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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EAF2-RGS9 (FusionGDB2 ID:24803)

Fusion Gene Summary for EAF2-RGS9

check button Fusion gene summary
Fusion gene informationFusion gene name: EAF2-RGS9
Fusion gene ID: 24803
HgeneTgene
Gene symbol

EAF2

RGS9

Gene ID

55929

388531

Gene nameDNA methyltransferase 1 associated protein 1regulator of G protein signaling 9 binding protein
SynonymsDNMAP1|DNMTAP1|EAF2|MEAF2|SWC4PERRS|R9AP|RGS9
Cytomap

1p34.1

19q13.11

Type of geneprotein-codingprotein-coding
DescriptionDNA methyltransferase 1-associated protein 1DNMT1 associated protein 1regulator of G-protein signaling 9-binding proteinRGS9 anchor proteinRGS9-anchoring protein
Modification date2020031320200313
UniProtAcc

Q96CJ1

.
Ensembl transtripts involved in fusion geneENST00000465664, ENST00000273668, 
ENST00000451944, 		ENST00000262406, 
ENST00000443584, ENST00000449996, 
ENST00000577186, 
Fusion gene scores* DoF score1 X 2 X 1=213 X 16 X 5=1040
# samples 215
** MAII scorelog2(2/2*10)=3.32192809488736log2(15/1040*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EAF2 [Title/Abstract] AND RGS9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEAF2(121554238)-RGS9(63221120), # samples:3
Anticipated loss of major functional domain due to fusion event.EAF2-RGS9 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
EAF2-RGS9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEAF2

GO:0000122

negative regulation of transcription by RNA polymerase II

15367675

HgeneEAF2

GO:0042307

positive regulation of protein import into nucleus

15367675

HgeneEAF2

GO:0043967

histone H4 acetylation

14966270

HgeneEAF2

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across EAF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RGS9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03L-01AEAF2chr3

121554237

+RGS9chr17

63221119

+
ChimerDB4BRCATCGA-AO-A03L-01AEAF2chr3

121554238

-RGS9chr17

63221120

+
ChimerDB4BRCATCGA-AO-A03L-01AEAF2chr3

121554238

+RGS9chr17

63221120

+
ChimerDB4BRCATCGA-AO-A03LEAF2chr3

121554238

+RGS9chr17

63221119

+


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Fusion Gene ORF analysis for EAF2-RGS9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000465664ENST00000262406EAF2chr3

121554237

+RGS9chr17

63221119

+
3UTR-3CDSENST00000465664ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221120

+
3UTR-3CDSENST00000465664ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221119

+
3UTR-3CDSENST00000465664ENST00000443584EAF2chr3

121554237

+RGS9chr17

63221119

+
3UTR-3CDSENST00000465664ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221120

+
3UTR-3CDSENST00000465664ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221119

+
3UTR-3CDSENST00000465664ENST00000449996EAF2chr3

121554237

+RGS9chr17

63221119

+
3UTR-3CDSENST00000465664ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221120

+
3UTR-3CDSENST00000465664ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221119

+
3UTR-intronENST00000465664ENST00000577186EAF2chr3

121554237

+RGS9chr17

63221119

+
3UTR-intronENST00000465664ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221120

+
3UTR-intronENST00000465664ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221119

+
5CDS-intronENST00000273668ENST00000577186EAF2chr3

121554237

+RGS9chr17

63221119

+
5CDS-intronENST00000273668ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221120

+
5CDS-intronENST00000273668ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221119

+
5CDS-intronENST00000451944ENST00000577186EAF2chr3

121554237

+RGS9chr17

63221119

+
5CDS-intronENST00000451944ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221120

+
5CDS-intronENST00000451944ENST00000577186EAF2chr3

121554238

+RGS9chr17

63221119

+
Frame-shiftENST00000273668ENST00000262406EAF2chr3

121554237

+RGS9chr17

63221119

+
Frame-shiftENST00000273668ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221120

+
Frame-shiftENST00000273668ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221119

+
Frame-shiftENST00000273668ENST00000449996EAF2chr3

121554237

+RGS9chr17

63221119

+
Frame-shiftENST00000273668ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221120

+
Frame-shiftENST00000273668ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221119

+
Frame-shiftENST00000451944ENST00000262406EAF2chr3

121554237

+RGS9chr17

63221119

+
Frame-shiftENST00000451944ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221120

+
Frame-shiftENST00000451944ENST00000262406EAF2chr3

121554238

+RGS9chr17

63221119

+
Frame-shiftENST00000451944ENST00000449996EAF2chr3

121554237

+RGS9chr17

63221119

+
Frame-shiftENST00000451944ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221120

+
Frame-shiftENST00000451944ENST00000449996EAF2chr3

121554238

+RGS9chr17

63221119

+
In-frameENST00000273668ENST00000443584EAF2chr3

121554237

+RGS9chr17

63221119

+
In-frameENST00000273668ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221120

+
In-frameENST00000273668ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221119

+
In-frameENST00000451944ENST00000443584EAF2chr3

121554237

+RGS9chr17

63221119

+
In-frameENST00000451944ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221120

+
In-frameENST00000451944ENST00000443584EAF2chr3

121554238

+RGS9chr17

63221119

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273668EAF2chr3121554238+ENST00000443584RGS9chr1763221120+764177649125174
ENST00000451944EAF2chr3121554238+ENST00000443584RGS9chr1763221120+742155627103174
ENST00000273668EAF2chr3121554238+ENST00000443584RGS9chr1763221119+764177649125174
ENST00000451944EAF2chr3121554238+ENST00000443584RGS9chr1763221119+742155627103174
ENST00000273668EAF2chr3121554237+ENST00000443584RGS9chr1763221119+764177649125174
ENST00000451944EAF2chr3121554237+ENST00000443584RGS9chr1763221119+742155627103174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273668ENST00000443584EAF2chr3121554238+RGS9chr1763221120+0.819049060.18095095
ENST00000451944ENST00000443584EAF2chr3121554238+RGS9chr1763221120+0.81230560.18769439
ENST00000273668ENST00000443584EAF2chr3121554238+RGS9chr1763221119+0.819049060.18095095
ENST00000451944ENST00000443584EAF2chr3121554238+RGS9chr1763221119+0.81230560.18769439
ENST00000273668ENST00000443584EAF2chr3121554237+RGS9chr1763221119+0.819049060.18095095
ENST00000451944ENST00000443584EAF2chr3121554237+RGS9chr1763221119+0.81230560.18769439

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Fusion Genomic Features for EAF2-RGS9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EAF2chr3121554238+RGS9chr1763221119+3.87E-050.99996126
EAF2chr3121554238+RGS9chr1763221119+3.87E-050.99996126
EAF2chr3121554238+RGS9chr1763221119+3.87E-050.99996126
EAF2chr3121554238+RGS9chr1763221119+3.87E-050.99996126

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EAF2-RGS9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:121554238/chr17:63221120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EAF2

Q96CJ1

.
FUNCTION: Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652, ECO:0000269|PubMed:16006523}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEAF2chr3:121554237chr17:63221119ENST00000273668+16126_13035261.0Compositional biasNote=Poly-Gln
HgeneEAF2chr3:121554237chr17:63221119ENST00000273668+16174_20735261.0Compositional biasNote=Ser-rich
HgeneEAF2chr3:121554238chr17:63221119ENST00000273668+16126_13035261.0Compositional biasNote=Poly-Gln
HgeneEAF2chr3:121554238chr17:63221119ENST00000273668+16174_20735261.0Compositional biasNote=Ser-rich
HgeneEAF2chr3:121554238chr17:63221120ENST00000273668+16126_13035261.0Compositional biasNote=Poly-Gln
HgeneEAF2chr3:121554238chr17:63221120ENST00000273668+16174_20735261.0Compositional biasNote=Ser-rich
HgeneEAF2chr3:121554237chr17:63221119ENST00000273668+16177_26035261.0RegionNote=Necessary for transactivation activity
HgeneEAF2chr3:121554238chr17:63221119ENST00000273668+16177_26035261.0RegionNote=Necessary for transactivation activity
HgeneEAF2chr3:121554238chr17:63221120ENST00000273668+16177_26035261.0RegionNote=Necessary for transactivation activity
TgeneRGS9chr3:121554237chr17:63221119ENST000002624061619219_280469675.0DomainNote=G protein gamma
TgeneRGS9chr3:121554237chr17:63221119ENST000002624061619298_413469675.0DomainRGS
TgeneRGS9chr3:121554237chr17:63221119ENST00000262406161930_105469675.0DomainDEP
TgeneRGS9chr3:121554237chr17:63221119ENST000004499961619219_280466672.0DomainNote=G protein gamma
TgeneRGS9chr3:121554237chr17:63221119ENST000004499961619298_413466672.0DomainRGS
TgeneRGS9chr3:121554237chr17:63221119ENST00000449996161930_105466672.0DomainDEP
TgeneRGS9chr3:121554238chr17:63221119ENST000002624061619219_280469675.0DomainNote=G protein gamma
TgeneRGS9chr3:121554238chr17:63221119ENST000002624061619298_413469675.0DomainRGS
TgeneRGS9chr3:121554238chr17:63221119ENST00000262406161930_105469675.0DomainDEP
TgeneRGS9chr3:121554238chr17:63221119ENST000004499961619219_280466672.0DomainNote=G protein gamma
TgeneRGS9chr3:121554238chr17:63221119ENST000004499961619298_413466672.0DomainRGS
TgeneRGS9chr3:121554238chr17:63221119ENST00000449996161930_105466672.0DomainDEP
TgeneRGS9chr3:121554238chr17:63221120ENST000002624061619219_280469675.0DomainNote=G protein gamma
TgeneRGS9chr3:121554238chr17:63221120ENST000002624061619298_413469675.0DomainRGS
TgeneRGS9chr3:121554238chr17:63221120ENST00000262406161930_105469675.0DomainDEP
TgeneRGS9chr3:121554238chr17:63221120ENST000004499961619219_280466672.0DomainNote=G protein gamma
TgeneRGS9chr3:121554238chr17:63221120ENST000004499961619298_413466672.0DomainRGS
TgeneRGS9chr3:121554238chr17:63221120ENST00000449996161930_105466672.0DomainDEP


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Fusion Gene Sequence for EAF2-RGS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24803_24803_1_EAF2-RGS9_EAF2_chr3_121554237_ENST00000273668_RGS9_chr17_63221119_ENST00000443584_length(transcript)=764nt_BP=177nt
AGCTGCTTCAGGCTGAGGTGGCAGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGAT
TCTCACACCTAGACCGTCGCGAGCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCG
GGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGC
CGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTG
GAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCC
CTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGT
CTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAG
CTGCCACGATTGAAATCCAAGAGAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCT

>24803_24803_1_EAF2-RGS9_EAF2_chr3_121554237_ENST00000273668_RGS9_chr17_63221119_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------
>24803_24803_2_EAF2-RGS9_EAF2_chr3_121554237_ENST00000451944_RGS9_chr17_63221119_ENST00000443584_length(transcript)=742nt_BP=155nt
AGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGATTCTCACACCTAGACCGTCGCGA
GCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCGGGCCAGCACATGGCTCCCAGCC
CCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCG
CCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGC
AGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCA
GCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCA
GGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGA
GAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCTGCATGTGAATATGCATGCTTTG

>24803_24803_2_EAF2-RGS9_EAF2_chr3_121554237_ENST00000451944_RGS9_chr17_63221119_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------
>24803_24803_3_EAF2-RGS9_EAF2_chr3_121554238_ENST00000273668_RGS9_chr17_63221119_ENST00000443584_length(transcript)=764nt_BP=177nt
AGCTGCTTCAGGCTGAGGTGGCAGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGAT
TCTCACACCTAGACCGTCGCGAGCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCG
GGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGC
CGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTG
GAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCC
CTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGT
CTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAG
CTGCCACGATTGAAATCCAAGAGAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCT

>24803_24803_3_EAF2-RGS9_EAF2_chr3_121554238_ENST00000273668_RGS9_chr17_63221119_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------
>24803_24803_4_EAF2-RGS9_EAF2_chr3_121554238_ENST00000273668_RGS9_chr17_63221120_ENST00000443584_length(transcript)=764nt_BP=177nt
AGCTGCTTCAGGCTGAGGTGGCAGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGAT
TCTCACACCTAGACCGTCGCGAGCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCG
GGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGC
CGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTG
GAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCC
CTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGT
CTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAG
CTGCCACGATTGAAATCCAAGAGAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCT

>24803_24803_4_EAF2-RGS9_EAF2_chr3_121554238_ENST00000273668_RGS9_chr17_63221120_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------
>24803_24803_5_EAF2-RGS9_EAF2_chr3_121554238_ENST00000451944_RGS9_chr17_63221119_ENST00000443584_length(transcript)=742nt_BP=155nt
AGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGATTCTCACACCTAGACCGTCGCGA
GCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCGGGCCAGCACATGGCTCCCAGCC
CCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCG
CCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGC
AGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCA
GCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCA
GGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGA
GAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCTGCATGTGAATATGCATGCTTTG

>24803_24803_5_EAF2-RGS9_EAF2_chr3_121554238_ENST00000451944_RGS9_chr17_63221119_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------
>24803_24803_6_EAF2-RGS9_EAF2_chr3_121554238_ENST00000451944_RGS9_chr17_63221120_ENST00000443584_length(transcript)=742nt_BP=155nt
AGATAGTGAGCGCTGGTGGCGGAGTTAAAGTCAAAGCAGGAGAGTAATTATGAATAGCGCAGCGGGATTCTCACACCTAGACCGTCGCGA
GCGGGTTCTCAAGTTAGGGGAGAGTTTCGAGAAGCAGCCGCGCTGCGCCTTCCACACTGTGCGCTCCGGGCCAGCACATGGCTCCCAGCC
CCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCG
CCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGC
AGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCA
GCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCA
GGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGA
GAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCCGTATGCATGGGTGGCTGTGGGTGTGCAGGCCTCTGCATGTGAATATGCATGCTTTG

>24803_24803_6_EAF2-RGS9_EAF2_chr3_121554238_ENST00000451944_RGS9_chr17_63221120_ENST00000443584_length(amino acids)=174AA_BP=1
MDFNRGSCWPTSPRGCTLPWDTAGHLGESLAKTGEARQPRLRNLLKDRAMRALGGALGRLRGQEVSREASLLSVTEGPRGAMDPLHSPFC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EAF2-RGS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EAF2-RGS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EAF2-RGS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource