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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ECE1-HP1BP3 (FusionGDB2 ID:24854)

Fusion Gene Summary for ECE1-HP1BP3

Fusion gene summary

Fusion gene information	Fusion gene name: ECE1-HP1BP3
	Fusion gene ID: 24854
		Hgene	Tgene
	Gene symbol	ECE1	HP1BP3
	Gene ID	1889	50809
	Gene name	endothelin converting enzyme 1	heterochromatin protein 1 binding protein 3
	Synonyms	ECE	HP1-BP74\|HP1BP74
	Cytomap	1p36.12	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	endothelin-converting enzyme 1ECE-1	heterochromatin protein 1-binding protein 3
	Modification date	20200313	20200313
	UniProtAcc	.	Q5SSJ5
	Ensembl transtripts involved in fusion gene	ENST00000264205, ENST00000357071, ENST00000374893, ENST00000415912, ENST00000436918, ENST00000528294,	ENST00000375000, ENST00000375003, ENST00000487117, ENST00000312239,
Fusion gene scores	* DoF score	16 X 15 X 9=2160	22 X 14 X 10=3080
	# samples	18	24
	** MAII score	log2(18/2160*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3080*10)=-3.68182403997374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ECE1 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ECE1(21571481)-HP1BP3(21097566), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ECE1	GO:0010814	substance P catabolic process	18039931
Hgene	ECE1	GO:0010815	bradykinin catabolic process	18039931
Hgene	ECE1	GO:0010816	calcitonin catabolic process	18039931
Hgene	ECE1	GO:0016485	protein processing	7805846
Hgene	ECE1	GO:0016486	peptide hormone processing	7864876
Hgene	ECE1	GO:0034959	endothelin maturation	7805846
Hgene	ECE1	GO:0042447	hormone catabolic process	7864876
Tgene	HP1BP3	GO:0071456	cellular response to hypoxia	25100860

Fusion gene breakpoints across ECE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HP1BP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-EJ-7123-11A	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-

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Fusion Gene ORF analysis for ECE1-HP1BP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000264205	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000264205	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000264205	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000357071	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000357071	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000357071	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000374893	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000374893	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000374893	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000415912	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000415912	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000415912	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000436918	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000436918	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5CDS-intron	ENST00000436918	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5UTR-3CDS	ENST00000528294	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5UTR-intron	ENST00000528294	ENST00000375000	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5UTR-intron	ENST00000528294	ENST00000375003	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
5UTR-intron	ENST00000528294	ENST00000487117	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
In-frame	ENST00000264205	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
In-frame	ENST00000357071	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
In-frame	ENST00000374893	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
In-frame	ENST00000415912	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-
In-frame	ENST00000436918	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415912	ECE1	chr1	21571481	-	ENST00000312239	HP1BP3	chr1	21097566	-	4644	1356	126	2507	793
ENST00000357071	ECE1	chr1	21571481	-	ENST00000312239	HP1BP3	chr1	21097566	-	4645	1357	46	2508	820
ENST00000374893	ECE1	chr1	21571481	-	ENST00000312239	HP1BP3	chr1	21097566	-	4641	1353	63	2504	813
ENST00000436918	ECE1	chr1	21571481	-	ENST00000312239	HP1BP3	chr1	21097566	-	4616	1328	38	2479	813
ENST00000264205	ECE1	chr1	21571481	-	ENST00000312239	HP1BP3	chr1	21097566	-	4616	1328	59	2479	806

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415912	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-	0.001630224	0.99836975
ENST00000357071	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-	0.000750223	0.99924976
ENST00000374893	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-	0.000544063	0.999456
ENST00000436918	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-	0.000550871	0.9994491
ENST00000264205	ENST00000312239	ECE1	chr1	21571481	-	HP1BP3	chr1	21097566	-	0.000827774	0.9991722

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Fusion Genomic Features for ECE1-HP1BP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ECE1-HP1BP3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21571481/chr1:21097566)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HP1BP3 Q5SSJ5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269\|PubMed:24830416, ECO:0000269\|PubMed:25100860}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000264205

1_68

423

768.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000357071

1_68

414

759.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000374893

1_68

426

771.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000415912

1_68

410

755.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000264205

69_89

423

768.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000357071

69_89

414

759.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000374893

69_89

426

771.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000415912

69_89

410

755.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000312239

454_553

170

554.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375000

454_553

134.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375003

454_553

402.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000312239

255_330

170

554.0

Domain

H15 2

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000312239

337_413

170

554.0

Domain

H15 3

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375000

157_232

134.0

Domain

H15 1

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375000

255_330

134.0

Domain

H15 2

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375000

337_413

134.0

Domain

H15 3

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375003

157_232

402.0

Domain

H15 1

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375003

255_330

402.0

Domain

H15 2

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375003

337_413

402.0

Domain

H15 3

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000312239

255_259

170

554.0

Motif

PxVxL motif

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375000

255_259

134.0

Motif

PxVxL motif

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000375003

255_259

402.0

Motif

PxVxL motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000264205

98_770

423

768.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000357071

98_770

414

759.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000374893

98_770

426

771.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000415912

98_770

410

755.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000264205

90_770

423

768.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000357071

90_770

414

759.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000374893

90_770

426

771.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21571481

chr1:21097566

ENST00000415912

90_770

410

755.0

Topological domain

Extracellular

Tgene

HP1BP3

chr1:21571481

chr1:21097566

ENST00000312239

157_232

170

554.0

Domain

H15 1

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Fusion Gene Sequence for ECE1-HP1BP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>24854_24854_1_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000264205_HP1BP3_chr1_21097566_ENST00000312239_length(transcript)=4616nt_BP=1328nt
GGGGCGCGGCGGCGGCGGCGCCAGGGTCGGGGCCGCTTCCCCATTCGGGCGCGAGAGCCATGGAGGCGCTGAGGGAGTCCGTGCTGCATT
TGGCCTTGCAGATGTCGACGTACAAGCGGGCCACGCTGGACGAGGAGGACCTGGTGGACTCGCTCTCCGAGGGCGACGCATACCCCAACG
GCCTGCAGGTGAACTTCCACAGCCCCCGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCAGGTGGAGAAGCGGCTGGTGGTGTTGGTGG
TACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAGACAAGATCCCCCTCTGTGTGCCTGAGCGAAGCTT
GTGTCTCAGTGACCAGCTCCATCTTGAGCTCCATGGACCCCACAGTGGACCCCTGCCATGACTTCTTCAGCTACGCCTGTGGGGGCTGGA
TCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTCTGGGAACACAACCAAGCAATCATCAAGCACCTCC
TCGAAAACTCCACGGCCAGCGTGAGCGAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGCGTGCATGAACGAGACCAGGATCGAGGAGC
TCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACAGGTCCCTGGGCCAAGGACAACTTCCAGGACACCC
TGCAGGTGGTCACCGCCCACTACCGCACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGATTCCAAGAACTCCAACAGCAACGTGATCC
AGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACTGAAAACGAGAAGGTGCTGACCGGATATCTGAACT
ACATGGTCCAGCTGGGGAAGCTGCTGGGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGATGCAGCAGATCTTGGACTTTGAGACGGCAC
TGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCACAAAGTGACGGCAGCCGAGCTGCAGACCTTGGCAC
CCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAAT
ACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCT
CCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGGCATGCTTCCAGAAGAGTGGTG
CATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGA
AAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACAC
CTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTA
CTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGC
CTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTCCAGC
TGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGA
CCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAAACCC
TGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCA
GCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCTGAGG
ATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCA
AACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGA
AGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGC
CGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAAT
CTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGA
CTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAA
TCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTT
TTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAA
GTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTATTTA
TAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTAGATT
TTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTTAACA
GCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGG
AGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTA
CAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTG
ACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGA
CTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTAT
TATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCC
CAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTTTAGT
AGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTA
CAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTT
GTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAA
ACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGAT
ATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGT
GTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGA
AGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGT
AGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTGGAAT
TTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAATAAACATGAAATTT

>24854_24854_1_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000264205_HP1BP3_chr1_21097566_ENST00000312239_length(amino acids)=806AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE
SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKACFQKSGASVVAIRKYIIHKYPSLELE
RRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQ
YYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNS
NYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPG

--------------------------------------------------------------
>24854_24854_2_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000357071_HP1BP3_chr1_21097566_ENST00000312239_length(transcript)=4645nt_BP=1357nt
GACTCTCTGATGTTTGGGAGCAGATCCGAGCAGCTGAGCAGGGTGGCTGTTCCTTTCCTGGATTAGGGCTGAATCTGTGGGAACCAGACC
ACCCCTGAGACAGGAGGCAGCCCTGATGCCTCTCCAGGGCCTGGGCCTGCAGCGGAACCCCTTCCTCCAAGGGAAGCGGGGCCCGGGGCT
CACGTCTTCCCCGCCCCTCCTGCCTCCTTCCCTGCAGGTGAACTTCCACAGCCCCCGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCA
GGTGGAGAAGCGGCTGGTGGTGTTGGTGGTACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAGACAAG
ATCCCCCTCTGTGTGCCTGAGCGAAGCTTGTGTCTCAGTGACCAGCTCCATCTTGAGCTCCATGGACCCCACAGTGGACCCCTGCCATGA
CTTCTTCAGCTACGCCTGTGGGGGCTGGATCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTCTGGGA
ACACAACCAAGCAATCATCAAGCACCTCCTCGAAAACTCCACGGCCAGCGTGAGCGAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGC
GTGCATGAACGAGACCAGGATCGAGGAGCTCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACAGGTCC
CTGGGCCAAGGACAACTTCCAGGACACCCTGCAGGTGGTCACCGCCCACTACCGCACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGA
TTCCAAGAACTCCAACAGCAACGTGATCCAGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACTGAAAA
CGAGAAGGTGCTGACCGGATATCTGAACTACATGGTCCAGCTGGGGAAGCTGCTGGGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGAT
GCAGCAGATCTTGGACTTTGAGACGGCACTGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCACAAAGT
GACGGCAGCCGAGCTGCAGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATC
CGAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACAT
GATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGAC
CAAGAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAG
AAGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTT
TGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAA
ATTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTA
TTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAAC
TGGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTC
TGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAA
CTATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCAC
CTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGA
AGATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAA
GGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGC
ACCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGC
AACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGA
AAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTT
TCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTT
TTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCC
CCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATC
AAGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCA
GTTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATA
AGCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCA
CTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTT
TGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCC
TGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCC
GTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACT
GTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAA
AATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGT
GATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACC
ACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACT
CACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTT
AATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAA
GTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGA
TATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTAT
TTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACT
TGACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATT
CCACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCAT
GTGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATAT

>24854_24854_2_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000357071_HP1BP3_chr1_21097566_ENST00000312239_length(amino acids)=820AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWL
PFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKACFQKSGASVVAI
RKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEP
KEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTA
LKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPP
KRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKS

--------------------------------------------------------------
>24854_24854_3_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000374893_HP1BP3_chr1_21097566_ENST00000312239_length(transcript)=4641nt_BP=1353nt
AGGTGGTGCAACGCCTGGCCCGGCCCATCCCATCCCGGCCACCCGGGCAGCGGGACCAGGCGTCTGGGGCACAGCATGCGGGGCGTGTGG
CCGCCCCCGGTGTCCGCCCTGCTGTCGGCGCTGGGGATGTCGACGTACAAGCGGGCCACGCTGGACGAGGAGGACCTGGTGGACTCGCTC
TCCGAGGGCGACGCATACCCCAACGGCCTGCAGGTGAACTTCCACAGCCCCCGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCAGGTG
GAGAAGCGGCTGGTGGTGTTGGTGGTACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAGACAAGATCC
CCCTCTGTGTGCCTGAGCGAAGCTTGTGTCTCAGTGACCAGCTCCATCTTGAGCTCCATGGACCCCACAGTGGACCCCTGCCATGACTTC
TTCAGCTACGCCTGTGGGGGCTGGATCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTCTGGGAACAC
AACCAAGCAATCATCAAGCACCTCCTCGAAAACTCCACGGCCAGCGTGAGCGAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGCGTGC
ATGAACGAGACCAGGATCGAGGAGCTCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACAGGTCCCTGG
GCCAAGGACAACTTCCAGGACACCCTGCAGGTGGTCACCGCCCACTACCGCACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGATTCC
AAGAACTCCAACAGCAACGTGATCCAGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACTGAAAACGAG
AAGGTGCTGACCGGATATCTGAACTACATGGTCCAGCTGGGGAAGCTGCTGGGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGATGCAG
CAGATCTTGGACTTTGAGACGGCACTGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCACAAAGTGACG
GCAGCCGAGCTGCAGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAG
CCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATC
TGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAG
AAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGG
GGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTT
GTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTG
GAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTAT
CCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGC
AAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCC
ATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTAT
CAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTC
CAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGAT
GAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCC
GCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCT
CCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACC
AGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAA
AGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCT
CCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCC
TTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTG
TTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGA
ACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTA
TAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCC
AAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGG
CCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAG
ACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCT
TCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGT
TGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGC
CTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATC
AAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATC
TTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGC
CCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACC
TCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATA
TTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGG
AAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATC
AAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGT
ATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGAC
ATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCAC
TTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGT
GATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTG

>24854_24854_3_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000374893_HP1BP3_chr1_21097566_ENST00000312239_length(amino acids)=813AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKACFQKSGASVVAIRKYIIHK
YPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSL
IRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLE
NHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKK
TPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFR

--------------------------------------------------------------
>24854_24854_4_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000415912_HP1BP3_chr1_21097566_ENST00000312239_length(transcript)=4644nt_BP=1356nt
GAGCGCGCCGCCTGGGCCAGGCAGCCGAGCCGTCCGAGCAGCTGGGCTGGGAGCAGGGAACCCGGAGCTGGGAATCGGGAGCCGGGCGCG
GGGAGCTGCGCGAAGCCGGGGCGGAGCACGCGAGCTATGATGTCGACGTACAAGCGGGCCACGCTGGACGAGGAGGACCTGGTGGACTCG
CTCTCCGAGGGCGACGCATACCCCAACGGCCTGCAGGTGAACTTCCACAGCCCCCGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCAG
GTGGAGAAGCGGCTGGTGGTGTTGGTGGTACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAGACAAGA
TCCCCCTCTGTGTGCCTGAGCGAAGCTTGTGTCTCAGTGACCAGCTCCATCTTGAGCTCCATGGACCCCACAGTGGACCCCTGCCATGAC
TTCTTCAGCTACGCCTGTGGGGGCTGGATCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTCTGGGAA
CACAACCAAGCAATCATCAAGCACCTCCTCGAAAACTCCACGGCCAGCGTGAGCGAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGCG
TGCATGAACGAGACCAGGATCGAGGAGCTCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACAGGTCCC
TGGGCCAAGGACAACTTCCAGGACACCCTGCAGGTGGTCACCGCCCACTACCGCACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGAT
TCCAAGAACTCCAACAGCAACGTGATCCAGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACTGAAAAC
GAGAAGGTGCTGACCGGATATCTGAACTACATGGTCCAGCTGGGGAAGCTGCTGGGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGATG
CAGCAGATCTTGGACTTTGAGACGGCACTGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCACAAAGTG
ACGGCAGCCGAGCTGCAGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCC
GAGCCTATTGTGGTCTATGACAAGGAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATG
ATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACC
AAGAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGA
AGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTT
GTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAA
TTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTAT
TATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACT
GGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCT
GCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAAC
TATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACC
TTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAA
GATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAG
GCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCA
CCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCA
ACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAA
AAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTT
CCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTT
TCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCC
CTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCA
AGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAG
TTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAA
GCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCAC
TGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTT
GAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCT
GCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCG
TGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTG
TGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAA
ATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTG
ATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCA
CGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTC
ACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTA
ATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAG
TGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGAT
ATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATT
TGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTT
GACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTC
CACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATG
TGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATT

>24854_24854_4_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000415912_HP1BP3_chr1_21097566_ENST00000312239_length(amino acids)=793AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRE
LNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL
LKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQK
CEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPA

--------------------------------------------------------------
>24854_24854_5_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000436918_HP1BP3_chr1_21097566_ENST00000312239_length(transcript)=4616nt_BP=1328nt
CATCCCATCCCGGCCACCCGGGCAGCGGGACCAGGCGTCTGGGGCACAGCATGCGGGGCGTGTGGCCGCCCCCGGTGTCCGCCCTGCTGT
CGGCGCTGGGGATGTCGACGTACAAGCGGGCCACGCTGGACGAGGAGGACCTGGTGGACTCGCTCTCCGAGGGCGACGCATACCCCAACG
GCCTGCAGGTGAACTTCCACAGCCCCCGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCAGGTGGAGAAGCGGCTGGTGGTGTTGGTGG
TACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAGACAAGATCCCCCTCTGTGTGCCTGAGCGAAGCTT
GTGTCTCAGTGACCAGCTCCATCTTGAGCTCCATGGACCCCACAGTGGACCCCTGCCATGACTTCTTCAGCTACGCCTGTGGGGGCTGGA
TCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTCTGGGAACACAACCAAGCAATCATCAAGCACCTCC
TCGAAAACTCCACGGCCAGCGTGAGCGAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGCGTGCATGAACGAGACCAGGATCGAGGAGC
TCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACAGGTCCCTGGGCCAAGGACAACTTCCAGGACACCC
TGCAGGTGGTCACCGCCCACTACCGCACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGATTCCAAGAACTCCAACAGCAACGTGATCC
AGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACTGAAAACGAGAAGGTGCTGACCGGATATCTGAACT
ACATGGTCCAGCTGGGGAAGCTGCTGGGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGATGCAGCAGATCTTGGACTTTGAGACGGCAC
TGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCACAAAGTGACGGCAGCCGAGCTGCAGACCTTGGCAC
CCGCCATCAACTGGTTGCCTTTTCTCAACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAGGAAT
ACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAACTACATGATCTGGAACCTGGTGCGGAAAACAAGCT
CCTTCCTTGACCAGCGCTTTCAGGACGCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGGCATGCTTCCAGAAGAGTGGTG
CATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGA
AAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACAC
CTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTA
CTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGC
CTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTCCAGC
TGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGA
CCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAAACCC
TGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCA
GCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCTGAGG
ATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCA
AACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGA
AGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGC
CGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAAT
CTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGA
CTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAA
TCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTT
TTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAA
GTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTATTTA
TAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTAGATT
TTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTTAACA
GCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGG
AGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTA
CAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTG
ACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGA
CTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTAT
TATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCC
CAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTTTAGT
AGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTA
CAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTT
GTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAA
ACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGAT
ATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGT
GTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGA
AGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGT
AGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTGGAAT
TTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAATAAACATGAAATTT

>24854_24854_5_ECE1-HP1BP3_ECE1_chr1_21571481_ENST00000436918_HP1BP3_chr1_21097566_ENST00000312239_length(amino acids)=813AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIF
YPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKACFQKSGASVVAIRKYIIHK
YPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSL
IRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLE
NHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKK
TPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ECE1-HP1BP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ECE1-HP1BP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ECE1-HP1BP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source