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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DYRK1A-MTMR1 (FusionGDB2 ID:24704)

Fusion Gene Summary for DYRK1A-MTMR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK1A-MTMR1
Fusion gene ID: 24704
HgeneTgene
Gene symbol

DYRK1A

MTMR1

Gene ID

1859

8776

Gene namedual specificity tyrosine phosphorylation regulated kinase 1Amyotubularin related protein 1
SynonymsDYRK|DYRK1|HP86|MNB|MNBH|MRD7-
Cytomap

21q22.13

Xq28

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologsmyotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatase
Modification date2020031520200313
UniProtAcc

Q13627

Q8NCE2

Ensembl transtripts involved in fusion geneENST00000321219, ENST00000338785, 
ENST00000339659, ENST00000398956, 
ENST00000398960, ENST00000451934, 
ENST00000455387, ENST00000462274, 
ENST00000370390, ENST00000445323, 
ENST00000451863, ENST00000541925, 
ENST00000542156, ENST00000544228, 
ENST00000538506, 
Fusion gene scores* DoF score32 X 23 X 11=80968 X 8 X 4=256
# samples 409
** MAII scorelog2(40/8096*10)=-4.33913738491959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK1A [Title/Abstract] AND MTMR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDYRK1A(38809313)-MTMR1(149895693), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

HgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

HgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345

TgeneMTMR1

GO:0046856

phosphatidylinositol dephosphorylation

11733541|27018598

TgeneMTMR1

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938


check buttonFusion gene breakpoints across DYRK1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MTMR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AM78377DYRK1Achr21

38809313

-MTMR1chrX

149895693

+


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Fusion Gene ORF analysis for DYRK1A-MTMR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000321219ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000321219ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000338785ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000339659ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000398956ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000398960ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000451934ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000455387ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000462274ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DYRK1A-MTMR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DYRK1A-MTMR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38809313/:149895693)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK1A

Q13627

MTMR1

Q8NCE2

FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.FUNCTION: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. {ECO:0000269|PubMed:17008356}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DYRK1A-MTMR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DYRK1A-MTMR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DYRK1A-MTMR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DYRK1A-MTMR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource