AATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATC
AACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACAT
GTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTT
TGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATC
AACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAG
CACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTC
CCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCT
CTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCAC
AGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAG
TAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATAT
CTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCT
CCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGG
CTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGG
AGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTAC
ACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCA
GCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGG
AAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGA
AAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAA
GAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAG
GAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACC
ATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATC
ATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGT
ATATGTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGT
GATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTC
CAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTC
CTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGT
GTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGA
TGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCG
GAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCG
CACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAG
CCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAA
CAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAA
GCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCC
CAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCAT
AAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAG
TAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTG
AGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTA
ATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGT
CTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTG
ACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAA
TGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTA
CATAACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAG
AGACATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCAT
ACACACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATAC
ACACACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCAT
ACACACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGAT
ATACACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTT
AAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTT
CCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGG
AAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTA
CCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGG
ATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAG
GCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAA
CCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTA
TAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACA
CTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAA
TAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATT
TAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCA
TATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGC
AATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTT
TGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGT
CTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGA
AGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTC
TCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTT
GTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAA
GACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTC
TGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCA
GTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAA
TATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAG
ATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTC
ACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCA
GGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGAC
AAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTT
GAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGT
TAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAG
ACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAA
TGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATA
TTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTG
ATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTA
AGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACA
GAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTA
TCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCC
GCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTC
AAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATT
GGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCT
GCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCA
AAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCC
AGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTT
TTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAA
GCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGG
GGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTT
TATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAA
CAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACAC
TAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAG
CCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGT
GAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCAT
CATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTT
TAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATT
AAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGT
AATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCC
AAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAA
AAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCA
TGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGC
AAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGA
ACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTA
TCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTAT
TTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATA
TTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGAC
AAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAA
CAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTT
AGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGG
CCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAA
TGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAG
CAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAA
AACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGT
GCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGC
ATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACT
TTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACA
AAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGAT
CCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTA
AGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCC
TGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCG
AAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGA

>24698_24698_2_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_3_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=1486nt_BP=239nt
CGAGGCTGAGACTCACCGGAGGAAGCGGCGCGAGCGCCCCGCCATCGTCCCGGCTGAAGTGCAGTGGCACGATCATAGGTGGTCACTACA
GTCTCAGATTCCTGGGCTTAAGCAGTCTTCCCACCTCAGCCTCCCCAGTAGCTGGGATTACAGTGTTATAGTTTTGCCGCTGGACTCTTC
CCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCA
GGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGAC
CAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGA
TATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAAT
GATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTT
CGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTAT
TCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAG
GGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAA
TTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGA
TATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTT
CTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATG
CCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGT
TGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCT
GCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGA

>24698_24698_3_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=419AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_4_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=19269nt_BP=239nt
CGAGGCTGAGACTCACCGGAGGAAGCGGCGCGAGCGCCCCGCCATCGTCCCGGCTGAAGTGCAGTGGCACGATCATAGGTGGTCACTACA
GTCTCAGATTCCTGGGCTTAAGCAGTCTTCCCACCTCAGCCTCCCCAGTAGCTGGGATTACAGTGTTATAGTTTTGCCGCTGGACTCTTC
CCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCA
GGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGAC
CAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGA
TATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAAT
GATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTT
CGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTAT
TCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAG
GGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAA
TTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGA
TATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTT
CTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATG
CCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGT
TGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCT
GCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGA
AAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATC
TTTCCTTGTCTCTCATTCTCTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAA
ATCTTCAAGGTGTAAAATATCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCT
CATTTGTGGCCCAAGCCTGGTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATA
CCAGATCACTCAAAAAGGTGTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACA
GAGTGGAGCCCTCAGTTTTATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGG
CCCAGGTGAGCTGAAGACAAACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTAC
AAAAGTACCATAGAACAGAACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAA
AAAAAAAAAGAAAGAAAGAAAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGA
CGGCTGGCCCTTCAGTGCATGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTG
AATCCAACAAGCCATAGGTCTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTA
CAAAACAGATGTCTTTTTTTAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCC
TGTCACCAAAGGTATGTTTTTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATT
CTCCAGCTGTAGTTTCTCTACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGG
CATGTAGTGAGTGGCATGCATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGG
CTTATCCATCAGCATTTCTTGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGAT
GATTGTCTAAGAAATGTCTCTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCC
AGCCTTAATTCACTTTAATCTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAA
TCTGAATTTTAAAATGAAAAAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCA
CATTCACTTTGCATTTATAAGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTC
CTACAGCTGTGCTCAGTTTGAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGAC
CTGATCGCACAGGCCTTTGGTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCT
CGGGGCCTCTCTTCTCCCATCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATA
GCCCTTTCCTGTTTGCCAGCATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTG
GTCCGGGAGGAGGAAGCTCGATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCT
TGGCTTGGGGAGCTCCCCTGCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGT
CTTCTAATTTAGCTCTTGAAGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGA
AGAGCAAGCAGCTCAGGGCCTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACC
TGTCAGTTCTGTGTCTGTGACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAAC
TTGAACCAAATCTCGTTTTTGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAA
ACATGTCTATTTTTCTACAGTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACT
GATTTTCTAAGCAGCGAGTAGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTC
CGCAATATCCAGTCCTCATTCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTA
TCCATAACTAATGAAGATCACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGAT
CCGTGAGCCAGATAAGAATTTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAG
GGCAGGTTCAGCTGCAAGCATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAAC
TGGAAGAGCACCCATTCATTTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTT
TTACATTAACATAGCAAATGTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCA
TGAGGCAGAACTCTCTCTTCCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGT
TTTAGTTCAGTACCTTATGTTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACC
AAGCTAGGGCTCTGAAATGTCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTC
CAGAGCAACATTCTTATGCTTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTA
AGCCAGTGTCTTTGGGATATTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACT
ACCTGAACTCACCAGAAGAATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTT
GCTAATAGTCTGGCTACTCTTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGT
TCAGTGTCCTCTATATATTGTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATAT
ACATAATAGATGATTCATTGATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGA
AAATGTTAGCCTTTAATTTAAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTG
TCATCTAGAAGTCAAAATTCTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCC
AACATGGTGTGGTGTTTGAGAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAAT
TTACATTTTATAGAGGGAAAACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTC
ACAGGGCCCTAAGCTGTGGGCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGT
TATTGTACCACTTGTGAGCTAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGA
AAATCATCCTAAATTCAAATTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTG
CTTCCACATGCACTCACAGAGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAA
AAAAGTTTGCTGACCCCTGTACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAG
TACTAAGTACTATGAAATATTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAA
GTCACTCATAAGTCTGTTCAAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCA
TTCAGTTAGGGTCTCAAAGGAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCG
GTCAACTCAGAAAGTGGATACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTC
AGTGGCACCCTCAGGCGTTGGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACA
CATCAAACCCGCCTCGCTCCTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTT
TTCTTGCTAGTTTTCTCTAGCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTT
TTTGCTCTCTCTAGCCACTAAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAG
AGCTCAGGGAGACACGGAAGTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAG
ACATAATGGATGGAAAAAGTCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTT
GTCTTCTAAGGAAGCATTTCTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTC
TCTTATGAGTGCTTTCCTGGAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGA
TAAAGGATGGATTTGATCCTGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTG
CATGGAAGAGTGGGAGGAAACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAA
ACTTTTACTTGGCCTCATTGCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAAT
ACTTTAAAGGCACACAAAAATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTA
TAGAGTTATTTTTAGACACTATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGA
TCTTGATTTCAGAGAATGAAATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGA
TCATCAATACTGTGATATCAACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAA
GCACTAGTGAAATAAACATGTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAG
GAGCCTAGGAGCAGACTTTTGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACA
CAACTAGTAGAACTCGATCAACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTT
CTTAGAAGAGGGGAAGGAGCACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCAT
GGGTATGAGAAATACCCTCCCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTT
CTCCCTGCAGGGTCTGGCTCTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGC
CCCACACCCTTGACCCCACAGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCC
TCCCATGTGAAAGTCCAAGTAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCT
TTTCTTTTTCATGACATATCTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGG
GCCAATGGCAGAACTCTCTCCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAAC
CAATAGAATCCCACCCTGGCTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGG
CAGATCACCTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCA
TGGTAGTTCCTGCCTGTACACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAG
ATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGA
AGGAAGGAAGGAAGGAAGGAAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAA
GAAAGAAAAGAAAGAAAGAAAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGA
AAGAGAAAAGAAAGAGAAAGAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAG
TCCCGTTATTATCTGCAAGGAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGAT
GGCAGATTGTCAGCCAACCATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCC
CCGTTGGAAGGTTAATATCATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACC
ACCAATTTTAACCGAGCGTATATGTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATT
GCCCAGAGAGTCTATGAGTGATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGA
AAGGACAGCTGGACTGGTCCAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCT
TTATTCAGCCCAGTGCTTCCTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGAC
TCCCCAAGTGTCTGCCTGTGTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTG
GGTGCCTGGTTACCGAGGATGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTG
GCAGAGGCCCCATGGGGCGGAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAG
CACACAGGAGCTCCCTCCGCACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCT
TAAAAGGCTCTTCTTCAAGCCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATT
TTTGTATTATCCCATGTAACAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGA
ACAGGGAGTGTTTTAATAAGCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAG
AAATACTCATTTTTGCCCCCAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATA
GACTCCCCTATATTGGCATAAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAG
AATAAACTCTGCTCACCAGTAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATG
CTGGGTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCA
GTCCGACCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGA
TTTCAGAAAGAGGACATTAATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTA
CCTGGTCAGCTTGCTGTGTCTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTG
TGTATTTTCTAATTCTGTGACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATT
TTTTCCTTTTCTAAAAGAATGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAA
TATAAGCACCCTCTCCCTACATAACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACACAGACACA
TGCATACACACACATACAGAGACATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCA
TACACAGAGACACATGCATACACACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCA
TACAGAGACACATGCATACACACACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACA
CGCACACAGACACATGCATACACACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACA
TGCATACGCACACACAGATATACACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAAT
TTCCAGAAATCAAAGCCTTAAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCT
GCAGGCAACAGCCTTTCTTCCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGT
ATATCATTTCACTGGTCGGAAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAG
CAAAATAGAGCAGAAATTACCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAAT
GGTACATCTGTGGAAATGGATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGA
TTTGGGCAAATGTATAAAGGCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAAT
TCATCTTGTGTCCTCCCAACCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACT
CATGCAGTACGCAGCCTTATAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTC
ACTTTTTTAGCACCAAACACTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCC
AAGTTTGGTCAGTTATGAATAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATAT
GATATGTTAAAGCTATATTTAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAAT
GAGGGTTCCCGTTGCTCCATATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTT
CATTGCTGTTTTAATTTGCAATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGA
GGTGTCTGTTCAGGTCTTTTGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAAT
AATTCTTTATCAGATGTGTCTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAG
ACGCTTTTAATTTTACTGAAGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATC
CAAGGTCATCTAAGTTTTCTCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTA
ATTTTTGTGAAAAGTGTTTGTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTT
CAACACCGTTTGTTGAAAAGACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCT
GTTTCTCAGCTCTCCATTCTGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTC
CATATAAACTGCAGACTCAGTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTG
GGAAGTGACATCTTGACAATATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTT
TGTAGTTTTCCTCATGTAGATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGT
GCTTTTAATTTCAAATTTCACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTA
TAATCCCTTATTAGTTCCAGGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCAT
GTCATCTGTAAACAAAGACAAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCA
GGACTTCCAGTATCATGTTGAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATC
ACGCCATTTAGTATGATGTTAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTG
AGTGTTTTTATCATGAAAGACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATT
ACATTAGTTGATCTTTGAATGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGT
TGGACTTGATTTGCTAATATTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTC
TGGTTTTGGTATTAAGGTGATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAAT
CAGTATCATTTCTTCCTTAAGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCAT
TGATTCAAATTATTTAACAGAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTG
GTTCATTTCATCTACATTATCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGG
GATTGCTAGTAACGTCCCCGCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTAT
GGAGCTTATTGATCTTTTCAAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATT
TTAATTATTTCTTCTCATTGGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAG
ATCTTCTTTTGTGCTATCTGCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTT
TTTATTTTCATTTATTTCAAAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCC
AAGTATTTTGGCATTTTCCAGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTA
TTCCTTTTTTTTTTTTTTTTTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAAC
CTCTGCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTT
GTATTTTTAATAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTA
AATGTGTTAAGGTATGTTTTATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTA
GTTTCCTCATCTTTTTCAACAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTT
CTAGACTGTACCTCTACACTAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAG
CAGGGAAATTAACTACCAGCCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGG
TAGCAGAGAGATGAGCTGTGAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAAT
GTCCAAGGAAGGTCAGCATCATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAG
GCTACTGACAATTTGCTTTTAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAAC
TAAACCAGACAGGATAATTAAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTT
ATTTTAGTTATATACCAGTAATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAA
TGGCATTATATTAAGGCCCAAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTC
CAGAAAGCTATTAGTTCAAAAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGC
ATCTAGTTTGGGGGTTGCATGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAA
CTAGTTAAGCAAAGAAAGCAAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTC
CAATATCCACACCTAGAGAACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTT
CAGGAACTTGAGTTCTTTATCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGG
AGCAGGCACACACTTGTATTTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAA
AGTTAGCTGATGCCCCATATTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTAC
AGTGAGTGATGTCCTTGACAAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCT
GCCAGCCCTTACCATGCAACAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGA
AGTAACTGAGTCTAGTTTTAGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTG
CGTAAGCAGTAAGAAATGGCCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATC
CAAGGGCAGGCAAGCACAATGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAG
ATTAGCCTGTGCAACACAGCAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCA
GCATGGGAGAGGGTCTTAAAACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAAT
ATGCATTTGGAAAACTGGTGCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTA
TTGATAAACCCATCATTGCATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTT
TACACAACTGTCAAGCACTTTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCA
TGTGTCCAGCAAAATCACAAAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTC
TCCAAGCAAAACCAATGATCCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTT
CTTTGGAATAAAGTCACTAAGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCT
CAAGTACTGGTTTGGCTCCTGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGA
CGAAAGCATGCTCAATGCGAAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATA
TATATATATATCTTTAAGAACTCGCTGTGTTAGGGAAACTGTTTACATATTGAGGTGTTCCTCTTTTTTTGACTGGAACAATAAAAGAAA

>24698_24698_4_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_5_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=2727nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA

>24698_24698_5_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_6_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=20510nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA
AACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCT
CTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATA
TCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTG
GTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGT
GTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTT
ATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACA
AACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGA
ACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGA
AAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCA
TGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGT
CTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTT
TAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTT
TTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCT
ACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGC
ATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCT
TGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCT
CTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAAT
CTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAA
AAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATA
AGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTT
GAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTG
GTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCA
TCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAG
CATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTC
GATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCT
GCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGA
AGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGC
CTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTG
ACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTT
TGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACA
GTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGT
AGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCAT
TCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATC
ACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAAT
TTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGC
ATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCAT
TTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAAT
GTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTT
CCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATG
TTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATG
TCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGC
TTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATA
TTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGA
ATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTC
TTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATT
GTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATT
GATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTT
AAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATT
CTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGA
GAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAA
AACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGG
GCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGC
TAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAA
TTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAG
AGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTG
TACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATA
TTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTC
AAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAG
GAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGAT
ACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTT
GGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTC
CTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTA
GCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACT
AAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAA
GTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAG
TCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTT
CTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTG
GAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCC
TGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAA
ACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATT
GCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAA
ATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACAC
TATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGA
AATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATC
AACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACAT
GTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTT
TGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATC
AACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAG
CACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTC
CCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCT
CTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCAC
AGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAG
TAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATAT
CTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCT
CCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGG
CTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGG
AGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTAC
ACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCA
GCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGG
AAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGA
AAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAA
GAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAG
GAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACC
ATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATC
ATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGT
ATATGTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGT
GATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTC
CAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTC
CTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGT
GTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGA
TGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCG
GAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCG
CACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAG
CCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAA
CAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAA
GCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCC
CAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCAT
AAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAG
TAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTG
AGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTA
ATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGT
CTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTG
ACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAA
TGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTA
CATAACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAG
AGACATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCAT
ACACACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATAC
ACACACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCAT
ACACACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGAT
ATACACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTT
AAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTT
CCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGG
AAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTA
CCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGG
ATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAG
GCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAA
CCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTA
TAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACA
CTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAA
TAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATT
TAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCA
TATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGC
AATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTT
TGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGT
CTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGA
AGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTC
TCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTT
GTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAA
GACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTC
TGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCA
GTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAA
TATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAG
ATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTC
ACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCA
GGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGAC
AAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTT
GAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGT
TAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAG
ACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAA
TGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATA
TTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTG
ATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTA
AGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACA
GAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTA
TCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCC
GCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTC
AAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATT
GGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCT
GCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCA
AAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCC
AGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTT
TTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAA
GCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGG
GGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTT
TATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAA
CAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACAC
TAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAG
CCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGT
GAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCAT
CATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTT
TAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATT
AAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGT
AATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCC
AAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAA
AAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCA
TGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGC
AAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGA
ACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTA
TCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTAT
TTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATA
TTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGAC
AAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAA
CAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTT
AGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGG
CCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAA
TGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAG
CAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAA
AACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGT
GCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGC
ATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACT
TTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACA
AAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGAT
CCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTA
AGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCC
TGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCG
AAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGA

>24698_24698_6_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_7_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=1257nt_BP=10nt
ATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAG
GCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTT
CATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATT
TTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAG
GACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTAT
GGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATG
GTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGAT
GGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAA
CAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCA
CCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTG
GTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGG
TTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTT
AGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTG

>24698_24698_7_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_8_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=19040nt_BP=10nt
ATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAG
GCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTT
CATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATT
TTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAG
GACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTAT
GGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATG
GTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGAT
GGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAA
CAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCA
CCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTG
GTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGG
TTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTT
AGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTG
GAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCAAAGTTTAGTGC
CCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCTCTTTCTTTTTCTGTCTCTCTTGCTTTGTTC
TTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATATCTACCTGCCCTCTCTCAGTTATTCAGATT
GACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTGGTCTCCTCCCAAAATACTACACATCCAACT
CCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGTGTGTCAAAGATTTTACCTGGGATATGACAA
GCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTTATGGATCCCAATTCATTTCATCTACTACAG
GGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACAAACCACTGTACATATATATGCCTTATGTAA
TTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGAACTGCTAAATACTGTACATAGATGTATCAT
TAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGAAAGATTCCTAACATGCAGTAGGCATTTCTG
TTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCATGGCCTTTGTTTGTGTCTCAGACTGGCAGA
CGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGTCTGGGGGAAATTGAGAGGTCTGGTAGATGG
CAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTTTAAAAGATAACAAGGGCCTCACTAACTGGC
CTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTTTTACTTTTCACATGAGCTCTTGCCCTTTGT
AGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCTACACTCTTACAATGAGACATGGTAAGTTAG
CAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGCATTATAATCATCGACCTCTCACTTTGACTC
TATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCTTGCATTGTGATCTTTTATTATTTTGAAATG
ACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCTCTAGAGTATGCCACAGGCTAGAAATCAAAT
CCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAATCTGCAAAAAGGAAAGAAGGGAGGAAGGGAG
GGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAAAAAATAAGGAAACAAATCTTAGATCAAACC
TCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATAAGCTGTTTGTTCTTTAACACAGTTGCCCAT
CATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTTGAGGCTCTGCACCATGGAGGTCAAAGAGAT
CAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTGGTGTAGTCTGGGGACCTTGTCTACTAAAAA
AGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCATCTCAGAGACCTTGGATCAGGACAACTGCC
TCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAGCATTTCCTTTTTTGCATTGAATCTCTGTTG
AATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTCGATACACTCCCCTTGAGGCTGCGGGGAGGA
GCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCTGCAACCTTGCCAGGGTCGCAGGGCAGGCCA
TGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGAAGACTCACTGGGCCTTTTTAATTCCATTGC
TAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGCCTCATCCCTGCTTGCCTGCCCTTTAGCACA
ACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTGACGGGCACCCAGATGTGAGGTCTCTCCCTG
TTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTTTGTAATGTGAGCCTCTGAATCTTTACATGG
GGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACAGTTGTTAACACAGTTTAACAGTGTATTTTG
TGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGTAGTGAGTGAATGGTGTTTTCCATTAAGACA
GCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCATTCCCTCAGTCACTCCATTAGCAAACCAAGT
GCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATCACTCTCAACTAGATCCTTTGGTCTGTTTGG
TTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAATTTGGAATTTAAGGGTTATGGTTTGCCACAG
TTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGCATGACCCCCCACCACAAGGCTGCTGAGTTC
CTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCATTTATAAATCAACTTTATGGAACCAATAAAA
TCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAATGTCAACTTTTCTGTTCCTTCAAACATGGCC
TTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTTCCCCCACTCCGTTCTTCCATCTATCCCCAT
CCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATGTTCCCTAACAGAAATCCAGCTGCAAATGTC
AACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATGTCTATTTTTCACTGCACTCCAATTTAAAAA
TTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGCTTTCCATCCCTACATTTTCTTACATTTCAG
TTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATATTTAGAAACTGCTTACAAAGGTGGGAACTG
GTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGAATGGGAAATCATTTGATTTGCTGAGAGAAT
ACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTCTTCAGTCTTTCTTTCCTTGACTTGGGTGAT
ACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATTGTAAACATTATCTTCAAGGATGATTTCCTT
TCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATTGATATTACTTTACAATACACTAAAATAACA
TTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTTAAAATTGAGTAAAGCACGCCTCTTCCTAAT
ATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATTCTGTCAGAAGGCTGCTAAGAGATTTTGATA
AATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGAGAGCATTAAGAGCACTTGTACAAATTATCT
TATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAAAACTAGGGTTTGGGCAAATTGGCCAAGTTT
AAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGGGCTATTTTTACTACAAAAAATTTCAGCAAA
CCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGCTAAGAGCAATTTTTACATTTTTTAATAATT
GGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAATTTCAATGTCCACAAACAAAGTTTTATTGG
AACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAGAGCTGAGTAATTACAACAGAGACCGTGTGG
CCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTGTACTGTACTGTTAAGTACTATTGGTACTAT
TAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATATTGTACTGTACTCTTAAGAGAGTCCTAGGC
AATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTCAAAATAACATAACTCTTTTTTTTCGGTTGT
CAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAGGAAGAATCCTTCCTTTTCATGCCATTCCTC
CAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGATACAGTAAAATTACTCCTTAATGAACTACAG
AGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTTGGATGATGTACATAGCTCAGGCTGCCAGTC
TCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTCCTCCACATGGCTTCTCTCTTAGGCTCTCTT
GGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTAGCCTACAGTTTACAACTGATCAAGGTGATG
AACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACTAAGCTAGAAGTTTAATGTGTAATTAAAGAA
CTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAAGTATAGTAAAGGGTTGTTGGATTTCTTGCG
CTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAGTCCAGACCTTGGGGTTTTTAGATGAGTCAA
TATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTTCTAATGCCAGAGGTAGTCAGCCAAGCTAGG
TTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTGGAAATCAGATGAGAAAGAAAAAAAAGTAAC
AATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCCTGCGTCTGAAACTAAGTAGGTAATGGTATC
TACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAAACAACTAAGTGGGAGGAAACAAATCTCAAA
GTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATTGCCTTGGTAAAAGAAAGCTTCATGTATCCA
CCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAAATATTTCACTGGGGTGGTCAACATGATTAA
GTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACACTATACCCCCTAGATGCAAATCCCAACATGC
ACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGAAATGTTCCTACCGACTTTGTGTAATTGCCC
ATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATCAACTAAGCCAATCTTTATAAGAATATGAAG
GGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACATGTAATCATCATCGTTTCTAAAACTCTGATA
GAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTTTGGCTACAAAGAGCCTAGTCCAGGCTGAAT
GCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATCAACTGGAGTGCAGAGATCAGAGTTTCGGTC
AGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAGCACTGTCCTCAGATCCGGCCATCACGGGCA
TCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTCCCGTAGCTCAGACTTGGGCAGAACAAAATC
CTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCTCTTGCCCATCTGGACAATGACCCCCTAGAA
GTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCACAGAGCACCTCCCTGGGTCAGGAATGATGAC
TAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAGTAAAATAAATGGAGTCAGGGTAAGGAAATC
CCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATATCTAATTCTCTTTTCTCTAGGAAGTCTCACG
TTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCTCCAGATAGTCTGACCTGGTCCCTCTTTTTG
AGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGGCTAAGAAATCTCACAAGGCCGGGTGCTGTG
GCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAATATGGTAA
TACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTACACCCAGCTACTCTGGAGGCTGAGGCACAAG
AATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGACTCAGTCTCA
AAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAAAAGATAAAGAAAGAAGGAAGGA
AGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGAAAAAGAAAGAAAAGAAAAGAAAAGAAAAGA
AAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAAGAAAGAAAGAGAAAAGAAATCGCACATCCC
CACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAGGAACTCTGCATTGCAGCACTTACAGACACA
ACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACCATTCCCCCCAGCTGCTCTCTCTTAATTTGC
TCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATCATTTTTGAGCATCCACAATCCAGCAACCTA
TTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGTATATGTTCAGAGTCTAACCATATATATATA
TATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGTGATGGTTGGGCGTATACATGGTCTCAGCCC
GGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTCCAGTGGGATCTTCTTGTCCTTTGCAGCATG
CCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTCCTCGTCTTAACCAAGAGCCACACAGAGACA
ACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGTGTTGGCAAAGTGCTCTTTCCTTTCCCACTG
TCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGATGTGCTTGGCTGCCATGGTAACTCCCAGCC
TCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCGGAGGCTCCCTAGGGCTGCTCCACCTGCAGA
CAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCGCACGCCAGGTCTGGGGTATTCCCATCCTTT
CTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAGCCATCATCCTCATATCACACTCATGCCCAC
ACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAACAGATGTCCAAAGAGTTGCCATTTTCTTAA
CACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAAGCACAAATATAAACAAAAGCAATTTTAAAA
TTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCCCAGAGCAAAGTTCCAGAATACTATTTCTTC
TTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCATAAAAGGTAAAGTGGAATTTACCACTGAAAC
TTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAGTAACAATTCTGCAGCCACCGTACTGAACAC
AAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGC
GGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAA
AAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTAATATTCAAATCCCTGAACCATGCCCACACT
GTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGTCTCATGGGGCATTAGAGGGTAGATGAGAAC
TTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTGACAACAGGCATCAACAAAACATGTGGCCTG
TTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAATGAGGATTCCTCTGAATGTTACACTATGCA
ACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTACATAACACACACACATACACACAAATACAC
ACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAGAGACATGCGCATACACACACACGCATACAT
GCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCATACACACACGTGCATACACACACAGACATAT
GCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATACACACACGCATACACACACACGCATACACAG
AGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCATACACACACACGCAGACACAGACACATGCAT
ACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGATATACACACACACACACACACACACACTCTT
ATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTTAAGATTGGCGTTCCTCCCCTGCATGCACTG
TGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTTCCAGTGTTTGGTAGGAACCCTGGATTCAGA
AGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGGAAATAGCTTCCTCCACCCCTTTTTTAAAAA
CTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTACCAAGAGCTCTCATTTACCCCCGGCCCCCG
CATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGGATGAGTCTACACTGAGACATTACTATCACC
CCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAGGCATGGATCCACCATTATAGAATCATACAG
GATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAACCCCTGGCAACCACTGATCTATTTACTGTC
TCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTATAAAATTGGCTTATTTCACTTAGTAACATG
CATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACACTCATCCATTTTCTGGATGTACCACTGTTT
ATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAATAAAGCCACTATAAATATCTGTATGCAGGT
TTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATTTAGTCTTGCAAGACACAGCCAAACTGCCTT
CCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCATATCTTCACCAGCATTTAGTGTTGTCAATG
ATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGCAATTCCCTAATGACATGATTTGGGACATAT
TTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTTTGGGCATTTTTTTAAATCGGGTTGTTTTCT
TATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGTCTTCTGTAAATATTTTCTCCCAGTCCGTGG
CTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGAAGTTCAGCTTATCATTTACTTCTTTCATGA
TCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTCTCTTATATGTTACCTTCTAGGAGTTGTATA
GTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTTGTTAGGTCTGTATTTAGACTCTTTTTTTTT
TTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAAGACCCTCTTTGCCGCACTGTTTTGCCTGTG
CTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTCTGTTCCACTGATCTATTTGTCTATTCCTTC
ACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCAGTTTTTTGGTACCAACAAAATAACTTGCTG
AGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAATATTGAGTCCCTCCATGAAATGGAATATCT
CTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAGATCTTATACATATTGTTAGATTTATACCTT
AAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTCACTTATTCATTGCCGGTATATAGGAAAACA
ATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCAGGAAGGTTCTGGGGCTTGTTTTTGTTTTGT
TTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGACAAAGTTTTATTTCTTCTTTCTTCCCAATCT
ATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTTGAAAAGCAGTAGTGATGGGGACACCTTTTT
TTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGTTAGCTGTAAGGTTTTTTTTTTAGATATTGT
TTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAGACTGTTTGGATTTTTCTGCATCTGTTGATA
TGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAATGTTGAACCAGCCTTATATACCTAGGACAA
ATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATATTTTGTTGAGGATTTCTGCATCTATGCTTA
TGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTGATGCTGGATTCATAGAATGAGTTAGCAAGT
GTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTAAGTCTTTGGTAGAATTCACCAGTGAACCCA
TCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACAGAGATATACCTATTCAGATTGTCTATTTGC
TCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTATCAAATTTGTGGGTATAAAGTCATTCATAA
AATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCCGCTCTCATTTCTGATAGTAGTAATTTGTGT
TCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTCAAAGAATCAACTTTGTTTCTATTTATTTTA
TTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATTGGCTTACTTTGGGTTTAATTTGCTCTTTTT
TTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCTGCATTCAATGTTATAAATTTCCCTTTAAGC
ATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCAAAATATTTTTTCACTTATCTTGAGATTTCT
TCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCCAGCTACCTTTCTGTTACTGATTTCTAGCTT
AATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTTTTTTTTTAAGACAGAGTCTCACTCTGTTGC
CCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAG
TTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTTG
AACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTTTATGACCCAGAATGCAGTCTAACTTGATGA
ACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAACAAACATTTGAACCCCATAGTCTCTGCTTT
AATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACACTAAATGACCCCAGATGGTTCAGCTTTAAGT
CTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAGCCACACACTTGTCTCCAACAGCACCCACCG
ACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGTGAGGTAGGTGCCTTCTAGATAAATGAGGTG
CTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCATCATTGATAGAAAATAAATGTGAGGCTGCAT
CTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTTTAACCCAAATCCAGCTCTACCCTCCCTAAA
GCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATTAAGGAGGCAAAAAGCTTAAACCATAATATT
TTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGTAATGGAAAATAGTGGCCACTTTTCATTATT
AATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCCAAAATGTTTACTATGGCCCAGTAAAATATA
GGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAAAAGTCTCTAGCAGTGCCAAGGTTTCAATAG
TCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCATGTTTGTGGACATTCATGTTTCTATGTACC
TGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGCAAAGCCCAGCAGGTGTCAGAATTGGGTCCC
CAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGAACGCACATCTTCCCAAAAGAAATGAAGCAC
AGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTATCAAATGCTCACATCCTACAGAGAAATAAA
GTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTATTTTTATACTCAGGGATCCCAACAGGCAACT
AAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATATTTTATTACTCCAAATGTGTATTCACTTGC
CTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGACAAGTTACTATGAAGACTCTGAGAAAAAGTA
ACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAACAACACTGCGCTAAGTGCATCGAACCACAC
AAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTTAGAAATACCTAAACGAAGAGGGACAGGCAC
AACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGGCCTCATGAGGAAGAAAGGGACATTTGCCCT
GACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAATGGTTCATGCCTGTAATTCCAGCACTTTGA
GAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAGCAAGACCCCATCTCTATTTTAAAAAGAGAG
AGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAAAACAGAAACACACAAGGTAAGATTGGGGGA
TGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGTGCTAATTTATAGAGACTTAGAATTTCAGGC
TAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGCATCTTAAAGGCTCTGAAGTCTTTAGTATTG
AATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACTTTGAAATGATTCAGCAAAAAGCAGAATAAA
TCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACAAAACAAGAGTTTATTTTAGAAGGGACTTAG
GGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGATCCTTTAGGGATGAACAGAAAGAAAACAAGA
AATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTAAGATTTGCTTCTGAGGTCAATCTTGCCAAC
TTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCCTGTCCCATTTTTTGGTCCTTTTGTAACTCC
CTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCGAAAGCACAAATTATGTATTGAGAAATCACT
ACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGAACTCGCTGTGTTAGGGAAACTGTTTACATA

>24698_24698_8_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_9_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=1332nt_BP=85nt
GTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAAC
GTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTG
CCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTG
AGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTAC
ACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACT
CCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATC
ACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTT
GTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTG
ATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGG
GAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGC
CATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGA
ATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTG
ACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTG
GCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAA

>24698_24698_9_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_10_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=19115nt_BP=85nt
GTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAAC
GTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTG
CCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTG
AGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTAC
ACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACT
CCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATC
ACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTT
GTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTG
ATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGG
GAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGC
CATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGA
ATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTG
ACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTG
GCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAA
GAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAAC
CCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCTCTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATAT
TTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATATCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATG
GATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTGGTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGT
TACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGTGTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTG
CCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTTATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCC
CCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACAAACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGT
AATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGAACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGA
TATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGAAAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGT
TTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCATGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCA
CTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGTCTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCA
ATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTTTAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAA
TACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTTTTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAG
GAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCTACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGG
GTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGCATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGA
GAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCTTGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTAT
TCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCTCTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAAT
CAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAATCTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAA
GGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAAAAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGA
GATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATAAGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTG
AATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTTGAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCC
TCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTGGTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATA
AGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCATCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTT
TAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAGCATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATT
TCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTCGATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCT
CTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCTGCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAAC
AAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGAAGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGAC
AGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGCCTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCC
TTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTGACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTT
GTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTTTGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGA
ACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACAGTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAA
TTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGTAGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGA
CCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCATTCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTT
TAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATCACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGT
CATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAATTTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGA
CAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGCATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCT
CCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCATTTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAG
CTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAATGTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGT
TCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTTCCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCC
TGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATGTTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAG
CACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATGTCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCA
TTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGCTTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTT
CCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATATTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGG
GGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGAATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTC
ATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTCTTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTA
AAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATTGTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTT
AACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATTGATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGA
ACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTTAAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAAT
GTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATTCTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATAT
AATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGAGAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATT
CACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAAAACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATC
ATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGGGCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAA
AAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGCTAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGA
AAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAATTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCC
ATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAGAGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAA
ATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTGTACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATA
GTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATATTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGA
CTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTCAAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGC
TTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAGGAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAG
AGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGATACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCC
CAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTTGGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGC
AGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTCCTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAAT
AGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTAGCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAA
CTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACTAAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTAT
GGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAAGTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAA
GCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAGTCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTC
TTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTTCTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTA
GTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTGGAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCAT
TGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCCTGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCAT
GCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAAACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAA
ACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATTGCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGA
GAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAAATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGA
TTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACACTATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGG
AGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGAAATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGG
CTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATCAACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAG
GCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACATGTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACAT
TCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTTTGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATG
TCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATCAACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCC
AAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAGCACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCAT
CTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTCCCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCAC
CCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCTCTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGA
CCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCACAGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTT
AGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAGTAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGAT
TTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATATCTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGAT
GCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCTCCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGT
TTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGGCTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAAT
CTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGGAGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACT
AAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTACACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTG
GGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAA
GAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAG
AAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGAAAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAA
GAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAAGAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGT
CACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAGGAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCC
TGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACCATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCA
CGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATCATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTC
CTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGTATATGTTCAGAGTCTAACCATATATATATATATATATATATATAT
GTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGTGATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAG
CAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTCCAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAG
CTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTCCTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAA
GTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGTGTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTA
CTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGATGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCA
CTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCGGAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAAC
CCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCGCACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGA
TGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAGCCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTT
GCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAACAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCT
GCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAAGCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTC
TTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCCCAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTT
TCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCATAAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATT
TAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAGTAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAAT
TCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAG
CCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAT
GCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTAATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCT
AACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGTCTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGA
CAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTGACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCC
TCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAATGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCA
GTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTACATAACACACACACATACACACAAATACACACACAGACACATGCA
TACACACACACATACACACAGACACATGCATACACACACATACAGAGACATGCGCATACACACACACGCATACATGCACATGCATACACA
CACCAAGACATGCATACACACACGCATACACAGAGACACATGCATACACACACGTGCATACACACACAGACATATGCATACACACACGCA
TACAGACATGCATACACACACATGCATACAGAGACACATGCATACACACACGCATACACACACACGCATACACAGAGACATGCATACACA
CATGCATACAGAGACACATGCATACACGCACACAGACACATGCATACACACACACGCAGACACAGACACATGCATACACACAGAGATACA
CGCATACTCACACAGACACAGACACATGCATACGCACACACAGATATACACACACACACACACACACACACTCTTATCCTTTCCAATCAG
TTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTTAAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAA
AATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTTCCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCC
CCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGGAAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTAT
TTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTACCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCC
CCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGGATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTT
TACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAGGCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCC
CTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAACCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCT
TTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTATAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCT
CATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACACTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACC
TACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAATAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATA
AGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATTTAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTAC
TGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCATATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCC
ATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGCAATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTT
TTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTTTGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTT
AAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGTCTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTA
TCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGAAGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGT
TCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTCTCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACA
TTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTTGTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCT
GTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAAGACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGA
TCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTCTGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCG
TCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCAGTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGA
TTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAATATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGT
TCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAGATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCA
AGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTCACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATAT
TAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCAGGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTAT
TTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGACAAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTC
CTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTTGAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGT
GAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGTTAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGG
GCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAGACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTT
TCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAATGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCAT
GGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATATTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTC
TGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTGATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCT
AGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTAAGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCT
TTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACAGAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTT
GACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTATCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATC
TTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCCGCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTT
CTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTCAAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTT
CAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATTGGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAA
ATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCTGCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCA
TCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCAAAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGAT
ATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCCAGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATC
TAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTTTTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGA
GTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTG
CCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAA
GTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTTTATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGC
TTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAACAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATC
CATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACACTAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCAT
CATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAGCCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCC
CCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGTGAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCAC
TGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCATCATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCC
ATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTTTAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGC
CCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATTAAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATT
TATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGTAATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATT
CATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCCAAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAG
CTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAAAAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGA
ATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCATGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTC
TCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGCAAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCAT
TAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGAACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATC
CTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTATCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAA
GGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTATTTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGA
CAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATATTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCAT
GAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGACAAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTC
CTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAACAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAA
AATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTTAGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGA
ATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGGCCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGA
CTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAATGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGA
GGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAGCAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAG
CAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAAAACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAG
CCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGTGCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTA
AGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGCATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATT
TTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACTTTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTT
CAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACAAAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATA
TAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGATCCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAA
AGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTAAGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTT
TTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCCTGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCA
AGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCGAAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTT
TTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGAACTCGCTGTGTTAGGGAAACTGTTTACATATTGAGGTGTTCCTCT

>24698_24698_10_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_11_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000288309_length(transcript)=2727nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA

>24698_24698_11_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------
>24698_24698_12_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000609713_length(transcript)=20510nt_BP=1480nt
AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGA
ACCTGGGAGTTCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCC
ACTTGTAGCACCACTTGGAATTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATT
ATTTTAGTCCAGTTGGTTTCTTTCTTTCTCTTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAA
AACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGGATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGT
GCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAATTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTG
CCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTGGCCAACATATGCAACATTGTTCTATTTAAA
ATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTTAGATTTTAGCTTGTACTTGT
CTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGGTCAACCATGA
GTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC
TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTT
ACCTCTGTCTTAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTT
TCCCCAGATAAAGTAAATGGTGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAA
ACTGTTTTTTTTTTCTCTGACAATTGAATATATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTT
AGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTTATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGT
CTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTATAGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCA
TCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGCTAACGTCCTGGAGGGCGACTCCATGGATCAGGACGTCGAAAGCCCAGTG
GCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTGCCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGG
TACGTGAGGAAAGACGGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATCTTCACCACATTAGTG
GACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTACACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCA
TACATACGGGGAGACATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTCTCTGCTTTTTTATTC
TCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATCACAGATAAATGCCCAGAGGGAATTATTCTTCTCTTAATCCAATCT
GTGTTGGGGTCCATTGTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCAGAGACCCTGGTCTTT
TCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTGATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCT
TCCATCAGAGCCAAGTTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATCAACGTAGGGTATTAC
ACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGCCATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCC
CAGCTGCCCAAAGAGGAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAAGCTCGAAGCTCCTAC
ATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTGACCCTGGAGGACGGGTTCTACGAAGTTGACTACAACAGCTTCCAT
GAGACCTATGAGACCAGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCCCTGAGTTGGTCTGTA
TCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAAGAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCA
AACCTGGAGAATGAATCCAAAGTTTAGTGCCCTAGCTGGGCAAACCCTTCTCTTCTCCCCCCAACACAATCTTTCCTTGTCTCTCATTCT
CTTTCTTTTTCTGTCTCTCTTGCTTTGTTCTTTATTTGTTTATATTTAATTTTTACATGACCAGAAAACAAATCTTCAAGGTGTAAAATA
TCTACCTGCCCTCTCTCAGTTATTCAGATTGACAAGGTAGACATGGATTTGATGAAAGTGCAAAGTGCCCTCATTTGTGGCCCAAGCCTG
GTCTCCTCCCAAAATACTACACATCCAACTCCTGGAGATTTCAGTTACTTACCTGCATGTGTTGTACAATACCAGATCACTCAAAAAGGT
GTGTCAAAGATTTTACCTGGGATATGACAAGCAAGGTTTCTGGTGCCTATTTATTCATTCAGTGAGACACAGAGTGGAGCCCTCAGTTTT
ATGGATCCCAATTCATTTCATCTACTACAGGGTGAGGTGCTTGCCCCCATGTGGGTGTGGCAGTTACAGGGCCCAGGTGAGCTGAAGACA
AACCACTGTACATATATATGCCTTATGTAATTATTTTCTTTTTGTAATTAGTAATAAAACCCAGCATGTACAAAAGTACCATAGAACAGA
ACTGCTAAATACTGTACATAGATGTATCATTAATGTAGGTTTAGATATATAACTTTAGAAATAAGAAGCAAAAAAAAAAAGAAAGAAAGA
AAGATTCCTAACATGCAGTAGGCATTTCTGTTTTGATGTCTGTGTTTTCCAGGTTATTTTGATCCAGTTGACGGCTGGCCCTTCAGTGCA
TGGCCTTTGTTTGTGTCTCAGACTGGCAGACGTTAGGGTACCTCACTGTTCCCACACGGATCCTTTCATTGAATCCAACAAGCCATAGGT
CTGGGGGAAATTGAGAGGTCTGGTAGATGGCAAAACCCACCACCAATATGCTGATATACTGTGAAATGTTACAAAACAGATGTCTTTTTT
TAAAAGATAACAAGGGCCTCACTAACTGGCCTGGAGGAGGGGGAATACCAGGAAGGAAATATTCTCTAGCCTGTCACCAAAGGTATGTTT
TTACTTTTCACATGAGCTCTTGCCCTTTGTAGTACAATAATTTAGGAAACTTTTCTGCAAAACCATTGATTCTCCAGCTGTAGTTTCTCT
ACACTCTTACAATGAGACATGGTAAGTTAGCAGAAGATGGTTTGGGTCTAAAGCCGTGAAATTCACAAAGGCATGTAGTGAGTGGCATGC
ATTATAATCATCGACCTCTCACTTTGACTCTATCTGGCTTTCTGAGAATGACATCTCGCCTGTCCCTGGGGCTTATCCATCAGCATTTCT
TGCATTGTGATCTTTTATTATTTTGAAATGACCAGAGTTCAGTATTCAAAGATTAGATCAACAATCTTGATGATTGTCTAAGAAATGTCT
CTAGAGTATGCCACAGGCTAGAAATCAAATCCAGTGTCTGTCAATCAAAAGAAAACAAATAAAAAAATTCCAGCCTTAATTCACTTTAAT
CTGCAAAAAGGAAAGAAGGGAGGAAGGGAGGGAGGAAGGAAGGAAGGAAGGAAGGGTATTTGTACTGGAAATCTGAATTTTAAAATGAAA
AAAATAAGGAAACAAATCTTAGATCAAACCTCCGGGGCAGGTGGAGATTTTGCACTGTTACAGATCTTTCACATTCACTTTGCATTTATA
AGCTGTTTGTTCTTTAACACAGTTGCCCATCATAAATATTCATTGAATGGATCCAAGTTTATTTTCAGCTCCTACAGCTGTGCTCAGTTT
GAGGCTCTGCACCATGGAGGTCAAAGAGATCAAACTAGCTGTCCCTCTTTGTTTCCCTTGCCTTCCCTGACCTGATCGCACAGGCCTTTG
GTGTAGTCTGGGGACCTTGTCTACTAAAAAAGAAGTCCCAGGATAAGGAAAGTGGCTCCTAAATATAACCTCGGGGCCTCTCTTCTCCCA
TCTCAGAGACCTTGGATCAGGACAACTGCCTCTTGGCACTGACTTTAAGGAAAACAAAACTGTTGGCTATAGCCCTTTCCTGTTTGCCAG
CATTTCCTTTTTTGCATTGAATCTCTGTTGAATCATTTCTTTATTTCGCACACTCTAAGAAGGAGGTGGTGGTCCGGGAGGAGGAAGCTC
GATACACTCCCCTTGAGGCTGCGGGGAGGAGCCATGGCTTGACCTCTCTGCAGCCTAATGAAGGGCACTCTTGGCTTGGGGAGCTCCCCT
GCAACCTTGCCAGGGTCGCAGGGCAGGCCATGGCAGGCACAAAACAAGATGGAATAGGGGCGGCAAAATGTCTTCTAATTTAGCTCTTGA
AGACTCACTGGGCCTTTTTAATTCCATTGCTAAGGTTTAAAGGACAGCGCACACCCCCGTGTCTGGTTGGAAGAGCAAGCAGCTCAGGGC
CTCATCCCTGCTTGCCTGCCCTTTAGCACAACTGAACGAAGAGCCTTGACAACACGTTGGCCACGTGCACCTGTCAGTTCTGTGTCTGTG
ACGGGCACCCAGATGTGAGGTCTCTCCCTGTTTCTCACTGTCTTTGTTGTCAATGTAGTTGGAGACAGAACTTGAACCAAATCTCGTTTT
TGTAATGTGAGCCTCTGAATCTTTACATGGGGATGCTCCTGAAGAACCTTTTACTAGAATGTCCCTATCAAACATGTCTATTTTTCTACA
GTTGTTAACACAGTTTAACAGTGTATTTTGTGTCAACTGTTAAAATTTGGAACTGAAAGTTCATTGAGACTGATTTTCTAAGCAGCGAGT
AGTGAGTGAATGGTGTTTTCCATTAAGACAGCTCAACAAAATTGACCCCACAATTTCCACTCATTCTATTCCGCAATATCCAGTCCTCAT
TCCCTCAGTCACTCCATTAGCAAACCAAGTGCAATGAGAATTTTTTAAAAGTCTCTTTTAATACAACAGTATCCATAACTAATGAAGATC
ACTCTCAACTAGATCCTTTGGTCTGTTTGGTTAATGTATTTGAGTCATTTTTCCATAAAGCATGGTGGGATCCGTGAGCCAGATAAGAAT
TTGGAATTTAAGGGTTATGGTTTGCCACAGTTGACCCCAATTTGACAGAACAAAGTGCTCCTGGATGGAAGGGCAGGTTCAGCTGCAAGC
ATGACCCCCCACCACAAGGCTGCTGAGTTCCTCGGATTCTCACCTCCACCCACCCCAACGTGCTCTCCAACTGGAAGAGCACCCATTCAT
TTATAAATCAACTTTATGGAACCAATAAAATCATTTCTGTTTTAGCTGTCCCCTGGGTAAGCTATACTCTTTTACATTAACATAGCAAAT
GTCAACTTTTCTGTTCCTTCAAACATGGCCTTCCAGCCTGGTTGTTCCAGCATATATCCCCTCTATGTCCATGAGGCAGAACTCTCTCTT
CCCCCACTCCGTTCTTCCATCTATCCCCATCCTTTGCTGTTTCCCTGGTTCTCCAGTTCCAATTCTATTGTTTTAGTTCAGTACCTTATG
TTCCCTAACAGAAATCCAGCTGCAAATGTCAACCTATTTCTTAAGCACAATTTTCTCTTGCAGGTCTAACCAAGCTAGGGCTCTGAAATG
TCTATTTTTCACTGCACTCCAATTTAAAAATTATTCATGACTTCATTTAATAGTCTAAATTTTGAATTCTCCAGAGCAACATTCTTATGC
TTTCCATCCCTACATTTTCTTACATTTCAGTTTTCTTACTTTTTTCCCCTTTGCTTTTTTATTTAGATTTAAGCCAGTGTCTTTGGGATA
TTTAGAAACTGCTTACAAAGGTGGGAACTGGTGGACAGAGAAAGGGGGCATAAGAATGCTATTAGAAAACTACCTGAACTCACCAGAAGA
ATGGGAAATCATTTGATTTGCTGAGAGAATACAATTAAAATACTCATAGTAAATCATTTCCAAAACAGTTTGCTAATAGTCTGGCTACTC
TTCAGTCTTTCTTTCCTTGACTTGGGTGATACTCTGTATGATTTAAAAATGTCAGGAAGGTAGTTGAAAGTTCAGTGTCCTCTATATATT
GTAAACATTATCTTCAAGGATGATTTCCTTTCAATGGATGGCTTTAACATTGAAAAACATAGGTAACATATACATAATAGATGATTCATT
GATATTACTTTACAATACACTAAAATAACATTATCTTGTTTCTGAACTTTATGGCCAACCGGTATCTAAGAAAATGTTAGCCTTTAATTT
AAAATTGAGTAAAGCACGCCTCTTCCTAATATTTCTGCCTTTAATGTCTTGAGTGCTTTAGATGCAGAGTGTCATCTAGAAGTCAAAATT
CTGTCAGAAGGCTGCTAAGAGATTTTGATAAATCACAGAATATATAATAATAACCCAACAATATTTTACCCAACATGGTGTGGTGTTTGA
GAGCATTAAGAGCACTTGTACAAATTATCTTATTTCATTCTAATTCACCATGAGAGGTTGAGTATTATAATTTACATTTTATAGAGGGAA
AACTAGGGTTTGGGCAAATTGGCCAAGTTTAAAGGCCAGTGAATCATAGCTCCTTGTCTCAAATCCAGGTCACAGGGCCCTAAGCTGTGG
GCTATTTTTACTACAAAAAATTTCAGCAAACCAAATCTGCTAAAAAAAAAAAAATCTGGCCTGCTGCCTGTTATTGTACCACTTGTGAGC
TAAGAGCAATTTTTACATTTTTTAATAATTGGGGGAAAAAAAAGAAAAGAAGAATATTTTGAGACATGTGAAAATCATCCTAAATTCAAA
TTTCAATGTCCACAAACAAAGTTTTATTGGAACACAGCCACAGCCATTTGTCTGTGTATTGCCTATGGCTGCTTCCACATGCACTCACAG
AGCTGAGTAATTACAACAGAGACCGTGTGGCCAGCAAAGATTGAAATATTTACTATCTGGCCCTGTATAAAAAAAGTTTGCTGACCCCTG
TACTGTACTGTTAAGTACTATTGGTACTATTAAGTACTAGTAATAGTACTATTAATAATAGTATGTAAGAGTACTAAGTACTATGAAATA
TTGTACTGTACTCTTAAGAGAGTCCTAGGCAATATAGAAGAATGACTTTTTTTCTAGCATAAATTATTGAAGTCACTCATAAGTCTGTTC
AAAATAACATAACTCTTTTTTTTCGGTTGTCAAAGAGACAACTGCTTCACAAGACTTAGAGAGCCCAGTCATTCAGTTAGGGTCTCAAAG
GAAGAATCCTTCCTTTTCATGCCATTCCTCCAGAGTGGCAAATAGAGTCAACAGCCAGCCAGGATCTAGCGGTCAACTCAGAAAGTGGAT
ACAGTAAAATTACTCCTTAATGAACTACAGAGAAATGGGCATTCCCAGCCCAGCCGCTGAAATATTGCTTCAGTGGCACCCTCAGGCGTT
GGATGATGTACATAGCTCAGGCTGCCAGTCTCTGCTCAGCAAAGCAGCCCAGACCTGCAGTGGTTGCCACACATCAAACCCGCCTCGCTC
CTCCACATGGCTTCTCTCTTAGGCTCTCTTGGAGGAGAGTTAAATAGGTGGCCCAGATGTCTCCCTCTGTTTTCTTGCTAGTTTTCTCTA
GCCTACAGTTTACAACTGATCAAGGTGATGAACGTGAACCTGGAACTAGCTCATGTTTAATTGCGCTAGTTTTTGCTCTCTCTAGCCACT
AAGCTAGAAGTTTAATGTGTAATTAAAGAACTAAATGCTTCTTATGGAAAACCAAAAGGTCCTTTGAAAAGAGCTCAGGGAGACACGGAA
GTATAGTAAAGGGTTGTTGGATTTCTTGCGCTTTCTGAGTCTGAAGCAAAGACAAAGATTGGTAATTACAGACATAATGGATGGAAAAAG
TCCAGACCTTGGGGTTTTTAGATGAGTCAATATTAAATGGCATTCTTTGTGTCACTAAGCTGAACTCCCTTGTCTTCTAAGGAAGCATTT
CTAATGCCAGAGGTAGTCAGCCAAGCTAGGTTCCTTATCTTTTTAGTTCTATGGAAAAACATATCAAGTTCTCTTATGAGTGCTTTCCTG
GAAATCAGATGAGAAAGAAAAAAAAGTAACAATGTAACAAATCATTGTGATGTTGTTATATTGTCGACAGATAAAGGATGGATTTGATCC
TGCGTCTGAAACTAAGTAGGTAATGGTATCTACAATATAGATCATGCAAAAAGCTTGTGACCCTTCAACTGCATGGAAGAGTGGGAGGAA
ACAACTAAGTGGGAGGAAACAAATCTCAAAGTTCAACACCATAAAACTTAAATAAATGTAAAAGGAGTCAAACTTTTACTTGGCCTCATT
GCCTTGGTAAAAGAAAGCTTCATGTATCCACCTAATTCAATAAGAGAGTCCTAGGAAAAGGAAGGCAAAATACTTTAAAGGCACACAAAA
ATATTTCACTGGGGTGGTCAACATGATTAAGTGATGGAGATTAGATTTATCACTGATGAAAACAGTATTTATAGAGTTATTTTTAGACAC
TATACCCCCTAGATGCAAATCCCAACATGCACTGTGGTTGGCCGGAGAATTGTGGCCACATAGTAAACAGATCTTGATTTCAGAGAATGA
AATGTTCCTACCGACTTTGTGTAATTGCCCATTTCAAGATTAAGGCTCAGTGCCCATTGTTTTAACACCGATCATCAATACTGTGATATC
AACTAAGCCAATCTTTATAAGAATATGAAGGGCTGTTTTTCTCAGGCAATGTAAATATCTGCTACCAACAAGCACTAGTGAAATAAACAT
GTAATCATCATCGTTTCTAAAACTCTGATAGAAATCACAAAACATTCAAGCAAAAGGGCAAGGTCTTCCAGGAGCCTAGGAGCAGACTTT
TGGCTACAAAGAGCCTAGTCCAGGCTGAATGCCTTATGGAGTATGTCAGTCTTGGGTCTTATCACTAAACACAACTAGTAGAACTCGATC
AACTGGAGTGCAGAGATCAGAGTTTCGGTCAGCCGTGCATTACCCAAACCTCTGGGTCTTCAGCCAGTCTTCTTAGAAGAGGGGAAGGAG
CACTGTCCTCAGATCCGGCCATCACGGGCATCGCCCTGACATCATCTCTCAGCATTGCTGACTGTGGGCATGGGTATGAGAAATACCCTC
CCGTAGCTCAGACTTGGGCAGAACAAAATCCTCAGCCATGCCCACCCACTGAGGTCTCTCTAGGGGAGCTTCTCCCTGCAGGGTCTGGCT
CTTGCCCATCTGGACAATGACCCCCTAGAAGTATCTTCCGGGGGACCCTGTATCTTTCAAGCTTAACTTGCCCCACACCCTTGACCCCAC
AGAGCACCTCCCTGGGTCAGGAATGATGACTAAATTAAGACCTTTAGCATCTGCTAAGCACAGGGGTGCCCTCCCATGTGAAAGTCCAAG
TAAAATAAATGGAGTCAGGGTAAGGAAATCCCCAAAAGTTCTGATTTTCTCATGGTGATGATCTCAGTGCTTTTCTTTTTCATGACATAT
CTAATTCTCTTTTCTCTAGGAAGTCTCACGTTTTGGTATCACGATGCCGTGGGCACAGACTCAGTCATCGGGCCAATGGCAGAACTCTCT
CCAGATAGTCTGACCTGGTCCCTCTTTTTGAGTAAGGCTGGGAGTTTGGTTTGTTTGAGCCACCCCACAACCAATAGAATCCCACCCTGG
CTAAGAAATCTCACAAGGCCGGGTGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGCAGATCACCTGAGGCCAGG
AGTTTGAGACCAGCCTGGCCAATATGGTAATACCCCGCCTCTACTAAAAATATGAAAAAGTTAGCTGGGCATGGTAGTTCCTGCCTGTAC
ACCCAGCTACTCTGGAGGCTGAGGCACAAGAATAGCTTAAACTTGGGAGGGGGAGGTTGCAGTAAGCTGAGATCATGCCACTGCACTCCA
GCCTGGGCCACGGAGCGAGACTCAGTCTCAAAAAAAGAAAGAAAAGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGGAAGG
AAGGAAAAAAGATAAAGAAAGAAGGAAGGAAGGAAGGAAAGAAAGAAGGAAGGAAGGAAGAAGGAAAGAAAGAAAGAAAAGAAAGAAAGA
AAAAGAAAGAAAAGAAAAGAAAAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAGAAAAGAAAGAGAAA
GAAAGAAAGAGAAAAGAAATCGCACATCCCCACCTCTATCAGGGTCACCAAATGAAGGCATCAATTTCAAGTCCCGTTATTATCTGCAAG
GAACTCTGCATTGCAGCACTTACAGACACAACTTATGCTGTCTCCTGGTGCCCACACAGCTTTCGGGTGATGGCAGATTGTCAGCCAACC
ATTCCCCCCAGCTGCTCTCTCTTAATTTGCTCCCTCATCTCACCACGAAAACTTCACTTTTCCTGGCACCCCCGTTGGAAGGTTAATATC
ATTTTTGAGCATCCACAATCCAGCAACCTATTATTGGGGTTAGTCCTATTCCTTACCACTTAATAGCCACCACCAATTTTAACCGAGCGT
ATATGTTCAGAGTCTAACCATATATATATATATATATATATATATGTACATTTTGTTCCTGCTTCATAATTGCCCAGAGAGTCTATGAGT
GATGGTTGGGCGTATACATGGTCTCAGCCCGGTAACTGACGAGAGCAGCATAAAGTTAGGTCTTGTGCTGAAAGGACAGCTGGACTGGTC
CAGTGGGATCTTCTTGTCCTTTGCAGCATGCCATTAGGGGACCAGCTTGCCAAAGAAGCTCCTGAACATCTTTATTCAGCCCAGTGCTTC
CTCGTCTTAACCAAGAGCCACACAGAGACAACAGTGAACTCACAAGTTCATAGGATTCCAAAATGATTGACTCCCCAAGTGTCTGCCTGT
GTTGGCAAAGTGCTCTTTCCTTTCCCACTGTCTGCACAGACTGTACTCTGGGGAAACTCCCAGCACTTGTGGGTGCCTGGTTACCGAGGA
TGTGCTTGGCTGCCATGGTAACTCCCAGCCTCTCAGTGTGGACCACTCTCCCGCAGGCTCGAGGAGACCTGGCAGAGGCCCCATGGGGCG
GAGGCTCCCTAGGGCTGCTCCACCTGCAGACAGCCTTGGGAGAACCCAAGGTAATGTGGAGTAGGACCCAGCACACAGGAGCTCCCTCCG
CACGCCAGGTCTGGGGTATTCCCATCCTTTCTTCCTAAGATGGGATGCACTTAGGTGGCCAAATTGCTTCTTAAAAGGCTCTTCTTCAAG
CCATCATCCTCATATCACACTCATGCCCACACTCCAGTCACATTTGCCTTTAAAAAATTTTCAAAATTATTTTTGTATTATCCCATGTAA
CAGATGTCCAAAGAGTTGCCATTTTCTTAACACTAAATAAATTCTGCCTAGAAGATTAAGATTGGTCCAGAACAGGGAGTGTTTTAATAA
GCACAAATATAAACAAAAGCAATTTTAAAATTTACTTATGGATTCTTTCAGAAAACCTGATTTCAAATCAGAAATACTCATTTTTGCCCC
CAGAGCAAAGTTCCAGAATACTATTTCTTCTTGAACTTGCCATTTTCCATCTGGCTTTGAACTTGAGAATAGACTCCCCTATATTGGCAT
AAAAGGTAAAGTGGAATTTACCACTGAAACTTTCAGAGCTCAATTTAGTCTGGCCCCATGGACCAGGCAAGAATAAACTCTGCTCACCAG
TAACAATTCTGCAGCCACCGTACTGAACACAAACCCTGGAGAAATTCTGGACATGGTACTGCTTAAGAATGCTGGGTACTCGGGAGGCTG
AGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGACCTGGGCGACAGA
GCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAGAATGCTGGGAATGTCAGTCGAGGGTCTGATTTCAGAAAGAGGACATTA
ATATTCAAATCCCTGAACCATGCCCACACTGTGGGAGTCAGGCCTAACAAGATCCCAGGGTCCATAGTTTACCTGGTCAGCTTGCTGTGT
CTCATGGGGCATTAGAGGGTAGATGAGAACTTTCCGCAATCTCGACAACTGCACTGTAAGAATTTCTTCTGTGTATTTTCTAATTCTGTG
ACAACAGGCATCAACAAAACATGTGGCCTGTTATCACATGGTTCCTCCCTGTGTGCACCTTCATAGAGATTTTTTCCTTTTCTAAAAGAA
TGAGGATTCCTCTGAATGTTACACTATGCAACAATAATGTCCCCAGTCCTTCATAAGTAACACAGTAACAATATAAGCACCCTCTCCCTA
CATAACACACACACATACACACAAATACACACACAGACACATGCATACACACACACATACACACAGACACATGCATACACACACATACAG
AGACATGCGCATACACACACACGCATACATGCACATGCATACACACACCAAGACATGCATACACACACGCATACACAGAGACACATGCAT
ACACACACGTGCATACACACACAGACATATGCATACACACACGCATACAGACATGCATACACACACATGCATACAGAGACACATGCATAC
ACACACGCATACACACACACGCATACACAGAGACATGCATACACACATGCATACAGAGACACATGCATACACGCACACAGACACATGCAT
ACACACACACGCAGACACAGACACATGCATACACACAGAGATACACGCATACTCACACAGACACAGACACATGCATACGCACACACAGAT
ATACACACACACACACACACACACACTCTTATCCTTTCCAATCAGTTATGAGTGACACCACAAAAGTAAATTTCCAGAAATCAAAGCCTT
AAGATTGGCGTTCCTCCCCTGCATGCACTGTGGCATTATTTTAAAAATGTACCATACACTTCCCTGAACCTGCAGGCAACAGCCTTTCTT
CCAGTGTTTGGTAGGAACCCTGGATTCAGAAGACCAGGTTTTGCCCCCAGATGAGCAATGTCATCCTGGGTATATCATTTCACTGGTCGG
AAATAGCTTCCTCCACCCCTTTTTTAAAAACTTGATAAATTTTATTTTTTAGAGCAGCATTAACTTCACAGCAAAATAGAGCAGAAATTA
CCAAGAGCTCTCATTTACCCCCGGCCCCCGCATGCATGGCCGCCCCCACGAGTGATATGCCAAACCACAATGGTACATCTGTGGAAATGG
ATGAGTCTACACTGAGACATTACTATCACCCCAGAGTCCATTGTTTACAATGGTGTTGTACATTCTATGGATTTGGGCAAATGTATAAAG
GCATGGATCCACCATTATAGAATCATACAGGATAGTCCCACGGCCCTAAAAATCCTCTGTGCTCTCCCAATTCATCTTGTGTCCTCCCAA
CCCCTGGCAACCACTGATCTATTTACTGTCTCCATAGTTTTGCCTTTTCCAGAATGGCATATAATTGGACTCATGCAGTACGCAGCCTTA
TAAAATTGGCTTATTTCACTTAGTAACATGCATTTAAGTTTCCCTCATATCTTTTTATGGCTTGAGAGCTCACTTTTTTAGCACCAAACA
CTCATCCATTTTCTGGATGTACCACTGTTTATTTATCCATTCACCTACTGAAGGACACCTTGGTTGCTTCCAAGTTTGGTCAGTTATGAA
TAAAGCCACTATAAATATCTGTATGCAGGTTTTTGTGTGGACATAAGTTTTCAATTCATTTGGGTAAATATGATATGTTAAAGCTATATT
TAGTCTTGCAAGACACAGCCAAACTGCCTTCCAAAGTGGCTGTACTGTTTTGCATTCCACTAGCGATGAATGAGGGTTCCCGTTGCTCCA
TATCTTCACCAGCATTTAGTGTTGTCAATGATCTGCATTTGGGCCATTCTAAAAGATGTACGGTGGTGTTTCATTGCTGTTTTAATTTGC
AATTCCCTAATGACATGATTTGGGACATATTTTTATATGCTTGTTTTCCATCTGTACATCTTCTTTGGTGAGGTGTCTGTTCAGGTCTTT
TGGGCATTTTTTTAAATCGGGTTGTTTTCTTATTGTTGATTTGTTAAAGTTCTTTGTAAATTTTAGATAATAATTCTTTATCAGATGTGT
CTTCTGTAAATATTTTCTCCCAGTCCGTGGCTTGTCTTCTCATTATCTTGACCTTGTCTTTTTCAGAGCAGACGCTTTTAATTTTACTGA
AGTTCAGCTTATCATTTACTTCTTTCATGATCATGTCTTTGGTGTTCTATCTAAAAATCTATTGCCATATCCAAGGTCATCTAAGTTTTC
TCTTATATGTTACCTTCTAGGAGTTGTATAGTTTTGCATTTTACATTAGATCTGTGACCGATTTTGAGTTAATTTTTGTGAAAAGTGTTT
GTTAGGTCTGTATTTAGACTCTTTTTTTTTTTTTTTTTTTTGCCTGTGGATGTGCAAATGTGCAGCTATTTCAACACCGTTTGTTGAAAA
GACCCTCTTTGCCGCACTGTTTTGCCTGTGCTCCTTTGCCAAGGATCAGTTAACTATATTTGTGTGGGTCTGTTTCTCAGCTCTCCATTC
TGTTCCACTGATCTATTTGTCTATTCCTTCACCAACACCACATCGTCTTGAGTACTGTAGCTTTCTTTCTCCATATAAACTGCAGACTCA
GTTTTTTGGTACCAACAAAATAACTTGCTGAGATTTTTATTGGGATTGTATTTAATCTACAGAGGAAGCTGGGAAGTGACATCTTGACAA
TATTGAGTCCCTCCATGAAATGGAATATCTCTGTATTTACTTAGTTCTTCTTTGATATCATTCACCAGTTTTGTAGTTTTCCTCATGTAG
ATCTTATACATATTGTTAGATTTATACCTTAAGTACTTCATTTCAAGGGATACTAATTTAAATAATCATGTGCTTTTAATTTCAAATTTC
ACTTATTCATTGCCGGTATATAGGAAAACAATTGACTTTGTATATTAACTTTGAATCCTAAAATCTTGCTATAATCCCTTATTAGTTCCA
GGAAGGTTCTGGGGCTTGTTTTTGTTTTGTTTTTTGGTCAGTTATTTCAGATTTTCTACATAGATGATCATGTCATCTGTAAACAAAGAC
AAAGTTTTATTTCTTCTTTCTTCCCAATCTATATATTTTTATTTCCTTTCCTTGTCTTATTGCATCAGCCAGGACTTCCAGTATCATGTT
GAAAAGCAGTAGTGATGGGGACACCTTTTTTTTCCTGATCTTAGTGAGACAGCTTCAGGTTTCTCACCATCACGCCATTTAGTATGATGT
TAGCTGTAAGGTTTTTTTTTTAGATATTGTTTATCAGGTTGAGGGGCTTCTCCTCTATTCCTGCTTTACTGAGTGTTTTTATCATGAAAG
ACTGTTTGGATTTTTCTGCATCTGTTGATATGATCATGCAATTTTTCTTCTTTTGCCTGTTGATATTCATTACATTAGTTGATCTTTGAA
TGTTGAACCAGCCTTATATACCTAGGACAAATTCCACCTGGTCATGGTGTTTAATTATTTTCATATATTGTTGGACTTGATTTGCTAATA
TTTTGTTGAGGATTTCTGCATCTATGCTTATGACAGGTATTGGTCTGTAGTTTTCTTGTAATGTCTTTGTCTGGTTTTGGTATTAAGGTG
ATGCTGGATTCATAGAATGAGTTAGCAAGTGTTCTCTCTGCTTCTAGCTTTTGAAAGAGATTGTAGATAATCAGTATCATTTCTTCCTTA
AGTCTTTGGTAGAATTCACCAGTGAACCCATCTGGGCCAAGTGCTTTCTGGTTGGGGAGGTTACTAACCATTGATTCAAATTATTTAACA
GAGATATACCTATTCAGATTGTCTATTTGCTCTTGTGTGAGTTTTGACAAATTCTATTTTTCAAGGAATTGGTTCATTTCATCTACATTA
TCAAATTTGTGGGTATAAAGTCATTCATAAAATTCCTTCATTATCTTTTATTATCCTTTTAACCTCCATGGGATTGCTAGTAACGTCCCC
GCTCTCATTTCTGATAGTAGTAATTTGTGTTCTTTCTCTTTTTTTCTTAGTTAGCATGCCTTGAGACTTATGGAGCTTATTGATCTTTTC
AAAGAATCAACTTTGTTTCTATTTATTTTATTGATTTCCTATTTTCAATTTCGTGAATTTTTAATCTAATTTTAATTATTTCTTCTCATT
GGCTTACTTTGGGTTTAATTTGCTCTTTTTTTCTACTTTTTTAAAATGGAAACTTAAATGATTGATTTCAGATCTTCTTTTGTGCTATCT
GCATTCAATGTTATAAATTTCCCTTTAAGCATTGTTTTTATTGCATCCCACAAATTATAATAAGCTATGTTTTTATTTTCATTTATTTCA
AAATATTTTTTCACTTATCTTGAGATTTCTTCTTTGACCCATGATATTTACACGTGTGTTGTTTAATCTCCAAGTATTTTGGCATTTTCC
AGCTACCTTTCTGTTACTGATTTCTAGCTTAATTCCATTGTTATCTAAGAGCAAACATTGTAGGACTTGTATTCCTTTTTTTTTTTTTTT
TTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTAGAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTCCGGGGTTCAA
GCGATTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGACTACAGGTGCCCACCACCAAACCTGGCTAATTTTTGTATTTTTAATAGAGATGG
GGTTTCAGCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCCCAAGTGATCTGAGAATTTCTATTCTTTTAAATGTGTTAAGGTATGTTT
TATGACCCAGAATGCAGTCTAACTTGATGAACATTCCATGCAAGCTTAAGCAAAAAGACTAATCTGCTGTAGTTTCCTCATCTTTTTCAA
CAAACATTTGAACCCCATAGTCTCTGCTTTAATAATTCTAGTATCCATTCCAACCTACACCACCATCAGTTCTAGACTGTACCTCTACAC
TAAATGACCCCAGATGGTTCAGCTTTAAGTCTCAGCTGTTTTCATCATTTAACTGATTCCCTTGCTGGCAGCAGGGAAATTAACTACCAG
CCACACACTTGTCTCCAACAGCACCCACCGACCACGTCCTGCTCCCCTGTCATTACCACCACTAAACCCGGTAGCAGAGAGATGAGCTGT
GAGGTAGGTGCCTTCTAGATAAATGAGGTGCTACTGGACATGCACTGTGGTCTTCTCTGCAGTAGAAAAATGTCCAAGGAAGGTCAGCAT
CATTGATAGAAAATAAATGTGAGGCTGCATCTCGCCAGCTCATCCATGAGCAATTCCTTCAGCTCCAGCAGGCTACTGACAATTTGCTTT
TAACCCAAATCCAGCTCTACCCTCCCTAAAGCATGCACCTAGGGCCCCAGTCAGAAAAACAAAACAAAAACTAAACCAGACAGGATAATT
AAGGAGGCAAAAAGCTTAAACCATAATATTTTAATTAAGCTGATTTATTTTAACCGTAGCACTACTGCTTTATTTTAGTTATATACCAGT
AATGGAAAATAGTGGCCACTTTTCATTATTAATCATAAGATAATTCATTGTATTTGTCTTTCCTAATAAAATGGCATTATATTAAGGCCC
AAAATGTTTACTATGGCCCAGTAAAATATAGGGTTGTTCTGTGAGCTATTTCTTAGGATAGAAAATTATTCCAGAAAGCTATTAGTTCAA
AAGTCTCTAGCAGTGCCAAGGTTTCAATAGTCTCTTTAATTTTGAATCTATGCGATTGAAGATAAGACTGCATCTAGTTTGGGGGTTGCA
TGTTTGTGGACATTCATGTTTCTATGTACCTGGAACTTCTTATTCTCACCATCACACAGAATTTTCAAGAACTAGTTAAGCAAAGAAAGC
AAAGCCCAGCAGGTGTCAGAATTGGGTCCCCAAGCTGAGGGTCATTAGGGTGCATGTCAGTGTGCCAACTCCAATATCCACACCTAGAGA
ACGCACATCTTCCCAAAAGAAATGAAGCACAGATGATACTTGATCCTCAACTTTGTCTCCAGAAATTTTTTCAGGAACTTGAGTTCTTTA
TCAAATGCTCACATCCTACAGAGAAATAAAGTGTTCCATTTTCAAGGTTCATGAAGCTCGTCAATGCTGGGAGCAGGCACACACTTGTAT
TTTTATACTCAGGGATCCCAACAGGCAACTAAAACTAGACAAGGACAAAACTCCACTCAAAATATTCTGAAAGTTAGCTGATGCCCCATA
TTTTATTACTCCAAATGTGTATTCACTTGCCTGAGTGCTGGCCATGAGCACTCAGTGAACACTTGCAGTACAGTGAGTGATGTCCTTGAC
AAGTTACTATGAAGACTCTGAGAAAAAGTAACATCCCCCACTGTCCTCAACAAGCCTGTAATCCCATGGCTGCCAGCCCTTACCATGCAA
CAACACTGCGCTAAGTGCATCGAACCACACAAAACCCTGTGAGAAAATACTGCTTCCCACTTCACACGTGAAGTAACTGAGTCTAGTTTT
AGAAATACCTAAACGAAGAGGGACAGGCACAACAAATTTGCTGGAATGTAAAGAAAGTAGATCAGTTTCTGCGTAAGCAGTAAGAAATGG
CCTCATGAGGAAGAAAGGGACATTTGCCCTGACATTTCTCAAAGACTGCTTAGGTTTTGGAGACAGAGATCCAAGGGCAGGCAAGCACAA
TGGTTCATGCCTGTAATTCCAGCACTTTGAGAGGCCAAGGTGGGAGGATTGCTTGAGCCCAGGAATTCAAGATTAGCCTGTGCAACACAG
CAAGACCCCATCTCTATTTTAAAAAGAGAGAGAGAGATCCAAAAGCAAAGGCATTTCAGTTTGCAAGGCCAGCATGGGAGAGGGTCTTAA
AACAGAAACACACAAGGTAAGATTGGGGGATGGTACCTAGACCAGCCTAGGATCATAGGATTTGATAAAATATGCATTTGGAAAACTGGT
GCTAATTTATAGAGACTTAGAATTTCAGGCTAAGGACAAGGACTAAGAAACGAATAGCATGAACAGTATTATTGATAAACCCATCATTGC
ATCTTAAAGGCTCTGAAGTCTTTAGTATTGAATTAAAAAATAATTTTCACTGGACAAAACCAAAAGGTCTTTACACAACTGTCAAGCACT
TTGAAATGATTCAGCAAAAAGCAGAATAAATCACTAGTGGAATTTCAATAGCATGTAGTTGTAAACCATCATGTGTCCAGCAAAATCACA
AAACAAGAGTTTATTTTAGAAGGGACTTAGGGATATTAAGAAATATAACATACAAAATAACTAAAGTTTTCTCCAAGCAAAACCAATGAT
CCTTTAGGGATGAACAGAAAGAAAACAAGAAATGCTTCTTTCAAAAGTTGCTACCAAGGCTTCTAAGATTTCTTTGGAATAAAGTCACTA
AGATTTGCTTCTGAGGTCAATCTTGCCAACTTTTCCACCATGCTTTTTAGGAAGGAACACCAGGTAGGGCTCAAGTACTGGTTTGGCTCC
TGTCCCATTTTTTGGTCCTTTTGTAACTCCCTTTACTCAACTCCAAGTATGTCTGTGCACGGACAATGAGACGAAAGCATGCTCAATGCG
AAAGCACAAATTATGTATTGAGAAATCACTACAATGCCAAATTTTTTTAAAATAAAAAAAAAATATATATATATATATATATCTTTAAGA

>24698_24698_12_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

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Fusion Gene PPI Analysis for DYRK1A-KCNJ6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYRK1A-KCNJ6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYRK1A-KCNJ6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource