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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC2-TSPAN14 (FusionGDB2 ID:247)

Fusion Gene Summary for ABCC2-TSPAN14

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC2-TSPAN14
Fusion gene ID: 247
HgeneTgene
Gene symbol

ABCC2

TSPAN14

Gene ID

1244

81619

Gene nameATP binding cassette subfamily C member 2tetraspanin 14
SynonymsABC30|CMOAT|DJS|MRP2|cMRPDC-TM4F2|TM4SF14|tspan-14
Cytomap

10q24.2

10q23.1

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 1ATP-binding cassette, sub-family C (CFTR/MRP), member 2canalicular multidrug resistance proteinmultidrug resistance-associated protein 2tetraspanin-14tetraspanin similar to TM4SF9transmembrane 4 superfamily member 14
Modification date2020032920200313
UniProtAcc

Q92887

.
Ensembl transtripts involved in fusion geneENST00000496621, ENST00000370434, 
ENST00000370449, 		ENST00000429989, 
ENST00000265450, ENST00000341863, 
ENST00000372156, ENST00000372158, 
ENST00000372164, ENST00000481124, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 10 X 3=300
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC2 [Title/Abstract] AND TSPAN14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC2(101552116)-TSPAN14(82264484), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSPAN14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CL-01AABCC2chr10

101552116

+TSPAN14chr10

82264484

+


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Fusion Gene ORF analysis for ABCC2-TSPAN14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000496621ENST00000429989ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000265450ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000341863ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000372156ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000372158ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000372164ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
3UTR-intronENST00000496621ENST00000481124ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000265450ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000341863ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000372156ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000372158ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000372164ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370434ENST00000481124ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000265450ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000341863ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000372156ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000372158ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000372164ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
5CDS-intronENST00000370449ENST00000481124ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
In-frameENST00000370434ENST00000429989ABCC2chr10

101552116

+TSPAN14chr10

82264484

+
In-frameENST00000370449ENST00000429989ABCC2chr10

101552116

+TSPAN14chr10

82264484

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370449ABCC2chr10101552116+ENST00000429989TSPAN14chr1082264484+163254461131177354
ENST00000370434ABCC2chr10101552116+ENST00000429989TSPAN14chr1082264484+16294415821146354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370449ENST00000429989ABCC2chr10101552116+TSPAN14chr1082264484+0.0036472760.9963527
ENST00000370434ENST00000429989ABCC2chr10101552116+TSPAN14chr1082264484+0.0036682880.99633175

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Fusion Genomic Features for ABCC2-TSPAN14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC2chr10101552116+TSPAN14chr1082264483+7.19E-050.9999281
ABCC2chr10101552116+TSPAN14chr1082264483+7.19E-050.9999281

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC2-TSPAN14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:101552116/chr10:82264484)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC2

Q92887

.
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321_271111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33249_681111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33290_931111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33228_481111546.0TransmembraneHelical%3B Name%3D1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33269_891111546.0TransmembraneHelical%3B Name%3D2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+33294_1141111546.0TransmembraneHelical%3B Name%3D3
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372156412254_27027271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641239_6127271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641283_9227271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372158311254_27027271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831139_6127271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831183_9227271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372164081_170254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037216408254_2700254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640839_610254.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640883_920254.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000042998919254_27027271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891939_6127271.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891983_9227271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000481124061_170148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000048112406254_2700148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240639_610148.0Topological domainExtracellular
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240683_920148.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372156412233_25327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641262_8227271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641293_11327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000372158311233_25327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831162_8227271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831193_11327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640818_380254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037216408233_2530254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640862_820254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721640893_1130254.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000042998919233_25327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891962_8227271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891993_11327271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240618_380148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000048112406233_2530148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240662_820148.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004811240693_1130148.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321300_15341111546.0DomainABC transporter 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332322_6051111546.0DomainABC transmembrane type-1 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332637_8611111546.0DomainABC transporter 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332979_12641111546.0DomainABC transmembrane type-1 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321334_13411111546.0Nucleotide bindingATP 2
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332671_6781111546.0Nucleotide bindingATP 1
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321055_10971111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321119_11191111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321141_12111111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332115_1261111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321233_12341111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321256_15451111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332148_1651111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332187_3131111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332335_3601111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332382_4371111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332459_4611111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332483_5441111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332566_5871111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332609_9711111546.0Topological domainCytoplasmic
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332993_10331111546.0Topological domainExtracellular
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321034_10541111546.0TransmembraneHelical%3B Name%3D13
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321098_11181111546.0TransmembraneHelical%3B Name%3D14
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321120_11401111546.0TransmembraneHelical%3B Name%3D15
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321212_12321111546.0TransmembraneHelical%3B Name%3D16
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+3321235_12551111546.0TransmembraneHelical%3B Name%3D17
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332127_1471111546.0TransmembraneHelical%3B Name%3D4
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332166_1861111546.0TransmembraneHelical%3B Name%3D5
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332314_3341111546.0TransmembraneHelical%3B Name%3D6
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332361_3811111546.0TransmembraneHelical%3B Name%3D7
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332438_4581111546.0TransmembraneHelical%3B Name%3D8
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332462_4821111546.0TransmembraneHelical%3B Name%3D9
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332545_5651111546.0TransmembraneHelical%3B Name%3D10
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332588_6081111546.0TransmembraneHelical%3B Name%3D11
HgeneABCC2chr10:101552116chr10:82264484ENST00000370449+332972_9921111546.0TransmembraneHelical%3B Name%3D12
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721564121_1727271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST000003721583111_1727271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST00000429989191_1727271.0Topological domainCytoplasmic
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215641218_3827271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST0000037215831118_3827271.0TransmembraneHelical
TgeneTSPAN14chr10:101552116chr10:82264484ENST000004299891918_3827271.0TransmembraneHelical


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Fusion Gene Sequence for ABCC2-TSPAN14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>247_247_1_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370434_TSPAN14_chr10_82264484_ENST00000429989_length(transcript)=16294nt_BP=415nt
TTTCTTTGATGAAACAAGTAAAGAAGAAACAACACAATCATATTAATAGAAGAGTCTTCGTTCCAGACGCAGTCCAGGAATCATGCTGGA
GAAGTTCTGCAACTCTACTTTTTGGAATTCCTCATTCCTGGACAGTCCGGAGGCAGACCTGCCACTTTGTTTTGAGCAAACTGTTCTGGT
GTGGATTCCCTTGGGCTACCTATGGCTCCTGGCCCCCTGGCAGCTTCTCCACGTGTATAAATCCAGGACCAAGAGATCCTCTACCACCAA
ACTCTATCTTGCTAAGCAGGTATTCGTTGGTTTTCTTCTTATTCTAGCAGCCATAGAGCTGGCCCTTGTACTCACAGAAGACTCTGGACA
AGCCACAGTCCCTGCTGTTCGATATACCAATCCAAGCCTCTACCTAGGCACATGGTTGGCTGGAGTTGTCTTCCTTGGAGTCGGGCTGTG
GGCATGGAGCGAAAAGGGTGTGCTGTCCGACCTCACCAAAGTGACCCGGATGCATGGAATCGACCCTGTGGTGCTGGTCCTGATGGTGGG
CGTGGTGATGTTCACCCTGGGGTTCGCCGGCTGCGTGGGGGCTCTGCGGGAGAATATCTGCTTGCTCAACTTTTTCTGTGGCACCATCGT
GCTCATCTTCTTCCTGGAGCTGGCTGTGGCCGTGCTGGCCTTCCTGTTCCAGGACTGGGTGAGGGACCGGTTCCGGGAGTTCTTCGAGAG
CAACATCAAGTCCTACCGGGACGATATCGATCTGCAAAACCTCATCGACTCCCTTCAGAAAGCTAACCAGTGCTGTGGCGCATATGGCCC
TGAAGACTGGGACCTCAACGTCTACTTCAATTGCAGCGGTGCCAGCTACAGCCGAGAGAAGTGCGGGGTCCCCTTCTCCTGCTGCGTGCC
AGATCCTGCGCAAAAAGTTGTGAACACACAGTGTGGATATGATGTCAGGATTCAGCTGAAGAGCAAGTGGGATGAGTCCATCTTCACGAA
AGGCTGCATCCAGGCGCTGGAAAGCTGGCTCCCGCGGAACATTTACATTGTGGCTGGCGTCTTCATCGCCATCTCGCTGTTGCAGATATT
TGGCATCTTCCTGGCAAGGACGCTGATCTCAGACATCGAGGCAGTGAAGGCCGGCCATCACTTCTGAGGAGCAGAGTTGAGGGAGCCGAG
CTGAGCCACGCTGGGAGGCCAGAGCCTTTCTCTGCCATCAGCCCTACGTCCAGAGGGAGAGGAGCCGACACCCCCAGAGCCAGTGCCCCA
TCTTAAGCATCAGCGTGACGTGACCTCTCTGTTTCTGCTTGCTGGTGCTGAAGACCAAGGGTCCCCCTTGTTACCTGCCCAAACTTGTGA
CTGCATCCCTCTGGAGTCTACCCAGAGACAGAGAATGTGTCTTTATGTGGGAGTGGTGACTCTGAAAGACAGAGAGGGCTCCTGTGGCTG
CCAGGAGGGCTTGACTCAGACCCCCTGCAGCTCAAGCATGTCTGCAGGACACCCTGGTCCCCTCTCCACTGGCATCCAGACATCTGCTTT
GGGTCATCCACATCTGTGGGTGGGCCGTGGGTAGAGGGACCCACAGGCGTGGACAGGGCATCTCTCTCCATCAAGCAAAGCAGCATGGGG
GCCTGCCCGTAACGGGAGGCGGACGTGGCCCCGCTGGGCCTCTGAGTGCCAGCGCAGTCTGCTGGGACATGCACATATCAGGGGTTGTTT
GCAGGATCCTCAGCCATGTTCAAGTGAAGTAAGCCTGAGCCAGTGCGTGGACTGGTGCCACGGGAGTGCCTTGTCCACTGTCCCCCTGTG
TCCACCAGCTATTCTCCTGGCGCCGGAACTGCCTCTGGTCTTGATAGCATTAAGCCCTGATGGCGCCGGTGGCGCGGTGGGCATGGTTCT
TCACTGAGAGCCGGCTCTCCTTTTCTTAAAGTGTGTAAATAGTTTATTTATAGGGGTAAGAATGTTCTCACACCATTTCACTTCCTCTTC
CTCTCCTCCAGCATTCTCCTCTGAGCAGCCTTAGATAGTGTCCATGGCTGGAGCCGACCCTTTGAGTCCCCTTGAGTGTCTTAAGAACCA
GCCCACAACAGCCTCTCTTTCTCCTCCACATACTGCAGCCTCCCTCCATGCATCCCACATACAAGCACTCCCCCACTCCCCAGCGTGGCC
TCACTGTCTTCTGGTCTTGGTGCTACTGAAATTGTCACCCAGAATTTGAATCCTGACCCTCCCCACTGCAAGCCCAGGGAGCCCCAGCCC
AAGATGGCCAGCCTGAAACTGTTGGCCAGGGCTCCTCTTGTGGCCATGTACCCAGGGCTGGCTGGCCTGCCATTTGCCTCTCCCCGGAGA
CAGCCGTTCTTCTGCAACCACACCCCGTGCCTAGCCACAACCCCAGGCTGCAGCTGCTCAGAAGCTCCAGGCATTTTGTTTCTGGTGACC
GCCCCTAATGGGATATCGGTGATCACTGGTCCACCCTTCCTGTCAGGGCTTTTCTGGGGCTGCTCTTGGAAATGAAGTCTTAAGTACTGA
ATAACTCCCCTGGGGATAGCTGGGGCATTTGTCTAGCTGGGCTACTTTCTAACACTTTGCCATAGCTCAGACCACTTCTCATCGTTCAGG
GATGGACTGCAACCTTAATTTACTTGCCGGAGTGTACATTCTAGTGTGGTGTATACTGGTGGCTGTTGATGATGATTTTTTTTTTTTTAC
ACAATTCTCTGTAGACTAGGAGAAGAATGCTTGTGTTTTTCGGAAGTGTGATGCTTCTCTTTGACTGCCAAACTCTTTTATGGAATATAT
CTTTATATTAATGCTGTTTTGGTCATTTTTGTTTGGGGTCACTATTGAGATATTGCTAAGCATCTCAGTGGTAAACGCGGCTGCCAGAGG
AACCAAGGGATAGGGTATGTAGACCTTACAGAAGGATGGATGGTAAAGGCAGTCCATCATCAGCACAATCTGACTTACATTTCATTGAGT
AATTTTTTTTTTTTTTAAGATTCTGTATGGCAGCACTTTCAGTTGCCCTTGTGTGCCGGCCACAGCCGCACAAGTTGGCTTGTGGTTTAT
CCCCCGCTATAAGTGAGAGCTGGAGAAACTTCAACTCCATAGGTCTAGAGGAAACATTGTTTTAGGTTATTTCTGTCCACCCCTGTGCGA
TACTATTTATTGATCCAAGCAGAAGAGCTTGGGGACACTGAGTCGAAGTGGGGACATGGGATTGAAGCCTGGGCACTGCTGCTGCATGAG
CTGTGTGTCCTGGGTGTGCCGGCCTTTCTGTGAAGGGGGTTGGTGGCAGTGCCCACCTCACTAGATGCCTCTGACCCAGCCTCCCCTGGG
GGAGTGGGTGGCCACAGACCCTCCCTGCCAGAGCTCCTGGAAGGCTCCTGCAGGCCTGACCCATCTATTCCTGTAGACCTGGTTTAGGAT
GAAGTCTCGGTGCGATTTTTGCAGAGTTGGGTTTATCTTTCAACTATAGACCCTTCTGGCTGTTCTCAGCCATATCATGTGACTCTGAAT
AGTTGGATGAGGAATGGAAAGAAAGCAAGGATGAGAGCCGGTCACGTGGCAGTCTCCGCCCAGCATCGGCTGTCCGCACAGAGGCACAGG
GCAGGCCTCCTGTGCACTCCCCACCTAGCACTGGCCTGTCCTGAATCCCCGCCTTCCCTGGTTGGAGGCCAGCTGTGGCATTTGCACCCT
CTTCTCACCTCACCATGCACATGCTAACTTTAAAGCCTTGGGGTCTTTCCTGTACCCCCTCCTCAACCCTGGTCCACCCCCTCTCAGGAT
CTTGTCAACGTTATTTTTCCTGTCCCGTCTTCCTATCGCTGGCCTTCCTTTCCCATCCTAAAAACTTGCCGAGGCCCTATGGCTCCCTCC
CTTTCTTTCCCAGGCAGCTTCTTATCTGGGCTGTCTGTACCCCTTCCTTTGCACCACCCACCATGCCCCACGTAGCTGAAAGCTGCTTAT
CCCAATTGTCAACTCTGGCCTTCTTCAGCCTCTGTAGCACCAGACACTGCACCTCCTGAATGTCCTCTGCTTCTCTGCTTCAGAGGCCCA
GGCTCGCCAGTTCTCTGACCTCTCCCATATGTCTGCTTAGGACTCTGCTGCAGCTGTCCTCACCAGCCTCCGGGGAATCCCACTACCCAC
AGGGCAGGGCTGTGGGCTGGGCTGAAAAACCATCTGCATGGTCCACAAGAAGCCTGGCACTGGGTTTCCCCATGAATAACAATGAAAATT
AATGGATGCACAACCTTCCTGGAACGTGGAATTTCTCTGGGAGATTCCATGCAGAGGCCACTGGGGAGGTGGCAGGCATGCATGTGACTG
TAGGTGGCTGCAGTGTTGGAAGGCTCCCAGCAGAGCAGAGAGGGTGTCAGTCTCATCAGGGAACCCACCTGATGGCTTCTCAGCCAGCAG
TCTCAGAGGAACATAGACGACTGCTGAGAAAGGAGGGAGGCAGCAGTGGTCCCAGCACCTGAGGCATCCTGCTGTCATGGGAAGGTCTCC
GCCCAAATGTCAGATGCATCAGCCTGTCACCCGCTGGTCCAGAGCTTTCAGCTGTACTGGTAGGGGGTGGGTGGTGGAGTGCTGAATGAC
CTTCACAGGTGGGCCTTTCCAGCTCTAGGGTCTTACGGGTGTCGGTCCACAGAACCACGGTTTTTAGGTTGTGTGTCCGGGGCTATGGGA
ACCTGTCCCCCATGATGGATCTTGGTAGAGACACTTCCCTCTGTCATCGTGCCCAGGAGGATGCTGCAGGTGACTACCTGCAGCCCTGTT
CTCATTCATTTGGATGCCCTCCAGAAATCTGGGGAGCCATACACCTTTAGAGCCTTTTTTGCTCCTTATCAAGTTGGCAAGGCTTGGCCA
ATTCCTGTTCAAGGCTGCATTAAAGGCATGTTCACCATCCTGGCTAATACGGTGAAACCCCTTCTCTACTAAAAATACAAAAAAATTAGC
CGGGCTTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGGGAATGGTGTGAACCCAGGAGGCGGAGCTTGCAGTGA
GCCGAGATCACACCACTGCACTCCAGCCTGGGCTCAAAAAAGAAAAAAAAAAAAAAAAAAAGGCCCGTTCATTCTCAAATGCTTTTGGCG
TCTCCAGGGTGCCTCAGGAAAACATGAAGTGGGCATTGTAGAACTTGGGGCTACTGTGTAACTTTGGAAGAAAAAGTTAAGGGTACTTTT
AAGTGGATACTGTTTTGATGAAATTGCCAACTTCAGGGAGCCCAGCTTGGAGAAGGAGGACGTGAGTATTCCTTACAAGGCTCCGAAACA
ATTCTTTCTTCACTTAGTTTTCTTTCTGTGCTCTGCATCTTATATTCCAGCAGGGTCTTCCAATGCATGGTTTAATAACTACTAGAACTG
GCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAGGCTAAGACAGGCAGATCACTTGAGGCCAGGAGTTCGAGACCAGCCT
GGACAACATGGTGATACCCAGTTTCTACTAAAAATACAAAAATTAGTCGGGCATGGTGATGTGCACCTGTAGTCCCAGCTGCTCGGGAGG
CTGAGGCAGGAGAATCGCTTGAACCCGGGAGACAGAGGTTGCAACGAGCCAAGATCGAGCCACTGCGCTCCGGCCTGGGTGACAGGAGAC
TCCATCTCAAAAAATAAAATTAAAAAAAAACTACTACAATAAATTATCACCTTGGACTGTATAAAACAACTTTTAAACTAGTCTTTTTAA
AAAGTACACTTAAATAAAAATCTAAACATAAGAGAATGTAAAGTGAAAAGTGAAAGTATGTCTTCTGTTACGCAGAGGTAACTACTATTA
GGAATCCTTCCTGAAAATGTCCATGCATCTACTCAGGTCATCACACCCATGGAATCATTTTACATACTATTTTATGAGTGTTACTTAATA
TACTGATCCACAGTGCGTTTTCACGGTCACGCCATCAGTTGTAGGAGTGTGCCAAGAACAGATGGGCCTTGCCTTTGTACCAGAGGAGTC
CATTTACAGTTGCAGGTAATAGAAAACCCAATTCAGACTGGCCTAAACAATGAGGGGAGGTTTTGGCTCTTGAAACTGGAAAGTCCCAAG
GTGGGGTGAGTTTCAGGTTTGGGTTGATCCAAGTGGCTCAGTGACGTCAACAGGATCTTGTTTCCATTTCTCTGCCTTCCACAGCCTCCC
CTTCATCTATGGTGGAGGGAAGGAGTCTACCACAGACAAACCCCGAGCCTCCCCCTGATGGGTGGTGTGGTGGTGAAGCCAGCAAGGGAA
GGGATCCCCGGACACACCCCTCCTCATGCTTTATCCCACTGAAACCATGCGGCTGTGAAATGCAGCATCCTCCAGGAGGGGGATGAAGGC
CGGGGATGCTGTCAGCTATTGCCATTGCACTTCTGTGGATGGGTGTTACAGTTTTTTGCAGGGTTTTGCACTTACAAGGACATATATATA
TATATATAAACTACAGTGTTATTGGAATTGCTTCTTACAGTTTGTAAGAAAAAAACATGTTTTTAGAGGAGTTCTCCTGGGAGGTGGGAT
CACATTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTGGCCCAGGCGGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAAGC
TCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTT
TTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGGGGATCACATTTTAATAAGTAGGTACTCAGGGCTGGGGTGTACC
TGTTGCTGCCTGACCACTGCTGGTGTGTGTGGGTATAAGGTGACAAAACCTCCTACCCCTGTGAGGTTGTTTCAAGGATTAAATGAGTTG
AGATGGGTAAGCATCTAACAAAGATCCAGATTATTTAGTATGCATCCCCTGAATTATTGCTAACATAATTTTAATGATTGGGGAATTTTA
TCTGTGGCTGCCAGTCCCTACGAGAGAGCTGCCTGGGTCACATGTCAGATAGCTCAAGCTTTGAATCACTGAAACGAAACGGTCCACTTC
CCTGTCCCTTTAGGAACAAGGCTTCGAGGTCTGTGGCAAGCCTCAGCAGGCATTTGGAGTTCAAGGTCTGTTCTCTTTCTGTGCCATAGA
GGTGGGGAGACAAGGTAGGGTGTTGCTTCTTGCCTGGAGCGCAGATGCTACCAGAAACCAACACAACCAAAGTTGCCCGGGAGCCCCCAG
AAGCAGCAGAGTGGCCATCAACTGCCAAGGGGCCAGGGTAGGCCACAGAGGCCTGGGGCCCAGGAGGGATGGTCTGTGGGGAGAAAGGGG
ATTATTGTGAACATCAACGCTGGGGATAATGTGCCCTGAAGACAGCAGCATATCACGTTTGGACGGTTGGTGGACCCCATCTGGTCCCAC
TCATAAGGAGAACAGAGGCCCTGGGGTGTGCTGGGACTTGCCTGAGGCCTCAGACCGGGACTGGGTGCTCCTCCGCACCTCCTATGAGGG
AGGGTGTCCGTGTCTGTGAGGACAGCTCAGCAGGGCTGGGAACCTGGGGGCAGTGCTGGGGGACATGTGTGAGACTAGCGTGTGTGGGCC
TTGCTCGGCTTGCCCTGGTGCCCTGAGAAAAACCTGGTATTTGAAAATACACATGGACTGCTGGAAGGTCAGGAAATCCAGGGTTTTGTT
CTGAGGCAGTGGAAGTGTTACCGTGAGCCTGTGTTGGCCTCTCTCCTCACTCCACCTGCAGCCAATTCAGCCACACTGCCTTTGCATGGA
ACCCAGGGTTGCAGGCCGCGTGTGTAGATGCTGATTTAGGCCCAAGCACTCAGCTGTCAGCAGGAAGGACCATAGTGTTTTCTTCTAGTT
TTAGATATGCACTCGTTCTGTGTTTTAAAGTCACAGCTGTGAGCCAATATGGGAAGAAGTGAAGTGGCCTCTAGGAGGGACTGAGCACCC
TGTCCTTGGAGGTATGCAAGCCCAGGCTACACCCTTCCTGTCTGGGATGATATGGCTGGGGGTGGGCTTTGTGCTGCGTGGACCATGGCA
AGCCTTTCCATCTCTGAGAGGTAGTGGTCCTTCCCGTGCCTTCTGTTAAAGATAATTTTTTAAAAAAAGGCATAACTCATATATATTACA
TGTACACATGTCAAAGATTTTATTTAACTCAGTAATTGAGAGTGCTGCTAAGATTAACAGCCAGTTCAAAAGAGAAATCACAATGAACCA
TAAATCTGTATGGAGTAAAGGAAAGTTGAAACTGGCTGGGGTTTTTTTTTTTTTTTTTTTTTTTGAGGAGAAAGGTCAATTGAATCTTAT
TCGTATAATATGCACATCCATAGACAAGAATTATTTTGCATTAACTCTACAACTTAGTTGTAAAAATAGCTCAAAGGCAGTGAAAGACTA
GAATCAGATAATTGGAAGGGTGCACCCTAAGCAATGCATAGTTCTATTTTCTTTCTTTTTTTTTTTGAGACAGAGTTTCCCTCTTGTCAC
ACAGGCTGGAGCGCAGTGGTGCAATCTTGGCTCATTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGACTCAGCCTCCTGAGTAG
CTGGGATTACAGGCGCATGCCACCACAACTGGCTAATTTTTGTATTTTTAGTAGATACAGGGTTTCACTGTGTTGGCCAGGTTGGTCTCA
TACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAATGTTGGGATTACAGGCGTCAGCCACCACGCCCGGCCCCAATGCATAG
TTTTTTACTGAAGACAACCAGAATCTCTGTTGCTTATTCCAAATTTCCTTCCACCACTTGTCCATCCAGCAGAGCCACTTTTAAAATAGG
ACACAGGCAGAAATTTAAAGGAGTCAATATCTCATGGTGAAAAGTGAATCCTGAGGGTTAGAGCATCCACCAGGTGCCCTAGGTAAGGGC
CAGCCACTCTGGGAGGCAGCCCGGGGCACTCACTGTCCTCTCAGTAGTAAATGAAATCACTCAGGCCATGTCTGCTACCCAGAGAGCCTG
AGTGTCCTCAAATGCTTGTTCTGCCTCTCCATCCACTCCTGCAGACACCTCAGTGGCTGCATCCCAAACCGCTGAACTTTGCTTCTCTTT
CTCCAACCCCCAATTCCACCCACATCCAAAACTGCTCTGCCCCCTATTCCCATCTCAGCTGAGGGTACTATCATCCACCCTGTGGCCACA
TCCAGGAATGTGTGTATCACCTGGGCTCTGAGGATGACATCAGCTCTTCTAAGTCAACAGAATGTCGGGTCTGTTCTAAAAGTCTCATCT
GACAAGGAGATCTTTAAGGCTTTACTCCCTTAAAGGCTTTACTCCCATCATGATGGGATAACCATCATGATGGATTTCAGTGTCATTCTG
TCTTTTTCTTCGGAATGATTCCTGGGACTCGCCTTGTTTGCAACATGTGCATTGAAATATCTTTTCAACATAACTTTGTTCTTAATTGTG
TTTACTTCCTTTCTCTGTGAATCTCAGTGATTCCTGGAAGCTGTGGTTGGTGGGGGATGGGGTGGGAGGACTTTGGTAGTATAAAAGAGT
ACCTGCAATGAATGTTCTAAGAAACTGGAGTGTTGGGGTCCTCCAGCCCTTGGCTGGTAAACTCTCCACTCCTTCCTCTTTGCAACACAA
TTCTCATAACTGGCAAAGGTGTGCATGTAAAATTTGTGACTGTAGTCTGAGGTTTTTTTTCCCTGTACAATTCCGCCTTCCCCCCTGTAA
GCCTGTACCAGGAGAGGTCTCAGCTGCCTTGGAGGCGGTGAGACACGTGGGTGCTCACTGTGGCCCTCAAGGGTGAGGCTGGCACTGGGG
CATCTGGGGCCAGAAGTCCTCCTTTAGTCCCAAGTCTCTGCCACTCAAGTGCATCAGTGAGAGGTCCTCATAGAAAATCTACTGTGGGCA
CAAAGCTGCCAGGCTGATGGGGGTGGGGAGCAAACGAACACCCTTTTCCCCTTTTACACCAGAGGAAAGAGACTTAGACTGAGGAACTTG
CCTGCTGCCAGACAGCTGGGAGGTGGTAGAACCGGGCTTACAGCCCAGGGTTTCCACTCTAGGAACTCTTCTCCCTTCCTCTGATGACAC
TAACTCGCAGGCCATGATCAATGAGCAACGATGTAGGCAGGCACTGACGAGGCACAGCAGGAAGGCAGCTCAGTGCCCATGACGGCCAGG
AACTGGGTACCATTTCCTCAGCAAAATGGGATAGTAACTCCCACACTGCAGCTACGCACTTGGGCAGTGGTTCACAAGGCCAGCAGCCAC
AACATCACCCCAGACCAGCAGCAGCTGCAGCATTACCCCCAGCACTTGTTAAAAGATGCAAATTCAGGCCAGGTGTGGTGGCTCGTGCCT
GTAATCCCAGTACTTTGGGAAGCCAAGGCGGGTGGGTCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAATGTGGTGAAACCCTGTC
TCTACTAAAAATACAAAAAATGACCCGGGCATGGTTGTGGGCGCCTGTAATCCCAGCTACCCAGGAGACCGAGGCAGGAGAATCACTTGA
ACCCGGGAGGCAGAGGTTGCAGTCAGCCGAGATTGTGCCATTACACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTTTCAATAAATAAA
TAAAAATGCAAATTGTATGCCCCTTCCTTCAGGCCTATGGGACCAAAAACTGGGATGGGGCCCAATAAAATGTTTTAACCAGCCCTTCGG
TGGTTACAGAAGGATAGAGCCAGAATAGACTAACCACTGTAACAAACATTACCTATACTTGGGAGGCTTTGAAAAATGTTTATTTAGCCG
GGTGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATTGAGACCAGCCTGGCTAA
CACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTGGCAGGTGCCTGTAGTCCCAGCTACTCTGGAGGCTGAG
GCAGTAGAATTTCTTGAACCCAGGAGGCGGGGCTTGCAGTAAGTCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTC
CATCTCAAAAAAAAAAAAAAAGGAAAGAAAAATGTTTATTTTTTTGCTCATGCCACAGTCTCTGGTAGTTGCTGGGAACTAGGGTGGGGG
ATTCTCTGCTCCACACAGTCTTTCATGGACCCAGGTTCCTTTCCTGTTGTGGGTCCAGCCTCCTGTAGCTGTTGGAGGCATCTCTAGTCA
GCTGGTGGTTGGGGAAGAGGTGAGGATCAGGGAGGGAAGATGGAGAGTACTCTGCTTGTTCTCACATTCTGCTGGCCAGAACTCACAAGC
CACCTGAAATGATGCAAAGGTCTAGCTGTGTGTGTAGGAGAAAGAAGAGAGGCCAGATATTGGAAGACAGCAGTGGTCTGTGCCCCAGGC
CCCATGGTTTAGGGAAGTGAACCTTGGCACTGGATTTCCTGGCTTTCTAAATCTCCCTTTATAGGGAACTTAGGGCCCAGTCTGTGGTGG
GTGGATTTGCCTGGTTCACAGCCTCTGGTCAGCCTTCTTTCTGCTCCACAGGGCGGCCTGGAGATGGTGGGCTCCTTGTCACACTGGTTG
GGGATGTGGGCTCCATGGGGCCAGAGATGTGTGTGCTCTGTGTTCAGATTAAGGGACAGACGGCACATGAATTCCTTCAGTGCCCTCCAG
ATTTGGTCACTGGGGAGGGGTAGGCTGAGCAGTAGCTCTTGGGTCTGTAGTAGTGTGACCCTGGAAGGACTGTCCAGCTGAAAACAAGAG
CCTGGGGCGTGGGGAGGGGAGGGGTTACTCAGGGTTCCATGAGACCTGGGTTTAAGTCCTGGATCCATCATTAGCAGCTATGTGAACTTA
TGCCTCACTTTCCTCAAATATGAACTTGAGATAATGAAATTACCTTCCTCATAATACTGTTCTAAGAATTGAATGAGGAAAGGTTTACAA
TTCGGCCCTGGTTGTTCCACTGGGGAGGGAACAGAGATTGGGGGCACAGGGCTCCCCTGGCCTGGGGGAGTCTGGCTCACTCAAGTTCTC
AGTCATTTGCAAGGCAAGGACCCTGCTTCTCCTTGCTCTGGGTCCGAGTAGTCTCAAGCCCAGTGGGCAGGGCCTGTGGTGTGGATGGAC
TCGTCTGCAGTGAGTCAGGCAGCAGGCAGAGCTGGCAGGCTGTGTGGTCTCTAGTGGGTACCAGGGGACCTGGGAGGGCCTTGTGGGAGG
TTGTCCACGGTGTGAGCCAGTTTGCCATCTGGGGTCCTGGAGTTCCCTCCCGCCCTTTGAGTTAAAAAGAGTCAGTCCTGGGCTGAGACT
TAATTGCGCTAGTGCTGAGTGACCTTGTGTCAGGGGAAATCGGATGGGGCAAAGTGTTTTTTAATTAGCAGGACTCACTGACCTTTCCTT
CACTGTCAGCAACTTCTCACAGGGAGGCAGAGCAAGGGGGGCTGGAGCCCCGCATCTCTCTAATGGAGCCTATGTCCAACAAGGAGGTGG
ATGGCTGGATTCAGGGCCCTGGGAGGACTTCATGTGGGAAGCAGACCTCAGGAAGGGCCCTTAGTGATGGTGTGGGCCAGGGTTCTCACC
TCCTTAGTCTCCTGTCCTGTCCATCTCCGCAGATCCTAGGCAAAAGAAGCGGAGAAACACTCAAGCCACTGGGGTGGTTAGGGCACACTG
GTGGCAACTGTTTAAAACCTTAACTAAAACAAGGTTAAGCAAAAGGAGTTTACAGGCTCTCATAGATGGGAAGGATGTGGGAGGGTCACA
GACTGAGAGGAACCAGGGCTGTGGCTGCTGGAAGGAGCCTCACCACCGCCAGTGTGTTTCCTCCCCGTCGTCGGCATCTCTGCTTCTCTC
TGCACGCCAGCAGCTCTCTCTTAGGGCACGCAGACCTTTCCTCTGCAGGGGAACACGAGTGCCGGCAGCCCCGAGTTAGTGACTATCATA
GAAACTCAGTGTATTTCTCTCTTGTTTATCATTCCGAGTCCTGAGTCACAGGCTTGTCCAGCACTCAAGACTTTTTCTTTTCTCTATTTT
TTGAAACGGATTCTCGCTCTGTCCCCCAGGCTGGAGTGCAGTGGCCCGATTTTGGGTGCAAGCGATTCTCCTGCCTCAACCTCCCGAGTA
GCTGGGACTACAGGTGTGCGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACTATGTTGGCCAGGCTGGTTTC
AAACTCCTGACCTCCCGCCGGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCTGGCCAAGATTTTTTCTTTTAA
ACCTGGAGTATGGAGATGCTCACTAGGCAGACAGAATCAGCCACCACAGCCCACTCCCTCAGCCAGTATTACTTTGACTAAGTTAGTGAG
GAACCAGGCCCCAGATTAAGAAGCAGAACTCACACTGTCATCTGCTGTGTGCCTGGCTGGCTCATGCATACCTTGTCTATCTAATGTGGA
CCAAAGCCCTGTGGCACACCCTGCTGGTTACCCCCAGTGGTTACCCTGGCACAGAGGAGGAAAGGGAGTCGTGGGAGGGAGAAGGACTTC
CCTGGGAGGTCTCTGGGCTGGCAAGTTGGGTGACACAGGTCCGGTTGGCTGCAAGCCTGGGCTCTGCTGTTGTAATCATAAATGTGTGTG
TGTGTACAGTTGTTTACAATGTCAGCATGGGTGTCCTTGTTTGTTAGAGATACATGCCACTGCTCCCATCATGAGGAAAATCCCAAGCCC
TCCCCATGATTTTTGCCAGTTTCTGGGGACTCATGCTCCTGGCAGCCCATGTGTCCCCAACTCCTGTGTCCTTTAGGGACCTCTGTTGAG
CCCTGCCTCTATTCTGGCAGAATTAGAGAAAATTCTTTAAAAAAACAATAAAGTTTAAATTCATTTAAAAAAATAATAAAAAATCTCACA
GCATGAGTTTTGATGAGATTTGGGGCAAGGTGGGCCACAACCTTGGGTTGTATGGCCACCTCCCCCTCTTCTTCCCCTGTTGTCTCTGCA
GCTCAGAAACCCCAATTTCCTGGCCTGTGTTATGTGGAGGAGCTGAGCTCACCCCCTACAGCTTCATCTCCAAACCTAGCAAGGATCCTG
CCCAGATCAGGAGATCCTCCTTTTAACAGAAGTTATTTACACTCCTTAGAAAGCAGTGGGGGTGGAACGATTCTTTTTCCTGATGCAGAG
ATGTAAAACTGGGACATTGCTACACATAATATTTTAAACCTGTCTTCCCTCTTACCAACGAACACATCACTAGCACCATCTATGCCAATA
CATTTCTCAACATCAATTTCAGTGGCTGTATTACATTTTATCCTACGGATGTGCTCTCATTTATAATCTAAACCACTTTTATTGAACACA
TCAGTTATTCTGAAATTTTCAGTGTTATGATGGATGTTGCAGTAATTATTCTTATATATGCACAGAACCCCCAGAGGACATGACTACTGA
AGGCTGTGCTGGCAGGATCACAGGTAAGGATCTAGCAAATTGTCCCAGCTTCATTGACTGAGCTTTCATCCTTGTTGCACTACTTTGAGC
TGCCATTTTGATCATATAATAATGATTTAGTAGAGCTCTTTTTTGGTTCAACCTACCTGTTCTTGTATCAGAACTGAAATGTTTGATTTT
ATAAATTTGAATAGTGGCACAATATAGAGTTCACTATTCCTCAATATTTTCAAGGCTGTTTCTTATCTGTTCATTCTTTTGGTTAACTTG
GGAATTATTTTATCAAGTCTCTCTACTTCCCAATTTCCTTTCACCTTTGGCTCGAAATGATATTCAATGTATACATTAACTTGAGTTACA
TTTTGCTGCATAATGCTTGAGTTACATTTTGAGTATTACGTGTTACTCATAATACATATTGAGTTACATTTTGCTGCATAATACATTATC
CCCAAGTTTAACACCTTAAAGCAGCACATATATATCTCATACCCTTCTGAGGGTCAGGAATCTAGAAGCAGCTTAGCTGGGTGACTGTGG
CTCTGGGTCTCTCATGAGGCTGCAGTGAAACTGTTGGCCAGGGCTGGAGGATCCCTTCCAACCTCACTCCATGACTGTTGGTGGGAGGCT
TCAGTTCTCCACCTGGTTCTCACAATATAATTTCCCCCAGAGTGAGTTATCAGAGAGAGTGTGCAACCAGTAATCTGTTAGAATATGTCA
CGTCTGTCATATTTGATTGGTCACTCAGACCAACCCTAATAGATGCGAGAGTGACTATGCAAGGGTGTGAGTTCCAGGAGGAAAGCATCA
TTGGAACCATCTTGGAGACTGGCTAATACACAGATAAATGGCACATCTGACAATATGGCATCTTTCTGAGTGTCAGTGTGGTGTGTTCCT
ATATGAACTTAATGCTATTAAACTTAATTAAATTGTAGGTATGCTCTCAGTGAAGATTTTTACTTTTACATTACAGGTTTCCACACTGTT
AAATTCATTCCAAGTATTTCATACATGCTGTTCCTATTATGAAAGGATCTTTTTTTTCACATGGCATTTTCTAAGTAGTTGTTGCATTCA
TATAGGAGATGCTATTGATTTTGACACCCATAATTTTTCAGTGGAGACAAGGCAGAAACTACTCCAGACTCTCACCTGCTGTTGCTGATC
CTTACATGGTGGCTGTGCCAGGCTCAGCCGCGCTGAGATGACAGGGCTGTCTGGCCATCATTGGTCATATGGACTTCAGATTTGAAAGGA
TTTTATGTAGAAGCAGAGTGCCTGATAGGACTCTCCGGGACCCCCATTTCTGCCCTGCTTGGCTCCCACTGGCAAGGCTGGCTCAGTTCC
TGTCACCTTCTCCTGGACTTTGGCCAGAGTCCACTGGCTGTTTCCCCTGCCTCCTGCTCTCCCAGTGCCCTCTCCACACCAGTGCCAGAG
CTGCTTCTAAGAGATGCCTCAAAGCCCGCTTCCAGCTTAGGAACCCCAGGGAACATGGATGGTTTCTCCATTGCCACTTCCTAGCCTTCC
TGGCATAGGAAGGTCTGGTTTGCCTGCAGGTCCCTCTCTGGGGGGGTCCCTGCTCCATAGATGCTGAGGCTCCAGAAGTCTGTTCTTTTA
TATCACATTTGAAAACCTTTGAAATGCATTATAGTTGAGTCATATGAATTATGTAAGTATATCCTACTCATTGTATAAAACAACACAGAA

>247_247_1_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370434_TSPAN14_chr10_82264484_ENST00000429989_length(amino acids)=354AA_BP=111
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED
SGQATVPAVRYTNPSLYLGTWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCG
TIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSC

--------------------------------------------------------------
>247_247_2_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370449_TSPAN14_chr10_82264484_ENST00000429989_length(transcript)=16325nt_BP=446nt
ACATCAGAATGGTAGATAATTCCTGTTCCACTTTCTTTGATGAAACAAGTAAAGAAGAAACAACACAATCATATTAATAGAAGAGTCTTC
GTTCCAGACGCAGTCCAGGAATCATGCTGGAGAAGTTCTGCAACTCTACTTTTTGGAATTCCTCATTCCTGGACAGTCCGGAGGCAGACC
TGCCACTTTGTTTTGAGCAAACTGTTCTGGTGTGGATTCCCTTGGGCTACCTATGGCTCCTGGCCCCCTGGCAGCTTCTCCACGTGTATA
AATCCAGGACCAAGAGATCCTCTACCACCAAACTCTATCTTGCTAAGCAGGTATTCGTTGGTTTTCTTCTTATTCTAGCAGCCATAGAGC
TGGCCCTTGTACTCACAGAAGACTCTGGACAAGCCACAGTCCCTGCTGTTCGATATACCAATCCAAGCCTCTACCTAGGCACATGGTTGG
CTGGAGTTGTCTTCCTTGGAGTCGGGCTGTGGGCATGGAGCGAAAAGGGTGTGCTGTCCGACCTCACCAAAGTGACCCGGATGCATGGAA
TCGACCCTGTGGTGCTGGTCCTGATGGTGGGCGTGGTGATGTTCACCCTGGGGTTCGCCGGCTGCGTGGGGGCTCTGCGGGAGAATATCT
GCTTGCTCAACTTTTTCTGTGGCACCATCGTGCTCATCTTCTTCCTGGAGCTGGCTGTGGCCGTGCTGGCCTTCCTGTTCCAGGACTGGG
TGAGGGACCGGTTCCGGGAGTTCTTCGAGAGCAACATCAAGTCCTACCGGGACGATATCGATCTGCAAAACCTCATCGACTCCCTTCAGA
AAGCTAACCAGTGCTGTGGCGCATATGGCCCTGAAGACTGGGACCTCAACGTCTACTTCAATTGCAGCGGTGCCAGCTACAGCCGAGAGA
AGTGCGGGGTCCCCTTCTCCTGCTGCGTGCCAGATCCTGCGCAAAAAGTTGTGAACACACAGTGTGGATATGATGTCAGGATTCAGCTGA
AGAGCAAGTGGGATGAGTCCATCTTCACGAAAGGCTGCATCCAGGCGCTGGAAAGCTGGCTCCCGCGGAACATTTACATTGTGGCTGGCG
TCTTCATCGCCATCTCGCTGTTGCAGATATTTGGCATCTTCCTGGCAAGGACGCTGATCTCAGACATCGAGGCAGTGAAGGCCGGCCATC
ACTTCTGAGGAGCAGAGTTGAGGGAGCCGAGCTGAGCCACGCTGGGAGGCCAGAGCCTTTCTCTGCCATCAGCCCTACGTCCAGAGGGAG
AGGAGCCGACACCCCCAGAGCCAGTGCCCCATCTTAAGCATCAGCGTGACGTGACCTCTCTGTTTCTGCTTGCTGGTGCTGAAGACCAAG
GGTCCCCCTTGTTACCTGCCCAAACTTGTGACTGCATCCCTCTGGAGTCTACCCAGAGACAGAGAATGTGTCTTTATGTGGGAGTGGTGA
CTCTGAAAGACAGAGAGGGCTCCTGTGGCTGCCAGGAGGGCTTGACTCAGACCCCCTGCAGCTCAAGCATGTCTGCAGGACACCCTGGTC
CCCTCTCCACTGGCATCCAGACATCTGCTTTGGGTCATCCACATCTGTGGGTGGGCCGTGGGTAGAGGGACCCACAGGCGTGGACAGGGC
ATCTCTCTCCATCAAGCAAAGCAGCATGGGGGCCTGCCCGTAACGGGAGGCGGACGTGGCCCCGCTGGGCCTCTGAGTGCCAGCGCAGTC
TGCTGGGACATGCACATATCAGGGGTTGTTTGCAGGATCCTCAGCCATGTTCAAGTGAAGTAAGCCTGAGCCAGTGCGTGGACTGGTGCC
ACGGGAGTGCCTTGTCCACTGTCCCCCTGTGTCCACCAGCTATTCTCCTGGCGCCGGAACTGCCTCTGGTCTTGATAGCATTAAGCCCTG
ATGGCGCCGGTGGCGCGGTGGGCATGGTTCTTCACTGAGAGCCGGCTCTCCTTTTCTTAAAGTGTGTAAATAGTTTATTTATAGGGGTAA
GAATGTTCTCACACCATTTCACTTCCTCTTCCTCTCCTCCAGCATTCTCCTCTGAGCAGCCTTAGATAGTGTCCATGGCTGGAGCCGACC
CTTTGAGTCCCCTTGAGTGTCTTAAGAACCAGCCCACAACAGCCTCTCTTTCTCCTCCACATACTGCAGCCTCCCTCCATGCATCCCACA
TACAAGCACTCCCCCACTCCCCAGCGTGGCCTCACTGTCTTCTGGTCTTGGTGCTACTGAAATTGTCACCCAGAATTTGAATCCTGACCC
TCCCCACTGCAAGCCCAGGGAGCCCCAGCCCAAGATGGCCAGCCTGAAACTGTTGGCCAGGGCTCCTCTTGTGGCCATGTACCCAGGGCT
GGCTGGCCTGCCATTTGCCTCTCCCCGGAGACAGCCGTTCTTCTGCAACCACACCCCGTGCCTAGCCACAACCCCAGGCTGCAGCTGCTC
AGAAGCTCCAGGCATTTTGTTTCTGGTGACCGCCCCTAATGGGATATCGGTGATCACTGGTCCACCCTTCCTGTCAGGGCTTTTCTGGGG
CTGCTCTTGGAAATGAAGTCTTAAGTACTGAATAACTCCCCTGGGGATAGCTGGGGCATTTGTCTAGCTGGGCTACTTTCTAACACTTTG
CCATAGCTCAGACCACTTCTCATCGTTCAGGGATGGACTGCAACCTTAATTTACTTGCCGGAGTGTACATTCTAGTGTGGTGTATACTGG
TGGCTGTTGATGATGATTTTTTTTTTTTTACACAATTCTCTGTAGACTAGGAGAAGAATGCTTGTGTTTTTCGGAAGTGTGATGCTTCTC
TTTGACTGCCAAACTCTTTTATGGAATATATCTTTATATTAATGCTGTTTTGGTCATTTTTGTTTGGGGTCACTATTGAGATATTGCTAA
GCATCTCAGTGGTAAACGCGGCTGCCAGAGGAACCAAGGGATAGGGTATGTAGACCTTACAGAAGGATGGATGGTAAAGGCAGTCCATCA
TCAGCACAATCTGACTTACATTTCATTGAGTAATTTTTTTTTTTTTTAAGATTCTGTATGGCAGCACTTTCAGTTGCCCTTGTGTGCCGG
CCACAGCCGCACAAGTTGGCTTGTGGTTTATCCCCCGCTATAAGTGAGAGCTGGAGAAACTTCAACTCCATAGGTCTAGAGGAAACATTG
TTTTAGGTTATTTCTGTCCACCCCTGTGCGATACTATTTATTGATCCAAGCAGAAGAGCTTGGGGACACTGAGTCGAAGTGGGGACATGG
GATTGAAGCCTGGGCACTGCTGCTGCATGAGCTGTGTGTCCTGGGTGTGCCGGCCTTTCTGTGAAGGGGGTTGGTGGCAGTGCCCACCTC
ACTAGATGCCTCTGACCCAGCCTCCCCTGGGGGAGTGGGTGGCCACAGACCCTCCCTGCCAGAGCTCCTGGAAGGCTCCTGCAGGCCTGA
CCCATCTATTCCTGTAGACCTGGTTTAGGATGAAGTCTCGGTGCGATTTTTGCAGAGTTGGGTTTATCTTTCAACTATAGACCCTTCTGG
CTGTTCTCAGCCATATCATGTGACTCTGAATAGTTGGATGAGGAATGGAAAGAAAGCAAGGATGAGAGCCGGTCACGTGGCAGTCTCCGC
CCAGCATCGGCTGTCCGCACAGAGGCACAGGGCAGGCCTCCTGTGCACTCCCCACCTAGCACTGGCCTGTCCTGAATCCCCGCCTTCCCT
GGTTGGAGGCCAGCTGTGGCATTTGCACCCTCTTCTCACCTCACCATGCACATGCTAACTTTAAAGCCTTGGGGTCTTTCCTGTACCCCC
TCCTCAACCCTGGTCCACCCCCTCTCAGGATCTTGTCAACGTTATTTTTCCTGTCCCGTCTTCCTATCGCTGGCCTTCCTTTCCCATCCT
AAAAACTTGCCGAGGCCCTATGGCTCCCTCCCTTTCTTTCCCAGGCAGCTTCTTATCTGGGCTGTCTGTACCCCTTCCTTTGCACCACCC
ACCATGCCCCACGTAGCTGAAAGCTGCTTATCCCAATTGTCAACTCTGGCCTTCTTCAGCCTCTGTAGCACCAGACACTGCACCTCCTGA
ATGTCCTCTGCTTCTCTGCTTCAGAGGCCCAGGCTCGCCAGTTCTCTGACCTCTCCCATATGTCTGCTTAGGACTCTGCTGCAGCTGTCC
TCACCAGCCTCCGGGGAATCCCACTACCCACAGGGCAGGGCTGTGGGCTGGGCTGAAAAACCATCTGCATGGTCCACAAGAAGCCTGGCA
CTGGGTTTCCCCATGAATAACAATGAAAATTAATGGATGCACAACCTTCCTGGAACGTGGAATTTCTCTGGGAGATTCCATGCAGAGGCC
ACTGGGGAGGTGGCAGGCATGCATGTGACTGTAGGTGGCTGCAGTGTTGGAAGGCTCCCAGCAGAGCAGAGAGGGTGTCAGTCTCATCAG
GGAACCCACCTGATGGCTTCTCAGCCAGCAGTCTCAGAGGAACATAGACGACTGCTGAGAAAGGAGGGAGGCAGCAGTGGTCCCAGCACC
TGAGGCATCCTGCTGTCATGGGAAGGTCTCCGCCCAAATGTCAGATGCATCAGCCTGTCACCCGCTGGTCCAGAGCTTTCAGCTGTACTG
GTAGGGGGTGGGTGGTGGAGTGCTGAATGACCTTCACAGGTGGGCCTTTCCAGCTCTAGGGTCTTACGGGTGTCGGTCCACAGAACCACG
GTTTTTAGGTTGTGTGTCCGGGGCTATGGGAACCTGTCCCCCATGATGGATCTTGGTAGAGACACTTCCCTCTGTCATCGTGCCCAGGAG
GATGCTGCAGGTGACTACCTGCAGCCCTGTTCTCATTCATTTGGATGCCCTCCAGAAATCTGGGGAGCCATACACCTTTAGAGCCTTTTT
TGCTCCTTATCAAGTTGGCAAGGCTTGGCCAATTCCTGTTCAAGGCTGCATTAAAGGCATGTTCACCATCCTGGCTAATACGGTGAAACC
CCTTCTCTACTAAAAATACAAAAAAATTAGCCGGGCTTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGGGAATG
GTGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGCTCAAAAAAGAAAAAAAAAAAAAAAAA
AAGGCCCGTTCATTCTCAAATGCTTTTGGCGTCTCCAGGGTGCCTCAGGAAAACATGAAGTGGGCATTGTAGAACTTGGGGCTACTGTGT
AACTTTGGAAGAAAAAGTTAAGGGTACTTTTAAGTGGATACTGTTTTGATGAAATTGCCAACTTCAGGGAGCCCAGCTTGGAGAAGGAGG
ACGTGAGTATTCCTTACAAGGCTCCGAAACAATTCTTTCTTCACTTAGTTTTCTTTCTGTGCTCTGCATCTTATATTCCAGCAGGGTCTT
CCAATGCATGGTTTAATAACTACTAGAACTGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGAACTTTGGGAGGCTAAGACAGGCAGA
TCACTTGAGGCCAGGAGTTCGAGACCAGCCTGGACAACATGGTGATACCCAGTTTCTACTAAAAATACAAAAATTAGTCGGGCATGGTGA
TGTGCACCTGTAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGACAGAGGTTGCAACGAGCCAAGATCGAG
CCACTGCGCTCCGGCCTGGGTGACAGGAGACTCCATCTCAAAAAATAAAATTAAAAAAAAACTACTACAATAAATTATCACCTTGGACTG
TATAAAACAACTTTTAAACTAGTCTTTTTAAAAAGTACACTTAAATAAAAATCTAAACATAAGAGAATGTAAAGTGAAAAGTGAAAGTAT
GTCTTCTGTTACGCAGAGGTAACTACTATTAGGAATCCTTCCTGAAAATGTCCATGCATCTACTCAGGTCATCACACCCATGGAATCATT
TTACATACTATTTTATGAGTGTTACTTAATATACTGATCCACAGTGCGTTTTCACGGTCACGCCATCAGTTGTAGGAGTGTGCCAAGAAC
AGATGGGCCTTGCCTTTGTACCAGAGGAGTCCATTTACAGTTGCAGGTAATAGAAAACCCAATTCAGACTGGCCTAAACAATGAGGGGAG
GTTTTGGCTCTTGAAACTGGAAAGTCCCAAGGTGGGGTGAGTTTCAGGTTTGGGTTGATCCAAGTGGCTCAGTGACGTCAACAGGATCTT
GTTTCCATTTCTCTGCCTTCCACAGCCTCCCCTTCATCTATGGTGGAGGGAAGGAGTCTACCACAGACAAACCCCGAGCCTCCCCCTGAT
GGGTGGTGTGGTGGTGAAGCCAGCAAGGGAAGGGATCCCCGGACACACCCCTCCTCATGCTTTATCCCACTGAAACCATGCGGCTGTGAA
ATGCAGCATCCTCCAGGAGGGGGATGAAGGCCGGGGATGCTGTCAGCTATTGCCATTGCACTTCTGTGGATGGGTGTTACAGTTTTTTGC
AGGGTTTTGCACTTACAAGGACATATATATATATATATAAACTACAGTGTTATTGGAATTGCTTCTTACAGTTTGTAAGAAAAAAACATG
TTTTTAGAGGAGTTCTCCTGGGAGGTGGGATCACATTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTGGCCCAGGCGGGAG
TGCAGTGGCGCAATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACA
GGCGCCCGCCACTACGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGGGGATCACATTTT
AATAAGTAGGTACTCAGGGCTGGGGTGTACCTGTTGCTGCCTGACCACTGCTGGTGTGTGTGGGTATAAGGTGACAAAACCTCCTACCCC
TGTGAGGTTGTTTCAAGGATTAAATGAGTTGAGATGGGTAAGCATCTAACAAAGATCCAGATTATTTAGTATGCATCCCCTGAATTATTG
CTAACATAATTTTAATGATTGGGGAATTTTATCTGTGGCTGCCAGTCCCTACGAGAGAGCTGCCTGGGTCACATGTCAGATAGCTCAAGC
TTTGAATCACTGAAACGAAACGGTCCACTTCCCTGTCCCTTTAGGAACAAGGCTTCGAGGTCTGTGGCAAGCCTCAGCAGGCATTTGGAG
TTCAAGGTCTGTTCTCTTTCTGTGCCATAGAGGTGGGGAGACAAGGTAGGGTGTTGCTTCTTGCCTGGAGCGCAGATGCTACCAGAAACC
AACACAACCAAAGTTGCCCGGGAGCCCCCAGAAGCAGCAGAGTGGCCATCAACTGCCAAGGGGCCAGGGTAGGCCACAGAGGCCTGGGGC
CCAGGAGGGATGGTCTGTGGGGAGAAAGGGGATTATTGTGAACATCAACGCTGGGGATAATGTGCCCTGAAGACAGCAGCATATCACGTT
TGGACGGTTGGTGGACCCCATCTGGTCCCACTCATAAGGAGAACAGAGGCCCTGGGGTGTGCTGGGACTTGCCTGAGGCCTCAGACCGGG
ACTGGGTGCTCCTCCGCACCTCCTATGAGGGAGGGTGTCCGTGTCTGTGAGGACAGCTCAGCAGGGCTGGGAACCTGGGGGCAGTGCTGG
GGGACATGTGTGAGACTAGCGTGTGTGGGCCTTGCTCGGCTTGCCCTGGTGCCCTGAGAAAAACCTGGTATTTGAAAATACACATGGACT
GCTGGAAGGTCAGGAAATCCAGGGTTTTGTTCTGAGGCAGTGGAAGTGTTACCGTGAGCCTGTGTTGGCCTCTCTCCTCACTCCACCTGC
AGCCAATTCAGCCACACTGCCTTTGCATGGAACCCAGGGTTGCAGGCCGCGTGTGTAGATGCTGATTTAGGCCCAAGCACTCAGCTGTCA
GCAGGAAGGACCATAGTGTTTTCTTCTAGTTTTAGATATGCACTCGTTCTGTGTTTTAAAGTCACAGCTGTGAGCCAATATGGGAAGAAG
TGAAGTGGCCTCTAGGAGGGACTGAGCACCCTGTCCTTGGAGGTATGCAAGCCCAGGCTACACCCTTCCTGTCTGGGATGATATGGCTGG
GGGTGGGCTTTGTGCTGCGTGGACCATGGCAAGCCTTTCCATCTCTGAGAGGTAGTGGTCCTTCCCGTGCCTTCTGTTAAAGATAATTTT
TTAAAAAAAGGCATAACTCATATATATTACATGTACACATGTCAAAGATTTTATTTAACTCAGTAATTGAGAGTGCTGCTAAGATTAACA
GCCAGTTCAAAAGAGAAATCACAATGAACCATAAATCTGTATGGAGTAAAGGAAAGTTGAAACTGGCTGGGGTTTTTTTTTTTTTTTTTT
TTTTTGAGGAGAAAGGTCAATTGAATCTTATTCGTATAATATGCACATCCATAGACAAGAATTATTTTGCATTAACTCTACAACTTAGTT
GTAAAAATAGCTCAAAGGCAGTGAAAGACTAGAATCAGATAATTGGAAGGGTGCACCCTAAGCAATGCATAGTTCTATTTTCTTTCTTTT
TTTTTTTGAGACAGAGTTTCCCTCTTGTCACACAGGCTGGAGCGCAGTGGTGCAATCTTGGCTCATTGCAACCTCTGCCTCCCGGGTTCA
AGTGATTCTCCTGACTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCATGCCACCACAACTGGCTAATTTTTGTATTTTTAGTAGATACA
GGGTTTCACTGTGTTGGCCAGGTTGGTCTCATACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAATGTTGGGATTACAGGC
GTCAGCCACCACGCCCGGCCCCAATGCATAGTTTTTTACTGAAGACAACCAGAATCTCTGTTGCTTATTCCAAATTTCCTTCCACCACTT
GTCCATCCAGCAGAGCCACTTTTAAAATAGGACACAGGCAGAAATTTAAAGGAGTCAATATCTCATGGTGAAAAGTGAATCCTGAGGGTT
AGAGCATCCACCAGGTGCCCTAGGTAAGGGCCAGCCACTCTGGGAGGCAGCCCGGGGCACTCACTGTCCTCTCAGTAGTAAATGAAATCA
CTCAGGCCATGTCTGCTACCCAGAGAGCCTGAGTGTCCTCAAATGCTTGTTCTGCCTCTCCATCCACTCCTGCAGACACCTCAGTGGCTG
CATCCCAAACCGCTGAACTTTGCTTCTCTTTCTCCAACCCCCAATTCCACCCACATCCAAAACTGCTCTGCCCCCTATTCCCATCTCAGC
TGAGGGTACTATCATCCACCCTGTGGCCACATCCAGGAATGTGTGTATCACCTGGGCTCTGAGGATGACATCAGCTCTTCTAAGTCAACA
GAATGTCGGGTCTGTTCTAAAAGTCTCATCTGACAAGGAGATCTTTAAGGCTTTACTCCCTTAAAGGCTTTACTCCCATCATGATGGGAT
AACCATCATGATGGATTTCAGTGTCATTCTGTCTTTTTCTTCGGAATGATTCCTGGGACTCGCCTTGTTTGCAACATGTGCATTGAAATA
TCTTTTCAACATAACTTTGTTCTTAATTGTGTTTACTTCCTTTCTCTGTGAATCTCAGTGATTCCTGGAAGCTGTGGTTGGTGGGGGATG
GGGTGGGAGGACTTTGGTAGTATAAAAGAGTACCTGCAATGAATGTTCTAAGAAACTGGAGTGTTGGGGTCCTCCAGCCCTTGGCTGGTA
AACTCTCCACTCCTTCCTCTTTGCAACACAATTCTCATAACTGGCAAAGGTGTGCATGTAAAATTTGTGACTGTAGTCTGAGGTTTTTTT
TCCCTGTACAATTCCGCCTTCCCCCCTGTAAGCCTGTACCAGGAGAGGTCTCAGCTGCCTTGGAGGCGGTGAGACACGTGGGTGCTCACT
GTGGCCCTCAAGGGTGAGGCTGGCACTGGGGCATCTGGGGCCAGAAGTCCTCCTTTAGTCCCAAGTCTCTGCCACTCAAGTGCATCAGTG
AGAGGTCCTCATAGAAAATCTACTGTGGGCACAAAGCTGCCAGGCTGATGGGGGTGGGGAGCAAACGAACACCCTTTTCCCCTTTTACAC
CAGAGGAAAGAGACTTAGACTGAGGAACTTGCCTGCTGCCAGACAGCTGGGAGGTGGTAGAACCGGGCTTACAGCCCAGGGTTTCCACTC
TAGGAACTCTTCTCCCTTCCTCTGATGACACTAACTCGCAGGCCATGATCAATGAGCAACGATGTAGGCAGGCACTGACGAGGCACAGCA
GGAAGGCAGCTCAGTGCCCATGACGGCCAGGAACTGGGTACCATTTCCTCAGCAAAATGGGATAGTAACTCCCACACTGCAGCTACGCAC
TTGGGCAGTGGTTCACAAGGCCAGCAGCCACAACATCACCCCAGACCAGCAGCAGCTGCAGCATTACCCCCAGCACTTGTTAAAAGATGC
AAATTCAGGCCAGGTGTGGTGGCTCGTGCCTGTAATCCCAGTACTTTGGGAAGCCAAGGCGGGTGGGTCACCTGAGGTCAGGAGTTCGAG
ACCAGCCTGGCCAATGTGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATGACCCGGGCATGGTTGTGGGCGCCTGTAATCCCAGCTA
CCCAGGAGACCGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTCAGCCGAGATTGTGCCATTACACTCCAGCCTGGGCA
ACAAGAGCGAAACTCTGTTTCAATAAATAAATAAAAATGCAAATTGTATGCCCCTTCCTTCAGGCCTATGGGACCAAAAACTGGGATGGG
GCCCAATAAAATGTTTTAACCAGCCCTTCGGTGGTTACAGAAGGATAGAGCCAGAATAGACTAACCACTGTAACAAACATTACCTATACT
TGGGAGGCTTTGAAAAATGTTTATTTAGCCGGGTGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCGGGCGGATCAC
GAGGTCAGGAGATTGAGACCAGCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGTGTGGTGGCAGGT
GCCTGTAGTCCCAGCTACTCTGGAGGCTGAGGCAGTAGAATTTCTTGAACCCAGGAGGCGGGGCTTGCAGTAAGTCGAGATCACGCCACT
GCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAGGAAAGAAAAATGTTTATTTTTTTGCTCATGCCACAGT
CTCTGGTAGTTGCTGGGAACTAGGGTGGGGGATTCTCTGCTCCACACAGTCTTTCATGGACCCAGGTTCCTTTCCTGTTGTGGGTCCAGC
CTCCTGTAGCTGTTGGAGGCATCTCTAGTCAGCTGGTGGTTGGGGAAGAGGTGAGGATCAGGGAGGGAAGATGGAGAGTACTCTGCTTGT
TCTCACATTCTGCTGGCCAGAACTCACAAGCCACCTGAAATGATGCAAAGGTCTAGCTGTGTGTGTAGGAGAAAGAAGAGAGGCCAGATA
TTGGAAGACAGCAGTGGTCTGTGCCCCAGGCCCCATGGTTTAGGGAAGTGAACCTTGGCACTGGATTTCCTGGCTTTCTAAATCTCCCTT
TATAGGGAACTTAGGGCCCAGTCTGTGGTGGGTGGATTTGCCTGGTTCACAGCCTCTGGTCAGCCTTCTTTCTGCTCCACAGGGCGGCCT
GGAGATGGTGGGCTCCTTGTCACACTGGTTGGGGATGTGGGCTCCATGGGGCCAGAGATGTGTGTGCTCTGTGTTCAGATTAAGGGACAG
ACGGCACATGAATTCCTTCAGTGCCCTCCAGATTTGGTCACTGGGGAGGGGTAGGCTGAGCAGTAGCTCTTGGGTCTGTAGTAGTGTGAC
CCTGGAAGGACTGTCCAGCTGAAAACAAGAGCCTGGGGCGTGGGGAGGGGAGGGGTTACTCAGGGTTCCATGAGACCTGGGTTTAAGTCC
TGGATCCATCATTAGCAGCTATGTGAACTTATGCCTCACTTTCCTCAAATATGAACTTGAGATAATGAAATTACCTTCCTCATAATACTG
TTCTAAGAATTGAATGAGGAAAGGTTTACAATTCGGCCCTGGTTGTTCCACTGGGGAGGGAACAGAGATTGGGGGCACAGGGCTCCCCTG
GCCTGGGGGAGTCTGGCTCACTCAAGTTCTCAGTCATTTGCAAGGCAAGGACCCTGCTTCTCCTTGCTCTGGGTCCGAGTAGTCTCAAGC
CCAGTGGGCAGGGCCTGTGGTGTGGATGGACTCGTCTGCAGTGAGTCAGGCAGCAGGCAGAGCTGGCAGGCTGTGTGGTCTCTAGTGGGT
ACCAGGGGACCTGGGAGGGCCTTGTGGGAGGTTGTCCACGGTGTGAGCCAGTTTGCCATCTGGGGTCCTGGAGTTCCCTCCCGCCCTTTG
AGTTAAAAAGAGTCAGTCCTGGGCTGAGACTTAATTGCGCTAGTGCTGAGTGACCTTGTGTCAGGGGAAATCGGATGGGGCAAAGTGTTT
TTTAATTAGCAGGACTCACTGACCTTTCCTTCACTGTCAGCAACTTCTCACAGGGAGGCAGAGCAAGGGGGGCTGGAGCCCCGCATCTCT
CTAATGGAGCCTATGTCCAACAAGGAGGTGGATGGCTGGATTCAGGGCCCTGGGAGGACTTCATGTGGGAAGCAGACCTCAGGAAGGGCC
CTTAGTGATGGTGTGGGCCAGGGTTCTCACCTCCTTAGTCTCCTGTCCTGTCCATCTCCGCAGATCCTAGGCAAAAGAAGCGGAGAAACA
CTCAAGCCACTGGGGTGGTTAGGGCACACTGGTGGCAACTGTTTAAAACCTTAACTAAAACAAGGTTAAGCAAAAGGAGTTTACAGGCTC
TCATAGATGGGAAGGATGTGGGAGGGTCACAGACTGAGAGGAACCAGGGCTGTGGCTGCTGGAAGGAGCCTCACCACCGCCAGTGTGTTT
CCTCCCCGTCGTCGGCATCTCTGCTTCTCTCTGCACGCCAGCAGCTCTCTCTTAGGGCACGCAGACCTTTCCTCTGCAGGGGAACACGAG
TGCCGGCAGCCCCGAGTTAGTGACTATCATAGAAACTCAGTGTATTTCTCTCTTGTTTATCATTCCGAGTCCTGAGTCACAGGCTTGTCC
AGCACTCAAGACTTTTTCTTTTCTCTATTTTTTGAAACGGATTCTCGCTCTGTCCCCCAGGCTGGAGTGCAGTGGCCCGATTTTGGGTGC
AAGCGATTCTCCTGCCTCAACCTCCCGAGTAGCTGGGACTACAGGTGTGCGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGAC
GGAGTTTCACTATGTTGGCCAGGCTGGTTTCAAACTCCTGACCTCCCGCCGGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGC
CACCACGCCTGGCCAAGATTTTTTCTTTTAAACCTGGAGTATGGAGATGCTCACTAGGCAGACAGAATCAGCCACCACAGCCCACTCCCT
CAGCCAGTATTACTTTGACTAAGTTAGTGAGGAACCAGGCCCCAGATTAAGAAGCAGAACTCACACTGTCATCTGCTGTGTGCCTGGCTG
GCTCATGCATACCTTGTCTATCTAATGTGGACCAAAGCCCTGTGGCACACCCTGCTGGTTACCCCCAGTGGTTACCCTGGCACAGAGGAG
GAAAGGGAGTCGTGGGAGGGAGAAGGACTTCCCTGGGAGGTCTCTGGGCTGGCAAGTTGGGTGACACAGGTCCGGTTGGCTGCAAGCCTG
GGCTCTGCTGTTGTAATCATAAATGTGTGTGTGTGTACAGTTGTTTACAATGTCAGCATGGGTGTCCTTGTTTGTTAGAGATACATGCCA
CTGCTCCCATCATGAGGAAAATCCCAAGCCCTCCCCATGATTTTTGCCAGTTTCTGGGGACTCATGCTCCTGGCAGCCCATGTGTCCCCA
ACTCCTGTGTCCTTTAGGGACCTCTGTTGAGCCCTGCCTCTATTCTGGCAGAATTAGAGAAAATTCTTTAAAAAAACAATAAAGTTTAAA
TTCATTTAAAAAAATAATAAAAAATCTCACAGCATGAGTTTTGATGAGATTTGGGGCAAGGTGGGCCACAACCTTGGGTTGTATGGCCAC
CTCCCCCTCTTCTTCCCCTGTTGTCTCTGCAGCTCAGAAACCCCAATTTCCTGGCCTGTGTTATGTGGAGGAGCTGAGCTCACCCCCTAC
AGCTTCATCTCCAAACCTAGCAAGGATCCTGCCCAGATCAGGAGATCCTCCTTTTAACAGAAGTTATTTACACTCCTTAGAAAGCAGTGG
GGGTGGAACGATTCTTTTTCCTGATGCAGAGATGTAAAACTGGGACATTGCTACACATAATATTTTAAACCTGTCTTCCCTCTTACCAAC
GAACACATCACTAGCACCATCTATGCCAATACATTTCTCAACATCAATTTCAGTGGCTGTATTACATTTTATCCTACGGATGTGCTCTCA
TTTATAATCTAAACCACTTTTATTGAACACATCAGTTATTCTGAAATTTTCAGTGTTATGATGGATGTTGCAGTAATTATTCTTATATAT
GCACAGAACCCCCAGAGGACATGACTACTGAAGGCTGTGCTGGCAGGATCACAGGTAAGGATCTAGCAAATTGTCCCAGCTTCATTGACT
GAGCTTTCATCCTTGTTGCACTACTTTGAGCTGCCATTTTGATCATATAATAATGATTTAGTAGAGCTCTTTTTTGGTTCAACCTACCTG
TTCTTGTATCAGAACTGAAATGTTTGATTTTATAAATTTGAATAGTGGCACAATATAGAGTTCACTATTCCTCAATATTTTCAAGGCTGT
TTCTTATCTGTTCATTCTTTTGGTTAACTTGGGAATTATTTTATCAAGTCTCTCTACTTCCCAATTTCCTTTCACCTTTGGCTCGAAATG
ATATTCAATGTATACATTAACTTGAGTTACATTTTGCTGCATAATGCTTGAGTTACATTTTGAGTATTACGTGTTACTCATAATACATAT
TGAGTTACATTTTGCTGCATAATACATTATCCCCAAGTTTAACACCTTAAAGCAGCACATATATATCTCATACCCTTCTGAGGGTCAGGA
ATCTAGAAGCAGCTTAGCTGGGTGACTGTGGCTCTGGGTCTCTCATGAGGCTGCAGTGAAACTGTTGGCCAGGGCTGGAGGATCCCTTCC
AACCTCACTCCATGACTGTTGGTGGGAGGCTTCAGTTCTCCACCTGGTTCTCACAATATAATTTCCCCCAGAGTGAGTTATCAGAGAGAG
TGTGCAACCAGTAATCTGTTAGAATATGTCACGTCTGTCATATTTGATTGGTCACTCAGACCAACCCTAATAGATGCGAGAGTGACTATG
CAAGGGTGTGAGTTCCAGGAGGAAAGCATCATTGGAACCATCTTGGAGACTGGCTAATACACAGATAAATGGCACATCTGACAATATGGC
ATCTTTCTGAGTGTCAGTGTGGTGTGTTCCTATATGAACTTAATGCTATTAAACTTAATTAAATTGTAGGTATGCTCTCAGTGAAGATTT
TTACTTTTACATTACAGGTTTCCACACTGTTAAATTCATTCCAAGTATTTCATACATGCTGTTCCTATTATGAAAGGATCTTTTTTTTCA
CATGGCATTTTCTAAGTAGTTGTTGCATTCATATAGGAGATGCTATTGATTTTGACACCCATAATTTTTCAGTGGAGACAAGGCAGAAAC
TACTCCAGACTCTCACCTGCTGTTGCTGATCCTTACATGGTGGCTGTGCCAGGCTCAGCCGCGCTGAGATGACAGGGCTGTCTGGCCATC
ATTGGTCATATGGACTTCAGATTTGAAAGGATTTTATGTAGAAGCAGAGTGCCTGATAGGACTCTCCGGGACCCCCATTTCTGCCCTGCT
TGGCTCCCACTGGCAAGGCTGGCTCAGTTCCTGTCACCTTCTCCTGGACTTTGGCCAGAGTCCACTGGCTGTTTCCCCTGCCTCCTGCTC
TCCCAGTGCCCTCTCCACACCAGTGCCAGAGCTGCTTCTAAGAGATGCCTCAAAGCCCGCTTCCAGCTTAGGAACCCCAGGGAACATGGA
TGGTTTCTCCATTGCCACTTCCTAGCCTTCCTGGCATAGGAAGGTCTGGTTTGCCTGCAGGTCCCTCTCTGGGGGGGTCCCTGCTCCATA
GATGCTGAGGCTCCAGAAGTCTGTTCTTTTATATCACATTTGAAAACCTTTGAAATGCATTATAGTTGAGTCATATGAATTATGTAAGTA

>247_247_2_ABCC2-TSPAN14_ABCC2_chr10_101552116_ENST00000370449_TSPAN14_chr10_82264484_ENST00000429989_length(amino acids)=354AA_BP=111
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTED
SGQATVPAVRYTNPSLYLGTWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCG
TIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCC2-TSPAN14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC2-TSPAN14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC2-TSPAN14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource