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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DZANK1-DTD1 (FusionGDB2 ID:24748)

Fusion Gene Summary for DZANK1-DTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: DZANK1-DTD1
Fusion gene ID: 24748
HgeneTgene
Gene symbol

DZANK1

DTD1

Gene ID

55184

92675

Gene namedouble zinc ribbon and ankyrin repeat domains 1D-aminoacyl-tRNA deacylase 1
SynonymsANKRD64|C20orf12|C20orf84C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
Cytomap

20p11.23

20p11.23

Type of geneprotein-codingprotein-coding
Descriptiondouble zinc ribbon and ankyrin repeat-containing protein 1ankyrin repeat domain 64ankyrin repeat-containing protein C20orf12D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2
Modification date2020031320200313
UniProtAcc

Q9NVP4

Q8TEA8

Ensembl transtripts involved in fusion geneENST00000262547, ENST00000329494, 
ENST00000357236, ENST00000358866, 
ENST00000487128, 		ENST00000377452, 
ENST00000494921, 
Fusion gene scores* DoF score2 X 4 X 3=2413 X 8 X 8=832
# samples 318
** MAII scorelog2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/832*10)=-2.20858662181142
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DZANK1 [Title/Abstract] AND DTD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTD1(18588016)-DZANK1(18366272), # samples:1
DZANK1(18407711)-DTD1(18724744), # samples:2
DZANK1(18429628)-DTD1(18744004), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DZANK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-DM-A0XD-01ADZANK1chr20

18407711

-DTD1chr20

18724744

+
ChimerDB4LUADTCGA-55-8206-01ADZANK1chr20

18429627

-DTD1chr20

18744003

+
ChimerDB4LUADTCGA-55-8206-01ADZANK1chr20

18429628

-DTD1chr20

18744004

+


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Fusion Gene ORF analysis for DZANK1-DTD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262547ENST00000377452DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-3UTRENST00000262547ENST00000377452DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-3UTRENST00000329494ENST00000377452DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-3UTRENST00000329494ENST00000377452DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-3UTRENST00000357236ENST00000377452DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-3UTRENST00000357236ENST00000377452DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-3UTRENST00000358866ENST00000377452DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-3UTRENST00000358866ENST00000377452DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-intronENST00000262547ENST00000494921DZANK1chr20

18407711

-DTD1chr20

18724744

+
5CDS-intronENST00000262547ENST00000494921DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-intronENST00000262547ENST00000494921DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-intronENST00000329494ENST00000494921DZANK1chr20

18407711

-DTD1chr20

18724744

+
5CDS-intronENST00000329494ENST00000494921DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-intronENST00000329494ENST00000494921DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-intronENST00000357236ENST00000494921DZANK1chr20

18407711

-DTD1chr20

18724744

+
5CDS-intronENST00000357236ENST00000494921DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-intronENST00000357236ENST00000494921DZANK1chr20

18429628

-DTD1chr20

18744004

+
5CDS-intronENST00000358866ENST00000494921DZANK1chr20

18407711

-DTD1chr20

18724744

+
5CDS-intronENST00000358866ENST00000494921DZANK1chr20

18429627

-DTD1chr20

18744003

+
5CDS-intronENST00000358866ENST00000494921DZANK1chr20

18429628

-DTD1chr20

18744004

+
5UTR-3CDSENST00000487128ENST00000377452DZANK1chr20

18407711

-DTD1chr20

18724744

+
5UTR-3UTRENST00000487128ENST00000377452DZANK1chr20

18429627

-DTD1chr20

18744003

+
5UTR-3UTRENST00000487128ENST00000377452DZANK1chr20

18429628

-DTD1chr20

18744004

+
5UTR-intronENST00000487128ENST00000494921DZANK1chr20

18407711

-DTD1chr20

18724744

+
5UTR-intronENST00000487128ENST00000494921DZANK1chr20

18429627

-DTD1chr20

18744003

+
5UTR-intronENST00000487128ENST00000494921DZANK1chr20

18429628

-DTD1chr20

18744004

+
Frame-shiftENST00000357236ENST00000377452DZANK1chr20

18407711

-DTD1chr20

18724744

+
Frame-shiftENST00000358866ENST00000377452DZANK1chr20

18407711

-DTD1chr20

18724744

+
In-frameENST00000262547ENST00000377452DZANK1chr20

18407711

-DTD1chr20

18724744

+
In-frameENST00000329494ENST00000377452DZANK1chr20

18407711

-DTD1chr20

18724744

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000329494DZANK1chr2018407711-ENST00000377452DTD1chr2018724744+189911692091321370
ENST00000262547DZANK1chr2018407711-ENST00000377452DTD1chr2018724744+189311632091315368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329494ENST00000377452DZANK1chr2018407711-DTD1chr2018724744+0.0009200190.99907994
ENST00000262547ENST00000377452DZANK1chr2018407711-DTD1chr2018724744+0.0009169050.99908304

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Fusion Genomic Features for DZANK1-DTD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DZANK1chr2018429627-DTD1chr2018744003+0.63174530.36825475
DZANK1chr2018407710-DTD1chr2018724743+5.48E-050.99994516
DZANK1chr2018429627-DTD1chr2018744003+0.63174530.36825475
DZANK1chr2018407710-DTD1chr2018724743+5.48E-050.99994516

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DZANK1-DTD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:18588016/chr20:18366272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DZANK1

Q9NVP4

DTD1

Q8TEA8

FUNCTION: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDZANK1chr20:18407711chr20:18724744ENST00000262547-1021211_270318753.0Zinc fingerNote=DZANK-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDZANK1chr20:18407711chr20:18724744ENST00000262547-1021605_636318753.0RepeatNote=ANK 1
HgeneDZANK1chr20:18407711chr20:18724744ENST00000262547-1021640_669318753.0RepeatNote=ANK 2
HgeneDZANK1chr20:18407711chr20:18724744ENST00000357236-1122605_636204639.0RepeatNote=ANK 1
HgeneDZANK1chr20:18407711chr20:18724744ENST00000357236-1122640_669204639.0RepeatNote=ANK 2
HgeneDZANK1chr20:18407711chr20:18724744ENST00000262547-1021339_387318753.0Zinc fingerNote=DZANK-type 2
HgeneDZANK1chr20:18407711chr20:18724744ENST00000357236-1122211_270204639.0Zinc fingerNote=DZANK-type 1
HgeneDZANK1chr20:18407711chr20:18724744ENST00000357236-1122339_387204639.0Zinc fingerNote=DZANK-type 2
TgeneDTD1chr20:18407711chr20:18724744ENST0000037745236139_140159321.6666666666667MotifGly-cisPro motif%2C important for rejection of L-amino acids


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Fusion Gene Sequence for DZANK1-DTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24748_24748_1_DZANK1-DTD1_DZANK1_chr20_18407711_ENST00000262547_DTD1_chr20_18724744_ENST00000377452_length(transcript)=1893nt_BP=1163nt
AGATGCCTATGGGAAAGCACTGGGAAAGGAACTCCAGGCGGGTACCAGGCTCCCTGCGGAGCGGCAGGGGCCGGTCTAGTTGCTAAGAAG
CTGAGTCTCCACCAATCATCTGCCCAGCACCCAGTGGGCGGGGCGCGGCTCGCCGCGTCTGTGGTAACCCGGGCGGCGGCGAAGGAGGAG
GCAAGAGGCGAGAGAGAGAGAGAGAGAAAATGACTGCTGGTTCAGTGTGTGTCCCTCAGATCATACCATTACGAGTGCCTCAGCCTGGAA
AAGCTAACCATGAAATTGATAACAATACGCTTTTGGAAATGAAATCAGACACTCCAGATGTCAACATATATTATACTCTGGATGGCAGCA
AACCTGAATTTCTAAAGAGAATTGGTTATGGGGAAAATAACACATTTAAGTATATAAAACCTATTACTCTGCCTGATGGAAAAATACAAG
TTAAAGCTATTGCTGTCTCTAAAGACTGCAGACAGAGTGGCATTGTGACAAAGGTGTTTCACGTAGACTATGAACCACCAAATATAGTCT
CTCCTGAAGACAATGTTGAAAATGTTCTCAAAGATTCTTCAAGGCAGGAATTCAAAAATGGATTTGTTGGATCAAAACTAAAGAAAAAAT
ATAAGAACTCTGAAAATCAACGCAGCTGGAATGTTAACCTTAGAAAGTTTCCAGAGAGTCCATTGGAAATCCCAGCTTATGGTGGAGGAT
CAGGTTCTAGACCACCCACCCGCCAGTCCCAGTCCCCCGGTTTTGCACACGTAAGCGGTCAGAAGTGTTTGACAAGCACGGAGATAATGA
GAATTCAAAGGGAGACAGACTTTCTCAAGTGTGCCCACTGCCTTGCCCCCCGGCCATCAGATCCCTTTGCTCGCTTCTGTCAAGAATGTG
GCTCTCCTGTCCCACCCATATTTGGCTGTCGTCTCCCACCCCCAGAAGGAGCTCAGATGGGCTTGTGTGCAGAATGCAGAAGCTTGGTAC
CCATGAACACTCCCATCTGTGTGGTGTGTGAGGCCCCTCTTGCTCTACAGCTGCAGCCACAGGCAAGCCTCCACTTGAAGGAGAAGGTAA
TTTGCCGGGCCTGTGGTACAGGAAATCCTGCTCACCTGAGATACTGTGTCACCTGTGAGGGGGCCCTGCCTTCATCACAAGAGCTGTCAA
AGCTCGAAAAACAGCAGCAGAGGAAAGAAAAGACCAGAGCTAAGGGACCTTCTGAATCAAGCAAGGAAAGAAACACTCCCCGAAAAGAAG
ACCGCAGTGCCAGCAGCGGGGCTGAGGGCGACGTGTCCTCTGAACGGGAGCCGTAGCTCAGGAGGCAGAATTCAGTGTGTTATCATTGGG
CAGAACTGGATCCTGAAAAATTCAAGATGCTAAGCACCTACACTACTTTAAGAATTTGGAACTGAAACATGAAGAGGAAGACAGAAATAA
GAATTTGGGAACCTGAATAGCTCTGCAAAAAACACCAAAGGACCGTTTTATCGTTTTCTGTTGTTGCTGTGGTGGAGTGATGCAGTGGGC
ACTGCCGGTGGGCCAGGGGGCGGGTGCGCATGTGGTAGAAGGTGTGCGCTCGTGCCTCCCCCACAGAAAGGCTTTGTTGGTTTCTACCAC
ATCTTGGCTTGCTTTTGGAACAGGCTGGCCCAGCATCATTTGTCATCAAGTCCACTGTGGTGTATTCTGCGTGTCCATGGCGGGGGTTCT
CCAATACACTCACACTGTCCATGTTCTTTTTATTGCCAGGGCCCGTGTTGAAGTGTCAAGAGAGCAATCATCAATGATAATGTATTGTGT
GAGACCTTTGCATCTTGTAAATTTTCTCTTTTTTCTAAAAATAAATAATAATAAAATCCTAAATCTCAACAAACCACTTTATTATCAAAC

>24748_24748_1_DZANK1-DTD1_DZANK1_chr20_18407711_ENST00000262547_DTD1_chr20_18724744_ENST00000377452_length(amino acids)=368AA_BP=318
MTAGSVCVPQIIPLRVPQPGKANHEIDNNTLLEMKSDTPDVNIYYTLDGSKPEFLKRIGYGENNTFKYIKPITLPDGKIQVKAIAVSKDC
RQSGIVTKVFHVDYEPPNIVSPEDNVENVLKDSSRQEFKNGFVGSKLKKKYKNSENQRSWNVNLRKFPESPLEIPAYGGGSGSRPPTRQS
QSPGFAHVSGQKCLTSTEIMRIQRETDFLKCAHCLAPRPSDPFARFCQECGSPVPPIFGCRLPPPEGAQMGLCAECRSLVPMNTPICVVC
EAPLALQLQPQASLHLKEKVICRACGTGNPAHLRYCVTCEGALPSSQELSKLEKQQQRKEKTRAKGPSESSKERNTPRKEDRSASSGAEG

--------------------------------------------------------------
>24748_24748_2_DZANK1-DTD1_DZANK1_chr20_18407711_ENST00000329494_DTD1_chr20_18724744_ENST00000377452_length(transcript)=1899nt_BP=1169nt
AGATGCCTATGGGAAAGCACTGGGAAAGGAACTCCAGGCGGGTACCAGGCTCCCTGCGGAGCGGCAGGGGCCGGTCTAGTTGCTAAGAAG
CTGAGTCTCCACCAATCATCTGCCCAGCACCCAGTGGGCGGGGCGCGGCTCGCCGCGTCTGTGGTAACCCGGGCGGCGGCGAAGGAGGAG
GCAAGAGGCGAGAGAGAGAGAGAGAGAAAATGACTGCTGGTTCAGTGTGTGTCCCTCAGATCATACCATTACGAGTGCCTCAGCCTGGAA
AAGCTAACCATGAAATTGATAACAATACGCTTTTGGAAATGAAATCAGACACTCCAGATGTCAACATATATTATACTCTGGATGGCAGCA
AACCTGAATTTCTAAAGAGAATTGGTTATGGGGAAAATAACACATTTAAGTATATAAAACCTATTACTCTGCCTGATGGAAAAATACAAG
TTAAAGCTATTGCTGTCTCTAAAGACTGCAGACAGAGTGGCATTGTGACAAAGGTGTTTCACGTAGACTATGAACCACCAAATATAGTCT
CTCCTGAAGACAATGTTGAAAATGTTCTCAAAGATTCTTCAAGGCAGGCAAGGGAATTCAAAAATGGATTTGTTGGATCAAAACTAAAGA
AAAAATATAAGAACTCTGAAAATCAACGCAGCTGGAATGTTAACCTTAGAAAGTTTCCAGAGAGTCCATTGGAAATCCCAGCTTATGGTG
GAGGATCAGGTTCTAGACCACCCACCCGCCAGTCCCAGTCCCCCGGTTTTGCACACGTAAGCGGTCAGAAGTGTTTGACAAGCACGGAGA
TAATGAGAATTCAAAGGGAGACAGACTTTCTCAAGTGTGCCCACTGCCTTGCCCCCCGGCCATCAGATCCCTTTGCTCGCTTCTGTCAAG
AATGTGGCTCTCCTGTCCCACCCATATTTGGCTGTCGTCTCCCACCCCCAGAAGGAGCTCAGATGGGCTTGTGTGCAGAATGCAGAAGCT
TGGTACCCATGAACACTCCCATCTGTGTGGTGTGTGAGGCCCCTCTTGCTCTACAGCTGCAGCCACAGGCAAGCCTCCACTTGAAGGAGA
AGGTAATTTGCCGGGCCTGTGGTACAGGAAATCCTGCTCACCTGAGATACTGTGTCACCTGTGAGGGGGCCCTGCCTTCATCACAAGAGC
TGTCAAAGCTCGAAAAACAGCAGCAGAGGAAAGAAAAGACCAGAGCTAAGGGACCTTCTGAATCAAGCAAGGAAAGAAACACTCCCCGAA
AAGAAGACCGCAGTGCCAGCAGCGGGGCTGAGGGCGACGTGTCCTCTGAACGGGAGCCGTAGCTCAGGAGGCAGAATTCAGTGTGTTATC
ATTGGGCAGAACTGGATCCTGAAAAATTCAAGATGCTAAGCACCTACACTACTTTAAGAATTTGGAACTGAAACATGAAGAGGAAGACAG
AAATAAGAATTTGGGAACCTGAATAGCTCTGCAAAAAACACCAAAGGACCGTTTTATCGTTTTCTGTTGTTGCTGTGGTGGAGTGATGCA
GTGGGCACTGCCGGTGGGCCAGGGGGCGGGTGCGCATGTGGTAGAAGGTGTGCGCTCGTGCCTCCCCCACAGAAAGGCTTTGTTGGTTTC
TACCACATCTTGGCTTGCTTTTGGAACAGGCTGGCCCAGCATCATTTGTCATCAAGTCCACTGTGGTGTATTCTGCGTGTCCATGGCGGG
GGTTCTCCAATACACTCACACTGTCCATGTTCTTTTTATTGCCAGGGCCCGTGTTGAAGTGTCAAGAGAGCAATCATCAATGATAATGTA
TTGTGTGAGACCTTTGCATCTTGTAAATTTTCTCTTTTTTCTAAAAATAAATAATAATAAAATCCTAAATCTCAACAAACCACTTTATTA

>24748_24748_2_DZANK1-DTD1_DZANK1_chr20_18407711_ENST00000329494_DTD1_chr20_18724744_ENST00000377452_length(amino acids)=370AA_BP=320
MTAGSVCVPQIIPLRVPQPGKANHEIDNNTLLEMKSDTPDVNIYYTLDGSKPEFLKRIGYGENNTFKYIKPITLPDGKIQVKAIAVSKDC
RQSGIVTKVFHVDYEPPNIVSPEDNVENVLKDSSRQAREFKNGFVGSKLKKKYKNSENQRSWNVNLRKFPESPLEIPAYGGGSGSRPPTR
QSQSPGFAHVSGQKCLTSTEIMRIQRETDFLKCAHCLAPRPSDPFARFCQECGSPVPPIFGCRLPPPEGAQMGLCAECRSLVPMNTPICV
VCEAPLALQLQPQASLHLKEKVICRACGTGNPAHLRYCVTCEGALPSSQELSKLEKQQQRKEKTRAKGPSESSKERNTPRKEDRSASSGA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DZANK1-DTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DZANK1-DTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DZANK1-DTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource